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The map label for this gene is cpxA [H]

Identifier: 220905532

GI number: 220905532

Start: 2733888

End: 2735327

Strand: Reverse

Name: cpxA [H]

Synonym: Ddes_2271

Alternate gene names: 220905532

Gene position: 2735327-2733888 (Counterclockwise)

Preceding gene: 220905533

Following gene: 220905530

Centisome position: 95.19

GC content: 59.65

Gene sequence:

>1440_bases
ATGAATACCGACCGCCATCTGCCCCAAAGCCTGTTTTCACGGTTGAGCCTTTTTTTGCTCGGGGCTTTTTTTATCCTGCA
CACCGTGACCATCCTGACCGTGGCCGACTTTTTTGAACGCCATATGGTGCAGAATATGCTGGCGAACCACAGCGCCACCA
TAGCCCTGTGTGTCCGCATGTTTGAAGCGGAACCCGCGCAGAGCAGGCCTGCGCTCATGAGCGGTCTGGCGCGGTTTTCA
GATGTGCGTGTGAAAATGCTGGATGAAAAACCCGACATGCCGCAGGGAACCGATACGCTTTCGCGCTTTTTTCTGGAGCA
TATCCGTGAGGCGCTGGACGATCTGGCCGCGCCCGGCCAGCAGCCGCGGGCCATGCAGGCTCAGGTGCGGGTGATCATAC
TCGGCAAAGAGGCCGGGCAATGGGCTTCGCTTTTTGAAAGATTTTTTTCCTTGTGGGACGTGTCCGGCTCGTTCGACGCC
CGCCTGACCATAGAGCTTGCCGATGGTTCCTGGCTGGGCATCAGTTACGACGGCCCCGCCCACCGCGCCCATCTTGAAGA
CATGCCTTTCGTGGTGCTTGGCCTGGAATTCATTGTTTTTGCGGCCTTGCTGCTGCTCATTGTGTACAGGCTGGTGCGCC
CTCTGCGCACCCTGGCGCGGGCCGCGGAAAAATTCGGCTCTTCACAACGCCTGCCCCACATGGTCCCCGACGAAGGCCCC
AGTGAAGTGCGTCACGCGGCACAGGCATTTAACGCCATGCAAAAGCGTATCAGCGGCATCATGGAAGAACGGGAACGGGT
TTTTGCAGCCCTGTCGCATGACTTGCGCACGCCGCTCACCCGCATGCGTTTGCGGCTTGAAAGCACGCCACCCGGGACGT
TCCGGCAGAAAATGCTTGAAGATGTGCAGAGCCTGCATTCCACCGTGGAAATGGGTACGGCCATGACCCAGTGCCGCAGA
CACACGGAGGATCGCGTCAAGGTAGACATGCAGGCCTTTCTTGAGTCCATTGTGGAGGATCGCCGCGAAATGGGGCAGGA
TGTAACGCTGGCCGGTCCGGAGCTTGAGCTGCTGGCCCTTGTCTATCCCGTGGCCCTGCGGCGCTGCCTGGACAATCTGC
TGGATAATGCCCTGCGCTATGGGCGGGAGGCTGTTCTTTCCGCTTCAGTGCAGACGCTGCCCGGCAGAAAAAGCGTGCTG
CGCGTGGATATTGACGACAAGGGGCCGGGCATGGACCCGGCCTTGCTCGAAAAGGTTTTTGAACCGTTTTTTCGTGTGGA
AGGTTCGCGTAACAGGCATACGGGCGGTCATGGCCTTGGGCTTTCCATTGCCCGCAGCATGGCGGGCCTGCATGAGGCCG
CGCTGTTTCTTGAAAATCTGCCCCAGGGCGGTCTCAGGGCGCGGCTGGAGTTGCCGCTGATGGATGAACGCCGCGCCTGA

Upstream 100 bases:

>100_bases
GTACCCGCCTGCATGACAAGGGCGGTGAAAAGACTGCGCTCATAAAGACTGTGCGCGGCGACGGCTATATCTGGACGGCG
GATGTGCGCCGGGAAAACGC

Downstream 100 bases:

>100_bases
GACCACAAGGCCCGCCACTGGCGGAAAGACGTTTTGGGCGAACGAGGTGCGCTGGGCGTCCGGCAGTCTTGACGGGGCGA
ACCGCCCGCCCGGCGGGAAC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MNTDRHLPQSLFSRLSLFLLGAFFILHTVTILTVADFFERHMVQNMLANHSATIALCVRMFEAEPAQSRPALMSGLARFS
DVRVKMLDEKPDMPQGTDTLSRFFLEHIREALDDLAAPGQQPRAMQAQVRVIILGKEAGQWASLFERFFSLWDVSGSFDA
RLTIELADGSWLGISYDGPAHRAHLEDMPFVVLGLEFIVFAALLLLIVYRLVRPLRTLARAAEKFGSSQRLPHMVPDEGP
SEVRHAAQAFNAMQKRISGIMEERERVFAALSHDLRTPLTRMRLRLESTPPGTFRQKMLEDVQSLHSTVEMGTAMTQCRR
HTEDRVKVDMQAFLESIVEDRREMGQDVTLAGPELELLALVYPVALRRCLDNLLDNALRYGREAVLSASVQTLPGRKSVL
RVDIDDKGPGMDPALLEKVFEPFFRVEGSRNRHTGGHGLGLSIARSMAGLHEAALFLENLPQGGLRARLELPLMDERRA

Sequences:

>Translated_479_residues
MNTDRHLPQSLFSRLSLFLLGAFFILHTVTILTVADFFERHMVQNMLANHSATIALCVRMFEAEPAQSRPALMSGLARFS
DVRVKMLDEKPDMPQGTDTLSRFFLEHIREALDDLAAPGQQPRAMQAQVRVIILGKEAGQWASLFERFFSLWDVSGSFDA
RLTIELADGSWLGISYDGPAHRAHLEDMPFVVLGLEFIVFAALLLLIVYRLVRPLRTLARAAEKFGSSQRLPHMVPDEGP
SEVRHAAQAFNAMQKRISGIMEERERVFAALSHDLRTPLTRMRLRLESTPPGTFRQKMLEDVQSLHSTVEMGTAMTQCRR
HTEDRVKVDMQAFLESIVEDRREMGQDVTLAGPELELLALVYPVALRRCLDNLLDNALRYGREAVLSASVQTLPGRKSVL
RVDIDDKGPGMDPALLEKVFEPFFRVEGSRNRHTGGHGLGLSIARSMAGLHEAALFLENLPQGGLRARLELPLMDERRA
>Mature_479_residues
MNTDRHLPQSLFSRLSLFLLGAFFILHTVTILTVADFFERHMVQNMLANHSATIALCVRMFEAEPAQSRPALMSGLARFS
DVRVKMLDEKPDMPQGTDTLSRFFLEHIREALDDLAAPGQQPRAMQAQVRVIILGKEAGQWASLFERFFSLWDVSGSFDA
RLTIELADGSWLGISYDGPAHRAHLEDMPFVVLGLEFIVFAALLLLIVYRLVRPLRTLARAAEKFGSSQRLPHMVPDEGP
SEVRHAAQAFNAMQKRISGIMEERERVFAALSHDLRTPLTRMRLRLESTPPGTFRQKMLEDVQSLHSTVEMGTAMTQCRR
HTEDRVKVDMQAFLESIVEDRREMGQDVTLAGPELELLALVYPVALRRCLDNLLDNALRYGREAVLSASVQTLPGRKSVL
RVDIDDKGPGMDPALLEKVFEPFFRVEGSRNRHTGGHGLGLSIARSMAGLHEAALFLENLPQGGLRARLELPLMDERRA

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=29.520295202952, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787894, Length=296, Percent_Identity=31.0810810810811, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1789808, Length=264, Percent_Identity=30.3030303030303, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786783, Length=282, Percent_Identity=27.3049645390071, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788393, Length=287, Percent_Identity=29.2682926829268, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082128, Length=295, Percent_Identity=27.1186440677966, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790861, Length=296, Percent_Identity=27.3648648648649, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1789403, Length=309, Percent_Identity=26.2135922330097, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=239, Percent_Identity=28.4518828451883, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=28.3783783783784, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790551, Length=298, Percent_Identity=26.510067114094, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=111, Percent_Identity=36.9369369369369, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=273, Percent_Identity=24.1758241758242, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53857; Mature: 53857

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDRHLPQSLFSRLSLFLLGAFFILHTVTILTVADFFERHMVQNMLANHSATIALCVRM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
FEAEPAQSRPALMSGLARFSDVRVKMLDEKPDMPQGTDTLSRFFLEHIREALDDLAAPGQ
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
QPRAMQAQVRVIILGKEAGQWASLFERFFSLWDVSGSFDARLTIELADGSWLGISYDGPA
CCCHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCH
HRAHLEDMPFVVLGLEFIVFAALLLLIVYRLVRPLRTLARAAEKFGSSQRLPHMVPDEGP
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
SEVRHAAQAFNAMQKRISGIMEERERVFAALSHDLRTPLTRMRLRLESTPPGTFRQKMLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHH
DVQSLHSTVEMGTAMTQCRRHTEDRVKVDMQAFLESIVEDRREMGQDVTLAGPELELLAL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHH
VYPVALRRCLDNLLDNALRYGREAVLSASVQTLPGRKSVLRVDIDDKGPGMDPALLEKVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHH
EPFFRVEGSRNRHTGGHGLGLSIARSMAGLHEAALFLENLPQGGLRARLELPLMDERRA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MNTDRHLPQSLFSRLSLFLLGAFFILHTVTILTVADFFERHMVQNMLANHSATIALCVRM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
FEAEPAQSRPALMSGLARFSDVRVKMLDEKPDMPQGTDTLSRFFLEHIREALDDLAAPGQ
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
QPRAMQAQVRVIILGKEAGQWASLFERFFSLWDVSGSFDARLTIELADGSWLGISYDGPA
CCCHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCH
HRAHLEDMPFVVLGLEFIVFAALLLLIVYRLVRPLRTLARAAEKFGSSQRLPHMVPDEGP
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
SEVRHAAQAFNAMQKRISGIMEERERVFAALSHDLRTPLTRMRLRLESTPPGTFRQKMLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHH
DVQSLHSTVEMGTAMTQCRRHTEDRVKVDMQAFLESIVEDRREMGQDVTLAGPELELLAL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHH
VYPVALRRCLDNLLDNALRYGREAVLSASVQTLPGRKSVLRVDIDDKGPGMDPALLEKVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHH
EPFFRVEGSRNRHTGGHGLGLSIARSMAGLHEAALFLENLPQGGLRARLELPLMDERRA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]