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The map label for this gene is ribBA [H]

Identifier: 220905398

GI number: 220905398

Start: 2573037

End: 2574251

Strand: Reverse

Name: ribBA [H]

Synonym: Ddes_2136

Alternate gene names: 220905398

Gene position: 2574251-2573037 (Counterclockwise)

Preceding gene: 220905399

Following gene: 220905397

Centisome position: 89.59

GC content: 59.01

Gene sequence:

>1215_bases
ATGCCATTGTGCAGCATTGAGGAAGCCGTTGCCGATATCAAACAGGGCAAAATGGTCATTCTTGTGGACGACGAAGGCCG
GGAGAATGAAGGCGACCTGACCATGGCCGCGGAATTTGTCACCCCCGAGGCCATCAACTTTATGGCTAAATACGGGCGGG
GCCTTATCTGCCTGCCTATGTCGCCGGAGATGATCGACCGGCTTGACCTGCCCCTTATGACGCAGCGCAACGGCTCGCGT
TTCGGCACCAACTTCACCATTTCCATTGAGGCCCGCGAGGGCGTTACCACGGGTATTTCCGCTGCGGACCGTGCCACCAC
CATTCTGGCCGCCGTTGGCGATGATGTGCGCCCCGATGACCTTGTGACGCCGGGGCATGTTTTTCCCCTGCGCGCCAAAG
CCGGGGGTGTACTTTCGCGCGCAGGGCAGACCGAAGGCGGCGTGGACCTGTCGAAACTGGCCGGGCTGAAGCCCGCCTCG
GTTATCTGCGAGATCATGCGGGATGACGGAACAATGGCCCGCATGCCCGATCTGGAAACTTTTGCTGAAGAGCACGGTCT
CAAGATTGTGGCCGTCAAGGATATCATCCGCCACCGCCTCAACCGGGGGCAGGTATCTGTGCGCAATGTGGCCAAGGCCC
ATCTGCCCACGAGGTTCGGTGATTTCACGGTATATGCCTATGAAAGCGAAACCGAGCAGGGTACGCATCTGGCTCTGGTC
AAGGGCGACCTCTCCGGGCCGGAGCCTGTGCTTGCCCGCGTACACAGCGAATGCCTCACGGGCGATGCCCTGGGATCGCT
GCGTTGCGATTGCGGTGGTCAACTCGGCGCGGCCCTGCGGCAGATAGAAAAAGAAGGGCGCGGCGCGCTGCTGTATATGC
GCCAGGAAGGACGCGGCATAGGCCTTGCCAATAAAATACGCGCCTATGCTCTTCAGGACGAAGGCTACGACACCGTAGAA
GCCAACCGCAAGCTGGGCTTTCCCCCGGATCTGCGGGATTACGGAACCGGCGCGCAGATGCTGGTTGACCTGGGCATACA
CAAGGTGCGTCTGCTGACCAACAATCCCAAAAAAATTGTGGGGCTTTCCGGTTACGGCATCGAAATTGTCGAAAGAGTGC
CCATTGAAATGGACGCCTGCCCTGAAAATGAGCACTACCTGCGCACCAAGAAAGAAAAAATGCAGCATATGCTGCACTGC
TCCTGCTGCCGTTAG

Upstream 100 bases:

>100_bases
GGGAGCTGCCGCGCTTGGTTGACAGAAGGCCGTCACGGTCCTACCTTACATAAATTATAATATTCACAGCCCGCGCCACG
GGCCAAACGAAGGAAGCATC

Downstream 100 bases:

>100_bases
GGGCTTCTTTTCCGGTTTTGCCATTGGGTATGCCGGACGATTCATTGCCGTCAGGCCAGGCAAGCGGCCTGGCGGCAGTA
AGTTGCGAGGGGGCTATGCC

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MPLCSIEEAVADIKQGKMVILVDDEGRENEGDLTMAAEFVTPEAINFMAKYGRGLICLPMSPEMIDRLDLPLMTQRNGSR
FGTNFTISIEAREGVTTGISAADRATTILAAVGDDVRPDDLVTPGHVFPLRAKAGGVLSRAGQTEGGVDLSKLAGLKPAS
VICEIMRDDGTMARMPDLETFAEEHGLKIVAVKDIIRHRLNRGQVSVRNVAKAHLPTRFGDFTVYAYESETEQGTHLALV
KGDLSGPEPVLARVHSECLTGDALGSLRCDCGGQLGAALRQIEKEGRGALLYMRQEGRGIGLANKIRAYALQDEGYDTVE
ANRKLGFPPDLRDYGTGAQMLVDLGIHKVRLLTNNPKKIVGLSGYGIEIVERVPIEMDACPENEHYLRTKKEKMQHMLHC
SCCR

Sequences:

>Translated_404_residues
MPLCSIEEAVADIKQGKMVILVDDEGRENEGDLTMAAEFVTPEAINFMAKYGRGLICLPMSPEMIDRLDLPLMTQRNGSR
FGTNFTISIEAREGVTTGISAADRATTILAAVGDDVRPDDLVTPGHVFPLRAKAGGVLSRAGQTEGGVDLSKLAGLKPAS
VICEIMRDDGTMARMPDLETFAEEHGLKIVAVKDIIRHRLNRGQVSVRNVAKAHLPTRFGDFTVYAYESETEQGTHLALV
KGDLSGPEPVLARVHSECLTGDALGSLRCDCGGQLGAALRQIEKEGRGALLYMRQEGRGIGLANKIRAYALQDEGYDTVE
ANRKLGFPPDLRDYGTGAQMLVDLGIHKVRLLTNNPKKIVGLSGYGIEIVERVPIEMDACPENEHYLRTKKEKMQHMLHC
SCCR
>Mature_403_residues
PLCSIEEAVADIKQGKMVILVDDEGRENEGDLTMAAEFVTPEAINFMAKYGRGLICLPMSPEMIDRLDLPLMTQRNGSRF
GTNFTISIEAREGVTTGISAADRATTILAAVGDDVRPDDLVTPGHVFPLRAKAGGVLSRAGQTEGGVDLSKLAGLKPASV
ICEIMRDDGTMARMPDLETFAEEHGLKIVAVKDIIRHRLNRGQVSVRNVAKAHLPTRFGDFTVYAYESETEQGTHLALVK
GDLSGPEPVLARVHSECLTGDALGSLRCDCGGQLGAALRQIEKEGRGALLYMRQEGRGIGLANKIRAYALQDEGYDTVEA
NRKLGFPPDLRDYGTGAQMLVDLGIHKVRLLTNNPKKIVGLSGYGIEIVERVPIEMDACPENEHYLRTKKEKMQHMLHCS
CCR

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=195, Percent_Identity=63.0769230769231, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=50, Blast_Score=215, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6320695, Length=203, Percent_Identity=43.8423645320197, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319438, Length=195, Percent_Identity=44.6153846153846, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44044; Mature: 43913

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLCSIEEAVADIKQGKMVILVDDEGRENEGDLTMAAEFVTPEAINFMAKYGRGLICLPM
CCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEECC
SPEMIDRLDLPLMTQRNGSRFGTNFTISIEAREGVTTGISAADRATTILAAVGDDVRPDD
CHHHHHHCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHEEEEECCCCCCCCC
LVTPGHVFPLRAKAGGVLSRAGQTEGGVDLSKLAGLKPASVICEIMRDDGTMARMPDLET
CCCCCCEEEEECCCCCHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCEECCCCHHH
FAEEHGLKIVAVKDIIRHRLNRGQVSVRNVAKAHLPTRFGDFTVYAYESETEQGTHLALV
HHHHHCEEEEEHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEE
KGDLSGPEPVLARVHSECLTGDALGSLRCDCGGQLGAALRQIEKEGRGALLYMRQEGRGI
ECCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCC
GLANKIRAYALQDEGYDTVEANRKLGFPPDLRDYGTGAQMLVDLGIHKVRLLTNNPKKIV
CCHHHEEEEEECCCCCCCHHCCCCCCCCCCHHHHCCCHHHHHHHCCEEEEEEECCCCEEE
GLSGYGIEIVERVPIEMDACPENEHYLRTKKEKMQHMLHCSCCR
EECCCCEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PLCSIEEAVADIKQGKMVILVDDEGRENEGDLTMAAEFVTPEAINFMAKYGRGLICLPM
CCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEECC
SPEMIDRLDLPLMTQRNGSRFGTNFTISIEAREGVTTGISAADRATTILAAVGDDVRPDD
CHHHHHHCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHEEEEECCCCCCCCC
LVTPGHVFPLRAKAGGVLSRAGQTEGGVDLSKLAGLKPASVICEIMRDDGTMARMPDLET
CCCCCCEEEEECCCCCHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCEECCCCHHH
FAEEHGLKIVAVKDIIRHRLNRGQVSVRNVAKAHLPTRFGDFTVYAYESETEQGTHLALV
HHHHHCEEEEEHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEE
KGDLSGPEPVLARVHSECLTGDALGSLRCDCGGQLGAALRQIEKEGRGALLYMRQEGRGI
ECCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCC
GLANKIRAYALQDEGYDTVEANRKLGFPPDLRDYGTGAQMLVDLGIHKVRLLTNNPKKIV
CCHHHEEEEEECCCCCCCHHCCCCCCCCCCHHHHCCCHHHHHHHCCEEEEEEECCCCEEE
GLSGYGIEIVERVPIEMDACPENEHYLRTKKEKMQHMLHCSCCR
EECCCCEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA