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The map label for this gene is ilvD [H]

Identifier: 220905372

GI number: 220905372

Start: 2541816

End: 2543498

Strand: Reverse

Name: ilvD [H]

Synonym: Ddes_2110

Alternate gene names: 220905372

Gene position: 2543498-2541816 (Counterclockwise)

Preceding gene: 220905374

Following gene: 220905371

Centisome position: 88.52

GC content: 61.2

Gene sequence:

>1683_bases
ATGGATGAGAGCCGCAGCAAAAAAATGAAGTCCGGCCTTGAAAAAGCCCCTCACCGTTCCCTGCTTTATGCACTCGGCTT
GACCAGGGAAGAAATGGACCGCCCGCTGGTAGGTGTGGTCAACGCAGCCAGCGAGGTTGTGCCGGGCCATCTACATCTTA
ATGCTCTGGCCGACGCGGTAAAAGCCGGGGTGCGCATGGCTGGCGGCACTCCCTTGCAGTTCCCGGCCATTGCCGTTTGC
GACGGCCTGGCCATGAATCATGAAGGCATGCGTTTTTCACTGCCCTCGCGCGAATTTATTGCTGATTCTGTAGAAATTAT
GGCGCGCGGTCACGCTTTTGACGCCCTGGTTTTCATACCCAACTGCGATAAATGCGTGCCCGGTATGCTGATGGCCATGA
TGCGCCTGAATATCCCTTCGGTCATGGTTTCCGGCGGTCCCATGCTGCCCGGCAATATCGGCCCGCGCGAGCGCGGCGAC
CTTATCACGGTCTTTGAGGCCGTGGGCAAGGTGCGCAGCGGCGTCATGAGTGAAGAAGAACTGGAATACATGGCCGAGCG
CGCCTGCCCCGGCTGTGGCGCATGTGCGGGCATGTTTACCGCCAACTCCATGAATTGTCTGGCAGAAACCATAGGCGTGG
CCCTGCCCGGCAACGGCACCATCCCCGCCGTAAGCGGGGCGCGCATCCGCCTGGCAAAGACGGCGGGCATGCGCGTTATG
GACCTGCTCAAGCGCAATATCCGTCCGCTGGACATCGTGACCCCCAAGGCGGTAGCCAATGCCGTTGCCGTGGACATGGC
CCTGGGCTGCTCCACCAACACGGTGCTGCACCTGCCCGCAGTGTTTGGCGAGGCCGGGCTTGATCTCGGTCTGGACATCT
TTGACGAGGTGAGCCGCAAAAGCCCCAACCTGTGCAAGCTTTCCCCTGCGGGCCATCACTACATGGTCGACCTCGACAAT
GCCGGCGGCATTCCCGCTGTCATGACCGAACTGGACAAGCTGAACCTGATCAACAAGGACTGTATGACCGTTACCGGGCG
TACCGTGGGCGAAAACCTGAGCGATATGAACGCCCGTGTGCTGGACGGAGACGTCATCCGTAGCGTGGACAATCCCTATT
CCCGACAGGGCGGCATAGCCATACTGCGCGGCAGCCTCGCCCCCGGCGGCGCTGTGGTCAAGCAGTCGGCCGTGGCCCCG
GAAATGATGTGCCGCGATGTGCGGGCGCGGGTTTTTGAATCTGAAGAAGAAGCCATGGCTGCCATTCTGGACGGCAAGAT
CAAGCCTGGCGATGGCGTGGTTATCCGCTACGAAGGGCCGAGAGGCGGTCCCGGCATGCGTGAAATGCTTTCGCCGACTT
CGGCCATCACGGGCATGGGCCTCGGCAAAGACGTGGCCCTGCTGACCGACGGTCGTTTTTCAGGCGGAACAAACGGCGCG
GCCATCGGGCATATTTCGCCCGAAGCGGCGGACGGTGGCATTATCGGCCTTGTGCAGGAGGGCGATATGATCCATATCGA
CATTCCCGGCCGCAAGCTTGACCTGATGGTGGACGCAGCCGAACTGGAGCGCCGTCGCGCGGTCCACAAGCCGGTGGAAA
AACGCAGCCCGTATTCCGTGCTGCGGCGCTATGCGCATCTGGTCAGCTCCGCAGCCAACGGCGGACGCTACAGGGATATC
TAA

Upstream 100 bases:

>100_bases
CGTGTATTTACGCACACAGTCTTTTGCCGTACCATAAAAAAGTTGCCCGCGCCGTGCATGGCTGCGGGAAAACCCGCTAT
TATAACGTAAGGATGCCGCC

Downstream 100 bases:

>100_bases
AGCCGTTTGTCTTACAAATGTTCTCGTGTGTTTTTATTGGGCCGCCTGCGAGGCGGCCCTTCTGCATCCCCCCAAGAATT
TTTAATTACCATGTGGCGTA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MDESRSKKMKSGLEKAPHRSLLYALGLTREEMDRPLVGVVNAASEVVPGHLHLNALADAVKAGVRMAGGTPLQFPAIAVC
DGLAMNHEGMRFSLPSREFIADSVEIMARGHAFDALVFIPNCDKCVPGMLMAMMRLNIPSVMVSGGPMLPGNIGPRERGD
LITVFEAVGKVRSGVMSEEELEYMAERACPGCGACAGMFTANSMNCLAETIGVALPGNGTIPAVSGARIRLAKTAGMRVM
DLLKRNIRPLDIVTPKAVANAVAVDMALGCSTNTVLHLPAVFGEAGLDLGLDIFDEVSRKSPNLCKLSPAGHHYMVDLDN
AGGIPAVMTELDKLNLINKDCMTVTGRTVGENLSDMNARVLDGDVIRSVDNPYSRQGGIAILRGSLAPGGAVVKQSAVAP
EMMCRDVRARVFESEEEAMAAILDGKIKPGDGVVIRYEGPRGGPGMREMLSPTSAITGMGLGKDVALLTDGRFSGGTNGA
AIGHISPEAADGGIIGLVQEGDMIHIDIPGRKLDLMVDAAELERRRAVHKPVEKRSPYSVLRRYAHLVSSAANGGRYRDI

Sequences:

>Translated_560_residues
MDESRSKKMKSGLEKAPHRSLLYALGLTREEMDRPLVGVVNAASEVVPGHLHLNALADAVKAGVRMAGGTPLQFPAIAVC
DGLAMNHEGMRFSLPSREFIADSVEIMARGHAFDALVFIPNCDKCVPGMLMAMMRLNIPSVMVSGGPMLPGNIGPRERGD
LITVFEAVGKVRSGVMSEEELEYMAERACPGCGACAGMFTANSMNCLAETIGVALPGNGTIPAVSGARIRLAKTAGMRVM
DLLKRNIRPLDIVTPKAVANAVAVDMALGCSTNTVLHLPAVFGEAGLDLGLDIFDEVSRKSPNLCKLSPAGHHYMVDLDN
AGGIPAVMTELDKLNLINKDCMTVTGRTVGENLSDMNARVLDGDVIRSVDNPYSRQGGIAILRGSLAPGGAVVKQSAVAP
EMMCRDVRARVFESEEEAMAAILDGKIKPGDGVVIRYEGPRGGPGMREMLSPTSAITGMGLGKDVALLTDGRFSGGTNGA
AIGHISPEAADGGIIGLVQEGDMIHIDIPGRKLDLMVDAAELERRRAVHKPVEKRSPYSVLRRYAHLVSSAANGGRYRDI
>Mature_560_residues
MDESRSKKMKSGLEKAPHRSLLYALGLTREEMDRPLVGVVNAASEVVPGHLHLNALADAVKAGVRMAGGTPLQFPAIAVC
DGLAMNHEGMRFSLPSREFIADSVEIMARGHAFDALVFIPNCDKCVPGMLMAMMRLNIPSVMVSGGPMLPGNIGPRERGD
LITVFEAVGKVRSGVMSEEELEYMAERACPGCGACAGMFTANSMNCLAETIGVALPGNGTIPAVSGARIRLAKTAGMRVM
DLLKRNIRPLDIVTPKAVANAVAVDMALGCSTNTVLHLPAVFGEAGLDLGLDIFDEVSRKSPNLCKLSPAGHHYMVDLDN
AGGIPAVMTELDKLNLINKDCMTVTGRTVGENLSDMNARVLDGDVIRSVDNPYSRQGGIAILRGSLAPGGAVVKQSAVAP
EMMCRDVRARVFESEEEAMAAILDGKIKPGDGVVIRYEGPRGGPGMREMLSPTSAITGMGLGKDVALLTDGRFSGGTNGA
AIGHISPEAADGGIIGLVQEGDMIHIDIPGRKLDLMVDAAELERRRAVHKPVEKRSPYSVLRRYAHLVSSAANGGRYRDI

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=43.1147540983607, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1786464, Length=496, Percent_Identity=33.2661290322581, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI2367371, Length=497, Percent_Identity=32.9979879275654, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1788157, Length=493, Percent_Identity=33.6713995943205, Blast_Score=210, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6322476, Length=543, Percent_Identity=43.0939226519337, Blast_Score=413, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59268; Mature: 59268

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDESRSKKMKSGLEKAPHRSLLYALGLTREEMDRPLVGVVNAASEVVPGHLHLNALADAV
CCCHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCEEHHHHHHHHCCCCEEHHHHHHHH
KAGVRMAGGTPLQFPAIAVCDGLAMNHEGMRFSLPSREFIADSVEIMARGHAFDALVFIP
HHCCEECCCCCCCCCHHHHHCCCEECCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEECC
NCDKCVPGMLMAMMRLNIPSVMVSGGPMLPGNIGPRERGDLITVFEAVGKVRSGVMSEEE
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCHHH
LEYMAERACPGCGACAGMFTANSMNCLAETIGVALPGNGTIPAVSGARIRLAKTAGMRVM
HHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHCEEECCCCCCCCCCCCEEEEEHHCCHHHH
DLLKRNIRPLDIVTPKAVANAVAVDMALGCSTNTVLHLPAVFGEAGLDLGLDIFDEVSRK
HHHHHCCCCEEEECHHHHHHHHHHHHHCCCCCCCEEEEHHHHCCCCCCCCHHHHHHHHCC
SPNLCKLSPAGHHYMVDLDNAGGIPAVMTELDKLNLINKDCMTVTGRTVGENLSDMNARV
CCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEECCCHHCCCHHHCCCEE
LDGDVIRSVDNPYSRQGGIAILRGSLAPGGAVVKQSAVAPEMMCRDVRARVFESEEEAMA
ECCHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCHHHHHH
AILDGKIKPGDGVVIRYEGPRGGPGMREMLSPTSAITGMGLGKDVALLTDGRFSGGTNGA
HHHCCCCCCCCCEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCE
AIGHISPEAADGGIIGLVQEGDMIHIDIPGRKLDLMVDAAELERRRAVHKPVEKRSPYSV
EEECCCCCCCCCCEEEEEECCCEEEEECCCCEEEEEEEHHHHHHHHHHHCCHHCCCCHHH
LRRYAHLVSSAANGGRYRDI
HHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDESRSKKMKSGLEKAPHRSLLYALGLTREEMDRPLVGVVNAASEVVPGHLHLNALADAV
CCCHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCEEHHHHHHHHCCCCEEHHHHHHHH
KAGVRMAGGTPLQFPAIAVCDGLAMNHEGMRFSLPSREFIADSVEIMARGHAFDALVFIP
HHCCEECCCCCCCCCHHHHHCCCEECCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEECC
NCDKCVPGMLMAMMRLNIPSVMVSGGPMLPGNIGPRERGDLITVFEAVGKVRSGVMSEEE
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCHHH
LEYMAERACPGCGACAGMFTANSMNCLAETIGVALPGNGTIPAVSGARIRLAKTAGMRVM
HHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHCEEECCCCCCCCCCCCEEEEEHHCCHHHH
DLLKRNIRPLDIVTPKAVANAVAVDMALGCSTNTVLHLPAVFGEAGLDLGLDIFDEVSRK
HHHHHCCCCEEEECHHHHHHHHHHHHHCCCCCCCEEEEHHHHCCCCCCCCHHHHHHHHCC
SPNLCKLSPAGHHYMVDLDNAGGIPAVMTELDKLNLINKDCMTVTGRTVGENLSDMNARV
CCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEECCCHHCCCHHHCCCEE
LDGDVIRSVDNPYSRQGGIAILRGSLAPGGAVVKQSAVAPEMMCRDVRARVFESEEEAMA
ECCHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCHHHHHH
AILDGKIKPGDGVVIRYEGPRGGPGMREMLSPTSAITGMGLGKDVALLTDGRFSGGTNGA
HHHCCCCCCCCCEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCE
AIGHISPEAADGGIIGLVQEGDMIHIDIPGRKLDLMVDAAELERRRAVHKPVEKRSPYSV
EEECCCCCCCCCCEEEEEECCCEEEEECCCCEEEEEEEHHHHHHHHHHHCCHHCCCCHHH
LRRYAHLVSSAANGGRYRDI
HHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA