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The map label for this gene is htpX [H]

Identifier: 220905316

GI number: 220905316

Start: 2468730

End: 2469590

Strand: Reverse

Name: htpX [H]

Synonym: Ddes_2054

Alternate gene names: 220905316

Gene position: 2469590-2468730 (Counterclockwise)

Preceding gene: 220905317

Following gene: 220905315

Centisome position: 85.95

GC content: 60.86

Gene sequence:

>861_bases
ATGACCAGCCAGATCAAGACCGTTCTTCTTCTGGGTTTGCTTTCGGGGATCATCATTGTGCTTGGCGGCCTGCTGGGCGG
GCGCACGGGCATCATCATCGCTTTTGGCATGGCCCTGATCATGAACGTGGGCAGTTACTGGTACTCGGACAAGATCGTGC
TATCCATGTACCGTGCGCGTGAACTCGCGCCGGAGGAAGCCCCATACCTGCACAGGATCGTCGAAGAGCTGTCGCACAAT
GCGGGCATTCCCAAGCCCCGCGTCTGCGTGGTTCCCGAAGAGGCCCCCAATGCTTTCGCCACGGGGCGTAATCCTGAAAA
TGCCGTGGTTGCCGTTACAGAAGGGCTTATGCGCCTGTTGCCGCCCGAAGAGCTGCGCGGCGTGGTAGCGCATGAAATCG
GGCATATCGTCAACCGCGACATACTTATCCAGACCATTGCCGGGGTGATGGCTTCCGCCATTGTGACCATGGCGAATATT
TTTCAGTTTACGGCCATTTTCGGCGGCAACCGCGACAGCGAGGGTAACGGCGTCAACCCCATCGCGGCGCTGGTGATGGC
CCTGCTGGCCCCTATGGCTGCAGGTCTGGTGCAGATGGCCATTTCGCGCTCGCGCGAATATCTGGCCGACGATACCGGGG
CGGAGCTTTGCGGGCAGCCCCTGGCCCTGGCAGGCGCCCTTGCCAAACTGGGCGCGGCCAGCGGGCGCATACCCATGCGT
GAAGGCAATCCCAGCACCGAGCAGATGTTCATTGTGTCCCCCATGTTTGCCCATGGCAGCATGGCCAATCTTTTCAGCAC
ACATCCGCCCCTGGAAGAGCGTATCCGCAGGCTTCAGGCCATGGCTGCTTCCCGGCGCTGA

Upstream 100 bases:

>100_bases
GCTTATATGCTGTCAGGGCGTTTCAGCGCGCGGCATGAGGATTTTCCGGCAATACACCGTGAAACGCGTTTGTATAATTT
CCGCAAGGTGAGGAGTTTGC

Downstream 100 bases:

>100_bases
CAGTCCGTCCAAAGGCGGCATATAACCGGGCGCGAGCGCCCGTCATACTGAGGTAGACAATGCAAGCACGCCTTTTGCTG
GTTACACTGTTGGCCCTGCC

Product: peptidase M48 Ste24p

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTSQIKTVLLLGLLSGIIIVLGGLLGGRTGIIIAFGMALIMNVGSYWYSDKIVLSMYRARELAPEEAPYLHRIVEELSHN
AGIPKPRVCVVPEEAPNAFATGRNPENAVVAVTEGLMRLLPPEELRGVVAHEIGHIVNRDILIQTIAGVMASAIVTMANI
FQFTAIFGGNRDSEGNGVNPIAALVMALLAPMAAGLVQMAISRSREYLADDTGAELCGQPLALAGALAKLGAASGRIPMR
EGNPSTEQMFIVSPMFAHGSMANLFSTHPPLEERIRRLQAMAASRR

Sequences:

>Translated_286_residues
MTSQIKTVLLLGLLSGIIIVLGGLLGGRTGIIIAFGMALIMNVGSYWYSDKIVLSMYRARELAPEEAPYLHRIVEELSHN
AGIPKPRVCVVPEEAPNAFATGRNPENAVVAVTEGLMRLLPPEELRGVVAHEIGHIVNRDILIQTIAGVMASAIVTMANI
FQFTAIFGGNRDSEGNGVNPIAALVMALLAPMAAGLVQMAISRSREYLADDTGAELCGQPLALAGALAKLGAASGRIPMR
EGNPSTEQMFIVSPMFAHGSMANLFSTHPPLEERIRRLQAMAASRR
>Mature_285_residues
TSQIKTVLLLGLLSGIIIVLGGLLGGRTGIIIAFGMALIMNVGSYWYSDKIVLSMYRARELAPEEAPYLHRIVEELSHNA
GIPKPRVCVVPEEAPNAFATGRNPENAVVAVTEGLMRLLPPEELRGVVAHEIGHIVNRDILIQTIAGVMASAIVTMANIF
QFTAIFGGNRDSEGNGVNPIAALVMALLAPMAAGLVQMAISRSREYLADDTGAELCGQPLALAGALAKLGAASGRIPMRE
GNPSTEQMFIVSPMFAHGSMANLFSTHPPLEERIRRLQAMAASRR

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=224, Percent_Identity=34.8214285714286, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.-

Molecular weight: Translated: 30503; Mature: 30372

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQIKTVLLLGLLSGIIIVLGGLLGGRTGIIIAFGMALIMNVGSYWYSDKIVLSMYRAR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ELAPEEAPYLHRIVEELSHNAGIPKPRVCVVPEEAPNAFATGRNPENAVVAVTEGLMRLL
HCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
PPEELRGVVAHEIGHIVNRDILIQTIAGVMASAIVTMANIFQFTAIFGGNRDSEGNGVNP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
IAALVMALLAPMAAGLVQMAISRSREYLADDTGAELCGQPLALAGALAKLGAASGRIPMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCC
EGNPSTEQMFIVSPMFAHGSMANLFSTHPPLEERIRRLQAMAASRR
CCCCCCCEEEEECCHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSQIKTVLLLGLLSGIIIVLGGLLGGRTGIIIAFGMALIMNVGSYWYSDKIVLSMYRAR
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ELAPEEAPYLHRIVEELSHNAGIPKPRVCVVPEEAPNAFATGRNPENAVVAVTEGLMRLL
HCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
PPEELRGVVAHEIGHIVNRDILIQTIAGVMASAIVTMANIFQFTAIFGGNRDSEGNGVNP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
IAALVMALLAPMAAGLVQMAISRSREYLADDTGAELCGQPLALAGALAKLGAASGRIPMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCC
EGNPSTEQMFIVSPMFAHGSMANLFSTHPPLEERIRRLQAMAASRR
CCCCCCCEEEEECCHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA