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The map label for this gene is msrAB [H]

Identifier: 220905211

GI number: 220905211

Start: 2349528

End: 2350583

Strand: Reverse

Name: msrAB [H]

Synonym: Ddes_1949

Alternate gene names: 220905211

Gene position: 2350583-2349528 (Counterclockwise)

Preceding gene: 220905212

Following gene: 220905208

Centisome position: 81.8

GC content: 61.84

Gene sequence:

>1056_bases
ATGAGCCAACGTGTCTTTTTTCTGATTCTGACCGCATGGCTGCTCTGCGGCGCTTTTGTCCCGGCCGCAGCGGATTGCGC
CGCTGCCGGGCCAGTTGATGCAGCTTTACCGGAGACTGCCATGAAACCATCTTTTCCCATGCCGCCCCTTTCCGGGCCGG
AAGCGGACATTATTTTGCGTAAAGCCACGGAAGCCCCGTATTCCGGGCAATATACCAACAAACGCGAAGCCGGGACCTAT
GTGTGCCGCCAGTGCGGCACGCCTCTTTACAGCTCGCGCGACAAGTTTGAATCCGGCTGCGGCTGGCCCAGCTTTGACGA
CGAACTGCCCGGTGCGGTGCGCCGCCAGCCCGATGCGGACGGCAGAAGGGTGGAAATTGTCTGTGCAAACTGCGGCGGGC
ATCTGGGGCATGTTTTTGCGGGCGAGGGTTTCACCGCCAAGAATACCCGGCATTGCGTCAACTCGCTGTCCATGTCCTTT
TATCCGGCAGGCAGCCCGGAAGAGGCGCAGGCGCTGGCCCGGTCCTCCCCGCAGGGTTGTACGGCCACCGCCATCGTGGC
CGGAGGATGTTTTTGGGGAGTGGAAGATGCTTTCAGAAAGATGCCGGGCGTATGCGCCGCTGTTTCCGGCTATACCGGAG
GCCGTACGCCGGACCCGACCTATGAGGCCGTGTGCGGCGGCAATACCGGACACGCCGAGGCAGTGCGCGTGAGCTTTGAC
CCGTCTGTGGTCAGCTACGAGCAGATTTTGCGCCGTTTTTTTGAAATCCACGATCCCACGCAGCTTGATCGCCAGGGACC
GGACGTGGGCGATCAGTACCGCTCGGCTGTATTTTTTCTTGATGCGGAGCAGGAAGCCGTGGCGCGCAGCCTTATGAGCC
GCCTGCGCGAACTGGGATACGATGTGGTGACACGGCTTGAACCGGCCGGGCCGTTTTACATGGCCGAAGAGTATCATCAG
CGTTTTGCAGAACGCACGGGGCGGGGACGCTGCCACATGCCCGTACCGCGCTTTGACATACCCGCCGGGGGCGGCGGTGG
CGCGTTGCGGAAGTGA

Upstream 100 bases:

>100_bases
GAGTGTCGCCCGCACGGCCCGGCCTGCATGCTGTCGGATGCGGCAAGGCATTGACCGTAAACGCAGAGGCCTTATTTATA
GAAAGAACTGAGAGGCAATT

Downstream 100 bases:

>100_bases
AAACAGTACGGCGGGCCGCAGTGCGGCCAGCCGTATATCTGAACAGAGCTTTGCCGGGGGATTCTTACAGTGCGCTGGCG
GCTGCGGGGGAGAGGCGCAC

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSQRVFFLILTAWLLCGAFVPAAADCAAAGPVDAALPETAMKPSFPMPPLSGPEADIILRKATEAPYSGQYTNKREAGTY
VCRQCGTPLYSSRDKFESGCGWPSFDDELPGAVRRQPDADGRRVEIVCANCGGHLGHVFAGEGFTAKNTRHCVNSLSMSF
YPAGSPEEAQALARSSPQGCTATAIVAGGCFWGVEDAFRKMPGVCAAVSGYTGGRTPDPTYEAVCGGNTGHAEAVRVSFD
PSVVSYEQILRRFFEIHDPTQLDRQGPDVGDQYRSAVFFLDAEQEAVARSLMSRLRELGYDVVTRLEPAGPFYMAEEYHQ
RFAERTGRGRCHMPVPRFDIPAGGGGGALRK

Sequences:

>Translated_351_residues
MSQRVFFLILTAWLLCGAFVPAAADCAAAGPVDAALPETAMKPSFPMPPLSGPEADIILRKATEAPYSGQYTNKREAGTY
VCRQCGTPLYSSRDKFESGCGWPSFDDELPGAVRRQPDADGRRVEIVCANCGGHLGHVFAGEGFTAKNTRHCVNSLSMSF
YPAGSPEEAQALARSSPQGCTATAIVAGGCFWGVEDAFRKMPGVCAAVSGYTGGRTPDPTYEAVCGGNTGHAEAVRVSFD
PSVVSYEQILRRFFEIHDPTQLDRQGPDVGDQYRSAVFFLDAEQEAVARSLMSRLRELGYDVVTRLEPAGPFYMAEEYHQ
RFAERTGRGRCHMPVPRFDIPAGGGGGALRK
>Mature_350_residues
SQRVFFLILTAWLLCGAFVPAAADCAAAGPVDAALPETAMKPSFPMPPLSGPEADIILRKATEAPYSGQYTNKREAGTYV
CRQCGTPLYSSRDKFESGCGWPSFDDELPGAVRRQPDADGRRVEIVCANCGGHLGHVFAGEGFTAKNTRHCVNSLSMSFY
PAGSPEEAQALARSSPQGCTATAIVAGGCFWGVEDAFRKMPGVCAAVSGYTGGRTPDPTYEAVCGGNTGHAEAVRVSFDP
SVVSYEQILRRFFEIHDPTQLDRQGPDVGDQYRSAVFFLDAEQEAVARSLMSRLRELGYDVVTRLEPAGPFYMAEEYHQR
FAERTGRGRCHMPVPRFDIPAGGGGGALRK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=160, Percent_Identity=42.5, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI6912516, Length=160, Percent_Identity=42.5, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI301336164, Length=117, Percent_Identity=41.025641025641, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI301336162, Length=117, Percent_Identity=41.025641025641, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI73089054, Length=117, Percent_Identity=41.025641025641, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI37620216, Length=117, Percent_Identity=41.025641025641, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI117606353, Length=121, Percent_Identity=42.9752066115703, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI208609993, Length=141, Percent_Identity=39.0070921985816, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1790665, Length=184, Percent_Identity=46.7391304347826, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1788077, Length=125, Percent_Identity=36.8, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17533973, Length=139, Percent_Identity=33.0935251798561, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17553450, Length=102, Percent_Identity=39.2156862745098, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI115532676, Length=102, Percent_Identity=39.2156862745098, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319816, Length=117, Percent_Identity=50.4273504273504, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320881, Length=153, Percent_Identity=37.2549019607843, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221378664, Length=133, Percent_Identity=36.8421052631579, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI221378662, Length=127, Percent_Identity=37.7952755905512, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24645799, Length=126, Percent_Identity=41.2698412698413, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45553335, Length=139, Percent_Identity=38.1294964028777, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21356369, Length=139, Percent_Identity=38.1294964028777, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24645801, Length=137, Percent_Identity=37.956204379562, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24645804, Length=150, Percent_Identity=35.3333333333333, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24664627, Length=146, Percent_Identity=32.1917808219178, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24664631, Length=146, Percent_Identity=31.5068493150685, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=31.6546762589928, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 37843; Mature: 37712

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRVFFLILTAWLLCGAFVPAAADCAAAGPVDAALPETAMKPSFPMPPLSGPEADIILR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHCCCCCCCCCCCCCCHHEEEE
KATEAPYSGQYTNKREAGTYVCRQCGTPLYSSRDKFESGCGWPSFDDELPGAVRRQPDAD
ECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHCCCCCC
GRRVEIVCANCGGHLGHVFAGEGFTAKNTRHCVNSLSMSFYPAGSPEEAQALARSSPQGC
CCEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCC
TATAIVAGGCFWGVEDAFRKMPGVCAAVSGYTGGRTPDPTYEAVCGGNTGHAEAVRVSFD
EEEHEECCCHHHCHHHHHHHCCCCEEECCCCCCCCCCCCCHHHEECCCCCCCEEEEEECC
PSVVSYEQILRRFFEIHDPTQLDRQGPDVGDQYRSAVFFLDAEQEAVARSLMSRLRELGY
CCHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHCCEEEEEECHHHHHHHHHHHHHHHHCH
DVVTRLEPAGPFYMAEEYHQRFAERTGRGRCHMPVPRFDIPAGGGGGALRK
HHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQRVFFLILTAWLLCGAFVPAAADCAAAGPVDAALPETAMKPSFPMPPLSGPEADIILR
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHCCCCCCCCCCCCCCHHEEEE
KATEAPYSGQYTNKREAGTYVCRQCGTPLYSSRDKFESGCGWPSFDDELPGAVRRQPDAD
ECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHCCCCCC
GRRVEIVCANCGGHLGHVFAGEGFTAKNTRHCVNSLSMSFYPAGSPEEAQALARSSPQGC
CCEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCC
TATAIVAGGCFWGVEDAFRKMPGVCAAVSGYTGGRTPDPTYEAVCGGNTGHAEAVRVSFD
EEEHEECCCHHHCHHHHHHHCCCCEEECCCCCCCCCCCCCHHHEECCCCCCCEEEEEECC
PSVVSYEQILRRFFEIHDPTQLDRQGPDVGDQYRSAVFFLDAEQEAVARSLMSRLRELGY
CCHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHCCEEEEEECHHHHHHHHHHHHHHHHCH
DVVTRLEPAGPFYMAEEYHQRFAERTGRGRCHMPVPRFDIPAGGGGGALRK
HHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]