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The map label for this gene is polC [H]

Identifier: 220904848

GI number: 220904848

Start: 1902874

End: 1903404

Strand: Reverse

Name: polC [H]

Synonym: Ddes_1582

Alternate gene names: 220904848

Gene position: 1903404-1902874 (Counterclockwise)

Preceding gene: 220904849

Following gene: 220904846

Centisome position: 66.24

GC content: 57.25

Gene sequence:

>531_bases
TTGTCTGACGTTTCCGCCCCGTCCTGCGTGGCCATAGATTTTGAAACATCCGGATATGCGGCCCACAGCGCTTGTGCTGT
GGGCCTTGCACGCATTGAAGACGGCCGCGTTACAGAGCAGTTTTACAGTCTTGTGCGGCCGCCTTCTTCGCGGGTGCTTT
TTACAGAAATTCATGGTCTTACCTGGCCCATGCTTAAAAATGCCCCTGTTTTTGGCGACGTATGGCCTCAAATGGAATCG
TTCATGAAAGGGGCAGGCGTGCTGCTGGCGCATAATGCCTCTTTTGACCGGCGTGTGCTGCTGGCCTGCTGCCGTGAGGC
GGGGGCGGGTGTGCCGGAGCAGCATTTTCTCTGTACGCTCAAGGGCGCGCGCCGCAGCCTGCCTTTGCCCTCCAAAAAGC
TGAATCATGTGTGCGAGCATTTCGGCATTGCCCTGGAACACCATCATGCGGGTTCTGATGCTGCGGCCTGCGCAGAGGTT
TATCTGCATCTGCGGGCTTTGGGTGTTACCGACAGCCAGATGCGCATCTAG

Upstream 100 bases:

>100_bases
GCTGCTTCAATCTTGAAAGCGACGATGCTCACATGCGCGACTATATCATGGCCCGCCTTGGTGAAGCCGCACGCAATGCC
GAAAACAACGTGGAGTAACC

Downstream 100 bases:

>100_bases
AACCTGTTTCCGCCATGCCGCCAGCCCGGCAACACCGCCGGGCACATTGATATACTGTCCTGTTTGCCGTGTGAACAGGA
CAGTATATTTTTTTGCCCTG

Product: Exonuclease RNase T and DNA polymerase III

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 176; Mature: 175

Protein sequence:

>176_residues
MSDVSAPSCVAIDFETSGYAAHSACAVGLARIEDGRVTEQFYSLVRPPSSRVLFTEIHGLTWPMLKNAPVFGDVWPQMES
FMKGAGVLLAHNASFDRRVLLACCREAGAGVPEQHFLCTLKGARRSLPLPSKKLNHVCEHFGIALEHHHAGSDAAACAEV
YLHLRALGVTDSQMRI

Sequences:

>Translated_176_residues
MSDVSAPSCVAIDFETSGYAAHSACAVGLARIEDGRVTEQFYSLVRPPSSRVLFTEIHGLTWPMLKNAPVFGDVWPQMES
FMKGAGVLLAHNASFDRRVLLACCREAGAGVPEQHFLCTLKGARRSLPLPSKKLNHVCEHFGIALEHHHAGSDAAACAEV
YLHLRALGVTDSQMRI
>Mature_175_residues
SDVSAPSCVAIDFETSGYAAHSACAVGLARIEDGRVTEQFYSLVRPPSSRVLFTEIHGLTWPMLKNAPVFGDVWPQMESF
MKGAGVLLAHNASFDRRVLLACCREAGAGVPEQHFLCTLKGARRSLPLPSKKLNHVCEHFGIALEHHHAGSDAAACAEVY
LHLRALGVTDSQMRI

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR016027
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 19113; Mature: 18982

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVSAPSCVAIDFETSGYAAHSACAVGLARIEDGRVTEQFYSLVRPPSSRVLFTEIHGL
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCCC
TWPMLKNAPVFGDVWPQMESFMKGAGVLLAHNASFDRRVLLACCREAGAGVPEQHFLCTL
CCCHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHEEEEE
KGARRSLPLPSKKLNHVCEHFGIALEHHHAGSDAAACAEVYLHLRALGVTDSQMRI
CCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure 
SDVSAPSCVAIDFETSGYAAHSACAVGLARIEDGRVTEQFYSLVRPPSSRVLFTEIHGL
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCCC
TWPMLKNAPVFGDVWPQMESFMKGAGVLLAHNASFDRRVLLACCREAGAGVPEQHFLCTL
CCCHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHEEEEE
KGARRSLPLPSKKLNHVCEHFGIALEHHHAGSDAAACAEVYLHLRALGVTDSQMRI
CCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]