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The map label for this gene is gyaR [H]

Identifier: 220904831

GI number: 220904831

Start: 1878993

End: 1879964

Strand: Reverse

Name: gyaR [H]

Synonym: Ddes_1564

Alternate gene names: 220904831

Gene position: 1879964-1878993 (Counterclockwise)

Preceding gene: 220904832

Following gene: 220904825

Centisome position: 65.43

GC content: 61.73

Gene sequence:

>972_bases
ATGACCAAAGCCCGTGTATACGTGACCCGTGCCCTTTTGCCTGAAGCTTTCACCCTGCTGCGCTCACGTTGCCATGTAGA
CGTGGGGCCGGAAAATGGCCTTCGCGGTGAGGATTTTGTGGAGGCCCTGCGCGGGGCTGATGCTGTTATCGCCACCTCGG
TGCGTCTTGGGCCTGAGGCCTTGGACGCTCTGGCGTCTTCCTGCAAGGTTATTTGCAGCTACGGGGTAGGGTATGACCAT
ATTCCTGTGGAGGAAGCTACCCGCCGCGGTATATGGGTGACGCACAATCCCGATGCCGTCACTGCGGACACGGCGGATCT
GGCCATGGCGCTCATGCTGGGGGTGGCCCGCAGATTGCGCGATTGCGATCTCAGTGTGCGCAATGGCGTGGCCCCCTGGG
GCGTGGCCATGCATATGGGGCTGCGCGTGAGCGGCAAGGTGCTTGGGCTTGTGGGCAGTGGGCGTATAGCCCTGGCAGTG
GCGCGGCGCGCACAGGGGTTCGGCATGCGCCTTGCCTATACCGGCCGACGCAGAAATGAAATATTTGAGGCCGCCACGGG
GGCGTGTTATCTGGACAAGAAAGAATTGCTGGCATCATCGGATTTCGTGAGCCTGCATATCCCGCTGACGCCTGAAACGC
GGCATTATATGGCGGCGGCGGATCTGGCGTTGATGCCGCCGCATGCCGTGCTCGTCAATACCGCACGCGGGGCGGTGGTG
GATGAAGAGGCCCTGGTGGAAGCTCTTGAAGGAGGCCGCCCTGGCGGCGCAGGGCTGGATGTTTTTGAGCGTGAACCGCA
TGCGCATCCGGGGCTGCGCATGCTGCCCAATGTGCTGATGACGCCACATCGCGGCGTAGCCACGCCGGATTCCCTGATAG
ATATGGGGGAGGCTTGTGCACACAAAATTTTTGATGCGCTGGACGGTAGGCTGCCGCAAGACTGCCTGAACCCACACGCC
CGTAAGGCATGA

Upstream 100 bases:

>100_bases
CGCAGGTTGCCTGTGCAGGAATATATTGCACAGGCGTCTTACAAACCTTGCGGATACACACTTGCAACGTTGCAATACCT
AAAATGCTACGGGAGTACTC

Downstream 100 bases:

>100_bases
ATGAAAAAGGCCACCCCTGTGGGCGGCCTTTGGTTCTTCCTTGCACCGTATGGCGGGCATGAGTGGCGGCATGGGTGCTC
GTTACGGCATTAGACCTGCG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTKARVYVTRALLPEAFTLLRSRCHVDVGPENGLRGEDFVEALRGADAVIATSVRLGPEALDALASSCKVICSYGVGYDH
IPVEEATRRGIWVTHNPDAVTADTADLAMALMLGVARRLRDCDLSVRNGVAPWGVAMHMGLRVSGKVLGLVGSGRIALAV
ARRAQGFGMRLAYTGRRRNEIFEAATGACYLDKKELLASSDFVSLHIPLTPETRHYMAAADLALMPPHAVLVNTARGAVV
DEEALVEALEGGRPGGAGLDVFEREPHAHPGLRMLPNVLMTPHRGVATPDSLIDMGEACAHKIFDALDGRLPQDCLNPHA
RKA

Sequences:

>Translated_323_residues
MTKARVYVTRALLPEAFTLLRSRCHVDVGPENGLRGEDFVEALRGADAVIATSVRLGPEALDALASSCKVICSYGVGYDH
IPVEEATRRGIWVTHNPDAVTADTADLAMALMLGVARRLRDCDLSVRNGVAPWGVAMHMGLRVSGKVLGLVGSGRIALAV
ARRAQGFGMRLAYTGRRRNEIFEAATGACYLDKKELLASSDFVSLHIPLTPETRHYMAAADLALMPPHAVLVNTARGAVV
DEEALVEALEGGRPGGAGLDVFEREPHAHPGLRMLPNVLMTPHRGVATPDSLIDMGEACAHKIFDALDGRLPQDCLNPHA
RKA
>Mature_322_residues
TKARVYVTRALLPEAFTLLRSRCHVDVGPENGLRGEDFVEALRGADAVIATSVRLGPEALDALASSCKVICSYGVGYDHI
PVEEATRRGIWVTHNPDAVTADTADLAMALMLGVARRLRDCDLSVRNGVAPWGVAMHMGLRVSGKVLGLVGSGRIALAVA
RRAQGFGMRLAYTGRRRNEIFEAATGACYLDKKELLASSDFVSLHIPLTPETRHYMAAADLALMPPHAVLVNTARGAVVD
EEALVEALEGGRPGGAGLDVFEREPHAHPGLRMLPNVLMTPHRGVATPDSLIDMGEACAHKIFDALDGRLPQDCLNPHAR
KA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=318, Percent_Identity=30.5031446540881, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI6912396, Length=253, Percent_Identity=36.7588932806324, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI145580578, Length=281, Percent_Identity=33.8078291814947, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4557499, Length=281, Percent_Identity=33.8078291814947, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI61743967, Length=281, Percent_Identity=33.0960854092527, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4557497, Length=281, Percent_Identity=33.0960854092527, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI145580575, Length=281, Percent_Identity=33.8078291814947, Blast_Score=126, Evalue=2e-29,
Organism=Escherichia coli, GI87082289, Length=257, Percent_Identity=40.4669260700389, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789279, Length=313, Percent_Identity=28.1150159744409, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1787645, Length=246, Percent_Identity=29.6747967479675, Blast_Score=108, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17532191, Length=304, Percent_Identity=30.2631578947368, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25147481, Length=285, Percent_Identity=31.9298245614035, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=271, Percent_Identity=33.9483394833948, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320925, Length=295, Percent_Identity=29.1525423728814, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6322116, Length=280, Percent_Identity=28.5714285714286, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=231, Percent_Identity=29.004329004329, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=185, Percent_Identity=29.7297297297297, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571528, Length=315, Percent_Identity=37.1428571428571, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI45551003, Length=311, Percent_Identity=33.7620578778135, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI45552429, Length=311, Percent_Identity=33.7620578778135, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24585514, Length=312, Percent_Identity=33.6538461538462, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI28574282, Length=312, Percent_Identity=33.6538461538462, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI28574284, Length=311, Percent_Identity=33.7620578778135, Blast_Score=147, Evalue=6e-36,
Organism=Drosophila melanogaster, GI28574286, Length=304, Percent_Identity=32.8947368421053, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19921140, Length=281, Percent_Identity=30.6049822064057, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24585516, Length=319, Percent_Identity=30.7210031347962, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646446, Length=281, Percent_Identity=34.5195729537367, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646448, Length=281, Percent_Identity=34.5195729537367, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646452, Length=281, Percent_Identity=34.5195729537367, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646450, Length=281, Percent_Identity=34.5195729537367, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI62472511, Length=281, Percent_Identity=34.5195729537367, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34618; Mature: 34487

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKARVYVTRALLPEAFTLLRSRCHVDVGPENGLRGEDFVEALRGADAVIATSVRLGPEA
CCCCCEEHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHCCCEEEEEHHHCCHHH
LDALASSCKVICSYGVGYDHIPVEEATRRGIWVTHNPDAVTADTADLAMALMLGVARRLR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
DCDLSVRNGVAPWGVAMHMGLRVSGKVLGLVGSGRIALAVARRAQGFGMRLAYTGRRRNE
HCCCHHHCCCCCHHHHHHHCEEECCEEEEEECCCCEEEEEHHHHCCCCEEEEECCCHHHH
IFEAATGACYLDKKELLASSDFVSLHIPLTPETRHYMAAADLALMPPHAVLVNTARGAVV
HHHHHCCCEEECHHHHHCCCCEEEEEEECCCCCHHHHHHHCHHCCCCCEEEEECCCCCEE
DEEALVEALEGGRPGGAGLDVFEREPHAHPGLRMLPNVLMTPHRGVATPDSLIDMGEACA
CHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
HKIFDALDGRLPQDCLNPHARKA
HHHHHHHCCCCCHHHCCCCCCCC
>Mature Secondary Structure 
TKARVYVTRALLPEAFTLLRSRCHVDVGPENGLRGEDFVEALRGADAVIATSVRLGPEA
CCCCEEHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHCCCEEEEEHHHCCHHH
LDALASSCKVICSYGVGYDHIPVEEATRRGIWVTHNPDAVTADTADLAMALMLGVARRLR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
DCDLSVRNGVAPWGVAMHMGLRVSGKVLGLVGSGRIALAVARRAQGFGMRLAYTGRRRNE
HCCCHHHCCCCCHHHHHHHCEEECCEEEEEECCCCEEEEEHHHHCCCCEEEEECCCHHHH
IFEAATGACYLDKKELLASSDFVSLHIPLTPETRHYMAAADLALMPPHAVLVNTARGAVV
HHHHHCCCEEECHHHHHCCCCEEEEEEECCCCCHHHHHHHCHHCCCCCEEEEECCCCCEE
DEEALVEALEGGRPGGAGLDVFEREPHAHPGLRMLPNVLMTPHRGVATPDSLIDMGEACA
CHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
HKIFDALDGRLPQDCLNPHARKA
HHHHHHHCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA