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The map label for this gene is pyc [H]

Identifier: 220904820

GI number: 220904820

Start: 1863713

End: 1867414

Strand: Reverse

Name: pyc [H]

Synonym: Ddes_1553

Alternate gene names: 220904820

Gene position: 1867414-1863713 (Counterclockwise)

Preceding gene: 220904821

Following gene: 220904819

Centisome position: 64.99

GC content: 58.29

Gene sequence:

>3702_bases
ATGGCCAACAAGACATTCTCGGAAGTGCAGGATTTTCTGAAGGGCAAGGTAATACTGGTTGCCAACCGGGGCATTCCGGC
CCGGCGGATTTGCCGTTCCATTCGCGAGCGATTTGACGCCGTAGCGGCCATGACAGCGACTGATGTGGACAAAACCGCTC
CTGCGGCCTCTACCGCCCAGGAACTGGTTTTGCTTGGTGCGGACCCCCGCGCCTACCTTGATATCGACAACATCATCGCC
AAGGCCAAACAGCGGGGCGTGGTGGGCATCCATCCCGGCTGGGGTTTTGCTTCTGAAGACACGCGCTTTCCCGCGCGTTG
CAAGGAGGCGGGCATCACCTTTATCGGGGCCACGGCCGAGGCCATGAATCTGCTCGGCAACAAGGTGCAGGCGCGTGAGG
TGGCGCGCAAGCTTGGCATTCCCGTTGTACCTGGTTCAGACGGCGCGGTGGACATCCCCACTGCCAGGCAGCTTATCAGT
GAAATAGGCCTGCCCATCATGCTCAAGGCCGAGGGCGGCGGCGGCGGACGCGGCATTTTTGCCATTCATAATGAGGCCGA
GCTTGAAGACGCCTTTTTCAAGGCTTCCACCATGGCTCAGGCTTCTTTCGGCAACCCGCGCCTTTTCGTGGAAAAATTTC
TTGCCGATGTGCGCCATATTGAAATTCAGGTCATTGCCGACATGTACGGCAATGTCTTTGCTTTTGACGAGCGTGACTGC
ACAGTGCAGCGTAACCACCAGAAACTTATTGAAATCACGCCTTCGCCCTGGCCGGGCATGACCCGCAACCTGCGCGAGCG
CCTCAAGGACTACTCCCGCCGTCTGGTGCGGGCTGTGGGCTATCACAGCCTTGCCACGGTGGAATTTCTGGTTACCCCCG
ACGGCACGCCGTATCTTATTGAAGTCAATACCCGCCTCCAGGTAGAGCACGGCATCACCGAATGCCGCTACGGCATTGAC
CTTGTGGAAGAGCAGATCGCCGTGGCTTTTGGCGCGGAACTGCGCTATCGCGAGGAAAACCTGCGGCCTTCCTACTGCGC
CATGCAAGTGCGCATCAACTGTGAAAATCCGCAGAACAGCTTTGCTCCCAACTCGGGCCTGATTTCGCGCTACGTATCGC
CCGGCGGCCCCGGTGTGCGGCTGGACTCGAACATCAGCGCCGGGTACGAGTTTCCCGCCAACTACGACTCGGCAGGTGCT
TTGCTCATCTCCTACGCCCATGACTGGGAAAAGACCCTGGGCATTATGGAGCGCGCGCTCAGCGAGTATGTCATCGGCGG
TATCAAGACGACCATTCCGTTCTACCGTCAGGTCATAAAAAATCCCCTGTTCCGCCAGGGCAACATCAATACCAACTTTA
TCGCGGATCATCCGGAGCTTATGGTCTACACAGACCTGGCCCCGGAGGGCGAGCGCCTTTCCAAGCTGGTGGCCGAAATA
TCCGCCAAGGGCTACAACCCGTACGTCCAGCTTGGCGAATACCGTTCCGATACCACGCCCTGTCTTGGTCCCTTCGAGCC
GGTATTGCCTGCCATCACATCTGCCCAGCGACGGCAGCCTTCGCCCTATCCGCAGGGCGACCGTCTGGCCACGCTGGATT
ATATCCGTGATTCTGGGCTGGTACATTTTACCGACACCACGCCGCGCGACTTTACCCAATCCAACTCGGGCAACCGCTTC
CGCCTGGCGGAAGACCGGCTCATAGGCCCGTATCTGGACAATGTGGGCTATTTTTCCATTGAAAACGGCGGTGGGGCGCA
TTTTCATGTGGCGATGCTGGCCAACATGACTTATCCCTTCACCGAGGCGAAGGAATGGAACCGCTTTGCGCCCAAAACCA
TGAAGCAGCTGCTGGTGCGCTCTACCAACGTGCTGGGCTATACGCCGCAGCCGCGTAACCTGATGCGTAAAACAGGCGAG
ATGATTTGTGATTATTACCAGATCATCCGCTGCTTCGATTTTCTGAACCATGTGGAAAACATGCGGCCCATCGCTGAAGT
GGTCATGGACCGCAAGGACGTCATCTTCCAGCCCGCCATTTCTCTTTCCTGGGCCAAGGGTTTTGACGTGCCGCATTACC
TCGGCGTGACCGAAGCCATGCTGCGTATGGTGGCCGACATTATGGGGGTCGACCCCAAGGCGGCATCGCGACACATCATT
CTGGGCCTCAAGGACATGGCCGGCGTATGCCCGCCGCGCTTCATGACCGAGCTTGTCTCAGCCATCCGTAAGGCCTGGCC
CGACCTCGTGCTTCACTACCACCGCCATTACACGGACGGGCTTTTTGTGCCCGCCTGCGGCGCGGCCGCCAAGGCCGGAA
CGCATATCATTGATGCCGGTCTGGGGTCTGCCGTGCGTTCTTACGGCCAGGGCGATGTGCTGGCGACCATGGCCTATATT
GAGGATGAGCTGGGCCTCCAGTGCAATCTGGACAAAAACGCCATCCGGGCCGCGAACTTTGTGTGCAAGCAGATCATGCC
CTATTACGACCGCTACTGTGCGCCGTACTTCCAGGGTATCGACTATGATGTGACCCTACACGGCATGCCCGGCGGAGCTA
CCTCTTCCTCGCAGGAAGGAGCCATGAAGCAGGGCTATATTCATCTTTTGCCCTATATGCTCAAATTCCTTGAAGGTTCA
CGCCAGATCGTGCGCTATCACGATGTGACACCCGGTTCGCAGATCACCTGGAATACGGCATTTCTGGCTGTGACCGGCGC
GTGGAAGCGCGGCGGCGAAGATGAAGTGCGTTATCTGCTTCAGGTGCTTGCTGAAGTGACACGCACCCCCGAAGGAGAGC
TTACAGAGGAAATGCGCAAGGCCCGTCTGCATATCTACCGCGATTGCAACGATGCCTTCCGCAACCTTCTGCTGGGCAAG
TTTGGCAAGCTGCCTCTGGGCTTTCCCGCCGACTGGGTGTACAGGAGCGCCTTCGGGGCGGAATGGAAGAATGCCATAGC
CAGCCGTACCGAGGTTTCGCCTCTCGAAGCTCTGCCGGACCTCAACCTGGCTGCGGAAGAAAAGGCCTGCACAGACATTC
TCAAGCGCGAACCCAATGCAGAAGAATTCGTGCTCTACCTCAACCATCCGGCTGACGCCCTCAAGACCATACAGTTCAAG
GCAAAGTTCGGTGACCCCAACAACCTGCCCCTGCATGTATGGTTTGAAGGCCTCAAGGCCGGGCAGGACCTGTACTTCAA
CGACAGCAGCGGCAAGCCCCACCACCTGCTTCTGCTGAGCATATCGTCGCCCAATGAGGCGGGGATATCCATCTGCCGTT
ATGTGCTGGACTCTGAATTCATGAGCTGCGAGGTGCAGGTGCGCCAGCCTGTGGGCACGGCAACCAAGGGGACGCTCATG
GCCGACCCCGCCAACCAGTATCATGTGGCTGCGCCCAGCAACGGCGACCTGTGGGTCATGTATGTGCATCCCGGCGATGT
GGTGAAAGCCGGTGAAGAACTGTTCAACGTGTCCATCATGAAGCAGGAAAAGGCCGTGCTCGCCCCTGTGGACGGTATGG
TCAAGCGCGTACTGAAAACTGCTGATTTCAAGGAAAGCAAGCAGATGGTCTCTGTGCGCGAAGGCGAGCTTATTGTGGAA
CTGGGGCCTGTGCCGCGTATATGCGCCAACGAGGCCTGCGGCCAGCCCATTCCGCTGGAGAACATCTCATTCTGTCCCCA
TTGCGGCTCACGGGTGAGTTAG

Upstream 100 bases:

>100_bases
CGGCAGGCGGCCTTTGTCTTAACCATAACGGGCGGCTTGAGGAATTTTTCAGCGGGAGCCTTCTGCTTACCGGCAGAGCA
GCAGTAAAGGGTTAAAGGGC

Downstream 100 bases:

>100_bases
CCGTGTAGATACCGCATCTTGCGGCTTTGTCTGCGCCAGCCCTGTGACGGGCGGCCAGGCGAAAGCTGCCCGCATCCACA
AAACCCGCCGGCCCCGCAAC

Product: pyruvate carboxylase

Products: NA

Alternate protein names: Pyruvic carboxylase; PYC [H]

Number of amino acids: Translated: 1233; Mature: 1232

Protein sequence:

>1233_residues
MANKTFSEVQDFLKGKVILVANRGIPARRICRSIRERFDAVAAMTATDVDKTAPAASTAQELVLLGADPRAYLDIDNIIA
KAKQRGVVGIHPGWGFASEDTRFPARCKEAGITFIGATAEAMNLLGNKVQAREVARKLGIPVVPGSDGAVDIPTARQLIS
EIGLPIMLKAEGGGGGRGIFAIHNEAELEDAFFKASTMAQASFGNPRLFVEKFLADVRHIEIQVIADMYGNVFAFDERDC
TVQRNHQKLIEITPSPWPGMTRNLRERLKDYSRRLVRAVGYHSLATVEFLVTPDGTPYLIEVNTRLQVEHGITECRYGID
LVEEQIAVAFGAELRYREENLRPSYCAMQVRINCENPQNSFAPNSGLISRYVSPGGPGVRLDSNISAGYEFPANYDSAGA
LLISYAHDWEKTLGIMERALSEYVIGGIKTTIPFYRQVIKNPLFRQGNINTNFIADHPELMVYTDLAPEGERLSKLVAEI
SAKGYNPYVQLGEYRSDTTPCLGPFEPVLPAITSAQRRQPSPYPQGDRLATLDYIRDSGLVHFTDTTPRDFTQSNSGNRF
RLAEDRLIGPYLDNVGYFSIENGGGAHFHVAMLANMTYPFTEAKEWNRFAPKTMKQLLVRSTNVLGYTPQPRNLMRKTGE
MICDYYQIIRCFDFLNHVENMRPIAEVVMDRKDVIFQPAISLSWAKGFDVPHYLGVTEAMLRMVADIMGVDPKAASRHII
LGLKDMAGVCPPRFMTELVSAIRKAWPDLVLHYHRHYTDGLFVPACGAAAKAGTHIIDAGLGSAVRSYGQGDVLATMAYI
EDELGLQCNLDKNAIRAANFVCKQIMPYYDRYCAPYFQGIDYDVTLHGMPGGATSSSQEGAMKQGYIHLLPYMLKFLEGS
RQIVRYHDVTPGSQITWNTAFLAVTGAWKRGGEDEVRYLLQVLAEVTRTPEGELTEEMRKARLHIYRDCNDAFRNLLLGK
FGKLPLGFPADWVYRSAFGAEWKNAIASRTEVSPLEALPDLNLAAEEKACTDILKREPNAEEFVLYLNHPADALKTIQFK
AKFGDPNNLPLHVWFEGLKAGQDLYFNDSSGKPHHLLLLSISSPNEAGISICRYVLDSEFMSCEVQVRQPVGTATKGTLM
ADPANQYHVAAPSNGDLWVMYVHPGDVVKAGEELFNVSIMKQEKAVLAPVDGMVKRVLKTADFKESKQMVSVREGELIVE
LGPVPRICANEACGQPIPLENISFCPHCGSRVS

Sequences:

>Translated_1233_residues
MANKTFSEVQDFLKGKVILVANRGIPARRICRSIRERFDAVAAMTATDVDKTAPAASTAQELVLLGADPRAYLDIDNIIA
KAKQRGVVGIHPGWGFASEDTRFPARCKEAGITFIGATAEAMNLLGNKVQAREVARKLGIPVVPGSDGAVDIPTARQLIS
EIGLPIMLKAEGGGGGRGIFAIHNEAELEDAFFKASTMAQASFGNPRLFVEKFLADVRHIEIQVIADMYGNVFAFDERDC
TVQRNHQKLIEITPSPWPGMTRNLRERLKDYSRRLVRAVGYHSLATVEFLVTPDGTPYLIEVNTRLQVEHGITECRYGID
LVEEQIAVAFGAELRYREENLRPSYCAMQVRINCENPQNSFAPNSGLISRYVSPGGPGVRLDSNISAGYEFPANYDSAGA
LLISYAHDWEKTLGIMERALSEYVIGGIKTTIPFYRQVIKNPLFRQGNINTNFIADHPELMVYTDLAPEGERLSKLVAEI
SAKGYNPYVQLGEYRSDTTPCLGPFEPVLPAITSAQRRQPSPYPQGDRLATLDYIRDSGLVHFTDTTPRDFTQSNSGNRF
RLAEDRLIGPYLDNVGYFSIENGGGAHFHVAMLANMTYPFTEAKEWNRFAPKTMKQLLVRSTNVLGYTPQPRNLMRKTGE
MICDYYQIIRCFDFLNHVENMRPIAEVVMDRKDVIFQPAISLSWAKGFDVPHYLGVTEAMLRMVADIMGVDPKAASRHII
LGLKDMAGVCPPRFMTELVSAIRKAWPDLVLHYHRHYTDGLFVPACGAAAKAGTHIIDAGLGSAVRSYGQGDVLATMAYI
EDELGLQCNLDKNAIRAANFVCKQIMPYYDRYCAPYFQGIDYDVTLHGMPGGATSSSQEGAMKQGYIHLLPYMLKFLEGS
RQIVRYHDVTPGSQITWNTAFLAVTGAWKRGGEDEVRYLLQVLAEVTRTPEGELTEEMRKARLHIYRDCNDAFRNLLLGK
FGKLPLGFPADWVYRSAFGAEWKNAIASRTEVSPLEALPDLNLAAEEKACTDILKREPNAEEFVLYLNHPADALKTIQFK
AKFGDPNNLPLHVWFEGLKAGQDLYFNDSSGKPHHLLLLSISSPNEAGISICRYVLDSEFMSCEVQVRQPVGTATKGTLM
ADPANQYHVAAPSNGDLWVMYVHPGDVVKAGEELFNVSIMKQEKAVLAPVDGMVKRVLKTADFKESKQMVSVREGELIVE
LGPVPRICANEACGQPIPLENISFCPHCGSRVS
>Mature_1232_residues
ANKTFSEVQDFLKGKVILVANRGIPARRICRSIRERFDAVAAMTATDVDKTAPAASTAQELVLLGADPRAYLDIDNIIAK
AKQRGVVGIHPGWGFASEDTRFPARCKEAGITFIGATAEAMNLLGNKVQAREVARKLGIPVVPGSDGAVDIPTARQLISE
IGLPIMLKAEGGGGGRGIFAIHNEAELEDAFFKASTMAQASFGNPRLFVEKFLADVRHIEIQVIADMYGNVFAFDERDCT
VQRNHQKLIEITPSPWPGMTRNLRERLKDYSRRLVRAVGYHSLATVEFLVTPDGTPYLIEVNTRLQVEHGITECRYGIDL
VEEQIAVAFGAELRYREENLRPSYCAMQVRINCENPQNSFAPNSGLISRYVSPGGPGVRLDSNISAGYEFPANYDSAGAL
LISYAHDWEKTLGIMERALSEYVIGGIKTTIPFYRQVIKNPLFRQGNINTNFIADHPELMVYTDLAPEGERLSKLVAEIS
AKGYNPYVQLGEYRSDTTPCLGPFEPVLPAITSAQRRQPSPYPQGDRLATLDYIRDSGLVHFTDTTPRDFTQSNSGNRFR
LAEDRLIGPYLDNVGYFSIENGGGAHFHVAMLANMTYPFTEAKEWNRFAPKTMKQLLVRSTNVLGYTPQPRNLMRKTGEM
ICDYYQIIRCFDFLNHVENMRPIAEVVMDRKDVIFQPAISLSWAKGFDVPHYLGVTEAMLRMVADIMGVDPKAASRHIIL
GLKDMAGVCPPRFMTELVSAIRKAWPDLVLHYHRHYTDGLFVPACGAAAKAGTHIIDAGLGSAVRSYGQGDVLATMAYIE
DELGLQCNLDKNAIRAANFVCKQIMPYYDRYCAPYFQGIDYDVTLHGMPGGATSSSQEGAMKQGYIHLLPYMLKFLEGSR
QIVRYHDVTPGSQITWNTAFLAVTGAWKRGGEDEVRYLLQVLAEVTRTPEGELTEEMRKARLHIYRDCNDAFRNLLLGKF
GKLPLGFPADWVYRSAFGAEWKNAIASRTEVSPLEALPDLNLAAEEKACTDILKREPNAEEFVLYLNHPADALKTIQFKA
KFGDPNNLPLHVWFEGLKAGQDLYFNDSSGKPHHLLLLSISSPNEAGISICRYVLDSEFMSCEVQVRQPVGTATKGTLMA
DPANQYHVAAPSNGDLWVMYVHPGDVVKAGEELFNVSIMKQEKAVLAPVDGMVKRVLKTADFKESKQMVSVREGELIVEL
GPVPRICANEACGQPIPLENISFCPHCGSRVS

Specific function: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second, leading to oxaloacetate production. Fulfills an anaplerotic functi

COG id: COG1038

COG function: function code C; Pyruvate carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=1205, Percent_Identity=31.7842323651452, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI106049295, Length=1205, Percent_Identity=31.7842323651452, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI106049292, Length=1205, Percent_Identity=31.7842323651452, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=40, Blast_Score=296, Evalue=1e-79,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=40, Blast_Score=296, Evalue=1e-79,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=40, Blast_Score=296, Evalue=1e-79,
Organism=Homo sapiens, GI116805327, Length=465, Percent_Identity=33.9784946236559, Blast_Score=271, Evalue=3e-72,
Organism=Homo sapiens, GI38679974, Length=502, Percent_Identity=29.4820717131474, Blast_Score=201, Evalue=5e-51,
Organism=Homo sapiens, GI38679960, Length=502, Percent_Identity=29.4820717131474, Blast_Score=201, Evalue=5e-51,
Organism=Homo sapiens, GI38679971, Length=502, Percent_Identity=29.4820717131474, Blast_Score=200, Evalue=6e-51,
Organism=Homo sapiens, GI38679977, Length=502, Percent_Identity=29.4820717131474, Blast_Score=200, Evalue=6e-51,
Organism=Homo sapiens, GI38679967, Length=502, Percent_Identity=29.4820717131474, Blast_Score=200, Evalue=6e-51,
Organism=Homo sapiens, GI134142062, Length=520, Percent_Identity=27.6923076923077, Blast_Score=189, Evalue=1e-47,
Organism=Escherichia coli, GI1789654, Length=441, Percent_Identity=39.4557823129252, Blast_Score=295, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17562816, Length=1226, Percent_Identity=30.9135399673736, Blast_Score=460, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17567343, Length=458, Percent_Identity=36.6812227074236, Blast_Score=288, Evalue=9e-78,
Organism=Caenorhabditis elegans, GI71987519, Length=446, Percent_Identity=37.4439461883408, Blast_Score=269, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI133931226, Length=401, Percent_Identity=30.6733167082294, Blast_Score=166, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71997168, Length=419, Percent_Identity=29.3556085918854, Blast_Score=164, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71997163, Length=419, Percent_Identity=29.5942720763723, Blast_Score=164, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6319695, Length=1214, Percent_Identity=28.9126853377265, Blast_Score=405, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6321376, Length=1238, Percent_Identity=28.9983844911147, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=32.9571106094808, Blast_Score=253, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6324343, Length=534, Percent_Identity=27.7153558052434, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323863, Length=509, Percent_Identity=29.0766208251473, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24652212, Length=1191, Percent_Identity=30.8984047019311, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24652210, Length=1191, Percent_Identity=30.8984047019311, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24652214, Length=1191, Percent_Identity=30.8984047019311, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI19921944, Length=1191, Percent_Identity=30.8984047019311, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24652216, Length=1191, Percent_Identity=30.8984047019311, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI281363050, Length=1199, Percent_Identity=30.8590492076731, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652224, Length=1199, Percent_Identity=30.8590492076731, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652222, Length=1199, Percent_Identity=30.8590492076731, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652220, Length=1199, Percent_Identity=30.8590492076731, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652218, Length=1199, Percent_Identity=30.8590492076731, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=35.1230425055928, Blast_Score=254, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24651759, Length=396, Percent_Identity=36.1111111111111, Blast_Score=244, Evalue=4e-64,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=28.9738430583501, Blast_Score=182, Evalue=1e-45,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=28.9738430583501, Blast_Score=182, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=28.9738430583501, Blast_Score=182, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=28.9738430583501, Blast_Score=182, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR003379
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR000891
- InterPro:   IPR005930
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 136835; Mature: 136704

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50975 ATP_GRASP ; PS00449 ATPASE_A ; PS00867 CPSASE_2 ; PS50979 BC ; PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKTFSEVQDFLKGKVILVANRGIPARRICRSIRERFDAVAAMTATDVDKTAPAASTAQ
CCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC
ELVLLGADPRAYLDIDNIIAKAKQRGVVGIHPGWGFASEDTRFPARCKEAGITFIGATAE
EEEEECCCCCCEEEHHHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHCCCEEEECHHH
AMNLLGNKVQAREVARKLGIPVVPGSDGAVDIPTARQLISEIGLPIMLKAEGGGGGRGIF
HHHHHCCHHHHHHHHHHCCCCEECCCCCCEECHHHHHHHHHCCCCEEEEECCCCCCCEEE
AIHNEAELEDAFFKASTMAQASFGNPRLFVEKFLADVRHIEIQVIADMYGNVFAFDERDC
EECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEEEEHHCCCEEEECCCCC
TVQRNHQKLIEITPSPWPGMTRNLRERLKDYSRRLVRAVGYHSLATVEFLVTPDGTPYLI
CEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEE
EVNTRLQVEHGITECRYGIDLVEEQIAVAFGAELRYREENLRPSYCAMQVRINCENPQNS
EECCEEEECCCHHHHHHHHHHHHHHHHHHHCCHHEEHHCCCCCCEEEEEEEEECCCCCCC
FAPNSGLISRYVSPGGPGVRLDSNISAGYEFPANYDSAGALLISYAHDWEKTLGIMERAL
CCCCCCHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHH
SEYVIGGIKTTIPFYRQVIKNPLFRQGNINTNFIADHPELMVYTDLAPEGERLSKLVAEI
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHH
SAKGYNPYVQLGEYRSDTTPCLGPFEPVLPAITSAQRRQPSPYPQGDRLATLDYIRDSGL
HCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHCCCE
VHFTDTTPRDFTQSNSGNRFRLAEDRLIGPYLDNVGYFSIENGGGAHFHVAMLANMTYPF
EEECCCCCCHHCCCCCCCEEEECCCCCCCHHHCCCCEEEEECCCCCEEEEEEECCCCCCC
TEAKEWNRFAPKTMKQLLVRSTNVLGYTPQPRNLMRKTGEMICDYYQIIRCFDFLNHVEN
CCHHHHCCCCHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRPIAEVVMDRKDVIFQPAISLSWAKGFDVPHYLGVTEAMLRMVADIMGVDPKAASRHII
HHHHHHHHHCCHHHEECCCCEEEHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
LGLKDMAGVCPPRFMTELVSAIRKAWPDLVLHYHRHYTDGLFVPACGAAAKAGTHIIDAG
EEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCEEEECC
LGSAVRSYGQGDVLATMAYIEDELGLQCNLDKNAIRAANFVCKQIMPYYDRYCAPYFQGI
HHHHHHHCCCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DYDVTLHGMPGGATSSSQEGAMKQGYIHLLPYMLKFLEGSRQIVRYHDVTPGSQITWNTA
CEEEEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEE
FLAVTGAWKRGGEDEVRYLLQVLAEVTRTPEGELTEEMRKARLHIYRDCNDAFRNLLLGK
EEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
FGKLPLGFPADWVYRSAFGAEWKNAIASRTEVSPLEALPDLNLAAEEKACTDILKREPNA
CCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCC
EEFVLYLNHPADALKTIQFKAKFGDPNNLPLHVWFEGLKAGQDLYFNDSSGKPHHLLLLS
CCEEEEECCCHHHHHEEEEEEECCCCCCCEEEEEEECCCCCCCEEEECCCCCCEEEEEEE
ISSPNEAGISICRYVLDSEFMSCEVQVRQPVGTATKGTLMADPANQYHVAAPSNGDLWVM
ECCCCHHHHHHHHHHHHCHHHEEEEEEECCCCCCCCCCEEECCCCCEEEECCCCCCEEEE
YVHPGDVVKAGEELFNVSIMKQEKAVLAPVDGMVKRVLKTADFKESKQMVSVREGELIVE
EECCCHHHHHHHHHHEEHEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHEECCCCEEEE
LGPVPRICANEACGQPIPLENISFCPHCGSRVS
ECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ANKTFSEVQDFLKGKVILVANRGIPARRICRSIRERFDAVAAMTATDVDKTAPAASTAQ
CCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC
ELVLLGADPRAYLDIDNIIAKAKQRGVVGIHPGWGFASEDTRFPARCKEAGITFIGATAE
EEEEECCCCCCEEEHHHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHCCCEEEECHHH
AMNLLGNKVQAREVARKLGIPVVPGSDGAVDIPTARQLISEIGLPIMLKAEGGGGGRGIF
HHHHHCCHHHHHHHHHHCCCCEECCCCCCEECHHHHHHHHHCCCCEEEEECCCCCCCEEE
AIHNEAELEDAFFKASTMAQASFGNPRLFVEKFLADVRHIEIQVIADMYGNVFAFDERDC
EECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEEEEHHCCCEEEECCCCC
TVQRNHQKLIEITPSPWPGMTRNLRERLKDYSRRLVRAVGYHSLATVEFLVTPDGTPYLI
CEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEE
EVNTRLQVEHGITECRYGIDLVEEQIAVAFGAELRYREENLRPSYCAMQVRINCENPQNS
EECCEEEECCCHHHHHHHHHHHHHHHHHHHCCHHEEHHCCCCCCEEEEEEEEECCCCCCC
FAPNSGLISRYVSPGGPGVRLDSNISAGYEFPANYDSAGALLISYAHDWEKTLGIMERAL
CCCCCCHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHH
SEYVIGGIKTTIPFYRQVIKNPLFRQGNINTNFIADHPELMVYTDLAPEGERLSKLVAEI
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHH
SAKGYNPYVQLGEYRSDTTPCLGPFEPVLPAITSAQRRQPSPYPQGDRLATLDYIRDSGL
HCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHCCCE
VHFTDTTPRDFTQSNSGNRFRLAEDRLIGPYLDNVGYFSIENGGGAHFHVAMLANMTYPF
EEECCCCCCHHCCCCCCCEEEECCCCCCCHHHCCCCEEEEECCCCCEEEEEEECCCCCCC
TEAKEWNRFAPKTMKQLLVRSTNVLGYTPQPRNLMRKTGEMICDYYQIIRCFDFLNHVEN
CCHHHHCCCCHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRPIAEVVMDRKDVIFQPAISLSWAKGFDVPHYLGVTEAMLRMVADIMGVDPKAASRHII
HHHHHHHHHCCHHHEECCCCEEEHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
LGLKDMAGVCPPRFMTELVSAIRKAWPDLVLHYHRHYTDGLFVPACGAAAKAGTHIIDAG
EEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCEEEECC
LGSAVRSYGQGDVLATMAYIEDELGLQCNLDKNAIRAANFVCKQIMPYYDRYCAPYFQGI
HHHHHHHCCCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DYDVTLHGMPGGATSSSQEGAMKQGYIHLLPYMLKFLEGSRQIVRYHDVTPGSQITWNTA
CEEEEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEE
FLAVTGAWKRGGEDEVRYLLQVLAEVTRTPEGELTEEMRKARLHIYRDCNDAFRNLLLGK
EEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
FGKLPLGFPADWVYRSAFGAEWKNAIASRTEVSPLEALPDLNLAAEEKACTDILKREPNA
CCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCC
EEFVLYLNHPADALKTIQFKAKFGDPNNLPLHVWFEGLKAGQDLYFNDSSGKPHHLLLLS
CCEEEEECCCHHHHHEEEEEEECCCCCCCEEEEEEECCCCCCCEEEECCCCCCEEEEEEE
ISSPNEAGISICRYVLDSEFMSCEVQVRQPVGTATKGTLMADPANQYHVAAPSNGDLWVM
ECCCCHHHHHHHHHHHHCHHHEEEEEEECCCCCCCCCCEEECCCCCEEEECCCCCCEEEE
YVHPGDVVKAGEELFNVSIMKQEKAVLAPVDGMVKRVLKTADFKESKQMVSVREGELIVE
EECCCHHHHHHHHHHEEHEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHEECCCCEEEE
LGPVPRICANEACGQPIPLENISFCPHCGSRVS
ECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]