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The map label for this gene is birA [C]

Identifier: 220904821

GI number: 220904821

Start: 1867420

End: 1868253

Strand: Reverse

Name: birA [C]

Synonym: Ddes_1554

Alternate gene names: 220904821

Gene position: 1868253-1867420 (Counterclockwise)

Preceding gene: 220904823

Following gene: 220904820

Centisome position: 65.02

GC content: 62.71

Gene sequence:

>834_bases
ATGGCTGAAGTATGCCATAGCCAGACATGTGAGGGAAGCGCCAACCCTGCTTCGCCACTGCTTTTTCACGAACCGTCGAT
CTGGCGGTTCGGCTGCCTGGGATCCTGCCTTGATACGGCCATGCACATGGCTGCCGCAGGGCGTCTGGCCCCCTGGGACA
GTGTGCAGTGCGCCGCACAGACAGCCGGGCGGGGGCAGTTGCGCCGCACCTGGCACTCGCCGCCGGGTAATGTTTACGCG
GCGTTGCGTCTGCCGCTGGAGGCGCCTTTTGACGGTTCGGCGGCGGCCCCGGCCGCGGCCTTTCTGCTGGCGGGCAGCCT
GCGGCTTCTTGGCTGGCCCGTACTGCTCAAGTGGCCCAACGATATTGTGCTGGTGGGCAGGGATGATCAACCCCGCAAGC
TGGCGGGCATTCTGCTTGAAGAGCGCGGGGGAGTGCTGCTGGCGGGCATGGGCATCAATGTGACTTTTGCGCCGCCCGCG
GCGGCCCTGCGGGCCGGAGCCGCTATGGAGGCCACCTGTCTGGACCGGCCCCCCGGGGGAGCAGGGGGGGGGTATATTTC
TACAGCTGAAGCCATATGGCAACAGCTTGTAAAGCGCATGTATTCGGCATATATTCACTGCCACTCTTTTTCCGGACAGT
GGAAAAACCACGCTGATGGTATTTTGCTCTGGCGTGGAAAAAATGTGGAGCTGCGCGACGATGGGCGTAGTGTGCGCGGC
TGGCTGGCGGGTCTTGGTCCGGCAGGCGGCCTTTGTCTTAACCATAACGGGCGGCTTGAGGAATTTTTCAGCGGGAGCCT
TCTGCTTACCGGCAGAGCAGCAGTAAAGGGTTAA

Upstream 100 bases:

>100_bases
CAGAAAATTTTTCATGCTGCCGGTAAAGGCGAAGTCCAGTTCCACGGGCGTACGCCCGAGCAGCATGTCGCGCACAGCGC
CGCCAACGAGGTAGAGTTCC

Downstream 100 bases:

>100_bases
AGGGCATGGCCAACAAGACATTCTCGGAAGTGCAGGATTTTCTGAAGGGCAAGGTAATACTGGTTGCCAACCGGGGCATT
CCGGCCCGGCGGATTTGCCG

Product: biotin/acetyl-CoA-carboxylase ligase

Products: AMP; diphosphate; [acetyl-CoA:carbon-dioxideligase (ADP-forming)] [C]

Alternate protein names: Biotin-Acetyl-CoA-Carboxylase Ligase; Biotin-[Acetyl-CoA-Carboxylase] Ligase; Biotin-(Acetyl-CoA Carboxylase) Ligase

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MAEVCHSQTCEGSANPASPLLFHEPSIWRFGCLGSCLDTAMHMAAAGRLAPWDSVQCAAQTAGRGQLRRTWHSPPGNVYA
ALRLPLEAPFDGSAAAPAAAFLLAGSLRLLGWPVLLKWPNDIVLVGRDDQPRKLAGILLEERGGVLLAGMGINVTFAPPA
AALRAGAAMEATCLDRPPGGAGGGYISTAEAIWQQLVKRMYSAYIHCHSFSGQWKNHADGILLWRGKNVELRDDGRSVRG
WLAGLGPAGGLCLNHNGRLEEFFSGSLLLTGRAAVKG

Sequences:

>Translated_277_residues
MAEVCHSQTCEGSANPASPLLFHEPSIWRFGCLGSCLDTAMHMAAAGRLAPWDSVQCAAQTAGRGQLRRTWHSPPGNVYA
ALRLPLEAPFDGSAAAPAAAFLLAGSLRLLGWPVLLKWPNDIVLVGRDDQPRKLAGILLEERGGVLLAGMGINVTFAPPA
AALRAGAAMEATCLDRPPGGAGGGYISTAEAIWQQLVKRMYSAYIHCHSFSGQWKNHADGILLWRGKNVELRDDGRSVRG
WLAGLGPAGGLCLNHNGRLEEFFSGSLLLTGRAAVKG
>Mature_276_residues
AEVCHSQTCEGSANPASPLLFHEPSIWRFGCLGSCLDTAMHMAAAGRLAPWDSVQCAAQTAGRGQLRRTWHSPPGNVYAA
LRLPLEAPFDGSAAAPAAAFLLAGSLRLLGWPVLLKWPNDIVLVGRDDQPRKLAGILLEERGGVLLAGMGINVTFAPPAA
ALRAGAAMEATCLDRPPGGAGGGYISTAEAIWQQLVKRMYSAYIHCHSFSGQWKNHADGILLWRGKNVELRDDGRSVRGW
LAGLGPAGGLCLNHNGRLEEFFSGSLLLTGRAAVKG

Specific function: Bira Acts Both As A Biotin-Operon Repressor And As The Enzyme That Synthesizes The Corepressor, Acetyl-CoA:Carbon- Dioxide Ligase. This Protein Also Activates Biotin To Form Biotinyl-5'-Adenylate And Transfers The Biotin Moiety To Biotin-Accepting Protei

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 6.3.4.15 [C]

Molecular weight: Translated: 29341; Mature: 29210

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVCHSQTCEGSANPASPLLFHEPSIWRFGCLGSCLDTAMHMAAAGRLAPWDSVQCAAQ
CCCCCCCCCCCCCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
TAGRGQLRRTWHSPPGNVYAALRLPLEAPFDGSAAAPAAAFLLAGSLRLLGWPVLLKWPN
CCCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCHHHHCCEEEEECCC
DIVLVGRDDQPRKLAGILLEERGGVLLAGMGINVTFAPPAAALRAGAAMEATCLDRPPGG
CEEEEECCCCCHHHHHHHEECCCCEEEEECCEEEEECCCHHHHHCCCCEEEEECCCCCCC
AGGGYISTAEAIWQQLVKRMYSAYIHCHSFSGQWKNHADGILLWRGKNVELRDDGRSVRG
CCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEEECCCEEECCCCCHHHH
WLAGLGPAGGLCLNHNGRLEEFFSGSLLLTGRAAVKG
HHHCCCCCCCEEECCCCCHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure 
AEVCHSQTCEGSANPASPLLFHEPSIWRFGCLGSCLDTAMHMAAAGRLAPWDSVQCAAQ
CCCCCCCCCCCCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
TAGRGQLRRTWHSPPGNVYAALRLPLEAPFDGSAAAPAAAFLLAGSLRLLGWPVLLKWPN
CCCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCHHHHCCEEEEECCC
DIVLVGRDDQPRKLAGILLEERGGVLLAGMGINVTFAPPAAALRAGAAMEATCLDRPPGG
CEEEEECCCCCHHHHHHHEECCCCEEEEECCEEEEECCCHHHHHCCCCEEEEECCCCCCC
AGGGYISTAEAIWQQLVKRMYSAYIHCHSFSGQWKNHADGILLWRGKNVELRDDGRSVRG
CCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEEECCCEEECCCCCHHHH
WLAGLGPAGGLCLNHNGRLEEFFSGSLLLTGRAAVKG
HHHCCCCCCCEEECCCCCHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; biotin; apo-[acetyl-CoA:carbon-dioxide ligase(ADP-forming)] [C]

Specific reaction: ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase(ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxideligase (ADP-forming)] [C]

General reaction: Amination; Carboxylic acid formation (carboxamide formation [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA