Click here to switch to the map view.

The map label for this gene is glpA [H]

Identifier: 220904789

GI number: 220904789

Start: 1817423

End: 1819030

Strand: Reverse

Name: glpA [H]

Synonym: Ddes_1521

Alternate gene names: 220904789

Gene position: 1819030-1817423 (Counterclockwise)

Preceding gene: 220904791

Following gene: 220904788

Centisome position: 63.31

GC content: 59.7

Gene sequence:

>1608_bases
ATGCTGGAAACAACCGTTGTAGTCATTGGAGGCGGCGCGACCGGTATTGGTGCGCTGCGAGACCTGTGCATGCGGGGAAT
TCCCGCCATTCTGCTTGAGCAGGGGGGCATCGCCCACGGCACCAGCTCACGCTTTCATGGTCTGCTGCACAGCGGAGCGC
GCTATGTCGTCAATGACAATGAATCCGCCCGGGAATGTATTGAGGAAAATATGATCGTGCGTCGTATCGGCAGACAATGC
GTTGAGGAAACCGAAGGGTTCTTCGCGCTTACGCCGCAGGACGACCCCGCATATGTTGAAAAATTTGTGGCTGGCTGTCG
CGAGGCAGGCATTGACGCGCAAGAAATTGAAGTTGCCGAGGCCTTGCGGCTGGAGCCGAATCTTTCGCCTGAGGTCCGCC
GGGTTTTTCGTGTGCCCGATTCCTGTGTAGACGGTTTTCGCCTGGTGCTGCATAACGCCATGTCGGCCCGGCGCCATGGC
GGGCGCATGCTCACCTATCATGAGGCCACCGCCATAACGCTGCGCAATGGCCGTGTATGCGGTGTCACAGCCGTTGATCG
CCATACCGGGGCAACAGTTGAAATCGCCTGTCAGTGCGTCATCAATGCGGCCGGCTCGTGGGCCGGGCGCATCGCGGGCA
TGGCGGGCCTTGATGTGGCGCTTTCGCCCGACAGGGGAACGCTGGTGGTTTTCAACCACCGTTTTACCTCCAGAGTCATC
AACCGTCTGCATCCCAGTGGCGACGGGGATATTTTTGTGCCGCATGGTTCCATCACCATTCTCGGCACCACATCCGCGTC
CACCGACAGACCGGACGACACCACGCCTACAACTGAAGAGGTGCTGCGTCTGCTTGATATCGGCGAACCGCTTTTTCCCC
AGGTGCGCCAGTACCGCATTCTGCGTGCCTTTGCCGGCACACGCCCGTTGTATACCCCGGGCGGAGCGGCAGGGCGCAAG
GCCAGCCGTAATTTTCATATTGTGGATCATGCGGATGAGGGCCTTGAGGGCATGGTCAGTATTTTCGGTGGCAAACTTAC
CACCTACCGTCTTATGGCTGAGCGGGTTGTTGACAGGGTTTGCGCCAAGCTGGGGCATAGTGCTGTCTGCCGCACGGCTA
CAGAAGCCCTTGTGCCGGACGCGGACGAAGCTACGCTCAAACGGGCGGCCCGCTTTTTTCCCATGCAGGGCCTGAATCTC
ATGGCCGACCGGCTTGGTGATGACCTTCCGTCAGTGCTGGAACTGGCCGAGCAGCAGGCGGGCAATCCGCTGATCTGCGA
ATGCGAAATGGTGAGCCTGGCTGAAATTGAATATGTGGCGCGCCAGCCTGCCACATATTCTCTTACTGACATACGCTTGC
GTACGCGCCTTGGCATGGGAACCTGCCAGGGAGCGTTTTGTTCCCTGCGCACGGTCGGTGCGCTTGCCGAGCACGGCGTG
CAGCTTGAGCTGACGCCCACGGACAATGTCCGGCGTTTTCTTCAGGAGCGGTGGGGCGGGCTGCGCTTTGCCCTATGGGG
CATGCAGGCCCGTGAAATGGAACTGAGCCGTGCCATTTACGCTACTACCCTCAACCTGGATGGAGCCGCTCATGAGCAGG
ATCGTTGA

Upstream 100 bases:

>100_bases
ACAGATGTCATCCTGCCCTGCAAGGCCGGCCCGAACAGGAGCGGCCCGCCTATCCTATCCGGACATGGTTGCATAAGCTA
CATATATATCAGGAGACTGC

Downstream 100 bases:

>100_bases
CGTACTTGTGGCCGGTTCCGGCATGGCCGGGCTTGTGGCCGCCCTTACTGCCGCGAGCCAGGGTAAAAAGGTCCGCATGC
TTACCACGGGCATGGGATCT

Product: glycerol-3-phosphate dehydrogenase, anaerobic subunit A

Products: NA

Alternate protein names: G-3-P dehydrogenase [H]

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MLETTVVVIGGGATGIGALRDLCMRGIPAILLEQGGIAHGTSSRFHGLLHSGARYVVNDNESARECIEENMIVRRIGRQC
VEETEGFFALTPQDDPAYVEKFVAGCREAGIDAQEIEVAEALRLEPNLSPEVRRVFRVPDSCVDGFRLVLHNAMSARRHG
GRMLTYHEATAITLRNGRVCGVTAVDRHTGATVEIACQCVINAAGSWAGRIAGMAGLDVALSPDRGTLVVFNHRFTSRVI
NRLHPSGDGDIFVPHGSITILGTTSASTDRPDDTTPTTEEVLRLLDIGEPLFPQVRQYRILRAFAGTRPLYTPGGAAGRK
ASRNFHIVDHADEGLEGMVSIFGGKLTTYRLMAERVVDRVCAKLGHSAVCRTATEALVPDADEATLKRAARFFPMQGLNL
MADRLGDDLPSVLELAEQQAGNPLICECEMVSLAEIEYVARQPATYSLTDIRLRTRLGMGTCQGAFCSLRTVGALAEHGV
QLELTPTDNVRRFLQERWGGLRFALWGMQAREMELSRAIYATTLNLDGAAHEQDR

Sequences:

>Translated_535_residues
MLETTVVVIGGGATGIGALRDLCMRGIPAILLEQGGIAHGTSSRFHGLLHSGARYVVNDNESARECIEENMIVRRIGRQC
VEETEGFFALTPQDDPAYVEKFVAGCREAGIDAQEIEVAEALRLEPNLSPEVRRVFRVPDSCVDGFRLVLHNAMSARRHG
GRMLTYHEATAITLRNGRVCGVTAVDRHTGATVEIACQCVINAAGSWAGRIAGMAGLDVALSPDRGTLVVFNHRFTSRVI
NRLHPSGDGDIFVPHGSITILGTTSASTDRPDDTTPTTEEVLRLLDIGEPLFPQVRQYRILRAFAGTRPLYTPGGAAGRK
ASRNFHIVDHADEGLEGMVSIFGGKLTTYRLMAERVVDRVCAKLGHSAVCRTATEALVPDADEATLKRAARFFPMQGLNL
MADRLGDDLPSVLELAEQQAGNPLICECEMVSLAEIEYVARQPATYSLTDIRLRTRLGMGTCQGAFCSLRTVGALAEHGV
QLELTPTDNVRRFLQERWGGLRFALWGMQAREMELSRAIYATTLNLDGAAHEQDR
>Mature_535_residues
MLETTVVVIGGGATGIGALRDLCMRGIPAILLEQGGIAHGTSSRFHGLLHSGARYVVNDNESARECIEENMIVRRIGRQC
VEETEGFFALTPQDDPAYVEKFVAGCREAGIDAQEIEVAEALRLEPNLSPEVRRVFRVPDSCVDGFRLVLHNAMSARRHG
GRMLTYHEATAITLRNGRVCGVTAVDRHTGATVEIACQCVINAAGSWAGRIAGMAGLDVALSPDRGTLVVFNHRFTSRVI
NRLHPSGDGDIFVPHGSITILGTTSASTDRPDDTTPTTEEVLRLLDIGEPLFPQVRQYRILRAFAGTRPLYTPGGAAGRK
ASRNFHIVDHADEGLEGMVSIFGGKLTTYRLMAERVVDRVCAKLGHSAVCRTATEALVPDADEATLKRAARFFPMQGLNL
MADRLGDDLPSVLELAEQQAGNPLICECEMVSLAEIEYVARQPATYSLTDIRLRTRLGMGTCQGAFCSLRTVGALAEHGV
QLELTPTDNVRRFLQERWGGLRFALWGMQAREMELSRAIYATTLNLDGAAHEQDR

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=511, Percent_Identity=26.2230919765166, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI285002231, Length=511, Percent_Identity=26.2230919765166, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1788574, Length=508, Percent_Identity=42.5196850393701, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI2367226, Length=347, Percent_Identity=26.2247838616715, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17509253, Length=391, Percent_Identity=28.1329923273657, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI115534726, Length=550, Percent_Identity=25.2727272727273, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161077125, Length=388, Percent_Identity=28.6082474226804, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24653942, Length=388, Percent_Identity=28.6082474226804, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24653944, Length=388, Percent_Identity=28.6082474226804, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20130025, Length=388, Percent_Identity=28.6082474226804, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24586295, Length=381, Percent_Identity=26.7716535433071, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR006076
- InterPro:   IPR017752
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO; PF04324 Fer2_BFD [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 58292; Mature: 58292

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLETTVVVIGGGATGIGALRDLCMRGIPAILLEQGGIAHGTSSRFHGLLHSGARYVVNDN
CCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCCEEEECCC
ESARECIEENMIVRRIGRQCVEETEGFFALTPQDDPAYVEKFVAGCREAGIDAQEIEVAE
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
ALRLEPNLSPEVRRVFRVPDSCVDGFRLVLHNAMSARRHGGRMLTYHEATAITLRNGRVC
HHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECEEEEEEECCEEE
GVTAVDRHTGATVEIACQCVINAAGSWAGRIAGMAGLDVALSPDRGTLVVFNHRFTSRVI
EEEEECCCCCCCCEEEEEEHHHCCCCHHHHHCCCCCCEEEECCCCCEEEEECCHHHHHHH
NRLHPSGDGDIFVPHGSITILGTTSASTDRPDDTTPTTEEVLRLLDIGEPLFPQVRQYRI
HHCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
LRAFAGTRPLYTPGGAAGRKASRNFHIVDHADEGLEGMVSIFGGKLTTYRLMAERVVDRV
HHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
CAKLGHSAVCRTATEALVPDADEATLKRAARFFPMQGLNLMADRLGDDLPSVLELAEQQA
HHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHC
GNPLICECEMVSLAEIEYVARQPATYSLTDIRLRTRLGMGTCQGAFCSLRTVGALAEHGV
CCCEEEEEECHHHHHHHHHHCCCCCEEEHHEEEHHHCCCCCCCCHHHHHHHHHHHHHCCE
QLELTPTDNVRRFLQERWGGLRFALWGMQAREMELSRAIYATTLNLDGAAHEQDR
EEEECCCHHHHHHHHHHHCCEEEEEECCCHHHHHHHHEEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MLETTVVVIGGGATGIGALRDLCMRGIPAILLEQGGIAHGTSSRFHGLLHSGARYVVNDN
CCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCCEEEECCC
ESARECIEENMIVRRIGRQCVEETEGFFALTPQDDPAYVEKFVAGCREAGIDAQEIEVAE
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
ALRLEPNLSPEVRRVFRVPDSCVDGFRLVLHNAMSARRHGGRMLTYHEATAITLRNGRVC
HHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECEEEEEEECCEEE
GVTAVDRHTGATVEIACQCVINAAGSWAGRIAGMAGLDVALSPDRGTLVVFNHRFTSRVI
EEEEECCCCCCCCEEEEEEHHHCCCCHHHHHCCCCCCEEEECCCCCEEEEECCHHHHHHH
NRLHPSGDGDIFVPHGSITILGTTSASTDRPDDTTPTTEEVLRLLDIGEPLFPQVRQYRI
HHCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
LRAFAGTRPLYTPGGAAGRKASRNFHIVDHADEGLEGMVSIFGGKLTTYRLMAERVVDRV
HHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
CAKLGHSAVCRTATEALVPDADEATLKRAARFFPMQGLNLMADRLGDDLPSVLELAEQQA
HHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHC
GNPLICECEMVSLAEIEYVARQPATYSLTDIRLRTRLGMGTCQGAFCSLRTVGALAEHGV
CCCEEEEEECHHHHHHHHHHCCCCCEEEHHEEEHHHCCCCCCCCHHHHHHHHHHHHHCCE
QLELTPTDNVRRFLQERWGGLRFALWGMQAREMELSRAIYATTLNLDGAAHEQDR
EEEECCCHHHHHHHHHHHCCEEEEEECCCHHHHHHHHEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]