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The map label for this gene is clpA [H]

Identifier: 220904697

GI number: 220904697

Start: 1710238

End: 1712736

Strand: Reverse

Name: clpA [H]

Synonym: Ddes_1429

Alternate gene names: 220904697

Gene position: 1712736-1710238 (Counterclockwise)

Preceding gene: 220904698

Following gene: 220904696

Centisome position: 59.61

GC content: 60.22

Gene sequence:

>2499_bases
ATGCTGAGCAAGAGTGTTCAAAGCGTCATTCGTGATGCGCTTATGGAAGCGCACCGGCGCCGCCATGATATGTTGACTGT
CGAGCACGTGCTTTATGCGCTCACAAACAGCATGCGCGGCCGTATCCTGCTTGAGGGCAGCGGGGCCAGCGTGGCCGTGC
TGCGCGAGCAGCTCGAGGACTTTTTTAATCGTGAACTGGAAGTGGTTCCTCTTGCGGGCAAGCACGAAGTGGCCCAGACA
GAAGGTGTGCAGCGCGTGCTTGAGCGCGCCCTTGGGCATATCCGTGCTGCCGGACGTGATACCGTGGAACTGGGCGATCT
GCTCATTTCCATTATGGATGAAGAGGAAAGCTATGCCCACTATTACCTGCGCAAGCAGGGGGTGGAACGTCTGGACGTGC
TCACGTTTGTGTCGCACGGCATGGACGAGGGCGGTGGCTCCCGCGGGGTGGACCAGGGCGGCGAAGGCGAAGAAAAAGAC
GCCAAGGCCGACCCCCTGGCCCAGTATGCCGTTGACCTCACGGCCCGCGCCCGCGAAGGCAAGATAGACCCGCTGGTAGG
GCGTGAAAATGAGCTTGACCGCGCGGTAGAGGTTTTGTGCCGCCGCCGCAAGAATAACCCTCTTTTTGTGGGCGACCCCG
GCGTGGGAAAAACCGCTCTGGCCGAAGGTCTGGCTTTGCGCATAGTTGAAGACGACGTGCCGGAGATGTTCAGCAATGCC
AAACTGTTCGCCCTGGATATGGGCCTTCTGCTGGCAGGTACGCGCTATCGGGGAGATTTTGAAAGCCGCCTCAAGGCAGT
GGTGCAGCGTCTGAAGGAACTGCCTGAAGCCATTCTGTTCATTGATGAAATACATACCATCGTAGGTGCCGGTTCCACGT
CCGGCGGCTCCATGGATGCTTCCAACCTGCTCAAACCCGTGCTTGCCAGTGGCGAACTGCGCTGCATCGGCTCCACCACA
TACGAAGAGTTTCGCAACCATTTTGAAAAAGACCGCGCCCTGGCCCGGCGTTTTCAGCGTATCGACCTGACCGAGCCAAG
CCCGGAGGAATGTCTCGCCATCCTTCAAGGATTGGAAAAACGCTATGCGGATTTCCACAAGGTCCGGTACAGCACGGCTG
CTGTCAAGGCGATGGTGGACCTGACGGCCCGCCACGTGCGTGACCGTCTGCTGCCCGACAAGGCCATTGACGTTATGGAC
GAATCCGGGGCGGCTGTGCGCCTGGGCCGTGGGGTGCAGGGGGCCAGGGCTTCATCCGGCAAAAAAGCCGTTGCAAGCGG
GAAAAAGCTGCCGCCCCTGGTAAGCGTGGGGGATGTGGAGCGTATTGTGGCCCGTATGGCGGGCATTCCCGTGCGTACTG
TCTCCGGCACGGAACGCAACCGGCTGGCCTCGCTTGAGAAAGATCTCAAGGAGCTGGTGTTCGGGCAGGATGCGGCTATC
GAGCTTACTGTACGGGCCATCTTGCGCGCCCGCGCCGGGCTTGGTCAGGAGCAGCGCCCGGCCGGAGCGTTTTTATTCTA
CGGCCCCACGGGTGTTGGTAAAACAGAGGTGGCCCGCAGCCTGGCAAAACTCATGGGCGTGGAGTTTCTGCGTTATGACA
TGAGCGAATATATGGAAAAGCACGCCGTGTCGCGTCTTATCGGCGCGCCTCCCGGCTATGTGGGCTTTGATCAGGGCGGC
CTGCTGACCGAGGCCGTGCGCAAGGCCCCGTATTCCGTGGTATTGCTGGACGAGGTGGAAAAAGCCCACCCCGACATTTT
CAATGTGCTCCTTCAGGTAATGGATTATGCCACGCTGACGGATAATACGGGCCGCAAGACGGACTTTTCGCATGTTGTCC
TGATCATGACCTCCAATGCCGGAGCCTTTGACATGTCCCGCCCGGCCATGGGCTTTGGCGGGGCTACACGGCAGGATGCG
GCTCATAAGGGACTCAAGGCTGTGGAAAATACCTTCAGCCCCGAGTTCCGCAACAGGCTTGATGCGCTTGTGCCGTTCGG
TAGCCTGACTGAAGATATGATGCTGCGCATTGTGGACAAGTTTATGGCTGAAATTATCGAAAGCCTCGAGCAGCGACAGG
TGAGCCTTGAGCTTGGGCAGAAGGCCCGGCAATGGCTGGCCCGCAAGGGCTTTGACCCCACCATGGGGGCGCGTCCCCTG
CGGCGTCTGCTGCGTACCGAGCTGGAAGACAGGCTGGCGCACGAATTGCTGTTCGGTTCGCTGGCCAAGGGCGGAACCGC
CCGGCTTGACCTCGTGGATGATGCCCTTGTGCTGGAATCCGCTGCCGCCAGGTCTTCGCGGGCTGCTGCGTCCGGTAAAC
AGATGGTGAAGGGCAAGCCCAGGACGTCCGGCCCGGCAGATGCAAAGACCGCCAGTGCGGGCGGCAAGAAAAAAGCCTCT
GGCAAGGGCAGAACGCCGGGAACTGCAGCAAGTGGTTCTGGTTCCGGGGCTACGGTTGCCAAGGGCGAGCCTGTGAAGAA
ATCCGGCAAGGCAGACTAG

Upstream 100 bases:

>100_bases
ATGAAGTGGCTGAAACCAAGGTGAAAAGAGTGCATCAGGCAGCCAGAGCCGCCGGATTTCCCCTCAAGTGCACCATGGAA
AAAATTTACTGAGATTGCCT

Downstream 100 bases:

>100_bases
AGTTTTTTTACTTTGAAATGCCTTGTGGGCGCGGGACCCTTTTGCAAAAGGGTCCCGCGCCACGCCTTTAGCGCCTAACC
CATTATTCTTGTTCAAATCT

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 832; Mature: 832

Protein sequence:

>832_residues
MLSKSVQSVIRDALMEAHRRRHDMLTVEHVLYALTNSMRGRILLEGSGASVAVLREQLEDFFNRELEVVPLAGKHEVAQT
EGVQRVLERALGHIRAAGRDTVELGDLLISIMDEEESYAHYYLRKQGVERLDVLTFVSHGMDEGGGSRGVDQGGEGEEKD
AKADPLAQYAVDLTARAREGKIDPLVGRENELDRAVEVLCRRRKNNPLFVGDPGVGKTALAEGLALRIVEDDVPEMFSNA
KLFALDMGLLLAGTRYRGDFESRLKAVVQRLKELPEAILFIDEIHTIVGAGSTSGGSMDASNLLKPVLASGELRCIGSTT
YEEFRNHFEKDRALARRFQRIDLTEPSPEECLAILQGLEKRYADFHKVRYSTAAVKAMVDLTARHVRDRLLPDKAIDVMD
ESGAAVRLGRGVQGARASSGKKAVASGKKLPPLVSVGDVERIVARMAGIPVRTVSGTERNRLASLEKDLKELVFGQDAAI
ELTVRAILRARAGLGQEQRPAGAFLFYGPTGVGKTEVARSLAKLMGVEFLRYDMSEYMEKHAVSRLIGAPPGYVGFDQGG
LLTEAVRKAPYSVVLLDEVEKAHPDIFNVLLQVMDYATLTDNTGRKTDFSHVVLIMTSNAGAFDMSRPAMGFGGATRQDA
AHKGLKAVENTFSPEFRNRLDALVPFGSLTEDMMLRIVDKFMAEIIESLEQRQVSLELGQKARQWLARKGFDPTMGARPL
RRLLRTELEDRLAHELLFGSLAKGGTARLDLVDDALVLESAAARSSRAAASGKQMVKGKPRTSGPADAKTASAGGKKKAS
GKGRTPGTAASGSGSGATVAKGEPVKKSGKAD

Sequences:

>Translated_832_residues
MLSKSVQSVIRDALMEAHRRRHDMLTVEHVLYALTNSMRGRILLEGSGASVAVLREQLEDFFNRELEVVPLAGKHEVAQT
EGVQRVLERALGHIRAAGRDTVELGDLLISIMDEEESYAHYYLRKQGVERLDVLTFVSHGMDEGGGSRGVDQGGEGEEKD
AKADPLAQYAVDLTARAREGKIDPLVGRENELDRAVEVLCRRRKNNPLFVGDPGVGKTALAEGLALRIVEDDVPEMFSNA
KLFALDMGLLLAGTRYRGDFESRLKAVVQRLKELPEAILFIDEIHTIVGAGSTSGGSMDASNLLKPVLASGELRCIGSTT
YEEFRNHFEKDRALARRFQRIDLTEPSPEECLAILQGLEKRYADFHKVRYSTAAVKAMVDLTARHVRDRLLPDKAIDVMD
ESGAAVRLGRGVQGARASSGKKAVASGKKLPPLVSVGDVERIVARMAGIPVRTVSGTERNRLASLEKDLKELVFGQDAAI
ELTVRAILRARAGLGQEQRPAGAFLFYGPTGVGKTEVARSLAKLMGVEFLRYDMSEYMEKHAVSRLIGAPPGYVGFDQGG
LLTEAVRKAPYSVVLLDEVEKAHPDIFNVLLQVMDYATLTDNTGRKTDFSHVVLIMTSNAGAFDMSRPAMGFGGATRQDA
AHKGLKAVENTFSPEFRNRLDALVPFGSLTEDMMLRIVDKFMAEIIESLEQRQVSLELGQKARQWLARKGFDPTMGARPL
RRLLRTELEDRLAHELLFGSLAKGGTARLDLVDDALVLESAAARSSRAAASGKQMVKGKPRTSGPADAKTASAGGKKKAS
GKGRTPGTAASGSGSGATVAKGEPVKKSGKAD
>Mature_832_residues
MLSKSVQSVIRDALMEAHRRRHDMLTVEHVLYALTNSMRGRILLEGSGASVAVLREQLEDFFNRELEVVPLAGKHEVAQT
EGVQRVLERALGHIRAAGRDTVELGDLLISIMDEEESYAHYYLRKQGVERLDVLTFVSHGMDEGGGSRGVDQGGEGEEKD
AKADPLAQYAVDLTARAREGKIDPLVGRENELDRAVEVLCRRRKNNPLFVGDPGVGKTALAEGLALRIVEDDVPEMFSNA
KLFALDMGLLLAGTRYRGDFESRLKAVVQRLKELPEAILFIDEIHTIVGAGSTSGGSMDASNLLKPVLASGELRCIGSTT
YEEFRNHFEKDRALARRFQRIDLTEPSPEECLAILQGLEKRYADFHKVRYSTAAVKAMVDLTARHVRDRLLPDKAIDVMD
ESGAAVRLGRGVQGARASSGKKAVASGKKLPPLVSVGDVERIVARMAGIPVRTVSGTERNRLASLEKDLKELVFGQDAAI
ELTVRAILRARAGLGQEQRPAGAFLFYGPTGVGKTEVARSLAKLMGVEFLRYDMSEYMEKHAVSRLIGAPPGYVGFDQGG
LLTEAVRKAPYSVVLLDEVEKAHPDIFNVLLQVMDYATLTDNTGRKTDFSHVVLIMTSNAGAFDMSRPAMGFGGATRQDA
AHKGLKAVENTFSPEFRNRLDALVPFGSLTEDMMLRIVDKFMAEIIESLEQRQVSLELGQKARQWLARKGFDPTMGARPL
RRLLRTELEDRLAHELLFGSLAKGGTARLDLVDDALVLESAAARSSRAAASGKQMVKGKPRTSGPADAKTASAGGKKKAS
GKGRTPGTAASGSGSGATVAKGEPVKKSGKAD

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=334, Percent_Identity=32.9341317365269, Blast_Score=164, Evalue=4e-40,
Organism=Escherichia coli, GI1787109, Length=776, Percent_Identity=51.0309278350515, Blast_Score=783, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=330, Percent_Identity=45.4545454545455, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6320464, Length=329, Percent_Identity=43.161094224924, Blast_Score=280, Evalue=9e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=410, Percent_Identity=36.0975609756098, Blast_Score=238, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 90364; Mature: 90364

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKSVQSVIRDALMEAHRRRHDMLTVEHVLYALTNSMRGRILLEGSGASVAVLREQLED
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
FFNRELEVVPLAGKHEVAQTEGVQRVLERALGHIRAAGRDTVELGDLLISIMDEEESYAH
HHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHH
YYLRKQGVERLDVLTFVSHGMDEGGGSRGVDQGGEGEEKDAKADPLAQYAVDLTARAREG
HHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
KIDPLVGRENELDRAVEVLCRRRKNNPLFVGDPGVGKTALAEGLALRIVEDDVPEMFSNA
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEEEHHHHHHHHCCC
KLFALDMGLLLAGTRYRGDFESRLKAVVQRLKELPEAILFIDEIHTIVGAGSTSGGSMDA
EEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
SNLLKPVLASGELRCIGSTTYEEFRNHFEKDRALARRFQRIDLTEPSPEECLAILQGLEK
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
RYADFHKVRYSTAAVKAMVDLTARHVRDRLLPDKAIDVMDESGAAVRLGRGVQGARASSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEECCCCCCCCCCCC
KKAVASGKKLPPLVSVGDVERIVARMAGIPVRTVSGTERNRLASLEKDLKELVFGQDAAI
CHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCHH
ELTVRAILRARAGLGQEQRPAGAFLFYGPTGVGKTEVARSLAKLMGVEFLRYDMSEYMEK
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAVSRLIGAPPGYVGFDQGGLLTEAVRKAPYSVVLLDEVEKAHPDIFNVLLQVMDYATLT
HHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEEHHHHHHHCHHHHHHHHHHHHHHHHC
DNTGRKTDFSHVVLIMTSNAGAFDMSRPAMGFGGATRQDAAHKGLKAVENTFSPEFRNRL
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
DALVPFGSLTEDMMLRIVDKFMAEIIESLEQRQVSLELGQKARQWLARKGFDPTMGARPL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RRLLRTELEDRLAHELLFGSLAKGGTARLDLVDDALVLESAAARSSRAAASGKQMVKGKP
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
RTSGPADAKTASAGGKKKASGKGRTPGTAASGSGSGATVAKGEPVKKSGKAD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLSKSVQSVIRDALMEAHRRRHDMLTVEHVLYALTNSMRGRILLEGSGASVAVLREQLED
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
FFNRELEVVPLAGKHEVAQTEGVQRVLERALGHIRAAGRDTVELGDLLISIMDEEESYAH
HHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHH
YYLRKQGVERLDVLTFVSHGMDEGGGSRGVDQGGEGEEKDAKADPLAQYAVDLTARAREG
HHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
KIDPLVGRENELDRAVEVLCRRRKNNPLFVGDPGVGKTALAEGLALRIVEDDVPEMFSNA
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEEEHHHHHHHHCCC
KLFALDMGLLLAGTRYRGDFESRLKAVVQRLKELPEAILFIDEIHTIVGAGSTSGGSMDA
EEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
SNLLKPVLASGELRCIGSTTYEEFRNHFEKDRALARRFQRIDLTEPSPEECLAILQGLEK
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
RYADFHKVRYSTAAVKAMVDLTARHVRDRLLPDKAIDVMDESGAAVRLGRGVQGARASSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEECCCCCCCCCCCC
KKAVASGKKLPPLVSVGDVERIVARMAGIPVRTVSGTERNRLASLEKDLKELVFGQDAAI
CHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCHH
ELTVRAILRARAGLGQEQRPAGAFLFYGPTGVGKTEVARSLAKLMGVEFLRYDMSEYMEK
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAVSRLIGAPPGYVGFDQGGLLTEAVRKAPYSVVLLDEVEKAHPDIFNVLLQVMDYATLT
HHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEEHHHHHHHCHHHHHHHHHHHHHHHHC
DNTGRKTDFSHVVLIMTSNAGAFDMSRPAMGFGGATRQDAAHKGLKAVENTFSPEFRNRL
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
DALVPFGSLTEDMMLRIVDKFMAEIIESLEQRQVSLELGQKARQWLARKGFDPTMGARPL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RRLLRTELEDRLAHELLFGSLAKGGTARLDLVDDALVLESAAARSSRAAASGKQMVKGKP
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
RTSGPADAKTASAGGKKKASGKGRTPGTAASGSGSGATVAKGEPVKKSGKAD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]