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The map label for this gene is panF [H]

Identifier: 220904560

GI number: 220904560

Start: 1520621

End: 1522066

Strand: Direct

Name: panF [H]

Synonym: Ddes_1291

Alternate gene names: 220904560

Gene position: 1520621-1522066 (Clockwise)

Preceding gene: 220904559

Following gene: 220904561

Centisome position: 52.92

GC content: 57.19

Gene sequence:

>1446_bases
ATGTTTGGCGACGCTCTCATATGGCTTGGTTACATAGCCGTCTTCATCTGGCTGGCGCGAAAAGGGCGCGGACACGACGC
CATGGCAACAGGGCGCGTAGGTTTCGTCATTCAGGCACTTGCCTACGTGGCGACATATATTTCCGCCGTGGCCCTGGTGG
GCTTCGGCGGACTTTCGTATATGTACGGCATGCAGATGCTCCTGGTGGCCGCAGGCAACGTATGGCTCGGCACATGGCTC
GTGTACCGCTATCTGGCATGGCCGACCAGGGTTTGCCAGCGCAATCTTCAGGCCCGTACGCCGACACAGCTTATTGCCAA
AGGACACAAAAGCCCGTTGCTGGGCAAGGCGCTTGCCCTGATTTTTGCCGTATTCCTTGGCGTGTATGCTTCTGCAGTCA
TCAAGGGCGCAGCCCTTATGCTGGCCCAGATATTGCCTGTGCCTGTCTGGGCGCTGATCTGGATAGCAGCCGTGGTCGTA
GGGGTGGTGGTTTTTATAGGTGGACTGCGCGGCGTTCTCTACACTGAAGCCATGCAGGGCATTGTCATGCTGGTGGGGAT
TGTGCTGCTTATAGGAGCCGTACTCAGCAAGGTTGGCGGCCCCATTGAGGGCATGGCACAGCTGGCGCAGTTGCCGCCGA
CCCCCATGGCAAATGCAGGGTTTCTTGCCCTTTCTTCCGGCGAACAGGGCTGGTTCATCATATCACTGGTCATGGTTACT
TCCGTGGCGGTATGGGCGCAACCGCAGATGATGCAACGGCACTTCGCGCTCAACTCGCCCCGCCAGATAAACCGCATCAC
CCCTCTGGCCATGCTGGTACTTACTGTTCTTGTGGGCGGAACGTATTTTGTAGCGGCATTGTCACGCCTTATCCTGCCAG
ATGTTGCCTCGGCAGATGACGTAGTGCCGCACCTTGTCAAAATGCTTATGCCCGATGTGGGGCTTCAGCTTTTCGTGCTG
GCGATTGTTTCGGCCTCCCTGTCCACAGCAACAGCCCTTTTTCACATTGCCGTATCAGCCATTGCCGAAGACTTGCCCGG
CCGTCCCGCCACACGTTTTTCATGGTTCATCGGCATTGTATTCTGCGTATTGATTTCCGGTGGCAGCGCCCAGATCAAGG
GGCAGCTTATCGCCCTGCTGTGCACTACCAGTTGGAGCATCGTCGGCGCTACGGTTCTTACAAGCTATGTAGCCCTTGTC
CGTTTCGGCAAACGCAGCCCCATAGCCGCATGGCTGAGCTGCGGCCTTGGTTTTGCTTCATGTCTGCTCTGGTATCTGCT
GGCCAACAAAGGCGTATCCCCCACTCCTGTGCTGGGAATGCAGGCAGCCCTCATCCCCCCTTTCTTTGTGGGTATAGCCT
TTTCGCTTATGGGCTGGTTTATTGGTTGGGCACTGGACCGGGAAGGACGCAAAGCTTCCACGTTCTGGCCGGCGCCCAAT
GCATGA

Upstream 100 bases:

>100_bases
GTTGACGGACGCCGCCGTGCGTATTGCCATGACACTACTCGCCGGTTCCTTTGTTCTGGCGCTTGTTACCCTGGTACGCC
AGGTCCAAAGAGGATAAGCC

Downstream 100 bases:

>100_bases
CCAGCATACCGCTTCTGATAGGCCGGGGAAACCCGGCTTTTTTATTAAAAAGTACGTTAGCTGGGCATTGAGGCTGGCGA
GATCTACCGACTTCTGCTAT

Product: Na+/solute symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MFGDALIWLGYIAVFIWLARKGRGHDAMATGRVGFVIQALAYVATYISAVALVGFGGLSYMYGMQMLLVAAGNVWLGTWL
VYRYLAWPTRVCQRNLQARTPTQLIAKGHKSPLLGKALALIFAVFLGVYASAVIKGAALMLAQILPVPVWALIWIAAVVV
GVVVFIGGLRGVLYTEAMQGIVMLVGIVLLIGAVLSKVGGPIEGMAQLAQLPPTPMANAGFLALSSGEQGWFIISLVMVT
SVAVWAQPQMMQRHFALNSPRQINRITPLAMLVLTVLVGGTYFVAALSRLILPDVASADDVVPHLVKMLMPDVGLQLFVL
AIVSASLSTATALFHIAVSAIAEDLPGRPATRFSWFIGIVFCVLISGGSAQIKGQLIALLCTTSWSIVGATVLTSYVALV
RFGKRSPIAAWLSCGLGFASCLLWYLLANKGVSPTPVLGMQAALIPPFFVGIAFSLMGWFIGWALDREGRKASTFWPAPN
A

Sequences:

>Translated_481_residues
MFGDALIWLGYIAVFIWLARKGRGHDAMATGRVGFVIQALAYVATYISAVALVGFGGLSYMYGMQMLLVAAGNVWLGTWL
VYRYLAWPTRVCQRNLQARTPTQLIAKGHKSPLLGKALALIFAVFLGVYASAVIKGAALMLAQILPVPVWALIWIAAVVV
GVVVFIGGLRGVLYTEAMQGIVMLVGIVLLIGAVLSKVGGPIEGMAQLAQLPPTPMANAGFLALSSGEQGWFIISLVMVT
SVAVWAQPQMMQRHFALNSPRQINRITPLAMLVLTVLVGGTYFVAALSRLILPDVASADDVVPHLVKMLMPDVGLQLFVL
AIVSASLSTATALFHIAVSAIAEDLPGRPATRFSWFIGIVFCVLISGGSAQIKGQLIALLCTTSWSIVGATVLTSYVALV
RFGKRSPIAAWLSCGLGFASCLLWYLLANKGVSPTPVLGMQAALIPPFFVGIAFSLMGWFIGWALDREGRKASTFWPAPN
A
>Mature_481_residues
MFGDALIWLGYIAVFIWLARKGRGHDAMATGRVGFVIQALAYVATYISAVALVGFGGLSYMYGMQMLLVAAGNVWLGTWL
VYRYLAWPTRVCQRNLQARTPTQLIAKGHKSPLLGKALALIFAVFLGVYASAVIKGAALMLAQILPVPVWALIWIAAVVV
GVVVFIGGLRGVLYTEAMQGIVMLVGIVLLIGAVLSKVGGPIEGMAQLAQLPPTPMANAGFLALSSGEQGWFIISLVMVT
SVAVWAQPQMMQRHFALNSPRQINRITPLAMLVLTVLVGGTYFVAALSRLILPDVASADDVVPHLVKMLMPDVGLQLFVL
AIVSASLSTATALFHIAVSAIAEDLPGRPATRFSWFIGIVFCVLISGGSAQIKGQLIALLCTTSWSIVGATVLTSYVALV
RFGKRSPIAAWLSCGLGFASCLLWYLLANKGVSPTPVLGMQAALIPPFFVGIAFSLMGWFIGWALDREGRKASTFWPAPN
A

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Escherichia coli, GI87082237, Length=326, Percent_Identity=26.0736196319018, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51277; Mature: 51277

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure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C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]