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The map label for this gene is moaA [H]

Identifier: 220904538

GI number: 220904538

Start: 1497826

End: 1498860

Strand: Reverse

Name: moaA [H]

Synonym: Ddes_1269

Alternate gene names: 220904538

Gene position: 1498860-1497826 (Counterclockwise)

Preceding gene: 220904540

Following gene: 220904537

Centisome position: 52.16

GC content: 58.84

Gene sequence:

>1035_bases
GTGGGGACAGCTTGCGAGCGGGCAGACTTTTCTGCTCCTGCGCCTCTGGTGGACGGCCATGGCCGTGTTGTGCGTTATTT
GCGACTTTCCGTCACGGATCGTTGTAATCTGCGCTGCATGTACTGCTGCAGCAATGCCAGACAGACCTGTATTCCACATA
CGCAGGTGCTGCGGTATGAGGAAATGGCGCGTATGGTCGGCATTATGGCCCGCCTTGGGGTGACCAAGGTGCGCCTGACC
GGGGGGGAGCCGTTCGCGCGAAAAGGCTGTGACGGCTTTTTATATATGCTGCACTCGCGTTTTCCGGATATGGACCTGCG
CCTTACTACCAACGGAACCTTGCTTGAGCCACATATTCCGCTGTTGCGTCAGGTGGGGGTCAAAGCCGTCAACTTGTCTC
TGGACAGCTTTGACCGGGAAACTTTCGCCAAGGTTACGGGGCGCGACATGCAGCCTGCCGTGTTGTCGGCACTGGACAGG
CTGCTGTCTGCGGGCATCAGGGTAAAGGTGAACGCCGTGGCCATGCGGGGCGTCAATGACGGGCAGATGGACGACTTTGT
CCACGCGGTACGAACCATGCCCATTGACCTGCGTTTTATTGAATTCATGCCTATGGGCAGCGGAACGCTCTGGAATGCCG
GCACATTCTGGCCGGCTGCGGATATCCGCGCCGAAGCGGAACGTCGGGTACGCCTTGTCCCCGAAAAAGAAGACAGGGCC
GAGGCCGGTCCCGCCCGTATGTTCCGGGTGAAAGGCGGCAAGGGGCGTCTCGGTTTTATTACCGCAGTCAGCTGCCATTT
TTGCGGCTCCTGCAATCGGCTGCGACTCACTAGCGATGGCAATCTGCGCACCTGTCTTTTTGATGACAGGGAGTATGCTT
TGCGCCATTTTTTGCGCGACCCTGCCATGACAGACGCCGATATTGAGCGGACCATACGTAAGGCCTGCACGGAAAAACCT
GTGGGAGCGGAATTGCTGGCAAACCGCTCCGGAGACGAGGTGGCCGCCAGGCAGATGGTAGGCATCGGCGGCTGA

Upstream 100 bases:

>100_bases
CAGGCTGCCCGCGAGGGCCGCTCCCATAAGCAGGTATTTCATGCAGGCAGATGTAAATCCATTTCCGCTTCTTGGCAACA
GGCATGATGTTGAAGAAGGC

Downstream 100 bases:

>100_bases
AGCCCGGTGGGGCCTATTTGAAAAAACAGGGCATTCGGTTATGCTGGCTGCGGTATGCGCACCTGTGGGGCTGCGCTGCC
GGTATTATCCATCTGACCCG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MGTACERADFSAPAPLVDGHGRVVRYLRLSVTDRCNLRCMYCCSNARQTCIPHTQVLRYEEMARMVGIMARLGVTKVRLT
GGEPFARKGCDGFLYMLHSRFPDMDLRLTTNGTLLEPHIPLLRQVGVKAVNLSLDSFDRETFAKVTGRDMQPAVLSALDR
LLSAGIRVKVNAVAMRGVNDGQMDDFVHAVRTMPIDLRFIEFMPMGSGTLWNAGTFWPAADIRAEAERRVRLVPEKEDRA
EAGPARMFRVKGGKGRLGFITAVSCHFCGSCNRLRLTSDGNLRTCLFDDREYALRHFLRDPAMTDADIERTIRKACTEKP
VGAELLANRSGDEVAARQMVGIGG

Sequences:

>Translated_344_residues
MGTACERADFSAPAPLVDGHGRVVRYLRLSVTDRCNLRCMYCCSNARQTCIPHTQVLRYEEMARMVGIMARLGVTKVRLT
GGEPFARKGCDGFLYMLHSRFPDMDLRLTTNGTLLEPHIPLLRQVGVKAVNLSLDSFDRETFAKVTGRDMQPAVLSALDR
LLSAGIRVKVNAVAMRGVNDGQMDDFVHAVRTMPIDLRFIEFMPMGSGTLWNAGTFWPAADIRAEAERRVRLVPEKEDRA
EAGPARMFRVKGGKGRLGFITAVSCHFCGSCNRLRLTSDGNLRTCLFDDREYALRHFLRDPAMTDADIERTIRKACTEKP
VGAELLANRSGDEVAARQMVGIGG
>Mature_343_residues
GTACERADFSAPAPLVDGHGRVVRYLRLSVTDRCNLRCMYCCSNARQTCIPHTQVLRYEEMARMVGIMARLGVTKVRLTG
GEPFARKGCDGFLYMLHSRFPDMDLRLTTNGTLLEPHIPLLRQVGVKAVNLSLDSFDRETFAKVTGRDMQPAVLSALDRL
LSAGIRVKVNAVAMRGVNDGQMDDFVHAVRTMPIDLRFIEFMPMGSGTLWNAGTFWPAADIRAEAERRVRLVPEKEDRAE
AGPARMFRVKGGKGRLGFITAVSCHFCGSCNRLRLTSDGNLRTCLFDDREYALRHFLRDPAMTDADIERTIRKACTEKPV
GAELLANRSGDEVAARQMVGIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=341, Percent_Identity=35.1906158357771, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI22027536, Length=341, Percent_Identity=35.1906158357771, Blast_Score=195, Evalue=6e-50,
Organism=Escherichia coli, GI1786999, Length=335, Percent_Identity=34.9253731343284, Blast_Score=178, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI32566329, Length=337, Percent_Identity=35.3115727002967, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI32566331, Length=325, Percent_Identity=35.0769230769231, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=340, Percent_Identity=35, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI28574488, Length=346, Percent_Identity=35.2601156069364, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI28574490, Length=321, Percent_Identity=35.8255451713396, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38217; Mature: 38086

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
8.1 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTACERADFSAPAPLVDGHGRVVRYLRLSVTDRCNLRCMYCCSNARQTCIPHTQVLRYE
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHH
EMARMVGIMARLGVTKVRLTGGEPFARKGCDGFLYMLHSRFPDMDLRLTTNGTLLEPHIP
HHHHHHHHHHHCCCEEEEEECCCCHHHCCCCHHHHHHHHCCCCCEEEEECCCCEECCCHH
LLRQVGVKAVNLSLDSFDRETFAKVTGRDMQPAVLSALDRLLSAGIRVKVNAVAMRGVND
HHHHCCCEEEEEEHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCC
GQMDDFVHAVRTMPIDLRFIEFMPMGSGTLWNAGTFWPAADIRAEAERRVRLVPEKEDRA
CCHHHHHHHHHCCCCEEEEEEEEECCCCCEECCCCCCCCHHHHHCCCCCEEECCCCCCCC
EAGPARMFRVKGGKGRLGFITAVSCHFCGSCNRLRLTSDGNLRTCLFDDREYALRHFLRD
CCCCCEEEEEECCCCCEEEEEEEEHHHCCCCCEEEEECCCCEEEEEECCHHHHHHHHHCC
PAMTDADIERTIRKACTEKPVGAELLANRSGDEVAARQMVGIGG
CCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
GTACERADFSAPAPLVDGHGRVVRYLRLSVTDRCNLRCMYCCSNARQTCIPHTQVLRYE
CCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHH
EMARMVGIMARLGVTKVRLTGGEPFARKGCDGFLYMLHSRFPDMDLRLTTNGTLLEPHIP
HHHHHHHHHHHCCCEEEEEECCCCHHHCCCCHHHHHHHHCCCCCEEEEECCCCEECCCHH
LLRQVGVKAVNLSLDSFDRETFAKVTGRDMQPAVLSALDRLLSAGIRVKVNAVAMRGVND
HHHHCCCEEEEEEHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCC
GQMDDFVHAVRTMPIDLRFIEFMPMGSGTLWNAGTFWPAADIRAEAERRVRLVPEKEDRA
CCHHHHHHHHHCCCCEEEEEEEEECCCCCEECCCCCCCCHHHHHCCCCCEEECCCCCCCC
EAGPARMFRVKGGKGRLGFITAVSCHFCGSCNRLRLTSDGNLRTCLFDDREYALRHFLRD
CCCCCEEEEEECCCCCEEEEEEEEHHHCCCCCEEEEECCCCEEEEEECCHHHHHHHHHCC
PAMTDADIERTIRKACTEKPVGAELLANRSGDEVAARQMVGIGG
CCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA