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The map label for this gene is fbp [H]

Identifier: 220904467

GI number: 220904467

Start: 1408854

End: 1409867

Strand: Direct

Name: fbp [H]

Synonym: Ddes_1197

Alternate gene names: 220904467

Gene position: 1408854-1409867 (Clockwise)

Preceding gene: 220904466

Following gene: 220904468

Centisome position: 49.03

GC content: 52.86

Gene sequence:

>1014_bases
ATGGCTGATATCACGGTCACGGAACATCTGCTGCTGCATCAAAAGCGCACCCCGCAGGCCACGGGGCAATTTACCGGCTT
GCTGTACGACCTTATCCTTTCCGGCAAAAGTATCTCCCGCCGCATTAACAAGGCTGGGTTGTTGGATATTCTCGGCGGTA
CAGGCGAGGTTAACGTTCAAGGCGAGAATGTTCAGAAAATGGATACAATCGCCAATCGCATCATGCTCTACCGCATGGAG
CGGTGTGGCGCCCTGTGTGCCATGAGTTCGGAAGAAGAGGCCGACCTGATACGCGTCAGCCCGGAATTTCCCCGTGGCGA
CTATATCTTGATTTTTGATCCGCTGGACGGTTCTTCCAACATTGATGTTAACATCAATGTTGGAACAATTTTTTCGATTT
TACGTCGTCCCGATGGGCATTCAGGCGAAGTGACGCTGGATGAGGTGCTGCAGCCGGGCAACAGGCAAGTGGCGGCAGGT
TATATTTTATATGGTCCCTCCACCATGCTTGTACTCAGCACGGGGCAAGGAGTTCATGGCTTCACCCTTGACCCTGGAGT
GGGAGAATTTTTGCTTTCCCATCCCAACATGTGCATCCCCGAGCAGGGGTACATCTATTCGGTAAATGAGGGGAACTGGA
AGAATTGGGATGCCCCTGCCCGCGAGGCTGTAAACTGGTTTCACGGCTGTGAAACTTCAGACGGAAAGCCGTATTCCTCC
CGGTATGTCGGTGCTCTTGTTGCGGATTTTCATCGCACGTTGATCAACGGCGGCATTTATATGTACCCATCGGATGCCAA
AAAACCCAACGGCAAACTGCGTCTTATGTGCGAGGCTGCCCCCTTGGCTTTTCTTGCGGAGCAGGCCGGGGGCAAGGCAA
GTGACGGCAGGGGCCGCATTCTTGAAAGGGTTCCCGAGCACTTGCATGCACGTACGCCTTTATTCATCGGCTCCGCCAAA
GATGTGGAAGCTGTTGAAAACATTTATGCCAAGTATGCCGGTTTGATAGCCTGA

Upstream 100 bases:

>100_bases
TTCGGGCCACGGAATTGACGCATATTATGAAGCTTGCGCCGCCCCGGGGCGGCGCAAGCCTTTAGGTATTCGGAACATCT
GTTTTTTGCAGGAGGCCTGC

Downstream 100 bases:

>100_bases
CAGCAAATCGTACGTAATTCTGGGGCCGCGTTCGGCGCGGCTCCTGTTTTTTGTTGAAAGAGAGACCATATGCTTTGCCT
TGGCATTGAAAGTTCCTGTG

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MADITVTEHLLLHQKRTPQATGQFTGLLYDLILSGKSISRRINKAGLLDILGGTGEVNVQGENVQKMDTIANRIMLYRME
RCGALCAMSSEEEADLIRVSPEFPRGDYILIFDPLDGSSNIDVNINVGTIFSILRRPDGHSGEVTLDEVLQPGNRQVAAG
YILYGPSTMLVLSTGQGVHGFTLDPGVGEFLLSHPNMCIPEQGYIYSVNEGNWKNWDAPAREAVNWFHGCETSDGKPYSS
RYVGALVADFHRTLINGGIYMYPSDAKKPNGKLRLMCEAAPLAFLAEQAGGKASDGRGRILERVPEHLHARTPLFIGSAK
DVEAVENIYAKYAGLIA

Sequences:

>Translated_337_residues
MADITVTEHLLLHQKRTPQATGQFTGLLYDLILSGKSISRRINKAGLLDILGGTGEVNVQGENVQKMDTIANRIMLYRME
RCGALCAMSSEEEADLIRVSPEFPRGDYILIFDPLDGSSNIDVNINVGTIFSILRRPDGHSGEVTLDEVLQPGNRQVAAG
YILYGPSTMLVLSTGQGVHGFTLDPGVGEFLLSHPNMCIPEQGYIYSVNEGNWKNWDAPAREAVNWFHGCETSDGKPYSS
RYVGALVADFHRTLINGGIYMYPSDAKKPNGKLRLMCEAAPLAFLAEQAGGKASDGRGRILERVPEHLHARTPLFIGSAK
DVEAVENIYAKYAGLIA
>Mature_336_residues
ADITVTEHLLLHQKRTPQATGQFTGLLYDLILSGKSISRRINKAGLLDILGGTGEVNVQGENVQKMDTIANRIMLYRMER
CGALCAMSSEEEADLIRVSPEFPRGDYILIFDPLDGSSNIDVNINVGTIFSILRRPDGHSGEVTLDEVLQPGNRQVAAGY
ILYGPSTMLVLSTGQGVHGFTLDPGVGEFLLSHPNMCIPEQGYIYSVNEGNWKNWDAPAREAVNWFHGCETSDGKPYSSR
YVGALVADFHRTLINGGIYMYPSDAKKPNGKLRLMCEAAPLAFLAEQAGGKASDGRGRILERVPEHLHARTPLFIGSAKD
VEAVENIYAKYAGLIA

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family [H]

Homologues:

Organism=Homo sapiens, GI189083692, Length=332, Percent_Identity=41.2650602409639, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI16579888, Length=332, Percent_Identity=41.2650602409639, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI22907028, Length=322, Percent_Identity=43.7888198757764, Blast_Score=259, Evalue=3e-69,
Organism=Escherichia coli, GI1790679, Length=328, Percent_Identity=50, Blast_Score=318, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI17508131, Length=329, Percent_Identity=46.5045592705167, Blast_Score=303, Evalue=7e-83,
Organism=Saccharomyces cerevisiae, GI6323409, Length=324, Percent_Identity=44.7530864197531, Blast_Score=271, Evalue=8e-74,
Organism=Drosophila melanogaster, GI45550998, Length=321, Percent_Identity=45.4828660436137, Blast_Score=281, Evalue=3e-76,
Organism=Drosophila melanogaster, GI19921562, Length=321, Percent_Identity=45.4828660436137, Blast_Score=281, Evalue=4e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000146 [H]

Pfam domain/function: PF00316 FBPase [H]

EC number: =3.1.3.11 [H]

Molecular weight: Translated: 36811; Mature: 36680

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADITVTEHLLLHQKRTPQATGQFTGLLYDLILSGKSISRRINKAGLLDILGGTGEVNVQ
CCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCEEEEECCCCEEEEE
GENVQKMDTIANRIMLYRMERCGALCAMSSEEEADLIRVSPEFPRGDYILIFDPLDGSSN
CCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEECCCCCCCCEEEEEECCCCCCC
IDVNINVGTIFSILRRPDGHSGEVTLDEVLQPGNRQVAAGYILYGPSTMLVLSTGQGVHG
EEEEEEHHHHHHHHHCCCCCCCCEEHHHHHCCCCCEEEEEEEEECCCEEEEEECCCCCCC
FTLDPGVGEFLLSHPNMCIPEQGYIYSVNEGNWKNWDAPAREAVNWFHGCETSDGKPYSS
EEECCCHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHH
RYVGALVADFHRTLINGGIYMYPSDAKKPNGKLRLMCEAAPLAFLAEQAGGKASDGRGRI
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEECCCCHHHHHHHCCCCCCCCCHHH
LERVPEHLHARTPLFIGSAKDVEAVENIYAKYAGLIA
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADITVTEHLLLHQKRTPQATGQFTGLLYDLILSGKSISRRINKAGLLDILGGTGEVNVQ
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCEEEEECCCCEEEEE
GENVQKMDTIANRIMLYRMERCGALCAMSSEEEADLIRVSPEFPRGDYILIFDPLDGSSN
CCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEECCCCCCCCEEEEEECCCCCCC
IDVNINVGTIFSILRRPDGHSGEVTLDEVLQPGNRQVAAGYILYGPSTMLVLSTGQGVHG
EEEEEEHHHHHHHHHCCCCCCCCEEHHHHHCCCCCEEEEEEEEECCCEEEEEECCCCCCC
FTLDPGVGEFLLSHPNMCIPEQGYIYSVNEGNWKNWDAPAREAVNWFHGCETSDGKPYSS
EEECCCHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHH
RYVGALVADFHRTLINGGIYMYPSDAKKPNGKLRLMCEAAPLAFLAEQAGGKASDGRGRI
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEECCCCHHHHHHHCCCCCCCCCHHH
LERVPEHLHARTPLFIGSAKDVEAVENIYAKYAGLIA
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA