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The map label for this gene is 220904453

Identifier: 220904453

GI number: 220904453

Start: 1391002

End: 1391556

Strand: Reverse

Name: 220904453

Synonym: Ddes_1183

Alternate gene names: NA

Gene position: 1391556-1391002 (Counterclockwise)

Preceding gene: 220904454

Following gene: 220904452

Centisome position: 48.43

GC content: 50.81

Gene sequence:

>555_bases
ATGAAACAATTGTGGGCACCTTGGCGTATTGAGTACATTCTTGGACCAAAGCCGGACACCTGTGTGTTCTGTCTTCCCGC
CGGCCCCCAGGAGGACGAACAGCGCCTCGTCCTTTACAGGGGGCGGCATGCCTTTGTCATCATGAACAAATTTCCGTATA
ATAACGGGCATCTTATGGTTTGTCCTTACAGGCATGTCATGAACATTGCCGACCTGGACACTACTGAAACCCATGAAATT
ATGGATCTTCTTCAAATATGCGCCACAATATTAAAGAAACACTTTAACTGTGAAGGTATCAATATCGGCCTTAATCAGGG
CGAAGCTGCCGGAGCTGGAATCAGGGAACACATGCATTTTCACCTGGTCCCGCGTTGGAACGGAGACTCGTCCTTCATGG
CGGTCTTTGACGAAGTGCGTACAATGCCTGAACACCTAAGACGCAGCTATGCGGCGTTGAAACCATATTTCACGAATGGC
GCTTTGGCTGGGGAGCCATACAGCGCCGGTTCCTCGCCCCATCAGGAAGGTTGCAGTCCGCAGCGGAACAGTTGA

Upstream 100 bases:

>100_bases
CATAATGTATTGAATATATTGCTCATATTACAATCAACATTTTATGCCAGACTGGTTTTCCGCTTGCTCCTGATGATCAG
GCGGTGTATAGAAAAAAACT

Downstream 100 bases:

>100_bases
CGGAATCAGTGGCGAAGGAAGTGTTTTTTACGCCGGGCGGCGTAAAAAATTCGGCTGGAGAGCGCAAGCTGTGCCCCTCA
TGGGCGGGCGGCATTCTCAA

Product: histidine triad (HIT) protein

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MKQLWAPWRIEYILGPKPDTCVFCLPAGPQEDEQRLVLYRGRHAFVIMNKFPYNNGHLMVCPYRHVMNIADLDTTETHEI
MDLLQICATILKKHFNCEGINIGLNQGEAAGAGIREHMHFHLVPRWNGDSSFMAVFDEVRTMPEHLRRSYAALKPYFTNG
ALAGEPYSAGSSPHQEGCSPQRNS

Sequences:

>Translated_184_residues
MKQLWAPWRIEYILGPKPDTCVFCLPAGPQEDEQRLVLYRGRHAFVIMNKFPYNNGHLMVCPYRHVMNIADLDTTETHEI
MDLLQICATILKKHFNCEGINIGLNQGEAAGAGIREHMHFHLVPRWNGDSSFMAVFDEVRTMPEHLRRSYAALKPYFTNG
ALAGEPYSAGSSPHQEGCSPQRNS
>Mature_184_residues
MKQLWAPWRIEYILGPKPDTCVFCLPAGPQEDEQRLVLYRGRHAFVIMNKFPYNNGHLMVCPYRHVMNIADLDTTETHEI
MDLLQICATILKKHFNCEGINIGLNQGEAAGAGIREHMHFHLVPRWNGDSSFMAVFDEVRTMPEHLRRSYAALKPYFTNG
ALAGEPYSAGSSPHQEGCSPQRNS

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320511, Length=104, Percent_Identity=25.9615384615385, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 20899; Mature: 20899

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00133 CARBOXYPEPT_ZN_2 ; PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLWAPWRIEYILGPKPDTCVFCLPAGPQEDEQRLVLYRGRHAFVIMNKFPYNNGHLMV
CCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCEEEEEEECCCCCCCCEEE
CPYRHVMNIADLDTTETHEIMDLLQICATILKKHFNCEGINIGLNQGEAAGAGIREHMHF
ECHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHCEEE
HLVPRWNGDSSFMAVFDEVRTMPEHLRRSYAALKPYFTNGALAGEPYSAGSSPHQEGCSP
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
QRNS
CCCC
>Mature Secondary Structure
MKQLWAPWRIEYILGPKPDTCVFCLPAGPQEDEQRLVLYRGRHAFVIMNKFPYNNGHLMV
CCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCEEEEEEECCCCCCCCEEE
CPYRHVMNIADLDTTETHEIMDLLQICATILKKHFNCEGINIGLNQGEAAGAGIREHMHF
ECHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHCEEE
HLVPRWNGDSSFMAVFDEVRTMPEHLRRSYAALKPYFTNGALAGEPYSAGSSPHQEGCSP
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
QRNS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]