Click here to switch to the map view.

The map label for this gene is argG [H]

Identifier: 220904367

GI number: 220904367

Start: 1284324

End: 1285529

Strand: Reverse

Name: argG [H]

Synonym: Ddes_1095

Alternate gene names: 220904367

Gene position: 1285529-1284324 (Counterclockwise)

Preceding gene: 220904373

Following gene: 220904366

Centisome position: 44.74

GC content: 57.38

Gene sequence:

>1206_bases
ATGCAAGACATAAAAAAAGTTGTTCTCGCCTACTCCGGCGGGCTTGATACATCGGTTATCCTGAAATGGCTTATTGAGAC
CTACAAATGCGAGGTCATTGCCGTCACCGCCGATCTGGGCCAGCCTGAAGATCTCTCCGGCGTGGAAGAAAAGGCACTTA
AAACCGGCGCTTCCAAAGCCTATGTGGTTGACCTGCGCGAAGAGATGGCCAAAGATTTTGTCTTTCCCATGATGCGTGGC
GCAGCCATCTACGAAGGCCGCTACCTGCTCGGCACTTCCATTGCCCGGCCCCTCATTGCCAAGGCTCTGGTGGACATCGC
CCGCAAGGAAGGTGCCGACGCCATAGCTCACGGTGCGACCGGCAAGGGCAACGATCAGGTCCGCTTTGAATTCGCTGCCA
GCGCCCTGGCTCCGGATATCAAGGTCATCGCCCCCTGGCGTGAATGGGAGCTTATGTCCCGTACAGCCCTTACCGCTTTT
GCTGAAAAGCACGGCATTCCCATTTCCAGCTCAGCCAAGCGGTACAGCATGGATGCCAACATGCTGCATACCAGTTTTGA
AGGCAGCGAACTGGAAAATCCGGGCAATGAACCGCACGAATCTTGCCATGAGCGCTGTGTGCCGGTGGAACAAGCCCCGG
ACACGCCTGAAATTGTCACTGTGGACTTTGAGCAAGGCAACCCCGTGGCTGTAAACAGCAAGGCTCTTTCCCCCGCCGCA
GTCATAACTACCCTGGCAGAAATCGCCGGACGCAACGGTATTGGCCGCGACGATATGGTAGAAAACCGTTTTGTGGGCAT
GAAGTGCCGCGGGGTATACGAAAACCCCGCAGGAACCCTGCTCTACAAGCTGCACCGCGACCTTGAGGGCATCTGCCTGG
ACCGCGAACTGCTCGGCATACGTGACATGCTGGCCGTGCGTTACTCCCAGTGCGTGTACAATGGGTTCTGGTATTCGCCC
GAGCGCGAAGCCATGCAGGCCTTTATGGACAAGGCGCAGGAAAGCGTTACCGGCACGGTACGCGCCAAGCTGTACAAGGG
CGGCGTATGGCCCCTGTCGCGCACGTCTCCCAACTCCCTCTTCTCTGAAGACCTGGCGACATTTGAAGGTGGCGACTACG
ACCACAAGGACGCGGCGGGCTTCATATGCCTTAACAGCCTGCGCCTGCGCCTGCATGCGGCCGTCGCCGACAAGTTGAAA
AAATAA

Upstream 100 bases:

>100_bases
TCTCCGTACAGTCCGCAGGTTTCCTTCCGGCACTAAAGCCTTGCGCCCCGCGCTGATTTACGCAATACTTCTTCTCTTGA
ATTCATAAGGGGGCTTGATA

Downstream 100 bases:

>100_bases
TACAGAACGCCGGATTACAGCCACCTGCGGCGACCCGTGAGGCGACGGTCTCCGGGTTGCCGGGGTTCTGAAAAAACAGC
TTTGCCGCCAAAAGCACGGC

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MQDIKKVVLAYSGGLDTSVILKWLIETYKCEVIAVTADLGQPEDLSGVEEKALKTGASKAYVVDLREEMAKDFVFPMMRG
AAIYEGRYLLGTSIARPLIAKALVDIARKEGADAIAHGATGKGNDQVRFEFAASALAPDIKVIAPWREWELMSRTALTAF
AEKHGIPISSSAKRYSMDANMLHTSFEGSELENPGNEPHESCHERCVPVEQAPDTPEIVTVDFEQGNPVAVNSKALSPAA
VITTLAEIAGRNGIGRDDMVENRFVGMKCRGVYENPAGTLLYKLHRDLEGICLDRELLGIRDMLAVRYSQCVYNGFWYSP
EREAMQAFMDKAQESVTGTVRAKLYKGGVWPLSRTSPNSLFSEDLATFEGGDYDHKDAAGFICLNSLRLRLHAAVADKLK
K

Sequences:

>Translated_401_residues
MQDIKKVVLAYSGGLDTSVILKWLIETYKCEVIAVTADLGQPEDLSGVEEKALKTGASKAYVVDLREEMAKDFVFPMMRG
AAIYEGRYLLGTSIARPLIAKALVDIARKEGADAIAHGATGKGNDQVRFEFAASALAPDIKVIAPWREWELMSRTALTAF
AEKHGIPISSSAKRYSMDANMLHTSFEGSELENPGNEPHESCHERCVPVEQAPDTPEIVTVDFEQGNPVAVNSKALSPAA
VITTLAEIAGRNGIGRDDMVENRFVGMKCRGVYENPAGTLLYKLHRDLEGICLDRELLGIRDMLAVRYSQCVYNGFWYSP
EREAMQAFMDKAQESVTGTVRAKLYKGGVWPLSRTSPNSLFSEDLATFEGGDYDHKDAAGFICLNSLRLRLHAAVADKLK
K
>Mature_401_residues
MQDIKKVVLAYSGGLDTSVILKWLIETYKCEVIAVTADLGQPEDLSGVEEKALKTGASKAYVVDLREEMAKDFVFPMMRG
AAIYEGRYLLGTSIARPLIAKALVDIARKEGADAIAHGATGKGNDQVRFEFAASALAPDIKVIAPWREWELMSRTALTAF
AEKHGIPISSSAKRYSMDANMLHTSFEGSELENPGNEPHESCHERCVPVEQAPDTPEIVTVDFEQGNPVAVNSKALSPAA
VITTLAEIAGRNGIGRDDMVENRFVGMKCRGVYENPAGTLLYKLHRDLEGICLDRELLGIRDMLAVRYSQCVYNGFWYSP
EREAMQAFMDKAQESVTGTVRAKLYKGGVWPLSRTSPNSLFSEDLATFEGGDYDHKDAAGFICLNSLRLRLHAAVADKLK
K

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=404, Percent_Identity=46.5346534653465, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI16950633, Length=404, Percent_Identity=46.5346534653465, Blast_Score=357, Evalue=1e-98,
Organism=Escherichia coli, GI1789563, Length=416, Percent_Identity=28.6057692307692, Blast_Score=138, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6324514, Length=404, Percent_Identity=44.0594059405941, Blast_Score=322, Evalue=8e-89,
Organism=Drosophila melanogaster, GI21358151, Length=401, Percent_Identity=44.8877805486284, Blast_Score=339, Evalue=2e-93,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 44046; Mature: 44046

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDIKKVVLAYSGGLDTSVILKWLIETYKCEVIAVTADLGQPEDLSGVEEKALKTGASKA
CCHHHHHHHHHCCCCCHHHHHHHHHHHHCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCE
YVVDLREEMAKDFVFPMMRGAAIYEGRYLLGTSIARPLIAKALVDIARKEGADAIAHGAT
EEEEHHHHHHHHHHHHHHCCCEEECCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
GKGNDQVRFEFAASALAPDIKVIAPWREWELMSRTALTAFAEKHGIPISSSAKRYSMDAN
CCCCCCEEEEEEHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHEECCCH
MLHTSFEGSELENPGNEPHESCHERCVPVEQAPDTPEIVTVDFEQGNPVAVNSKALSPAA
HHEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCHHH
VITTLAEIAGRNGIGRDDMVENRFVGMKCRGVYENPAGTLLYKLHRDLEGICLDRELLGI
HHHHHHHHHCCCCCCCCHHHHCCEECEEECCCCCCCHHHHHHHHHHCCCCEEECHHHHHH
RDMLAVRYSQCVYNGFWYSPEREAMQAFMDKAQESVTGTVRAKLYKGGVWPLSRTSPNSL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHH
FSEDLATFEGGDYDHKDAAGFICLNSLRLRLHAAVADKLKK
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQDIKKVVLAYSGGLDTSVILKWLIETYKCEVIAVTADLGQPEDLSGVEEKALKTGASKA
CCHHHHHHHHHCCCCCHHHHHHHHHHHHCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCE
YVVDLREEMAKDFVFPMMRGAAIYEGRYLLGTSIARPLIAKALVDIARKEGADAIAHGAT
EEEEHHHHHHHHHHHHHHCCCEEECCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
GKGNDQVRFEFAASALAPDIKVIAPWREWELMSRTALTAFAEKHGIPISSSAKRYSMDAN
CCCCCCEEEEEEHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHEECCCH
MLHTSFEGSELENPGNEPHESCHERCVPVEQAPDTPEIVTVDFEQGNPVAVNSKALSPAA
HHEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCHHH
VITTLAEIAGRNGIGRDDMVENRFVGMKCRGVYENPAGTLLYKLHRDLEGICLDRELLGI
HHHHHHHHHCCCCCCCCHHHHCCEECEEECCCCCCCHHHHHHHHHHCCCCEEECHHHHHH
RDMLAVRYSQCVYNGFWYSPEREAMQAFMDKAQESVTGTVRAKLYKGGVWPLSRTSPNSL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHH
FSEDLATFEGGDYDHKDAAGFICLNSLRLRLHAAVADKLKK
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA