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The map label for this gene is argH

Identifier: 220904366

GI number: 220904366

Start: 1282689

End: 1284089

Strand: Reverse

Name: argH

Synonym: Ddes_1094

Alternate gene names: 220904366

Gene position: 1284089-1282689 (Counterclockwise)

Preceding gene: 220904367

Following gene: 220904365

Centisome position: 44.69

GC content: 60.31

Gene sequence:

>1401_bases
ATGAAGACCAACCAGAGCTGGGGTGGGCGTTTTGCCGAAGGCCCCAAGGAAGCCGTGGCCCAGTACACAGACTCCCAGTC
TTACGACAGGGCACTTTACGCCCAGGACATCCGTGCCTCGCAGGCACATGCCCGCATGCTGGGCCGTCAGGGTGTCATCA
CGCCCGAAGAGGCCCAACTGCTGGTTGAAGGGCTTGACCGGGTGCGTGAAGAAATCCGCTCCGACAGCTTCATCTGGAAG
CCGGAACTGGAAGACGTGCATATGAATATTGAGGCACGCCTGACAGAAATTATGGGCAATGTGGGCAAAAAACTGCATAC
GGGCCGCAGCCGCAATGATCAGGTAGGCTTGAGCTTTCGCCTTTTTGTGGCAGACAGGCTGGAAACGTGGCGGCAGCGCG
CCGCTGCCCTGTGCGCCATTCTGGTGCAGCGTGCCACTGAGCATGCCGGTGATATCCTGCCCGGCTGCACACACCTGCAG
CCCGCGCAGCCCGTGAGTCTGGCTCACCACCTGCTGGCCTACGCCTGGATGTTCCGGCGCGACGCCATGCGCCTTGGAGA
CTGCCTGGACCGGGTGCGTATCTCCCCTCTGGGTGCAGCTGCCCTGGCCGGTACAACATATCCGCTTGATCCGCAAAGTG
TGGCCAAGGACGTAGGCTTTGACGGAATTTACGGCAACTCGATGGATGCCGTGTCCGACAGAGATTTTGTGCTTGAAGCC
CTGTTTGGCGGCTCCACCATCATGATGCATCTCTCGCGTCTGTGCGAGGAAATCATCCTGTGGGCCAACCCCGCCTTCGG
CTTTGTCCGCCTGCCTGACAGCTATTCCACCGGCTCATCAATCATGCCGCAAAAGAAAAATCCCGACGTGGCCGAACTTA
TGCGCGGCAAAACAGGGCGCGTCTACGGCTCGCTCATGGGCATGCTCACAATCATGAAAGGCCTGCCCCTCGCCTATAAT
CGCGACATGCAGGAAGACAAGGAAGGCTTTCTTGACGCCGACAGAACGGTGGAGGCATCTCTGCGGCTCATGGCCGGCAT
GATGGAAGAAATCGCCTTTCGCACGGACCGCATGCGTGAAGCCTGCAAGGCCGGTTTTCTCAACGCCACGGAACTGGCCG
ACTACCTTGTGGGCAAAGGGCTTCCCTTCCGCGAGGCGCACCATGTTACCGGGCAGTGTGTCGCCGCGGCAGAAAAGCAG
GCCAAAGGGCTTGAAGACCTTACTCTGCCTGAAATGCAGGCCCTTGAACCTCGCATCGGGGAAGACGTATACGCCATACT
GGACTACGCGGCCGCTGTGCAGCGGCGCGAAACCCCCGGCGGCACCGGGCCGCAATCCGTAGCCGCGCAGGTGGCTCAGC
TCAGGACATGGCTTGCCGGTATGGACGGCATGGTCCAGTAA

Upstream 100 bases:

>100_bases
GCTGCTGCCAACGGGTAAAAACCATATCCAGTCCATCAGCAAAACGCCGAACCGGCAACGCCCCTTCCTGTAACACACGA
TCTTTCAAACGGATGCTGCC

Downstream 100 bases:

>100_bases
CAGGAAGCCTGCCATGTCTGCACCGACACCCCCGAGCACTGGCGACACGCCTGACATCAACTGGCCCCAATGGCCCCAAT
GGATGGAAGACGCACGCCTG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKTNQSWGGRFAEGPKEAVAQYTDSQSYDRALYAQDIRASQAHARMLGRQGVITPEEAQLLVEGLDRVREEIRSDSFIWK
PELEDVHMNIEARLTEIMGNVGKKLHTGRSRNDQVGLSFRLFVADRLETWRQRAAALCAILVQRATEHAGDILPGCTHLQ
PAQPVSLAHHLLAYAWMFRRDAMRLGDCLDRVRISPLGAAALAGTTYPLDPQSVAKDVGFDGIYGNSMDAVSDRDFVLEA
LFGGSTIMMHLSRLCEEIILWANPAFGFVRLPDSYSTGSSIMPQKKNPDVAELMRGKTGRVYGSLMGMLTIMKGLPLAYN
RDMQEDKEGFLDADRTVEASLRLMAGMMEEIAFRTDRMREACKAGFLNATELADYLVGKGLPFREAHHVTGQCVAAAEKQ
AKGLEDLTLPEMQALEPRIGEDVYAILDYAAAVQRRETPGGTGPQSVAAQVAQLRTWLAGMDGMVQ

Sequences:

>Translated_466_residues
MKTNQSWGGRFAEGPKEAVAQYTDSQSYDRALYAQDIRASQAHARMLGRQGVITPEEAQLLVEGLDRVREEIRSDSFIWK
PELEDVHMNIEARLTEIMGNVGKKLHTGRSRNDQVGLSFRLFVADRLETWRQRAAALCAILVQRATEHAGDILPGCTHLQ
PAQPVSLAHHLLAYAWMFRRDAMRLGDCLDRVRISPLGAAALAGTTYPLDPQSVAKDVGFDGIYGNSMDAVSDRDFVLEA
LFGGSTIMMHLSRLCEEIILWANPAFGFVRLPDSYSTGSSIMPQKKNPDVAELMRGKTGRVYGSLMGMLTIMKGLPLAYN
RDMQEDKEGFLDADRTVEASLRLMAGMMEEIAFRTDRMREACKAGFLNATELADYLVGKGLPFREAHHVTGQCVAAAEKQ
AKGLEDLTLPEMQALEPRIGEDVYAILDYAAAVQRRETPGGTGPQSVAAQVAQLRTWLAGMDGMVQ
>Mature_466_residues
MKTNQSWGGRFAEGPKEAVAQYTDSQSYDRALYAQDIRASQAHARMLGRQGVITPEEAQLLVEGLDRVREEIRSDSFIWK
PELEDVHMNIEARLTEIMGNVGKKLHTGRSRNDQVGLSFRLFVADRLETWRQRAAALCAILVQRATEHAGDILPGCTHLQ
PAQPVSLAHHLLAYAWMFRRDAMRLGDCLDRVRISPLGAAALAGTTYPLDPQSVAKDVGFDGIYGNSMDAVSDRDFVLEA
LFGGSTIMMHLSRLCEEIILWANPAFGFVRLPDSYSTGSSIMPQKKNPDVAELMRGKTGRVYGSLMGMLTIMKGLPLAYN
RDMQEDKEGFLDADRTVEASLRLMAGMMEEIAFRTDRMREACKAGFLNATELADYLVGKGLPFREAHHVTGQCVAAAEKQ
AKGLEDLTLPEMQALEPRIGEDVYAILDYAAAVQRRETPGGTGPQSVAAQVAQLRTWLAGMDGMVQ

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=457, Percent_Identity=40.7002188183807, Blast_Score=351, Evalue=7e-97,
Organism=Homo sapiens, GI68303542, Length=457, Percent_Identity=40.7002188183807, Blast_Score=351, Evalue=7e-97,
Organism=Homo sapiens, GI68303549, Length=457, Percent_Identity=38.7308533916849, Blast_Score=321, Evalue=8e-88,
Organism=Homo sapiens, GI68303547, Length=457, Percent_Identity=38.5120350109409, Blast_Score=317, Evalue=2e-86,
Organism=Escherichia coli, GI1790398, Length=447, Percent_Identity=46.7561521252796, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=41.8300653594771, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI221473854, Length=449, Percent_Identity=40.3118040089087, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI78706858, Length=449, Percent_Identity=40.3118040089087, Blast_Score=349, Evalue=2e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_DESDA (B8IZS3)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002479678.1
- ProteinModelPortal:   B8IZS3
- GeneID:   7284776
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_1094
- HOGENOM:   HBG539632
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51484; Mature: 51484

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTNQSWGGRFAEGPKEAVAQYTDSQSYDRALYAQDIRASQAHARMLGRQGVITPEEAQL
CCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LVEGLDRVREEIRSDSFIWKPELEDVHMNIEARLTEIMGNVGKKLHTGRSRNDQVGLSFR
HHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
LFVADRLETWRQRAAALCAILVQRATEHAGDILPGCTHLQPAQPVSLAHHLLAYAWMFRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
DAMRLGDCLDRVRISPLGAAALAGTTYPLDPQSVAKDVGFDGIYGNSMDAVSDRDFVLEA
HHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LFGGSTIMMHLSRLCEEIILWANPAFGFVRLPDSYSTGSSIMPQKKNPDVAELMRGKTGR
HHCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCH
VYGSLMGMLTIMKGLPLAYNRDMQEDKEGFLDADRTVEASLRLMAGMMEEIAFRTDRMRE
HHHHHHHHHHHHHCCCCHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ACKAGFLNATELADYLVGKGLPFREAHHVTGQCVAAAEKQAKGLEDLTLPEMQALEPRIG
HHHHCCCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCC
EDVYAILDYAAAVQRRETPGGTGPQSVAAQVAQLRTWLAGMDGMVQ
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKTNQSWGGRFAEGPKEAVAQYTDSQSYDRALYAQDIRASQAHARMLGRQGVITPEEAQL
CCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LVEGLDRVREEIRSDSFIWKPELEDVHMNIEARLTEIMGNVGKKLHTGRSRNDQVGLSFR
HHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
LFVADRLETWRQRAAALCAILVQRATEHAGDILPGCTHLQPAQPVSLAHHLLAYAWMFRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
DAMRLGDCLDRVRISPLGAAALAGTTYPLDPQSVAKDVGFDGIYGNSMDAVSDRDFVLEA
HHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LFGGSTIMMHLSRLCEEIILWANPAFGFVRLPDSYSTGSSIMPQKKNPDVAELMRGKTGR
HHCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCH
VYGSLMGMLTIMKGLPLAYNRDMQEDKEGFLDADRTVEASLRLMAGMMEEIAFRTDRMRE
HHHHHHHHHHHHHCCCCHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ACKAGFLNATELADYLVGKGLPFREAHHVTGQCVAAAEKQAKGLEDLTLPEMQALEPRIG
HHHHCCCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCC
EDVYAILDYAAAVQRRETPGGTGPQSVAAQVAQLRTWLAGMDGMVQ
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA