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The map label for this gene is fmt

Identifier: 218904996

GI number: 218904996

Start: 3717457

End: 3718401

Strand: Reverse

Name: fmt

Synonym: BCAH820_3880

Alternate gene names: 218904996

Gene position: 3718401-3717457 (Counterclockwise)

Preceding gene: 218904997

Following gene: 218904995

Centisome position: 70.12

GC content: 38.41

Gene sequence:

>945_bases
ATGATAAAAGTAGTATTTATGGGAACACCGGACTTTTCAGTGCCGGTGCTTCGTCGTCTTATTGAAGATGGCTATGATGT
AATAGGTGTTGTGACGCAACCAGATCGTCCGGTAGGTAGAAAAAAAGTATTAACACCTACACCTGTCAAAGTGGAAGCAG
AAAAGCATGGTATCCCGGTCTTACAGCCGTTAAGAATTCGTGAAAAAGACGAATATGAAAAAGTATTGGCATTAGAGCCA
GATTTAATTGTAACAGCTGCGTTCGGTCAAATTGTACCAAATGAAATTTTAGAAGCACCGAAGTATGGTTGTATTAACGT
CCACGCTTCTTTACTTCCTGAACTTCGTGGTGGCGCACCAATCCATTATGCAATTATGGAAGGGAAAGAAAAAACAGGTA
TTACAATTATGTATATGGTAGAAAAATTGGATGCTGGTGATATCTTAACGCAAGTAGAAGTGGAAATTGAAGAGCGTGAA
ACGACAGGTTCGTTATTTGATAAGTTAAGTGAAGCAGGGGCACATCTTCTATCTAAAACAGTACCTTTACTAATTCAAGG
TAAGTTAGAACCAATTAAACAAAACGAGGAAGAAGTAACGTTTGCATATAATATAAAACGTGAACAAGAGAAAATTGATT
GGACAAAAACAGGTGAAGAAGTATACAATCACATTCGCGGATTGAATCCATGGCCAGTTGCTTATACAACTTTAGCAGGA
CAAGTTGTTAAAGTATGGTGGGGAGAAAAAGTACCTGTAACGAAATCAGCTGAAGCGGGTACGATTGTTGCGATTGAAGA
AGATGGTTTCGTTGTAGCAACTGGTAATGAAACGGGTGTTAAAATTACTGAATTGCAACCTTCTGGTAAAAAGCGTATGA
GTTGTTCGCAATTTTTACGTGGCACAAAACCTGAAATTGGAACGAAGTTAGGAGAAAATGCATGA

Upstream 100 bases:

>100_bases
ATGAAATCGATCATTTACACGGTGTGTTATTTACATCGAAAGTGACAAGATATTATGAGGAAAACGAATTAGAATAGGTA
TTAAAAGGAGCGGTTTTTAA

Downstream 100 bases:

>100_bases
GACAAAATGTTCGTGAATTAGCTCTTGATGGTTTAATTCAAGTAGAAAAAAGTGGTGCATACAGTAACTTACTTTTAAAT
AATCTAATTGAAAAAAGTAC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MIKVVFMGTPDFSVPVLRRLIEDGYDVIGVVTQPDRPVGRKKVLTPTPVKVEAEKHGIPVLQPLRIREKDEYEKVLALEP
DLIVTAAFGQIVPNEILEAPKYGCINVHASLLPELRGGAPIHYAIMEGKEKTGITIMYMVEKLDAGDILTQVEVEIEERE
TTGSLFDKLSEAGAHLLSKTVPLLIQGKLEPIKQNEEEVTFAYNIKREQEKIDWTKTGEEVYNHIRGLNPWPVAYTTLAG
QVVKVWWGEKVPVTKSAEAGTIVAIEEDGFVVATGNETGVKITELQPSGKKRMSCSQFLRGTKPEIGTKLGENA

Sequences:

>Translated_314_residues
MIKVVFMGTPDFSVPVLRRLIEDGYDVIGVVTQPDRPVGRKKVLTPTPVKVEAEKHGIPVLQPLRIREKDEYEKVLALEP
DLIVTAAFGQIVPNEILEAPKYGCINVHASLLPELRGGAPIHYAIMEGKEKTGITIMYMVEKLDAGDILTQVEVEIEERE
TTGSLFDKLSEAGAHLLSKTVPLLIQGKLEPIKQNEEEVTFAYNIKREQEKIDWTKTGEEVYNHIRGLNPWPVAYTTLAG
QVVKVWWGEKVPVTKSAEAGTIVAIEEDGFVVATGNETGVKITELQPSGKKRMSCSQFLRGTKPEIGTKLGENA
>Mature_314_residues
MIKVVFMGTPDFSVPVLRRLIEDGYDVIGVVTQPDRPVGRKKVLTPTPVKVEAEKHGIPVLQPLRIREKDEYEKVLALEP
DLIVTAAFGQIVPNEILEAPKYGCINVHASLLPELRGGAPIHYAIMEGKEKTGITIMYMVEKLDAGDILTQVEVEIEERE
TTGSLFDKLSEAGAHLLSKTVPLLIQGKLEPIKQNEEEVTFAYNIKREQEKIDWTKTGEEVYNHIRGLNPWPVAYTTLAG
QVVKVWWGEKVPVTKSAEAGTIVAIEEDGFVVATGNETGVKITELQPSGKKRMSCSQFLRGTKPEIGTKLGENA

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=322, Percent_Identity=28.8819875776398, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI238814322, Length=314, Percent_Identity=28.0254777070064, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI164663775, Length=236, Percent_Identity=30.9322033898305, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1789683, Length=302, Percent_Identity=41.7218543046358, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788589, Length=276, Percent_Identity=28.2608695652174, Blast_Score=140, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI133930964, Length=325, Percent_Identity=32.3076923076923, Blast_Score=134, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6319458, Length=278, Percent_Identity=26.978417266187, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45550868, Length=306, Percent_Identity=32.3529411764706, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI28571984, Length=283, Percent_Identity=31.8021201413428, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24585660, Length=245, Percent_Identity=26.9387755102041, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_BACAA (C3P637)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868103.1
- ProteinModelPortal:   C3P637
- SMR:   C3P637
- EnsemblBacteria:   EBBACT00000124670
- GeneID:   7850748
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_4028
- GeneTree:   EBGT00050000001190
- ProtClustDB:   PRK00005
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 34737; Mature: 34737

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVVFMGTPDFSVPVLRRLIEDGYDVIGVVTQPDRPVGRKKVLTPTPVKVEAEKHGIPV
CEEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEHHHCCCCC
LQPLRIREKDEYEKVLALEPDLIVTAAFGQIVPNEILEAPKYGCINVHASLLPELRGGAP
CCCCCCCCCCCHHHEEEECCCEEEEEHHHHCCCHHHHCCCCCCEEEEHHHHHHHHCCCCC
IHYAIMEGKEKTGITIMYMVEKLDAGDILTQVEVEIEERETTGSLFDKLSEAGAHLLSKT
EEEEEECCCCCCCEEEEEEEECCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHCC
VPLLIQGKLEPIKQNEEEVTFAYNIKREQEKIDWTKTGEEVYNHIRGLNPWPVAYTTLAG
CCEEEECCCCCCCCCCCEEEEEEEECHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHC
QVVKVWWGEKVPVTKSAEAGTIVAIEEDGFVVATGNETGVKITELQPSGKKRMSCSQFLR
EEEEEECCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCEEEEEECCCCCCCCCHHHHHC
GTKPEIGTKLGENA
CCCCCHHCCCCCCC
>Mature Secondary Structure
MIKVVFMGTPDFSVPVLRRLIEDGYDVIGVVTQPDRPVGRKKVLTPTPVKVEAEKHGIPV
CEEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEHHHCCCCC
LQPLRIREKDEYEKVLALEPDLIVTAAFGQIVPNEILEAPKYGCINVHASLLPELRGGAP
CCCCCCCCCCCHHHEEEECCCEEEEEHHHHCCCHHHHCCCCCCEEEEHHHHHHHHCCCCC
IHYAIMEGKEKTGITIMYMVEKLDAGDILTQVEVEIEERETTGSLFDKLSEAGAHLLSKT
EEEEEECCCCCCCEEEEEEEECCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHCC
VPLLIQGKLEPIKQNEEEVTFAYNIKREQEKIDWTKTGEEVYNHIRGLNPWPVAYTTLAG
CCEEEECCCCCCCCCCCEEEEEEEECHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHC
QVVKVWWGEKVPVTKSAEAGTIVAIEEDGFVVATGNETGVKITELQPSGKKRMSCSQFLR
EEEEEECCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCEEEEEECCCCCCCCCHHHHHC
GTKPEIGTKLGENA
CCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA