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The map label for this gene is infB [H]

Identifier: 218904941

GI number: 218904941

Start: 3660456

End: 3661748

Strand: Reverse

Name: infB [H]

Synonym: BCAH820_3825

Alternate gene names: 218904941

Gene position: 3661748-3660456 (Counterclockwise)

Preceding gene: 218904942

Following gene: 218904940

Centisome position: 69.05

GC content: 38.05

Gene sequence:

>1293_bases
ATGAGTAAAATTCGAGTGCATGAATATGCGAAAAAACATAATATCTCAAGTAAAGATCTTATGACAAAACTAAAAGAAAT
GAATATCGAGGTTTCGAATCATATGACAATGTTAGACGATGAAGTAGTAAACAAATTAGATAATGAGTATCAAGCTGAAA
AACCTTCTGTTGCAGATGAGTTTGAAGTAGAAGAAAAAGTTGTTCGTAGTAAAAAGAACAGCAATAAGAAAAAGAAAAAA
GGCAAAGGAAACGAAGACAAGCGTCAAGAGAACTTTGCTGGAAGACAACAAACACAAACTGTAGAAACACCAGATAAAAT
TACTTTCTCTGGAAGCCTTACAGTAGGTGACCTTGCTAAGAAATTAAGCAAAGAGCCATCTGAAATTATTAAAAAGCTCT
TCATGCTTGGAATTATGGCAACAATTAACCAAGACTTAGATAAAGATACAATTGAGTTAATTGCTAACGACTACGGTATT
GAAGTAGAAGAAGAAGTAATTGTTAGCGAGACTGAGTTTGAAACATTCATCGATGAGCAAGATGATGAAGAGAACTTAAA
AGAGCGTCCAGCTGTAGTTACAATCATGGGACACGTTGACCATGGTAAAACAACATTACTTGACTCTATCCGTAACTCTA
AAGTAACTGCTGGCGAAGCAGGTGGAATTACTCAGCATATCGGTGCATACCAAGTTGAAGTAAATGACAAGAAGATTACA
TTCTTAGACACACCTGGTCACGCGGCGTTTACAACGATGCGTGCTCGTGGTGCACAAGTAACGGATATTACAATCCTTGT
TGTTGCAGCTGATGACGGCGTAATGCCACAAACAGTTGAAGCGATTAACCATGCGAAAGCAGCAGGAGTACCAATTATTG
TTGCTGTGAATAAAATGGATAAACCAGCAGCAAATCCTGATCGCGTAATGCAAGAATTAACAGAATATGAATTAGTTCCA
GAAGCATGGGGCGGAGACACAATTTTCGTACCAATTTCTGCAATTCAAGGCGAAGGAATTGACAACTTACTAGAAATGAT
TCTTCTTGTAAGTGAAGTAGAAGAATATAAAGCAAATCCAAACCGCTATGCAACTGGTACTGTAATTGAAGCACAGCTTG
ATAAAGGTAAAGGAACTATCGCGACATTACTTGTTCAAAACGGTACGCTTCGAGTTGGAGACCCAATCGTTGTTGGTACT
TCATTCGGACGTGTTCGTGCAATGGTAAGTGATATTGGTCGCCGTGTAAAAGTTGCTGGTCCATCAACTCCTGTTTTGAA
ATTACAGGTTTAA

Upstream 100 bases:

>100_bases
GCGATTGGGAGAGATGAGCGAGTCGTTGTAGCTGTGTTAGATGAAGGCTTTGCGAAAAAGCTGCGTAGCATGCTCGATAC
AAATTACCGGGGGTGAAGGT

Downstream 100 bases:

>100_bases
ACGAAGTGCCACAAGCGGGAGATCGTTTCATGGCATTCGCTGATGAGAAGAAAGCTCGTCAAATCGGTGAATCACGTGCG
CAAGAAGCGTTACTTGCTCA

Product: translation initiation factor IF-2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSKIRVHEYAKKHNISSKDLMTKLKEMNIEVSNHMTMLDDEVVNKLDNEYQAEKPSVADEFEVEEKVVRSKKNSNKKKKK
GKGNEDKRQENFAGRQQTQTVETPDKITFSGSLTVGDLAKKLSKEPSEIIKKLFMLGIMATINQDLDKDTIELIANDYGI
EVEEEVIVSETEFETFIDEQDDEENLKERPAVVTIMGHVDHGKTTLLDSIRNSKVTAGEAGGITQHIGAYQVEVNDKKIT
FLDTPGHAAFTTMRARGAQVTDITILVVAADDGVMPQTVEAINHAKAAGVPIIVAVNKMDKPAANPDRVMQELTEYELVP
EAWGGDTIFVPISAIQGEGIDNLLEMILLVSEVEEYKANPNRYATGTVIEAQLDKGKGTIATLLVQNGTLRVGDPIVVGT
SFGRVRAMVSDIGRRVKVAGPSTPVLKLQV

Sequences:

>Translated_430_residues
MSKIRVHEYAKKHNISSKDLMTKLKEMNIEVSNHMTMLDDEVVNKLDNEYQAEKPSVADEFEVEEKVVRSKKNSNKKKKK
GKGNEDKRQENFAGRQQTQTVETPDKITFSGSLTVGDLAKKLSKEPSEIIKKLFMLGIMATINQDLDKDTIELIANDYGI
EVEEEVIVSETEFETFIDEQDDEENLKERPAVVTIMGHVDHGKTTLLDSIRNSKVTAGEAGGITQHIGAYQVEVNDKKIT
FLDTPGHAAFTTMRARGAQVTDITILVVAADDGVMPQTVEAINHAKAAGVPIIVAVNKMDKPAANPDRVMQELTEYELVP
EAWGGDTIFVPISAIQGEGIDNLLEMILLVSEVEEYKANPNRYATGTVIEAQLDKGKGTIATLLVQNGTLRVGDPIVVGT
SFGRVRAMVSDIGRRVKVAGPSTPVLKLQV
>Mature_429_residues
SKIRVHEYAKKHNISSKDLMTKLKEMNIEVSNHMTMLDDEVVNKLDNEYQAEKPSVADEFEVEEKVVRSKKNSNKKKKKG
KGNEDKRQENFAGRQQTQTVETPDKITFSGSLTVGDLAKKLSKEPSEIIKKLFMLGIMATINQDLDKDTIELIANDYGIE
VEEEVIVSETEFETFIDEQDDEENLKERPAVVTIMGHVDHGKTTLLDSIRNSKVTAGEAGGITQHIGAYQVEVNDKKITF
LDTPGHAAFTTMRARGAQVTDITILVVAADDGVMPQTVEAINHAKAAGVPIIVAVNKMDKPAANPDRVMQELTEYELVPE
AWGGDTIFVPISAIQGEGIDNLLEMILLVSEVEEYKANPNRYATGTVIEAQLDKGKGTIATLLVQNGTLRVGDPIVVGTS
FGRVRAMVSDIGRRVKVAGPSTPVLKLQV

Specific function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 7

COG id: COG0532

COG function: function code J; Translation initiation factor 2 (IF-2; GTPase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IF-2 family [H]

Homologues:

Organism=Homo sapiens, GI53729339, Length=353, Percent_Identity=43.342776203966, Blast_Score=271, Evalue=7e-73,
Organism=Homo sapiens, GI53729337, Length=353, Percent_Identity=43.342776203966, Blast_Score=271, Evalue=7e-73,
Organism=Homo sapiens, GI84043963, Length=271, Percent_Identity=31.3653136531365, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI157426893, Length=252, Percent_Identity=27.3809523809524, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI34147630, Length=258, Percent_Identity=30.2325581395349, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI18390331, Length=142, Percent_Identity=31.6901408450704, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789559, Length=315, Percent_Identity=57.7777777777778, Blast_Score=344, Evalue=8e-96,
Organism=Escherichia coli, GI2367247, Length=213, Percent_Identity=31.924882629108, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788922, Length=230, Percent_Identity=30, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI48994988, Length=137, Percent_Identity=36.4963503649635, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790412, Length=240, Percent_Identity=32.9166666666667, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789737, Length=240, Percent_Identity=32.9166666666667, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994658, Length=243, Percent_Identity=51.440329218107, Blast_Score=251, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI212656558, Length=278, Percent_Identity=31.294964028777, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17557151, Length=219, Percent_Identity=30.5936073059361, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17556456, Length=266, Percent_Identity=30.8270676691729, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25141371, Length=254, Percent_Identity=28.3464566929134, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324550, Length=333, Percent_Identity=41.7417417417417, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319282, Length=288, Percent_Identity=29.8611111111111, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324761, Length=258, Percent_Identity=31.0077519379845, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28572034, Length=362, Percent_Identity=41.4364640883978, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24656849, Length=268, Percent_Identity=32.8358208955224, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI160714833, Length=122, Percent_Identity=54.0983606557377, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI78706572, Length=224, Percent_Identity=28.125, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281363316, Length=263, Percent_Identity=30.7984790874525, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17864358, Length=263, Percent_Identity=30.7984790874525, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921738, Length=248, Percent_Identity=31.0483870967742, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137380, Length=272, Percent_Identity=28.3088235294118, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922690, Length=230, Percent_Identity=27.8260869565217, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: 1150 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006847
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000178
- InterPro:   IPR015760
- InterPro:   IPR023115
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF11987 IF-2; PF04760 IF2_N [H]

EC number: NA

Molecular weight: Translated: 47299; Mature: 47168

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIRVHEYAKKHNISSKDLMTKLKEMNIEVSNHMTMLDDEVVNKLDNEYQAEKPSVADE
CCCCCHHHHHHHCCCCHHHHHHHHHHCCEEHHCCEEHHHHHHHHHHHHHHCCCCCCCCHH
FEVEEKVVRSKKNSNKKKKKGKGNEDKRQENFAGRQQTQTVETPDKITFSGSLTVGDLAK
HHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHCCCHHCCCCCCCCCEEEECCCCHHHHHH
KLSKEPSEIIKKLFMLGIMATINQDLDKDTIELIANDYGIEVEEEVIVSETEFETFIDEQ
HHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHEEEECHHHHHHCCCC
DDEENLKERPAVVTIMGHVDHGKTTLLDSIRNSKVTAGEAGGITQHIGAYQVEVNDKKIT
CCHHHHHHCCEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCHHHCCEEEEEECCCEEE
FLDTPGHAAFTTMRARGAQVTDITILVVAADDGVMPQTVEAINHAKAAGVPIIVAVNKMD
EEECCCCHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCC
KPAANPDRVMQELTEYELVPEAWGGDTIFVPISAIQGEGIDNLLEMILLVSEVEEYKANP
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCC
NRYATGTVIEAQLDKGKGTIATLLVQNGTLRVGDPIVVGTSFGRVRAMVSDIGRRVKVAG
CCEECCEEEEEEECCCCCEEEEEEEECCEEEECCEEEEECCHHHHHHHHHHHCCEEEECC
PSTPVLKLQV
CCCCEEEEEC
>Mature Secondary Structure 
SKIRVHEYAKKHNISSKDLMTKLKEMNIEVSNHMTMLDDEVVNKLDNEYQAEKPSVADE
CCCCHHHHHHHCCCCHHHHHHHHHHCCEEHHCCEEHHHHHHHHHHHHHHCCCCCCCCHH
FEVEEKVVRSKKNSNKKKKKGKGNEDKRQENFAGRQQTQTVETPDKITFSGSLTVGDLAK
HHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHCCCHHCCCCCCCCCEEEECCCCHHHHHH
KLSKEPSEIIKKLFMLGIMATINQDLDKDTIELIANDYGIEVEEEVIVSETEFETFIDEQ
HHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHEEEECHHHHHHCCCC
DDEENLKERPAVVTIMGHVDHGKTTLLDSIRNSKVTAGEAGGITQHIGAYQVEVNDKKIT
CCHHHHHHCCEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCHHHCCEEEEEECCCEEE
FLDTPGHAAFTTMRARGAQVTDITILVVAADDGVMPQTVEAINHAKAAGVPIIVAVNKMD
EEECCCCHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCC
KPAANPDRVMQELTEYELVPEAWGGDTIFVPISAIQGEGIDNLLEMILLVSEVEEYKANP
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCC
NRYATGTVIEAQLDKGKGTIATLLVQNGTLRVGDPIVVGTSFGRVRAMVSDIGRRVKVAG
CCEECCEEEEEEECCCCCEEEEEEEECCEEEECCEEEEECCHHHHHHHHHHHCCEEEECC
PSTPVLKLQV
CCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA