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The map label for this gene is 218884531

Identifier: 218884531

GI number: 218884531

Start: 1143397

End: 1143900

Strand: Direct

Name: 218884531

Synonym: DKAM_1220

Alternate gene names: NA

Gene position: 1143397-1143900 (Clockwise)

Preceding gene: 218884527

Following gene: 218884532

Centisome position: 83.75

GC content: 46.83

Gene sequence:

>504_bases
ATGAGGATCCTCTGGAATCCATGGAGGTACGAGTATATTAAACGGTTCAACAGCGGGGAGAAGGAGATTGGCGAATGCCT
TTTCTGCCGGTTGAAGTCCATGAACGATAACGAAGCACTCATAATCTATAGAGGCGTATACTCATTCATAGTATTGAATG
CATACCCCTATAACTCCGGCCATGTCATGATCGCCCCATATGACCACATAGGAAGCCTCGAAGATCTCCAAGATGAAGCC
TTACTAGAGATGGTTAAACTAGTTAAGCTATCAATGAAGATTATCAGGAAGGCATTCAACCCGGATGGCTTCAATATTGG
AGTTAATATCGGCAGGGTTGCCGGGGCCGGGGTGCCTGGACACGTACACATACACGTAGTACCCCGCTGGGTCGGTGATA
CAAATTTCATGGGTGTAATAGCCGGGGTCAAGACCCTTCCCATAAGTCTCCAAGAAACATACTCTATACTCAGGAAAACC
CTTAATGAGATCCAGGGGGCTTGA

Upstream 100 bases:

>100_bases
CCTGTTGCCGGGATGTTCCTAACCCAGCGGATAAGGATACATATGTTTTTAAAGTGGGTGTCTATAAGGGATAATGAAGC
ACCTTGAAGGGTTCTGCTAG

Downstream 100 bases:

>100_bases
GATGGTTTCATCCAGGGACCTGATCATACTAGAGAAATACAGCTTACTAAACGAGCAACGCTATAGGTTATGTGTCAAAG
GCACGAATATAGTAGTCAAC

Product: putative bis(5'-adenosyl)-triphosphatase, HIT family

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MRILWNPWRYEYIKRFNSGEKEIGECLFCRLKSMNDNEALIIYRGVYSFIVLNAYPYNSGHVMIAPYDHIGSLEDLQDEA
LLEMVKLVKLSMKIIRKAFNPDGFNIGVNIGRVAGAGVPGHVHIHVVPRWVGDTNFMGVIAGVKTLPISLQETYSILRKT
LNEIQGA

Sequences:

>Translated_167_residues
MRILWNPWRYEYIKRFNSGEKEIGECLFCRLKSMNDNEALIIYRGVYSFIVLNAYPYNSGHVMIAPYDHIGSLEDLQDEA
LLEMVKLVKLSMKIIRKAFNPDGFNIGVNIGRVAGAGVPGHVHIHVVPRWVGDTNFMGVIAGVKTLPISLQETYSILRKT
LNEIQGA
>Mature_167_residues
MRILWNPWRYEYIKRFNSGEKEIGECLFCRLKSMNDNEALIIYRGVYSFIVLNAYPYNSGHVMIAPYDHIGSLEDLQDEA
LLEMVKLVKLSMKIIRKAFNPDGFNIGVNIGRVAGAGVPGHVHIHVVPRWVGDTNFMGVIAGVKTLPISLQETYSILRKT
LNEIQGA

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17556280, Length=122, Percent_Identity=32.7868852459016, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 18910; Mature: 18910

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILWNPWRYEYIKRFNSGEKEIGECLFCRLKSMNDNEALIIYRGVYSFIVLNAYPYNSG
CCEEECHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECHHEEEEEECCCCCCC
HVMIAPYDHIGSLEDLQDEALLEMVKLVKLSMKIIRKAFNPDGFNIGVNIGRVAGAGVPG
EEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEECCCCCC
HVHIHVVPRWVGDTNFMGVIAGVKTLPISLQETYSILRKTLNEIQGA
EEEEEEEEEECCCCCHHHHHHCHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRILWNPWRYEYIKRFNSGEKEIGECLFCRLKSMNDNEALIIYRGVYSFIVLNAYPYNSG
CCEEECHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECHHEEEEEECCCCCCC
HVMIAPYDHIGSLEDLQDEALLEMVKLVKLSMKIIRKAFNPDGFNIGVNIGRVAGAGVPG
EEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEECCCCCC
HVHIHVVPRWVGDTNFMGVIAGVKTLPISLQETYSILRKTLNEIQGA
EEEEEEEEEECCCCCHHHHHHCHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]