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The map label for this gene is kbl [C]

Identifier: 218884129

GI number: 218884129

Start: 785676

End: 786866

Strand: Reverse

Name: kbl [C]

Synonym: DKAM_0818

Alternate gene names: 218884129

Gene position: 786866-785676 (Counterclockwise)

Preceding gene: 218884135

Following gene: 218884128

Centisome position: 57.64

GC content: 47.61

Gene sequence:

>1191_bases
ATGGTAAAACATTGGGTAAAGGAGTACTATGGATTAAAGCTCAAAGAATTAATTGAGAGAGGAGAGATATGGGAGATAAA
GAGGCTTATGGGCCCCGCTGGTCCCCGTGCTATAGTTGATGGAAGAGAGGTCATAGTGCTTGCATCCAACAATTATCTGA
ATCTAGCCAATGACCCCAGGCTTAAACAGGCGGCCATCGAGGCCATGGAGAAATATGGATGGGGTCCAGGCGCGGTCTGG
GCTATTGCAGGATACCATGAGATACTGGATGCTCTACACAAGAAGATAGCCGAGTTCAAGAGAACGGAGGCCGCGCTAGT
CTTCCCCACAGGCTTCGCTGTGAATGCTGGCACTATTCCAGCCATAGTCGAGCAAGGAGACGTCATAGTCTCTGATGAAT
TAAACCATGGAAGCATAATTGATGGTATAAGGCTTTCAAGGGCTGATAAAGTAATATATAAGCACTGTGACGTAGCAGAC
CTAGAGGACAAGCTTAAGCAAGTACATGGGAAATACAAAAAGATCCTTATAATAACCGATGGAGTATTCTCAATGGACGG
TGATATAGCGCCCCTGAGAGAGATAGTTAGGTTGGCGAGAGAATATAATGCAATGGTGTATGTGGATGATGCCCATGGTG
AAGGGGTATTGGGAGAGGGACACGGATCCCCAGCCCATCTGGGTGTCGAGGAGGAAGTAGACTTCCACGTTGGCACGTTC
TCTAAAGCCCTCGGCTCCTCAGGAGGCATGATAGGCTCAGACTATGAGGTCATAGAATTTATTAGGAACAAGGCTAGGAC
ATGGCTGTTAAGCACTGGATTCCCGCCTGCAGTAGCCGCTGCCAACCTGAAGGCGCTTGAAATAGTTATGAGCGATGAAG
GGAAGGAGAGGATCAGGAGGCTATGGGATAATAGAAACTACTTCAAGAAGGAGTTAGACAACCTTGGATTCAACACAGGG
AAGAGCCAGACGCCCATAATACCAGTTATAATAGGTGACACTAAGAAAACACGTGAGCTAGCCAGGTCTCTCTTCGAGGA
AGGAGTATTCGTCGTGCCAATAGTATACCCGATGGTTGCTAGAGGGACAGAGAGGATCAGGAATCAAGTCAATGCAGGGC
ACACCAGGGAAGACCTGGATAAAGCGCTGGCAGCATATGAGAAGCATGGAAAGAGGCTTGGAATAATATAG

Upstream 100 bases:

>100_bases
TGGATTGGAGTAGTTGATTTCACAATTGATACCATTTACCGTAAAAATAAAGTTATAAATAGACGGGTAAGTATAGTATA
TATGTCTATGGTGGAAACAT

Downstream 100 bases:

>100_bases
GGTGAACTGGTAATATGCCCCATGTACTAGTGATCGGTGCAACAGGGCAGATAGGCTCAGCACTGGTGCCGGCTCTAAGG
GAGAGATACGGTAAATACAA

Product: pyridoxal phosphate-dependent acyltransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MVKHWVKEYYGLKLKELIERGEIWEIKRLMGPAGPRAIVDGREVIVLASNNYLNLANDPRLKQAAIEAMEKYGWGPGAVW
AIAGYHEILDALHKKIAEFKRTEAALVFPTGFAVNAGTIPAIVEQGDVIVSDELNHGSIIDGIRLSRADKVIYKHCDVAD
LEDKLKQVHGKYKKILIITDGVFSMDGDIAPLREIVRLAREYNAMVYVDDAHGEGVLGEGHGSPAHLGVEEEVDFHVGTF
SKALGSSGGMIGSDYEVIEFIRNKARTWLLSTGFPPAVAAANLKALEIVMSDEGKERIRRLWDNRNYFKKELDNLGFNTG
KSQTPIIPVIIGDTKKTRELARSLFEEGVFVVPIVYPMVARGTERIRNQVNAGHTREDLDKALAAYEKHGKRLGII

Sequences:

>Translated_396_residues
MVKHWVKEYYGLKLKELIERGEIWEIKRLMGPAGPRAIVDGREVIVLASNNYLNLANDPRLKQAAIEAMEKYGWGPGAVW
AIAGYHEILDALHKKIAEFKRTEAALVFPTGFAVNAGTIPAIVEQGDVIVSDELNHGSIIDGIRLSRADKVIYKHCDVAD
LEDKLKQVHGKYKKILIITDGVFSMDGDIAPLREIVRLAREYNAMVYVDDAHGEGVLGEGHGSPAHLGVEEEVDFHVGTF
SKALGSSGGMIGSDYEVIEFIRNKARTWLLSTGFPPAVAAANLKALEIVMSDEGKERIRRLWDNRNYFKKELDNLGFNTG
KSQTPIIPVIIGDTKKTRELARSLFEEGVFVVPIVYPMVARGTERIRNQVNAGHTREDLDKALAAYEKHGKRLGII
>Mature_396_residues
MVKHWVKEYYGLKLKELIERGEIWEIKRLMGPAGPRAIVDGREVIVLASNNYLNLANDPRLKQAAIEAMEKYGWGPGAVW
AIAGYHEILDALHKKIAEFKRTEAALVFPTGFAVNAGTIPAIVEQGDVIVSDELNHGSIIDGIRLSRADKVIYKHCDVAD
LEDKLKQVHGKYKKILIITDGVFSMDGDIAPLREIVRLAREYNAMVYVDDAHGEGVLGEGHGSPAHLGVEEEVDFHVGTF
SKALGSSGGMIGSDYEVIEFIRNKARTWLLSTGFPPAVAAANLKALEIVMSDEGKERIRRLWDNRNYFKKELDNLGFNTG
KSQTPIIPVIIGDTKKTRELARSLFEEGVFVVPIVYPMVARGTERIRNQVNAGHTREDLDKALAAYEKHGKRLGII

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=378, Percent_Identity=38.0952380952381, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI284448556, Length=355, Percent_Identity=38.5915492957746, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI4758668, Length=368, Percent_Identity=34.5108695652174, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=33.5135135135135, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI83977442, Length=348, Percent_Identity=30.4597701149425, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI83977444, Length=348, Percent_Identity=30.4597701149425, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI83977440, Length=348, Percent_Identity=30.4597701149425, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI4502025, Length=348, Percent_Identity=31.6091954022989, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI40316939, Length=348, Percent_Identity=31.6091954022989, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI5454084, Length=257, Percent_Identity=32.295719844358, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1790046, Length=362, Percent_Identity=40.6077348066298, Blast_Score=271, Evalue=6e-74,
Organism=Escherichia coli, GI1786993, Length=359, Percent_Identity=34.5403899721448, Blast_Score=192, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI71994529, Length=359, Percent_Identity=37.883008356546, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=34.0540540540541, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17560914, Length=357, Percent_Identity=31.9327731092437, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17560912, Length=357, Percent_Identity=31.9327731092437, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71982617, Length=275, Percent_Identity=29.0909090909091, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71982625, Length=275, Percent_Identity=29.0909090909091, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320267, Length=365, Percent_Identity=31.7808219178082, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6320438, Length=367, Percent_Identity=30.2452316076294, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6323954, Length=260, Percent_Identity=27.6923076923077, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24662918, Length=398, Percent_Identity=37.9396984924623, Blast_Score=281, Evalue=7e-76,
Organism=Drosophila melanogaster, GI17137420, Length=354, Percent_Identity=34.180790960452, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17136286, Length=369, Percent_Identity=31.9783197831978, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24653280, Length=265, Percent_Identity=29.811320754717, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24653276, Length=265, Percent_Identity=29.811320754717, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24653278, Length=265, Percent_Identity=29.811320754717, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43992; Mature: 43992

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKHWVKEYYGLKLKELIERGEIWEIKRLMGPAGPRAIVDGREVIVLASNNYLNLANDPR
CCHHHHHHHHCCHHHHHHCCCCHHHHHHHHCCCCCCEEECCCEEEEEECCCEEECCCCCH
LKQAAIEAMEKYGWGPGAVWAIAGYHEILDALHKKIAEFKRTEAALVFPTGFAVNAGTIP
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEECCCCCH
AIVEQGDVIVSDELNHGSIIDGIRLSRADKVIYKHCDVADLEDKLKQVHGKYKKILIITD
HHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEC
GVFSMDGDIAPLREIVRLAREYNAMVYVDDAHGEGVLGEGHGSPAHLGVEEEVDFHVGTF
CCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCEEHHHH
SKALGSSGGMIGSDYEVIEFIRNKARTWLLSTGFPPAVAAANLKALEIVMSDEGKERIRR
HHHHCCCCCCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHCCCEEEEEEECCCHHHHHHH
LWDNRNYFKKELDNLGFNTGKSQTPIIPVIIGDTKKTRELARSLFEEGVFVVPIVYPMVA
HHCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEHHHHHHH
RGTERIRNQVNAGHTREDLDKALAAYEKHGKRLGII
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCC
>Mature Secondary Structure
MVKHWVKEYYGLKLKELIERGEIWEIKRLMGPAGPRAIVDGREVIVLASNNYLNLANDPR
CCHHHHHHHHCCHHHHHHCCCCHHHHHHHHCCCCCCEEECCCEEEEEECCCEEECCCCCH
LKQAAIEAMEKYGWGPGAVWAIAGYHEILDALHKKIAEFKRTEAALVFPTGFAVNAGTIP
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEECCCCCH
AIVEQGDVIVSDELNHGSIIDGIRLSRADKVIYKHCDVADLEDKLKQVHGKYKKILIITD
HHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEC
GVFSMDGDIAPLREIVRLAREYNAMVYVDDAHGEGVLGEGHGSPAHLGVEEEVDFHVGTF
CCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCEEHHHH
SKALGSSGGMIGSDYEVIEFIRNKARTWLLSTGFPPAVAAANLKALEIVMSDEGKERIRR
HHHHCCCCCCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHCCCEEEEEEECCCHHHHHHH
LWDNRNYFKKELDNLGFNTGKSQTPIIPVIIGDTKKTRELARSLFEEGVFVVPIVYPMVA
HHCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEHHHHHHH
RGTERIRNQVNAGHTREDLDKALAAYEKHGKRLGII
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA