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The map label for this gene is flpA [H]

Identifier: 218884125

GI number: 218884125

Start: 782514

End: 783227

Strand: Reverse

Name: flpA [H]

Synonym: DKAM_0814

Alternate gene names: 218884125

Gene position: 783227-782514 (Counterclockwise)

Preceding gene: 218884126

Following gene: 218884124

Centisome position: 57.37

GC content: 44.54

Gene sequence:

>714_bases
GTGATCCATGTGAGTCAACCGGTCTCGGTAAAACCACATGAAAAATACTACGGGGTATACGTTGTAGAGCTTGATGACGG
TAGCCTTAAACTTGCCACAAGGAACCTGGTTCCAGGTCACAGGGTATATGGTGAGAAACTATATAGAATAAACAATGTCG
AGTACAGGGAGTGGAATCTATACAGGAGCAAGTTGGCTGGTGCATTAGCCAATGGTCTCAGTGAGCAGCCGATCAGGGAG
GGACATAGAATACTATACCTTGGAATAGCCTCTGGAACCACTGCCAGTCACATCTCGGACATCGTCGGCTTAAAAGGCAG
AATTTACGGTGTTGAATTCGCTCCCAGGGTTATGAGGGAACTAGTATTAGTGGCCGATGTGAGAAAGAACATTTATCCAA
TACTAGGCGATGCTAGAAAGCCGCATGAATATAGGCATGTTGTTGAAACAGTTGACGGGATATATGCGGATGTTGCACAA
CCGGATCAAGCTGCTATAGTCGCAGACAATGCATTACTATTTCTAAGGGATGGAGGATACTTGCTTCTAGCAATAAAGGC
TAGAAGCATTGATGTGACAAAGGAGCCTAGTGAAGTATACCGTAGGGAGATAGAGACGTTAAAGCAGAGGGGATTCGAGA
TAGTCGACGTTGTTCACCTGGAACCCTATGATAAAGATCATGCAATGATATACAGTATATACAGGAGAAAGTAG

Upstream 100 bases:

>100_bases
GAGTTGAAGAAATAAAGAAACTATATCCTAAGCCTCCACCAAAAAAAGAGGAGGAGAAGAGGCCTAGGCCGCCTCCTAAA
TCCAGGAGGAAGGGTGGGAG

Downstream 100 bases:

>100_bases
CTTAGACATGGAAAATAAATTCCCTTTTAAACATGTTTAAACATAATTTAGAAAACGGGGTCTGTTTTGTCTAGAAACAG
GGGTACAGGGGACATCGCTG

Product: fibrillarin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIHVSQPVSVKPHEKYYGVYVVELDDGSLKLATRNLVPGHRVYGEKLYRINNVEYREWNLYRSKLAGALANGLSEQPIRE
GHRILYLGIASGTTASHISDIVGLKGRIYGVEFAPRVMRELVLVADVRKNIYPILGDARKPHEYRHVVETVDGIYADVAQ
PDQAAIVADNALLFLRDGGYLLLAIKARSIDVTKEPSEVYRREIETLKQRGFEIVDVVHLEPYDKDHAMIYSIYRRK

Sequences:

>Translated_237_residues
MIHVSQPVSVKPHEKYYGVYVVELDDGSLKLATRNLVPGHRVYGEKLYRINNVEYREWNLYRSKLAGALANGLSEQPIRE
GHRILYLGIASGTTASHISDIVGLKGRIYGVEFAPRVMRELVLVADVRKNIYPILGDARKPHEYRHVVETVDGIYADVAQ
PDQAAIVADNALLFLRDGGYLLLAIKARSIDVTKEPSEVYRREIETLKQRGFEIVDVVHLEPYDKDHAMIYSIYRRK
>Mature_237_residues
MIHVSQPVSVKPHEKYYGVYVVELDDGSLKLATRNLVPGHRVYGEKLYRINNVEYREWNLYRSKLAGALANGLSEQPIRE
GHRILYLGIASGTTASHISDIVGLKGRIYGVEFAPRVMRELVLVADVRKNIYPILGDARKPHEYRHVVETVDGIYADVAQ
PDQAAIVADNALLFLRDGGYLLLAIKARSIDVTKEPSEVYRREIETLKQRGFEIVDVVHLEPYDKDHAMIYSIYRRK

Specific function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the sub

COG id: COG1889

COG function: function code J; Fibrillarin-like rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Fibrillarin family [H]

Homologues:

Organism=Homo sapiens, GI12056465, Length=232, Percent_Identity=46.551724137931, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17563672, Length=234, Percent_Identity=48.2905982905983, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6320190, Length=240, Percent_Identity=42.9166666666667, Blast_Score=197, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17647425, Length=232, Percent_Identity=45.6896551724138, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24646406, Length=233, Percent_Identity=33.9055793991416, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000692
- InterPro:   IPR020813 [H]

Pfam domain/function: PF01269 Fibrillarin [H]

EC number: NA

Molecular weight: Translated: 26986; Mature: 26986

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS00566 FIBRILLARIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHVSQPVSVKPHEKYYGVYVVELDDGSLKLATRNLVPGHRVYGEKLYRINNVEYREWNL
CEECCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCHHHHHHHEEEECCCEEHHHHH
YRSKLAGALANGLSEQPIREGHRILYLGIASGTTASHISDIVGLKGRIYGVEFAPRVMRE
HHHHHHHHHHCCCCCCHHHCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEHHHHHHHH
LVLVADVRKNIYPILGDARKPHEYRHVVETVDGIYADVAQPDQAAIVADNALLFLRDGGY
HHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEEECCCE
LLLAIKARSIDVTKEPSEVYRREIETLKQRGFEIVDVVHLEPYDKDHAMIYSIYRRK
EEEEEEECEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEECCC
>Mature Secondary Structure
MIHVSQPVSVKPHEKYYGVYVVELDDGSLKLATRNLVPGHRVYGEKLYRINNVEYREWNL
CEECCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCHHHHHHHEEEECCCEEHHHHH
YRSKLAGALANGLSEQPIREGHRILYLGIASGTTASHISDIVGLKGRIYGVEFAPRVMRE
HHHHHHHHHHCCCCCCHHHCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEHHHHHHHH
LVLVADVRKNIYPILGDARKPHEYRHVVETVDGIYADVAQPDQAAIVADNALLFLRDGGY
HHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEEECCCE
LLLAIKARSIDVTKEPSEVYRREIETLKQRGFEIVDVVHLEPYDKDHAMIYSIYRRK
EEEEEEECEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA