The gene/protein map for NC_011766 is currently unavailable.
Definition Desulfurococcus kamchatkensis 1221n chromosome, complete genome.
Accession NC_011766
Length 1,365,223

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The map label for this gene is hmgA [H]

Identifier: 218884031

GI number: 218884031

Start: 692469

End: 693752

Strand: Direct

Name: hmgA [H]

Synonym: DKAM_0720

Alternate gene names: 218884031

Gene position: 692469-693752 (Clockwise)

Preceding gene: 218884028

Following gene: 218884032

Centisome position: 50.72

GC content: 51.79

Gene sequence:

>1284_bases
ATGGAGAAGACAAGCCGTATACAGGGCTTCTACAAGCTTCCCCTTGAAGAAAGACGGAGGATAGTCTGCGAGTGGGCTGG
GCTAACAGAGGAAGAGTGCAGGACACTGAGCGAATTCGGTAATCTACCAGTTAAGATAGGGGACAGCATGATTGAGAACG
TTATAGGCGCGATGAGCTATCCCTTCGCAGTAGCGACAAACTTCCTGATCAATGGGAGGGATTACCTTGTCCCAATGGTT
ATAGAGGAGACAAGCGTCGTAGCGGCTGCAAGCAATGCGGCCAGGATGCTTAGGCATGGGAAAGGGATACTTGCAAATGC
TGAGAGACAGGAGATGATCAGCCAAATACACCTGGTTAAAGTAAACTCCCCACGCTTTAAAGCCATGAAGATTATCGAGG
CCAAGAAGGAGCTACTGGACTACGCGGCACAGCAGGATCCAACCCTGCTAAAGTACGGCGGGGGTCCCAGGGACCTCGAG
GTAAGAGCAATGGAGCACCCTGCTTTAGGCGGGGTCATAATAGTCCACCTAGTAGTAGACGTCAGAGACGCCATGGGTGC
TAACACTGTTAACACGATGGCTGAAGCGATAGCCCCGCTTCTAGAGAAGATAACGGGTGGGGAAGCAAGGCTCAGAATAG
TTTCAAACCACGCAGTATACAGGGTTACACGGGCATGGGCTGCGACACCTGTCGAAGAAGTGGGAGGCCTTGAAGTAGCC
AGGAGGATAATGGAGGCATCTATACTCGCCGAGATAGATCCCTATAGGGCGGTAACCCATAACAAGGGCATAATGAATGG
AGTAATAGCAGTAGCCCTCGCGACGGGACAGGATCACCGCGCCATAGAGGCTGGAGCCCATGCATACGCCTCTAGAACGG
GGGTCTACAAGCCCCTCAGCTACTGGGAGGTAACAAGCGATAACTATCTTGCGGGAAGCCTTGAGATACCTCTCCAAATA
GGCGTTGTTGGAGGAGCAGTCAAGGTACACCCTGTGGCAAAGATAGCATTGAAGATCCTAGGGGTAAACACGGCTAGGGA
GCTCGCCGAGGTAATGGCTGCGGTAGGGCTAGCCCAGAACCTAGCCGCTCTAAGAGCCCTCGTGACAGAGGGTATTCAGA
AAGGCCATATGAGGCTCCACGCCAGAAACCTCGCTATAATGGCTGGTGCATCAGGAGATCTAATAGATAAGATAGCCGAG
AAAATGATCAGGGACGGTAGAATAAGATACGACTACGCTAAACAACTAGTAGAGAAAGCACTACAGGGCGAGCCATTAGA
CTAG

Upstream 100 bases:

>100_bases
TATTGACTCTGCGAGAGCCCACTCGTGAACCATGACTCTACACCACTCGCTCTGTATTTATTTTATTTCTACATAATATA
GTTACCTATGGTGTGTATAC

Downstream 100 bases:

>100_bases
TTTTCTCCTTATCCACTTGTATACATTTTTAAAGGTGTACCAGCTCTAGATGTGGTTTCCTACGTTATTTCCACAAACTT
CTGCTTCTTAAGAAGCGTAT

Product: hydroxymethylglutaryl-CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MEKTSRIQGFYKLPLEERRRIVCEWAGLTEEECRTLSEFGNLPVKIGDSMIENVIGAMSYPFAVATNFLINGRDYLVPMV
IEETSVVAAASNAARMLRHGKGILANAERQEMISQIHLVKVNSPRFKAMKIIEAKKELLDYAAQQDPTLLKYGGGPRDLE
VRAMEHPALGGVIIVHLVVDVRDAMGANTVNTMAEAIAPLLEKITGGEARLRIVSNHAVYRVTRAWAATPVEEVGGLEVA
RRIMEASILAEIDPYRAVTHNKGIMNGVIAVALATGQDHRAIEAGAHAYASRTGVYKPLSYWEVTSDNYLAGSLEIPLQI
GVVGGAVKVHPVAKIALKILGVNTARELAEVMAAVGLAQNLAALRALVTEGIQKGHMRLHARNLAIMAGASGDLIDKIAE
KMIRDGRIRYDYAKQLVEKALQGEPLD

Sequences:

>Translated_427_residues
MEKTSRIQGFYKLPLEERRRIVCEWAGLTEEECRTLSEFGNLPVKIGDSMIENVIGAMSYPFAVATNFLINGRDYLVPMV
IEETSVVAAASNAARMLRHGKGILANAERQEMISQIHLVKVNSPRFKAMKIIEAKKELLDYAAQQDPTLLKYGGGPRDLE
VRAMEHPALGGVIIVHLVVDVRDAMGANTVNTMAEAIAPLLEKITGGEARLRIVSNHAVYRVTRAWAATPVEEVGGLEVA
RRIMEASILAEIDPYRAVTHNKGIMNGVIAVALATGQDHRAIEAGAHAYASRTGVYKPLSYWEVTSDNYLAGSLEIPLQI
GVVGGAVKVHPVAKIALKILGVNTARELAEVMAAVGLAQNLAALRALVTEGIQKGHMRLHARNLAIMAGASGDLIDKIAE
KMIRDGRIRYDYAKQLVEKALQGEPLD
>Mature_427_residues
MEKTSRIQGFYKLPLEERRRIVCEWAGLTEEECRTLSEFGNLPVKIGDSMIENVIGAMSYPFAVATNFLINGRDYLVPMV
IEETSVVAAASNAARMLRHGKGILANAERQEMISQIHLVKVNSPRFKAMKIIEAKKELLDYAAQQDPTLLKYGGGPRDLE
VRAMEHPALGGVIIVHLVVDVRDAMGANTVNTMAEAIAPLLEKITGGEARLRIVSNHAVYRVTRAWAATPVEEVGGLEVA
RRIMEASILAEIDPYRAVTHNKGIMNGVIAVALATGQDHRAIEAGAHAYASRTGVYKPLSYWEVTSDNYLAGSLEIPLQI
GVVGGAVKVHPVAKIALKILGVNTARELAEVMAAVGLAQNLAALRALVTEGIQKGHMRLHARNLAIMAGASGDLIDKIAE
KMIRDGRIRYDYAKQLVEKALQGEPLD

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 46450; Mature: 46450

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTSRIQGFYKLPLEERRRIVCEWAGLTEEECRTLSEFGNLPVKIGDSMIENVIGAMSY
CCCCHHCCCCEECCHHHCCEEEEHCCCCCHHHHHHHHHHCCCCEEECHHHHHHHHHHHCC
PFAVATNFLINGRDYLVPMVIEETSVVAAASNAARMLRHGKGILANAERQEMISQIHLVK
CHHHHHHHEECCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEEE
VNSPRFKAMKIIEAKKELLDYAAQQDPTLLKYGGGPRDLEVRAMEHPALGGVIIVHLVVD
ECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHH
VRDAMGANTVNTMAEAIAPLLEKITGGEARLRIVSNHAVYRVTRAWAATPVEEVGGLEVA
HHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEHHHHHCCCHHHHCCHHHH
RRIMEASILAEIDPYRAVTHNKGIMNGVIAVALATGQDHRAIEAGAHAYASRTGVYKPLS
HHHHHHHHHHHCCCCHHHHCCCCHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
YWEVTSDNYLAGSLEIPLQIGVVGGAVKVHPVAKIALKILGVNTARELAEVMAAVGLAQN
CEEECCCCEEEEEEECCEEEEEECCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LAALRALVTEGIQKGHMRLHARNLAIMAGASGDLIDKIAEKMIRDGRIRYDYAKQLVEKA
HHHHHHHHHHHHHHCCCEEEECCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LQGEPLD
HCCCCCC
>Mature Secondary Structure
MEKTSRIQGFYKLPLEERRRIVCEWAGLTEEECRTLSEFGNLPVKIGDSMIENVIGAMSY
CCCCHHCCCCEECCHHHCCEEEEHCCCCCHHHHHHHHHHCCCCEEECHHHHHHHHHHHCC
PFAVATNFLINGRDYLVPMVIEETSVVAAASNAARMLRHGKGILANAERQEMISQIHLVK
CHHHHHHHEECCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEEE
VNSPRFKAMKIIEAKKELLDYAAQQDPTLLKYGGGPRDLEVRAMEHPALGGVIIVHLVVD
ECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHH
VRDAMGANTVNTMAEAIAPLLEKITGGEARLRIVSNHAVYRVTRAWAATPVEEVGGLEVA
HHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEHHHHHCCCHHHHCCHHHH
RRIMEASILAEIDPYRAVTHNKGIMNGVIAVALATGQDHRAIEAGAHAYASRTGVYKPLS
HHHHHHHHHHHCCCCHHHHCCCCHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
YWEVTSDNYLAGSLEIPLQIGVVGGAVKVHPVAKIALKILGVNTARELAEVMAAVGLAQN
CEEECCCCEEEEEEECCEEEEEECCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LAALRALVTEGIQKGHMRLHARNLAIMAGASGDLIDKIAEKMIRDGRIRYDYAKQLVEKA
HHHHHHHHHHHHHHCCCEEEECCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LQGEPLD
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]