Click here to switch to the map view.

The map label for this gene is accD [C]

Identifier: 218883971

GI number: 218883971

Start: 634115

End: 635680

Strand: Reverse

Name: accD [C]

Synonym: DKAM_0660

Alternate gene names: 218883971

Gene position: 635680-634115 (Counterclockwise)

Preceding gene: 218883972

Following gene: 218883970

Centisome position: 46.56

GC content: 46.1

Gene sequence:

>1566_bases
GTGGAGGTAGTGAGTCACGAGGACTTATTGAGAAAGGTGAATGAGTACAGGGAGAAATCCATAGAGGGCGGCGGCAGGGA
TAAGATTGAACAGCAACGACAGAAAGGTAAGCTGTGGGTAAGGGATAGGTTAAACAGGTTACTTGATCCCGACTCCTTCA
CTGAGCTACAGTGGATGAGGACGCATAGATCAACATATTTCGGTCTGGATAAACTCAAATATTATGGCGATGGAGTTGTA
ACAGGTTACGGTGTGATCGATAAGAGACTGGTTTACGTTTATGCCCAGGATTTCACGGTTCTAGGTGGAAGCATAGGCGA
AGTACATGGTGAGAAAATAGCTAGGCTAATCGAGCTAGCCATCAAGACAGGTGCACCGGTGATAGGATTATACGACTCCG
GTGGAGCCCGCATACAGGAGGGCGTTGGATCGCTTCACGGATGCGGTAGGATATTTAATGCCAATGTAAAAGCCAGTGGA
GTGATACCACAGATAGCCGTTATAATGGGGCCATGCGCCGGTGCTGCTGCCTATAGTCCAGCACTCATGGATTTCGTTAT
AATGGTTAAGTCGTCATACATGTTTATAACTGGTCCAGAAGTAGTTAAAGCTGCACTTGGCGTCGATGTAACATTTGAGC
AGCTTGGCGGAGCTAATATCCATGCATCAACAAGCGGTGTAGCACACTTTATCACCGAGGATGAAGACTCAGCATTGGCC
TTGGTCAGGAAGCTCCTCTCATATCTCCCCAGCAATAACATGGAGGAACCACCCTTCATTCAAACGGAGGATCCTGTAGA
TAGAAGAATAGATGAGATCTATGAGATTGTGCCAACAGATCCTGTTAAATCCTTTGATGTCAAGAAGGTTATTAGCTTAC
TTGTTGATGAAGGCGACTTCCTAGAGGTGCATGAACACTACGGTAGATCAGCGGTTGTAGGATTTGGCAGGATAGGCGGG
TACACTATTGGTATAGTCGCCAATCAGCCAGCTGTGAATGCTGGCGTAATAGATATCGATGCAAGCAATAAAATAGCTAG
ATTCGTTAGATTCTGTGATTCATTCAACATACCAATAGTGACACTAGTAGATACACCAGGCTTTATGCCTGGAGTAGATC
AGGAGCATGGTGGTATAATAAGGCATGGCGCAAAGGTATTATACGCGTACTCGGAGGCGACAGTACCAAAGATAACACTG
GTTATGAGGAAGGCCTATGGAGGAGCCTACATAGCTATGGGTAGCCTCTCGCTGGAAAGCGATATAAACCTAGCATGGCC
TACAGCAGAGATAGCGGTAATGGGGCCCGAGGGAGCTATAAGAATACTCTATAGGAAGGAGTTATCCCAGGCACCTGACC
CCGAGGAGCTTGCACGAAAGAAGCTGGCTGAGTATAGGGAGACATTCGCAAACCCGTTTAGAGCTGCCGAGCTGGGATAC
ATAGATGATATAATAGATCCAGCCTTAACAAGGTTGAAGATATATGAGGCGCTTAAGGCTTTAAAGAATAAGAGGGAAGA
ATTCCTAGGCATGATACCCAAGAAACATGGTAATATACCTCTCTAA

Upstream 100 bases:

>100_bases
GCGGAGACTTTCCAGGGTTTAAGGCCAGTACCCCAGCGACGGCTCTAACACATAACATAGGTGGTGTAAGCACCATAGCA
GTGGTATCAGTGTTGAAAAG

Downstream 100 bases:

>100_bases
TATTCTTTTCCAGTATCATTTACCTTAATATGGCTTGCCCTCTCGACTACCCCATAGATGAAAGATGCAGCCCCCGAATA
GATGCAGGGAATCTCCCCGC

Product: carboxyl transferase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MEVVSHEDLLRKVNEYREKSIEGGGRDKIEQQRQKGKLWVRDRLNRLLDPDSFTELQWMRTHRSTYFGLDKLKYYGDGVV
TGYGVIDKRLVYVYAQDFTVLGGSIGEVHGEKIARLIELAIKTGAPVIGLYDSGGARIQEGVGSLHGCGRIFNANVKASG
VIPQIAVIMGPCAGAAAYSPALMDFVIMVKSSYMFITGPEVVKAALGVDVTFEQLGGANIHASTSGVAHFITEDEDSALA
LVRKLLSYLPSNNMEEPPFIQTEDPVDRRIDEIYEIVPTDPVKSFDVKKVISLLVDEGDFLEVHEHYGRSAVVGFGRIGG
YTIGIVANQPAVNAGVIDIDASNKIARFVRFCDSFNIPIVTLVDTPGFMPGVDQEHGGIIRHGAKVLYAYSEATVPKITL
VMRKAYGGAYIAMGSLSLESDINLAWPTAEIAVMGPEGAIRILYRKELSQAPDPEELARKKLAEYRETFANPFRAAELGY
IDDIIDPALTRLKIYEALKALKNKREEFLGMIPKKHGNIPL

Sequences:

>Translated_521_residues
MEVVSHEDLLRKVNEYREKSIEGGGRDKIEQQRQKGKLWVRDRLNRLLDPDSFTELQWMRTHRSTYFGLDKLKYYGDGVV
TGYGVIDKRLVYVYAQDFTVLGGSIGEVHGEKIARLIELAIKTGAPVIGLYDSGGARIQEGVGSLHGCGRIFNANVKASG
VIPQIAVIMGPCAGAAAYSPALMDFVIMVKSSYMFITGPEVVKAALGVDVTFEQLGGANIHASTSGVAHFITEDEDSALA
LVRKLLSYLPSNNMEEPPFIQTEDPVDRRIDEIYEIVPTDPVKSFDVKKVISLLVDEGDFLEVHEHYGRSAVVGFGRIGG
YTIGIVANQPAVNAGVIDIDASNKIARFVRFCDSFNIPIVTLVDTPGFMPGVDQEHGGIIRHGAKVLYAYSEATVPKITL
VMRKAYGGAYIAMGSLSLESDINLAWPTAEIAVMGPEGAIRILYRKELSQAPDPEELARKKLAEYRETFANPFRAAELGY
IDDIIDPALTRLKIYEALKALKNKREEFLGMIPKKHGNIPL
>Mature_521_residues
MEVVSHEDLLRKVNEYREKSIEGGGRDKIEQQRQKGKLWVRDRLNRLLDPDSFTELQWMRTHRSTYFGLDKLKYYGDGVV
TGYGVIDKRLVYVYAQDFTVLGGSIGEVHGEKIARLIELAIKTGAPVIGLYDSGGARIQEGVGSLHGCGRIFNANVKASG
VIPQIAVIMGPCAGAAAYSPALMDFVIMVKSSYMFITGPEVVKAALGVDVTFEQLGGANIHASTSGVAHFITEDEDSALA
LVRKLLSYLPSNNMEEPPFIQTEDPVDRRIDEIYEIVPTDPVKSFDVKKVISLLVDEGDFLEVHEHYGRSAVVGFGRIGG
YTIGIVANQPAVNAGVIDIDASNKIARFVRFCDSFNIPIVTLVDTPGFMPGVDQEHGGIIRHGAKVLYAYSEATVPKITL
VMRKAYGGAYIAMGSLSLESDINLAWPTAEIAVMGPEGAIRILYRKELSQAPDPEELARKKLAEYRETFANPFRAAELGY
IDDIIDPALTRLKIYEALKALKNKREEFLGMIPKKHGNIPL

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=513, Percent_Identity=51.8518518518518, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI295821216, Length=533, Percent_Identity=49.906191369606, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI11545863, Length=509, Percent_Identity=35.5599214145383, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679971, Length=481, Percent_Identity=25.1559251559252, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI134142062, Length=392, Percent_Identity=25.765306122449, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI38679960, Length=481, Percent_Identity=25.1559251559252, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI38679977, Length=481, Percent_Identity=25.1559251559252, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI38679967, Length=481, Percent_Identity=25.1559251559252, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI38679974, Length=481, Percent_Identity=25.1559251559252, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25147362, Length=512, Percent_Identity=53.125, Blast_Score=543, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI25147359, Length=511, Percent_Identity=53.2289628180039, Blast_Score=543, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17552936, Length=499, Percent_Identity=34.0681362725451, Blast_Score=247, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI71997163, Length=425, Percent_Identity=23.2941176470588, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323863, Length=340, Percent_Identity=23.8235294117647, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324343, Length=380, Percent_Identity=23.4210526315789, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24586065, Length=534, Percent_Identity=35.7677902621723, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24586458, Length=378, Percent_Identity=24.3386243386243, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161076407, Length=378, Percent_Identity=24.3386243386243, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24586460, Length=378, Percent_Identity=24.3386243386243, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161076409, Length=378, Percent_Identity=24.3386243386243, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 57297; Mature: 57297

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVVSHEDLLRKVNEYREKSIEGGGRDKIEQQRQKGKLWVRDRLNRLLDPDSFTELQWMR
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHH
THRSTYFGLDKLKYYGDGVVTGYGVIDKRLVYVYAQDFTVLGGSIGEVHGEKIARLIELA
HHHHHHHCHHHHHHHCCCEEEECCHHCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHH
IKTGAPVIGLYDSGGARIQEGVGSLHGCGRIFNANVKASGVIPQIAVIMGPCAGAAAYSP
HHCCCCEEEEECCCCCHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHCCCCCCHHHHH
ALMDFVIMVKSSYMFITGPEVVKAALGVDVTFEQLGGANIHASTSGVAHFITEDEDSALA
HHHHHHHHHHCCEEEEECHHHHHHHHCCCEEHHHCCCCEEEECCCCEEEEEECCCCHHHH
LVRKLLSYLPSNNMEEPPFIQTEDPVDRRIDEIYEIVPTDPVKSFDVKKVISLLVDEGDF
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCE
LEVHEHYGRSAVVGFGRIGGYTIGIVANQPAVNAGVIDIDASNKIARFVRFCDSFNIPIV
EHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHCCCCCCEE
TLVDTPGFMPGVDQEHGGIIRHGAKVLYAYSEATVPKITLVMRKAYGGAYIAMGSLSLES
EEECCCCCCCCCCCCCCCEECCCCEEEEEECCCCCCHHHEEHHHHCCCEEEEEECEEECC
DINLAWPTAEIAVMGPEGAIRILYRKELSQAPDPEELARKKLAEYRETFANPFRAAELGY
CCCEECCCEEEEEECCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCH
IDDIIDPALTRLKIYEALKALKNKREEFLGMIPKKHGNIPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEVVSHEDLLRKVNEYREKSIEGGGRDKIEQQRQKGKLWVRDRLNRLLDPDSFTELQWMR
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHH
THRSTYFGLDKLKYYGDGVVTGYGVIDKRLVYVYAQDFTVLGGSIGEVHGEKIARLIELA
HHHHHHHCHHHHHHHCCCEEEECCHHCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHH
IKTGAPVIGLYDSGGARIQEGVGSLHGCGRIFNANVKASGVIPQIAVIMGPCAGAAAYSP
HHCCCCEEEEECCCCCHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHCCCCCCHHHHH
ALMDFVIMVKSSYMFITGPEVVKAALGVDVTFEQLGGANIHASTSGVAHFITEDEDSALA
HHHHHHHHHHCCEEEEECHHHHHHHHCCCEEHHHCCCCEEEECCCCEEEEEECCCCHHHH
LVRKLLSYLPSNNMEEPPFIQTEDPVDRRIDEIYEIVPTDPVKSFDVKKVISLLVDEGDF
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCE
LEVHEHYGRSAVVGFGRIGGYTIGIVANQPAVNAGVIDIDASNKIARFVRFCDSFNIPIV
EHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHCCCCCCEE
TLVDTPGFMPGVDQEHGGIIRHGAKVLYAYSEATVPKITLVMRKAYGGAYIAMGSLSLES
EEECCCCCCCCCCCCCCCEECCCCEEEEEECCCCCCHHHEEHHHHCCCEEEEEECEEECC
DINLAWPTAEIAVMGPEGAIRILYRKELSQAPDPEELARKKLAEYRETFANPFRAAELGY
CCCEECCCEEEEEECCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCH
IDDIIDPALTRLKIYEALKALKNKREEFLGMIPKKHGNIPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]