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The map label for this gene is paaJ [C]

Identifier: 218883972

GI number: 218883972

Start: 635671

End: 636846

Strand: Reverse

Name: paaJ [C]

Synonym: DKAM_0661

Alternate gene names: 218883972

Gene position: 636846-635671 (Counterclockwise)

Preceding gene: 218883973

Following gene: 218883971

Centisome position: 46.65

GC content: 48.81

Gene sequence:

>1176_bases
ATGGATAGTGTATTCATAGTCGGAGTTGGCATGACCAAGATTAGCAGGTTTTACGAGCAATCCGCTAGAGAGCTTTTCTC
CCAGGCACTATGGAAGGCTATCGAGGACGCTGGAGGAGTTAAGCCAAAGGCGCTTGTAGTAGGCAACATGATGTCGAGTG
TTTTAATGAACCAGGATAGCTTGGGTGCTTTACTAGCAGATTACGCTGGTTTAAGAGGAATACCGGCATTCAAGGTCGAG
GCTGCATGTGGCAGTGGTGGGGCAGCCCTGTATGCAGGCTACGCGATGGTCAAGGCTGGAATAACTGATGTAGTCGCTGT
CGGAGGTATCGAGAAGCAGACAGAGGCTACAACACCATATGTTACTCGTGCATTAGCCCAGGCAGCTGATGCTGACTTTG
AGGTTTTCTACGGTGTTTCATTTACAGGGCTAAATGCGATGATCGCCAGGCTATATATGCAGTTGTTTGGTTATAGCGAG
GAGGATTTATCACACTGGCCTCTTAAAATGCATGAATATGCCAGCTATAATCCATATGCACAACTACCTAGGAAAACAAG
TATGAAGGAGATACTTGAAAGCCCCATGATCGCTGACCCGATAAGATTATTCCATGCAGCCCCGCTTGGTGATGGAGCAG
CTGCCGTGCTCCTTGTAAGGGGAGAGGAGAAGGCACGCGAGATAGCGAAGTCGACTGGTAGAGATACACTTGTAGAGCTG
GCTGGGATAGGCATGGCTACGGACAGCGTTGACCTGGCATCGAGAAATAATATACTTGTAATGGAATCCACTGTCAAGGC
GGCACAGGAAGCGTTGAAAATGGCTGGATTAAGCCTCAAAGATATAGATTACGCCGAGATACACGATGCATTCCATATAA
CTGGCTATGCAGCATTAGAGGACATAGGCTTCGCACCGAAAGGAGAGGCACCTAAGCTATTCAAGGAGGGGCGTTTCCAG
AAAGGTGATAAGCCCGAGGTGAACTTTAGCGGTGGATTAAAGGCGAGGGGACACCCAGTTGGTGCGACAGGCATATACCA
GGTTGTTGAATCAGTGATGCAGTTACGCGGAGACTTTCCAGGGTTTAAGGCCAGTACCCCAGCGACGGCTCTAACACATA
ACATAGGTGGTGTAAGCACCATAGCAGTGGTATCAGTGTTGAAAAGGTGGAGGTAG

Upstream 100 bases:

>100_bases
CCCCTCGGGACGTTTCTTGTTCAGTCCAGAGTGTTTAAATAATTGCTGTATAATTTATTCTATCAAGGCAATGCATGTCT
ATCTTAGGGTGCGATTAGAA

Downstream 100 bases:

>100_bases
TGAGTCACGAGGACTTATTGAGAAAGGTGAATGAGTACAGGGAGAAATCCATAGAGGGCGGCGGCAGGGATAAGATTGAA
CAGCAACGACAGAAAGGTAA

Product: Thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MDSVFIVGVGMTKISRFYEQSARELFSQALWKAIEDAGGVKPKALVVGNMMSSVLMNQDSLGALLADYAGLRGIPAFKVE
AACGSGGAALYAGYAMVKAGITDVVAVGGIEKQTEATTPYVTRALAQAADADFEVFYGVSFTGLNAMIARLYMQLFGYSE
EDLSHWPLKMHEYASYNPYAQLPRKTSMKEILESPMIADPIRLFHAAPLGDGAAAVLLVRGEEKAREIAKSTGRDTLVEL
AGIGMATDSVDLASRNNILVMESTVKAAQEALKMAGLSLKDIDYAEIHDAFHITGYAALEDIGFAPKGEAPKLFKEGRFQ
KGDKPEVNFSGGLKARGHPVGATGIYQVVESVMQLRGDFPGFKASTPATALTHNIGGVSTIAVVSVLKRWR

Sequences:

>Translated_391_residues
MDSVFIVGVGMTKISRFYEQSARELFSQALWKAIEDAGGVKPKALVVGNMMSSVLMNQDSLGALLADYAGLRGIPAFKVE
AACGSGGAALYAGYAMVKAGITDVVAVGGIEKQTEATTPYVTRALAQAADADFEVFYGVSFTGLNAMIARLYMQLFGYSE
EDLSHWPLKMHEYASYNPYAQLPRKTSMKEILESPMIADPIRLFHAAPLGDGAAAVLLVRGEEKAREIAKSTGRDTLVEL
AGIGMATDSVDLASRNNILVMESTVKAAQEALKMAGLSLKDIDYAEIHDAFHITGYAALEDIGFAPKGEAPKLFKEGRFQ
KGDKPEVNFSGGLKARGHPVGATGIYQVVESVMQLRGDFPGFKASTPATALTHNIGGVSTIAVVSVLKRWR
>Mature_391_residues
MDSVFIVGVGMTKISRFYEQSARELFSQALWKAIEDAGGVKPKALVVGNMMSSVLMNQDSLGALLADYAGLRGIPAFKVE
AACGSGGAALYAGYAMVKAGITDVVAVGGIEKQTEATTPYVTRALAQAADADFEVFYGVSFTGLNAMIARLYMQLFGYSE
EDLSHWPLKMHEYASYNPYAQLPRKTSMKEILESPMIADPIRLFHAAPLGDGAAAVLLVRGEEKAREIAKSTGRDTLVEL
AGIGMATDSVDLASRNNILVMESTVKAAQEALKMAGLSLKDIDYAEIHDAFHITGYAALEDIGFAPKGEAPKLFKEGRFQ
KGDKPEVNFSGGLKARGHPVGATGIYQVVESVMQLRGDFPGFKASTPATALTHNIGGVSTIAVVSVLKRWR

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=398, Percent_Identity=27.8894472361809, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI302344760, Length=397, Percent_Identity=27.7078085642317, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI302344767, Length=328, Percent_Identity=27.7439024390244, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI302344762, Length=398, Percent_Identity=26.6331658291457, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI55956775, Length=354, Percent_Identity=25.9887005649718, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17537653, Length=392, Percent_Identity=28.5714285714286, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24585051, Length=394, Percent_Identity=27.4111675126904, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI19921506, Length=388, Percent_Identity=25.7731958762887, Blast_Score=132, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 41817; Mature: 41817

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSVFIVGVGMTKISRFYEQSARELFSQALWKAIEDAGGVKPKALVVGNMMSSVLMNQDS
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCH
LGALLADYAGLRGIPAFKVEAACGSGGAALYAGYAMVKAGITDVVAVGGIEKQTEATTPY
HHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCHHCCCCHH
VTRALAQAADADFEVFYGVSFTGLNAMIARLYMQLFGYSEEDLSHWPLKMHEYASYNPYA
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHCCCCCCHH
QLPRKTSMKEILESPMIADPIRLFHAAPLGDGAAAVLLVRGEEKAREIAKSTGRDTLVEL
HCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHCCHHHHHHH
AGIGMATDSVDLASRNNILVMESTVKAAQEALKMAGLSLKDIDYAEIHDAFHITGYAALE
HHCCCCCCCCHHCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEHHHHHH
DIGFAPKGEAPKLFKEGRFQKGDKPEVNFSGGLKARGHPVGATGIYQVVESVMQLRGDFP
HCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
GFKASTPATALTHNIGGVSTIAVVSVLKRWR
CCCCCCCHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDSVFIVGVGMTKISRFYEQSARELFSQALWKAIEDAGGVKPKALVVGNMMSSVLMNQDS
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCH
LGALLADYAGLRGIPAFKVEAACGSGGAALYAGYAMVKAGITDVVAVGGIEKQTEATTPY
HHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCHHCCCCHH
VTRALAQAADADFEVFYGVSFTGLNAMIARLYMQLFGYSEEDLSHWPLKMHEYASYNPYA
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHCCCCCCHH
QLPRKTSMKEILESPMIADPIRLFHAAPLGDGAAAVLLVRGEEKAREIAKSTGRDTLVEL
HCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHCCHHHHHHH
AGIGMATDSVDLASRNNILVMESTVKAAQEALKMAGLSLKDIDYAEIHDAFHITGYAALE
HHCCCCCCCCHHCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEHHHHHH
DIGFAPKGEAPKLFKEGRFQKGDKPEVNFSGGLKARGHPVGATGIYQVVESVMQLRGDFP
HCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
GFKASTPATALTHNIGGVSTIAVVSVLKRWR
CCCCCCCHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]