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The map label for this gene is speA [H]

Identifier: 218883962

GI number: 218883962

Start: 626876

End: 628654

Strand: Reverse

Name: speA [H]

Synonym: DKAM_0651

Alternate gene names: 218883962

Gene position: 628654-626876 (Counterclockwise)

Preceding gene: 218883963

Following gene: 218883957

Centisome position: 46.05

GC content: 43.45

Gene sequence:

>1779_bases
GTGTATGAAAAAGAGATGAATAGGGAAGAATGGGATATCAACGTAGCGAAAGAACTATGGGGACTGAACCATAGCATCAG
GGGAAGCATTATAACTGTGGATGAAGAGGGATATCTAGTAATAAGTCTTGGAGAGCAGAAAATAAGAGTAAAAAACCTAC
TGGAAAAACATGGTTTCGATGTAGCATATATAAGGGTACTTCCATTAATAGAAAGGGCAATTAGGACAGTATACGAGGCA
TTCACAGAGCTGGCTAAAGTCCATGGTTTTAAAGGCAGTCTTCAACCAGTTTTCCCTATGAAGGTCAACCCTATAGAAGT
AGTTATAGATGCTATATGGAGGTATGGTGAAAAATATAAATGGGGATTCAACACCGGCTCCCTTGGAGAGCTGGAATTAC
TCTCAAAGTACTTGGAGAAAGGCGGCAGGATACTCATATATGATGGAGTAGTTTCAGACAGTGTTATGAAGATCTTAGTA
AGGTTCAAGGAGAATGGCTGGAGAGTAATAATCGACGTGGAAAGTGAGCACGACCTGGACATCCTATCAAAGTACCCCGA
GTTCGAAATAGGGCTCAGGATAAAGCCTCTCTTCAGGCCTGGAGGTAAGTGGGCTCATTCAGCTGGGCTAGAAGGCAAGT
TTGGGCTAACAGTAAACACTCTCGTGAAACTCAGAGAGGAATACAAGTGGATAGAGGAGAGGGGTCGCCTCCTCCACATA
CACCCAGGATCGCAAATCTATAAATGGAGTGATATGGAGGCATTCATTAATGAGGTTTACAATATATTCACACAGCTGCA
GTCACATGGATTCCCCAGTATAGAAATAGTAGACCTAGGCGGTGGGCTAGCCTACCCATACCTAGATACTAGGGATGGAA
CAATTGAGTCGCCGGATTATGGTTTAATAGAATACTTCAACCACATTCTTAAGATCTTCAGCAGGCTTGAAAAACACCCA
ACCCTGGTATATGAGGGGGGAAGATACATTGTATCAGCTCATAGAATACTTGTTGCGAAAGTTGTCGACATCCGCCCTTA
TTCAACAGAACAGGCACAATCCTTAAGAAGTGCCCAGGTGGAGGATTTCCTAAGTAATGTGAGATCTATAGATGACCTGA
AGAAACTGGTGAACGAATACAAGAAGTATATTCATAAGAGTAAGCAAGTGCATCAATACACGTTAGAGGAGAGAGAGCTG
GCTGAGGATGTAGTATCTAAGGTAAGGGATGAGTTACTAGCTAAAATATATGAGCTGGTTAGAAACAAGCCGTCCCAGAT
AGAATCCGTGATAAACGATCCCCTCCTATACAAGCTGGTCACCTCGCCTTCTAAAAGATACATTCTGAACTTCTCGATAT
TCGCCGATATCCCCGATTCAGTCCTGGTAAACCAGTACTTCCAGGCTGTGCCAGCGCAGAGACTAAACGAGAAACCCGAT
GTATTAGCGGTACTAGGGGATCTAACCTGTGACAGCATGGGGGAAATCAACGAGTATATAAGCCATGTAAAGACACCCCT
CGAGGCATCCGACTGGTTTACTAAAATGGATCTAAGACTCATGTTGATCCCTGGTAGAAGACTCAAGCTTGGAGGAGTCC
CATTACACCTGCCAATAAAGGGTGAGAATTATTATATCGCAATACTAGACACGGGTGCATACCAAGACCCCCTCGCTATG
AAGCACAACCTCATCTATGGTGCTCCCGAGATAATATTAGATGAGAAAGACGGGGAGGTAGAGGTAAAAATCATTGAGAA
AAACGGTAAATACCTCTAG

Upstream 100 bases:

>100_bases
TAGATGAGATACTATCTCAATCACATGTGCCAATTGAAGAAATTGAATAGTTTAAGCTTAAAAATCCTTAGTATTAATTG
AAGACATAGCAAGCCTCTAG

Downstream 100 bases:

>100_bases
TGCTCAGAGGTTTCTAAGAGATATAGGTTCACCAGACACGCTTTTAGCTGAGTATCTCTTCACCCTTACAGCTAGGATAC
TCCATAAAGGTATCTCCCCC

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MYEKEMNREEWDINVAKELWGLNHSIRGSIITVDEEGYLVISLGEQKIRVKNLLEKHGFDVAYIRVLPLIERAIRTVYEA
FTELAKVHGFKGSLQPVFPMKVNPIEVVIDAIWRYGEKYKWGFNTGSLGELELLSKYLEKGGRILIYDGVVSDSVMKILV
RFKENGWRVIIDVESEHDLDILSKYPEFEIGLRIKPLFRPGGKWAHSAGLEGKFGLTVNTLVKLREEYKWIEERGRLLHI
HPGSQIYKWSDMEAFINEVYNIFTQLQSHGFPSIEIVDLGGGLAYPYLDTRDGTIESPDYGLIEYFNHILKIFSRLEKHP
TLVYEGGRYIVSAHRILVAKVVDIRPYSTEQAQSLRSAQVEDFLSNVRSIDDLKKLVNEYKKYIHKSKQVHQYTLEEREL
AEDVVSKVRDELLAKIYELVRNKPSQIESVINDPLLYKLVTSPSKRYILNFSIFADIPDSVLVNQYFQAVPAQRLNEKPD
VLAVLGDLTCDSMGEINEYISHVKTPLEASDWFTKMDLRLMLIPGRRLKLGGVPLHLPIKGENYYIAILDTGAYQDPLAM
KHNLIYGAPEIILDEKDGEVEVKIIEKNGKYL

Sequences:

>Translated_592_residues
MYEKEMNREEWDINVAKELWGLNHSIRGSIITVDEEGYLVISLGEQKIRVKNLLEKHGFDVAYIRVLPLIERAIRTVYEA
FTELAKVHGFKGSLQPVFPMKVNPIEVVIDAIWRYGEKYKWGFNTGSLGELELLSKYLEKGGRILIYDGVVSDSVMKILV
RFKENGWRVIIDVESEHDLDILSKYPEFEIGLRIKPLFRPGGKWAHSAGLEGKFGLTVNTLVKLREEYKWIEERGRLLHI
HPGSQIYKWSDMEAFINEVYNIFTQLQSHGFPSIEIVDLGGGLAYPYLDTRDGTIESPDYGLIEYFNHILKIFSRLEKHP
TLVYEGGRYIVSAHRILVAKVVDIRPYSTEQAQSLRSAQVEDFLSNVRSIDDLKKLVNEYKKYIHKSKQVHQYTLEEREL
AEDVVSKVRDELLAKIYELVRNKPSQIESVINDPLLYKLVTSPSKRYILNFSIFADIPDSVLVNQYFQAVPAQRLNEKPD
VLAVLGDLTCDSMGEINEYISHVKTPLEASDWFTKMDLRLMLIPGRRLKLGGVPLHLPIKGENYYIAILDTGAYQDPLAM
KHNLIYGAPEIILDEKDGEVEVKIIEKNGKYL
>Mature_592_residues
MYEKEMNREEWDINVAKELWGLNHSIRGSIITVDEEGYLVISLGEQKIRVKNLLEKHGFDVAYIRVLPLIERAIRTVYEA
FTELAKVHGFKGSLQPVFPMKVNPIEVVIDAIWRYGEKYKWGFNTGSLGELELLSKYLEKGGRILIYDGVVSDSVMKILV
RFKENGWRVIIDVESEHDLDILSKYPEFEIGLRIKPLFRPGGKWAHSAGLEGKFGLTVNTLVKLREEYKWIEERGRLLHI
HPGSQIYKWSDMEAFINEVYNIFTQLQSHGFPSIEIVDLGGGLAYPYLDTRDGTIESPDYGLIEYFNHILKIFSRLEKHP
TLVYEGGRYIVSAHRILVAKVVDIRPYSTEQAQSLRSAQVEDFLSNVRSIDDLKKLVNEYKKYIHKSKQVHQYTLEEREL
AEDVVSKVRDELLAKIYELVRNKPSQIESVINDPLLYKLVTSPSKRYILNFSIFADIPDSVLVNQYFQAVPAQRLNEKPD
VLAVLGDLTCDSMGEINEYISHVKTPLEASDWFTKMDLRLMLIPGRRLKLGGVPLHLPIKGENYYIAILDTGAYQDPLAM
KHNLIYGAPEIILDEKDGEVEVKIIEKNGKYL

Specific function: Catalyzes the biosynthesis of agmatine from arginine [H]

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789307, Length=613, Percent_Identity=24.7960848287113, Blast_Score=152, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 68094; Mature: 68094

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYEKEMNREEWDINVAKELWGLNHSIRGSIITVDEEGYLVISLGEQKIRVKNLLEKHGFD
CCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHCCCC
VAYIRVLPLIERAIRTVYEAFTELAKVHGFKGSLQPVFPMKVNPIEVVIDAIWRYGEKYK
EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHHHCCCCEE
WGFNTGSLGELELLSKYLEKGGRILIYDGVVSDSVMKILVRFKENGWRVIIDVESEHDLD
ECCCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHH
ILSKYPEFEIGLRIKPLFRPGGKWAHSAGLEGKFGLTVNTLVKLREEYKWIEERGRLLHI
HHHCCCCEEECEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
HPGSQIYKWSDMEAFINEVYNIFTQLQSHGFPSIEIVDLGGGLAYPYLDTRDGTIESPDY
CCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEECCEECCCCCCCCCCCC
GLIEYFNHILKIFSRLEKHPTLVYEGGRYIVSAHRILVAKVVDIRPYSTEQAQSLRSAQV
CHHHHHHHHHHHHHHHHHCCCEEEECCEEEEEHHHEEEEHEEECCCCCCHHHHHHHHHHH
EDFLSNVRSIDDLKKLVNEYKKYIHKSKQVHQYTLEERELAEDVVSKVRDELLAKIYELV
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNKPSQIESVINDPLLYKLVTSPSKRYILNFSIFADIPDSVLVNQYFQAVPAQRLNEKPD
CCCHHHHHHHHCCCCEEEECCCCCCEEEEEEEEEECCCHHHHHHHHHHHCCHHHCCCCCC
VLAVLGDLTCDSMGEINEYISHVKTPLEASDWFTKMDLRLMLIPGRRLKLGGVPLHLPIK
EEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHEEECEEEEEECCCEEEECCEEEEEEEE
GENYYIAILDTGAYQDPLAMKHNLIYGAPEIILDEKDGEVEVKIIEKNGKYL
CCCEEEEEEECCCCCCCHHHHCCEEECCCEEEEECCCCEEEEEEEECCCCCC
>Mature Secondary Structure
MYEKEMNREEWDINVAKELWGLNHSIRGSIITVDEEGYLVISLGEQKIRVKNLLEKHGFD
CCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHCCCC
VAYIRVLPLIERAIRTVYEAFTELAKVHGFKGSLQPVFPMKVNPIEVVIDAIWRYGEKYK
EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHHHCCCCEE
WGFNTGSLGELELLSKYLEKGGRILIYDGVVSDSVMKILVRFKENGWRVIIDVESEHDLD
ECCCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHH
ILSKYPEFEIGLRIKPLFRPGGKWAHSAGLEGKFGLTVNTLVKLREEYKWIEERGRLLHI
HHHCCCCEEECEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
HPGSQIYKWSDMEAFINEVYNIFTQLQSHGFPSIEIVDLGGGLAYPYLDTRDGTIESPDY
CCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEECCEECCCCCCCCCCCC
GLIEYFNHILKIFSRLEKHPTLVYEGGRYIVSAHRILVAKVVDIRPYSTEQAQSLRSAQV
CHHHHHHHHHHHHHHHHHCCCEEEECCEEEEEHHHEEEEHEEECCCCCCHHHHHHHHHHH
EDFLSNVRSIDDLKKLVNEYKKYIHKSKQVHQYTLEERELAEDVVSKVRDELLAKIYELV
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNKPSQIESVINDPLLYKLVTSPSKRYILNFSIFADIPDSVLVNQYFQAVPAQRLNEKPD
CCCHHHHHHHHCCCCEEEECCCCCCEEEEEEEEEECCCHHHHHHHHHHHCCHHHCCCCCC
VLAVLGDLTCDSMGEINEYISHVKTPLEASDWFTKMDLRLMLIPGRRLKLGGVPLHLPIK
EEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHEEECEEEEEECCCEEEECCEEEEEEEE
GENYYIAILDTGAYQDPLAMKHNLIYGAPEIILDEKDGEVEVKIIEKNGKYL
CCCEEEEEEECCCCCCCHHHHCCEEECCCEEEEECCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA