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The map label for this gene is rad50 [H]

Identifier: 218883921

GI number: 218883921

Start: 573882

End: 576338

Strand: Reverse

Name: rad50 [H]

Synonym: DKAM_0610

Alternate gene names: 218883921

Gene position: 576338-573882 (Counterclockwise)

Preceding gene: 218883922

Following gene: 218883920

Centisome position: 42.22

GC content: 41.15

Gene sequence:

>2457_bases
ATGAGAATTTATGGATTAATGCTTGAAAATATACGGAGCTTTAAGAACGAGTACATAGTGTTCCCTAAGAAAGGGGTAAC
CGTTATACATGGCGAGACAGGAAGTGGTAAAACAAGCATACTCATGTCTATAAGTGCAGCATTATTTGGGCTCCAAAAAG
AGGGCAAGGATCCATTTAGGGCATTTGCATATCCAACAGGTAAAGACCTATTGAGGGCTGATGCATTAAGGGGTAGGATA
CGACTCTTATTCGAGCATGAAGGCAGGGTATACCTTGTTGAAAGAGAATTCAAGAGAAGTAGTAACAGCGTGGTTAATGT
TGACCGGAATAGGCTTGAAGAATACATCATAAAGGAGGATAAGTTGATCAAAGTAAACAGCCTGATTCTCGGAACAGAAG
AATTGAACAAGAGAATCCGGGAGATCCTCGGGATAAAAGAGAGGGCTAGGGAGAAACCACTCCTATTCACAAGCGTGCTC
TATGCCCCCCAATTCAACATACATGAAATTCTCAGTCTAGATAGCGAGGAGAGAGGCGAGATCATAGAGAGATCCCTGGG
ACTATACAAGTACAAGGAGTACAAGAATAATAGCAATGCAGTAAGAGACGTGATTAAGGATAAAATAGATGAATTAACCG
ATAAAATCGATGGGCTGAAGAAAAAGCTTAAAGACAAAAACAAGGAGAAACTACTCGAAGAGAAGCAGAGATTAGAAAAG
CAGTTAAAAGAGCTTGAAAAAATACTCGTGGAGAAGCAAAAAGAGCGTGATGAGCTAGATAAAAGAATAAAGGAGCACCA
GAATCGCCTTAGGGATATGGAGCGAAGAATAGGCGAGTTACAGAGCAGGATAGGGCAAGCTAGGAAACAAGAGGCTAGGC
TGAAAGATGTGAGAAACGAACTAGCTAAAATAGCGCTTAATCTAGGCAAGAATGCTTCGACTGGTTATACAGAGTTACTA
GAAGAATTAAGGAGAAGAGAAAGAGAAATAGAGGGGAAAGTAAGGGAGCTACAAGACATAGAATCTGAGCTAGTAGATAA
GCGTAAGGAAATTGAGGAAGAATTAAACGAGGCTAAGAGAAAAAGGGAAGATATAATGATGAGGCTTGGGAGACTTGAAG
CCGACGAGGAAAACCTTACAAGACAAGAACAAGAGTTAAATAAGCAACTCGAAAAATACAGGGATCTCTTAAACAAGGGG
ATATGCCCCCTATGCCTCCAGCCGATACCACATGAACACGGCATTAAACTAATTGATGAAGTCCAAGGAAGATTAGAGGA
AGTAGGGAAAAAGATAAGGGAGCTGAAGGAAGAAGAAACTAGTCGCTATAAGGAATTAGAGGATATCAATAAGAGGATCA
ATGCTCTCGAGGAAAACCGGGAGGAAGTAGAGGAAAAACTGGACAAAGTGAGAAGAGATTCGACAAGACTTTTACAGGAA
TTACTAAGTCTTAAGCACACTGCTGAAAAGATAAATAGCCTGGTAGATGAGGCTTCAAGAATAGAAAAGGAGATCTCCGA
GGCTAGAAGCCTGGAAGAAGAATTAGCCAGAATCAATAGTGAGAAAGAAAACACTATAAGCATCATACATGAACTCGAAG
ACAAGTACCGTGAAGCCAAGGAAAAACTGGAGGGATTAATTGCTGAAAAAGCTGGGACTGAGAAATCAATTAAGTACATT
GAATTAGAGATACAAGACATTGAGAAAGAAGAGGATGAACTGAGACAACTCGAGGATGAGAAGAAATTCCATGAATGGAT
GGACACGACGATGAATATACTAGATAAATTAGTCGACGAGGTTGAAAAAAGAGTCTCACTAGAGATGGTCTCGGAATTCC
GAAGGATCTTCTATATGATACTAGATACATTATTACAGGGGCAACCAGTGGAAGTAGGCATAAGAGACGACTTCACAATA
GAGCCGAAAATAAGGATAGGTGGTAGAATCTACACTATATCATCACTCAGCGGTGGGCAAAACATAGCCATCAGCCTAGC
ATACAGGCTCGCCTTAAACGCTACAGTAAGAACATACTCGCCATTCCTGAGGAAAACCGTCCTGATACTAGATGAGCCAA
CAACAGGCTTCAGCCAGGAGCTTGTTAAAAGGCTTAGTGAGGTACTACGTAAAATAGGGGATCTAGAAGGACAAGTAATA
GTCGTAACACATGATGAATTATTGAAAGAAATAGGAGATTGCAAGATAATGCTAGAACGTGATCCCATAAACCATGTCTC
TAAGGTACGGGAACAGGAGTGTGATATAGAGGAGTTCAATAAATTCAAGAATCTGGTCGAAGGCCTCTTACGTGGCTCAC
TACAGGTAGATACCGTGAAAATGGAAAAGATAGAGGTGGAGCCAGCAGGCTTCAAGCCGGAAGTGAGGTTAGGAGCTGGA
ACTGTTCAGCAAGCCAAGAGAAAAAGCTTGTTTGACTTCCATGATAAACCTAAGTAG

Upstream 100 bases:

>100_bases
GATATAAGGAGAATAGAGGAGAAACCCGGTGAACCGGATAAGGGTAAATCCAGCAAGGAGGATCTAAAAAGTATTCTCCT
GTGATTAAGGGGGCTCCCTG

Downstream 100 bases:

>100_bases
TAGTGAAAAATATGGAACAGGAGTGTGGTGAAAAAACCCGTGAAATAATAGAGGAGACAGCGGGTTTCTTCAGGAATATA
GGGAGATACAGGAGTACTGG

Product: DNA double-strand break repair rad50 ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 818; Mature: 818

Protein sequence:

>818_residues
MRIYGLMLENIRSFKNEYIVFPKKGVTVIHGETGSGKTSILMSISAALFGLQKEGKDPFRAFAYPTGKDLLRADALRGRI
RLLFEHEGRVYLVEREFKRSSNSVVNVDRNRLEEYIIKEDKLIKVNSLILGTEELNKRIREILGIKERAREKPLLFTSVL
YAPQFNIHEILSLDSEERGEIIERSLGLYKYKEYKNNSNAVRDVIKDKIDELTDKIDGLKKKLKDKNKEKLLEEKQRLEK
QLKELEKILVEKQKERDELDKRIKEHQNRLRDMERRIGELQSRIGQARKQEARLKDVRNELAKIALNLGKNASTGYTELL
EELRRREREIEGKVRELQDIESELVDKRKEIEEELNEAKRKREDIMMRLGRLEADEENLTRQEQELNKQLEKYRDLLNKG
ICPLCLQPIPHEHGIKLIDEVQGRLEEVGKKIRELKEEETSRYKELEDINKRINALEENREEVEEKLDKVRRDSTRLLQE
LLSLKHTAEKINSLVDEASRIEKEISEARSLEEELARINSEKENTISIIHELEDKYREAKEKLEGLIAEKAGTEKSIKYI
ELEIQDIEKEEDELRQLEDEKKFHEWMDTTMNILDKLVDEVEKRVSLEMVSEFRRIFYMILDTLLQGQPVEVGIRDDFTI
EPKIRIGGRIYTISSLSGGQNIAISLAYRLALNATVRTYSPFLRKTVLILDEPTTGFSQELVKRLSEVLRKIGDLEGQVI
VVTHDELLKEIGDCKIMLERDPINHVSKVREQECDIEEFNKFKNLVEGLLRGSLQVDTVKMEKIEVEPAGFKPEVRLGAG
TVQQAKRKSLFDFHDKPK

Sequences:

>Translated_818_residues
MRIYGLMLENIRSFKNEYIVFPKKGVTVIHGETGSGKTSILMSISAALFGLQKEGKDPFRAFAYPTGKDLLRADALRGRI
RLLFEHEGRVYLVEREFKRSSNSVVNVDRNRLEEYIIKEDKLIKVNSLILGTEELNKRIREILGIKERAREKPLLFTSVL
YAPQFNIHEILSLDSEERGEIIERSLGLYKYKEYKNNSNAVRDVIKDKIDELTDKIDGLKKKLKDKNKEKLLEEKQRLEK
QLKELEKILVEKQKERDELDKRIKEHQNRLRDMERRIGELQSRIGQARKQEARLKDVRNELAKIALNLGKNASTGYTELL
EELRRREREIEGKVRELQDIESELVDKRKEIEEELNEAKRKREDIMMRLGRLEADEENLTRQEQELNKQLEKYRDLLNKG
ICPLCLQPIPHEHGIKLIDEVQGRLEEVGKKIRELKEEETSRYKELEDINKRINALEENREEVEEKLDKVRRDSTRLLQE
LLSLKHTAEKINSLVDEASRIEKEISEARSLEEELARINSEKENTISIIHELEDKYREAKEKLEGLIAEKAGTEKSIKYI
ELEIQDIEKEEDELRQLEDEKKFHEWMDTTMNILDKLVDEVEKRVSLEMVSEFRRIFYMILDTLLQGQPVEVGIRDDFTI
EPKIRIGGRIYTISSLSGGQNIAISLAYRLALNATVRTYSPFLRKTVLILDEPTTGFSQELVKRLSEVLRKIGDLEGQVI
VVTHDELLKEIGDCKIMLERDPINHVSKVREQECDIEEFNKFKNLVEGLLRGSLQVDTVKMEKIEVEPAGFKPEVRLGAG
TVQQAKRKSLFDFHDKPK
>Mature_818_residues
MRIYGLMLENIRSFKNEYIVFPKKGVTVIHGETGSGKTSILMSISAALFGLQKEGKDPFRAFAYPTGKDLLRADALRGRI
RLLFEHEGRVYLVEREFKRSSNSVVNVDRNRLEEYIIKEDKLIKVNSLILGTEELNKRIREILGIKERAREKPLLFTSVL
YAPQFNIHEILSLDSEERGEIIERSLGLYKYKEYKNNSNAVRDVIKDKIDELTDKIDGLKKKLKDKNKEKLLEEKQRLEK
QLKELEKILVEKQKERDELDKRIKEHQNRLRDMERRIGELQSRIGQARKQEARLKDVRNELAKIALNLGKNASTGYTELL
EELRRREREIEGKVRELQDIESELVDKRKEIEEELNEAKRKREDIMMRLGRLEADEENLTRQEQELNKQLEKYRDLLNKG
ICPLCLQPIPHEHGIKLIDEVQGRLEEVGKKIRELKEEETSRYKELEDINKRINALEENREEVEEKLDKVRRDSTRLLQE
LLSLKHTAEKINSLVDEASRIEKEISEARSLEEELARINSEKENTISIIHELEDKYREAKEKLEGLIAEKAGTEKSIKYI
ELEIQDIEKEEDELRQLEDEKKFHEWMDTTMNILDKLVDEVEKRVSLEMVSEFRRIFYMILDTLLQGQPVEVGIRDDFTI
EPKIRIGGRIYTISSLSGGQNIAISLAYRLALNATVRTYSPFLRKTVLILDEPTTGFSQELVKRLSEVLRKIGDLEGQVI
VVTHDELLKEIGDCKIMLERDPINHVSKVREQECDIEEFNKFKNLVEGLLRGSLQVDTVKMEKIEVEPAGFKPEVRLGAG
TVQQAKRKSLFDFHDKPK

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of mre11 by unwinding and

COG id: COG0419

COG function: function code L; ATPase involved in DNA repair

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 zinc-hook domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022982
- InterPro:   IPR013134 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 95670; Mature: 95670

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS51131 ZN_HOOK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIYGLMLENIRSFKNEYIVFPKKGVTVIHGETGSGKTSILMSISAALFGLQKEGKDPFR
CCHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHH
AFAYPTGKDLLRADALRGRIRLLFEHEGRVYLVEREFKRSSNSVVNVDRNRLEEYIIKED
HHCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEEHHHCCCCCCEEECCHHHHHHHHHCCC
KLIKVNSLILGTEELNKRIREILGIKERAREKPLLFTSVLYAPQFNIHEILSLDSEERGE
CEEEEHHHEECHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCHHHHH
IIERSLGLYKYKEYKNNSNAVRDVIKDKIDELTDKIDGLKKKLKDKNKEKLLEEKQRLEK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QLKELEKILVEKQKERDELDKRIKEHQNRLRDMERRIGELQSRIGQARKQEARLKDVRNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKIALNLGKNASTGYTELLEELRRREREIEGKVRELQDIESELVDKRKEIEEELNEAKR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KREDIMMRLGRLEADEENLTRQEQELNKQLEKYRDLLNKGICPLCLQPIPHEHGIKLIDE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCHHHHH
VQGRLEEVGKKIRELKEEETSRYKELEDINKRINALEENREEVEEKLDKVRRDSTRLLQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSLKHTAEKINSLVDEASRIEKEISEARSLEEELARINSEKENTISIIHELEDKYREAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EKLEGLIAEKAGTEKSIKYIELEIQDIEKEEDELRQLEDEKKFHEWMDTTMNILDKLVDE
HHHHHHHHHHCCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEKRVSLEMVSEFRRIFYMILDTLLQGQPVEVGIRDDFTIEPKIRIGGRIYTISSLSGGQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEECCCEEECCEEEEEECCCCCC
NIAISLAYRLALNATVRTYSPFLRKTVLILDEPTTGFSQELVKRLSEVLRKIGDLEGQVI
CHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEE
VVTHDELLKEIGDCKIMLERDPINHVSKVREQECDIEEFNKFKNLVEGLLRGSLQVDTVK
EEEHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEE
MEKIEVEPAGFKPEVRLGAGTVQQAKRKSLFDFHDKPK
EHEEEECCCCCCCCCEECCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRIYGLMLENIRSFKNEYIVFPKKGVTVIHGETGSGKTSILMSISAALFGLQKEGKDPFR
CCHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHH
AFAYPTGKDLLRADALRGRIRLLFEHEGRVYLVEREFKRSSNSVVNVDRNRLEEYIIKED
HHCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEEHHHCCCCCCEEECCHHHHHHHHHCCC
KLIKVNSLILGTEELNKRIREILGIKERAREKPLLFTSVLYAPQFNIHEILSLDSEERGE
CEEEEHHHEECHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCHHHHH
IIERSLGLYKYKEYKNNSNAVRDVIKDKIDELTDKIDGLKKKLKDKNKEKLLEEKQRLEK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QLKELEKILVEKQKERDELDKRIKEHQNRLRDMERRIGELQSRIGQARKQEARLKDVRNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKIALNLGKNASTGYTELLEELRRREREIEGKVRELQDIESELVDKRKEIEEELNEAKR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KREDIMMRLGRLEADEENLTRQEQELNKQLEKYRDLLNKGICPLCLQPIPHEHGIKLIDE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCHHHHH
VQGRLEEVGKKIRELKEEETSRYKELEDINKRINALEENREEVEEKLDKVRRDSTRLLQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSLKHTAEKINSLVDEASRIEKEISEARSLEEELARINSEKENTISIIHELEDKYREAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EKLEGLIAEKAGTEKSIKYIELEIQDIEKEEDELRQLEDEKKFHEWMDTTMNILDKLVDE
HHHHHHHHHHCCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEKRVSLEMVSEFRRIFYMILDTLLQGQPVEVGIRDDFTIEPKIRIGGRIYTISSLSGGQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEECCCEEECCEEEEEECCCCCC
NIAISLAYRLALNATVRTYSPFLRKTVLILDEPTTGFSQELVKRLSEVLRKIGDLEGQVI
CHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEE
VVTHDELLKEIGDCKIMLERDPINHVSKVREQECDIEEFNKFKNLVEGLLRGSLQVDTVK
EEEHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEE
MEKIEVEPAGFKPEVRLGAGTVQQAKRKSLFDFHDKPK
EHEEEECCCCCCCCCEECCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]