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The map label for this gene is mre11 [H]

Identifier: 218883922

GI number: 218883922

Start: 576355

End: 578394

Strand: Reverse

Name: mre11 [H]

Synonym: DKAM_0611

Alternate gene names: 218883922

Gene position: 578394-576355 (Counterclockwise)

Preceding gene: 218883923

Following gene: 218883921

Centisome position: 42.37

GC content: 42.25

Gene sequence:

>2040_bases
ATGCCCGTTCAGATAGGATTTATATATGAATTGGAGGGCAATACTATCAGGGTGGCCCTTACATCTCAAGATTATAATCC
AGGACTAGGCGACCTATTATATGTTAAAGAAGGAGACAGGACAATCATACTTCAAACAGTAAGCTACGAGGGAAGGATAC
CTATAACCCCTGCAAGTATACGGGCTCCAAGTCAAAACGTTTTAACCGATATATCCAAGGAGATGGGGGTTCTCGCATCA
CTGTTCCTTGAGATATCCAGTATCAACAATAAGCCGACTCTACTAAAGCCGAGAAGGCCACCTAGATTAATGCAACCCGT
ATTTCTCCTGGATCCCAGTGACACCGAAGCCCTTGAGATACTGAAGACCCTCAGCGAGCTTACAAGCGAGAAAAAAGACG
ATACATCAACCATAGCATACCTAAGAGCTGGCACTACCTGGTATGGCGGATCAAAGTATGTTAGGGAGGCCGGGTTCAAG
GTAAGCCTGAAGAATATGCTAAGAAAACACGTTATTATAATTGGTCAAACCGGTTCAGGTAAAACCTCCGGCCTGAAAGG
ATTACTCATTAGATACGCGTTGGAGTCCCAGGAGAAAGTAGGATGGCTTATAATAGATAGGCATGGAGAATATACTGAGG
GATATAGTAGTGGAAAAGGCTTCATATGGTATATGAATACGGCTTTGCGCAACAATAAATGGCTTTCCAACGTGGAAATT
AAGGCGATTCGATTAACAACCAGCATAGACGCCAATAAAGATAAAAGCTATCACCATGAAACATTCAGCCTTGTTGAGTC
ACCATTAAACGCCAGCAGTATAGAGCTTAAAGAATTCATGGCTCTGCTTGAGAGACGTATGGGGATAGAAATGACTGGGA
TGCTCGAGGAGTTCGCCGACATAGTATCTAATATCTTCTATGAATTAGGGAAAAGCGGTGATGAAATAGCGAGGAAAATA
AGTAGTGTATTCATAAGTACGGATAACGAGCCGAATGGAAACTTAATTGCTCTCATACCACTACTCTACGCTAACATGGT
GGTATATGAGAGGGAAGCCCAGGGAAAAGATAGAAAGGGTCTCTTTAAAATGCTTATCGATAGAGGCATATATACCCATC
ACATCAGGATCATTAGAAGAAACATCCTGAATATAATGGGATGGAAGATCAGGCGAGAGAAGATCACTGATACAAGCACT
ATGAGTAAGAAGAGCATCTATATAGACGTGATAGATGATTCAAATAGTATTGTAAAAGTTAACCAGTTATTGAAAGATCC
TGTATCGCTTGCAGTGGTACTTGTGAAATTCCTTGGAAAACTTAGTGAACTCGGTGAACCAGGAGACTTTAATTATCCAT
GGAAAAGCATTGTATCCATACATGGTGTTAAATCTGATAGTGTTGGTGAACCCGGGGTAGTGTTTACTAGTGAACCAGGG
ATAAACATAGATGAAATCATTAACACCATCGAAAACGGGAACACAGTCATCCTGGATGTCTCGCAACTTAGTAATGAACA
AGCAGACTTAATTGCTCTAACCATCTCAAGGAAGATCTTCGAGAACAGGTTGATGGCTGGTGTTGAAGAGTCGGCAAGAA
AACCCGTTGTGGCCATAGTCTCTGAGGAAGCCCCCCTCTATTTAAGCCCTGATAGGGTTGAAAACCCATTCAACCCCTTT
GCCAGGATAGCCAGGGAAGGCCGTAAGTTCAACGTTGGCCTTATAGCTATAACGCAACTTGCCAGTATGATCGAGAAGCA
GATACTAGGCAACTTCAACACCCTAATAGTATTAAGGACCAAGAGTAGAAGCGATATTGAATTACTAAAGGATATAGGAG
TACCATCGGAAACCCTCCCATTCCTCAATGATAGAGAGGGATATCTCTATACGCCGGATCTCCCCATTAAAGAACCATTA
CCAGTATATATACCAGCGTGGTTTGAGCATGAAGATGATATAAGGAGAATAGAGGAGAAACCCGGTGAACCGGATAAGGG
TAAATCCAGCAAGGAGGATCTAAAAAGTATTCTCCTGTGA

Upstream 100 bases:

>100_bases
TCCTGGTAAAGCTTCATGACATCACCGGTAGGGAAGACCATCCCTTAATACAGGTTTTCGAGTCTACCTTGAAAATGAGG
TATGGTTACAGGTGATCTAC

Downstream 100 bases:

>100_bases
TTAAGGGGGCTCCCTGATGAGAATTTATGGATTAATGCTTGAAAATATACGGAGCTTTAAGAACGAGTACATAGTGTTCC
CTAAGAAAGGGGTAACCGTT

Product: DNA double-strand break repair protein mre11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MPVQIGFIYELEGNTIRVALTSQDYNPGLGDLLYVKEGDRTIILQTVSYEGRIPITPASIRAPSQNVLTDISKEMGVLAS
LFLEISSINNKPTLLKPRRPPRLMQPVFLLDPSDTEALEILKTLSELTSEKKDDTSTIAYLRAGTTWYGGSKYVREAGFK
VSLKNMLRKHVIIIGQTGSGKTSGLKGLLIRYALESQEKVGWLIIDRHGEYTEGYSSGKGFIWYMNTALRNNKWLSNVEI
KAIRLTTSIDANKDKSYHHETFSLVESPLNASSIELKEFMALLERRMGIEMTGMLEEFADIVSNIFYELGKSGDEIARKI
SSVFISTDNEPNGNLIALIPLLYANMVVYEREAQGKDRKGLFKMLIDRGIYTHHIRIIRRNILNIMGWKIRREKITDTST
MSKKSIYIDVIDDSNSIVKVNQLLKDPVSLAVVLVKFLGKLSELGEPGDFNYPWKSIVSIHGVKSDSVGEPGVVFTSEPG
INIDEIINTIENGNTVILDVSQLSNEQADLIALTISRKIFENRLMAGVEESARKPVVAIVSEEAPLYLSPDRVENPFNPF
ARIAREGRKFNVGLIAITQLASMIEKQILGNFNTLIVLRTKSRSDIELLKDIGVPSETLPFLNDREGYLYTPDLPIKEPL
PVYIPAWFEHEDDIRRIEEKPGEPDKGKSSKEDLKSILL

Sequences:

>Translated_679_residues
MPVQIGFIYELEGNTIRVALTSQDYNPGLGDLLYVKEGDRTIILQTVSYEGRIPITPASIRAPSQNVLTDISKEMGVLAS
LFLEISSINNKPTLLKPRRPPRLMQPVFLLDPSDTEALEILKTLSELTSEKKDDTSTIAYLRAGTTWYGGSKYVREAGFK
VSLKNMLRKHVIIIGQTGSGKTSGLKGLLIRYALESQEKVGWLIIDRHGEYTEGYSSGKGFIWYMNTALRNNKWLSNVEI
KAIRLTTSIDANKDKSYHHETFSLVESPLNASSIELKEFMALLERRMGIEMTGMLEEFADIVSNIFYELGKSGDEIARKI
SSVFISTDNEPNGNLIALIPLLYANMVVYEREAQGKDRKGLFKMLIDRGIYTHHIRIIRRNILNIMGWKIRREKITDTST
MSKKSIYIDVIDDSNSIVKVNQLLKDPVSLAVVLVKFLGKLSELGEPGDFNYPWKSIVSIHGVKSDSVGEPGVVFTSEPG
INIDEIINTIENGNTVILDVSQLSNEQADLIALTISRKIFENRLMAGVEESARKPVVAIVSEEAPLYLSPDRVENPFNPF
ARIAREGRKFNVGLIAITQLASMIEKQILGNFNTLIVLRTKSRSDIELLKDIGVPSETLPFLNDREGYLYTPDLPIKEPL
PVYIPAWFEHEDDIRRIEEKPGEPDKGKSSKEDLKSILL
>Mature_678_residues
PVQIGFIYELEGNTIRVALTSQDYNPGLGDLLYVKEGDRTIILQTVSYEGRIPITPASIRAPSQNVLTDISKEMGVLASL
FLEISSINNKPTLLKPRRPPRLMQPVFLLDPSDTEALEILKTLSELTSEKKDDTSTIAYLRAGTTWYGGSKYVREAGFKV
SLKNMLRKHVIIIGQTGSGKTSGLKGLLIRYALESQEKVGWLIIDRHGEYTEGYSSGKGFIWYMNTALRNNKWLSNVEIK
AIRLTTSIDANKDKSYHHETFSLVESPLNASSIELKEFMALLERRMGIEMTGMLEEFADIVSNIFYELGKSGDEIARKIS
SVFISTDNEPNGNLIALIPLLYANMVVYEREAQGKDRKGLFKMLIDRGIYTHHIRIIRRNILNIMGWKIRREKITDTSTM
SKKSIYIDVIDDSNSIVKVNQLLKDPVSLAVVLVKFLGKLSELGEPGDFNYPWKSIVSIHGVKSDSVGEPGVVFTSEPGI
NIDEIINTIENGNTVILDVSQLSNEQADLIALTISRKIFENRLMAGVEESARKPVVAIVSEEAPLYLSPDRVENPFNPFA
RIAREGRKFNVGLIAITQLASMIEKQILGNFNTLIVLRTKSRSDIELLKDIGVPSETLPFLNDREGYLYTPDLPIKEPLP
VYIPAWFEHEDDIRRIEEKPGEPDKGKSSKEDLKSILL

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity [H]

COG id: COG0433

COG function: function code R; Predicted ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003701
- InterPro:   IPR004843 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 76242; Mature: 76111

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVQIGFIYELEGNTIRVALTSQDYNPGLGDLLYVKEGDRTIILQTVSYEGRIPITPASI
CCEEEEEEEEECCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCHHC
RAPSQNVLTDISKEMGVLASLFLEISSINNKPTLLKPRRPPRLMQPVFLLDPSDTEALEI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHCCEEEECCCCHHHHHH
LKTLSELTSEKKDDTSTIAYLRAGTTWYGGSKYVREAGFKVSLKNMLRKHVIIIGQTGSG
HHHHHHHHHCCCCCCCEEEEEECCCEEECCCHHHHHCCCEEEHHHHHHCEEEEEECCCCC
KTSGLKGLLIRYALESQEKVGWLIIDRHGEYTEGYSSGKGFIWYMNTALRNNKWLSNVEI
CCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEECHHCCCCCCCCCEE
KAIRLTTSIDANKDKSYHHETFSLVESPLNASSIELKEFMALLERRMGIEMTGMLEEFAD
EEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IVSNIFYELGKSGDEIARKISSVFISTDNEPNGNLIALIPLLYANMVVYEREAQGKDRKG
HHHHHHHHHCCCHHHHHHHHHHEEEECCCCCCCCEEEEHHHHHHHHEEEECCCCCCCHHH
LFKMLIDRGIYTHHIRIIRRNILNIMGWKIRREKITDTSTMSKKSIYIDVIDDSNSIVKV
HHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEHHHCCCCCCCCCCEEEEEEEECCCCEEEH
NQLLKDPVSLAVVLVKFLGKLSELGEPGDFNYPWKSIVSIHGVKSDSVGEPGVVFTSEPG
HHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEECCCCCCCCCCCEEEECCCC
INIDEIINTIENGNTVILDVSQLSNEQADLIALTISRKIFENRLMAGVEESARKPVVAIV
CCHHHHHHHHCCCCEEEEEHHHCCCCCCCEEEEEHHHHHHHHHHHHCHHHHHCCCEEEEE
SEEAPLYLSPDRVENPFNPFARIAREGRKFNVGLIAITQLASMIEKQILGNFNTLIVLRT
ECCCCEEECCHHCCCCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEE
KSRSDIELLKDIGVPSETLPFLNDREGYLYTPDLPIKEPLPVYIPAWFEHEDDIRRIEEK
CCCCHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHC
PGEPDKGKSSKEDLKSILL
CCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
PVQIGFIYELEGNTIRVALTSQDYNPGLGDLLYVKEGDRTIILQTVSYEGRIPITPASI
CEEEEEEEEECCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCHHC
RAPSQNVLTDISKEMGVLASLFLEISSINNKPTLLKPRRPPRLMQPVFLLDPSDTEALEI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHCCEEEECCCCHHHHHH
LKTLSELTSEKKDDTSTIAYLRAGTTWYGGSKYVREAGFKVSLKNMLRKHVIIIGQTGSG
HHHHHHHHHCCCCCCCEEEEEECCCEEECCCHHHHHCCCEEEHHHHHHCEEEEEECCCCC
KTSGLKGLLIRYALESQEKVGWLIIDRHGEYTEGYSSGKGFIWYMNTALRNNKWLSNVEI
CCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEECHHCCCCCCCCCEE
KAIRLTTSIDANKDKSYHHETFSLVESPLNASSIELKEFMALLERRMGIEMTGMLEEFAD
EEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IVSNIFYELGKSGDEIARKISSVFISTDNEPNGNLIALIPLLYANMVVYEREAQGKDRKG
HHHHHHHHHCCCHHHHHHHHHHEEEECCCCCCCCEEEEHHHHHHHHEEEECCCCCCCHHH
LFKMLIDRGIYTHHIRIIRRNILNIMGWKIRREKITDTSTMSKKSIYIDVIDDSNSIVKV
HHHHHHHCCCHHHHHHHHHHHHHHHHCCEEEHHHCCCCCCCCCCEEEEEEEECCCCEEEH
NQLLKDPVSLAVVLVKFLGKLSELGEPGDFNYPWKSIVSIHGVKSDSVGEPGVVFTSEPG
HHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEECCCCCCCCCCCEEEECCCC
INIDEIINTIENGNTVILDVSQLSNEQADLIALTISRKIFENRLMAGVEESARKPVVAIV
CCHHHHHHHHCCCCEEEEEHHHCCCCCCCEEEEEHHHHHHHHHHHHCHHHHHCCCEEEEE
SEEAPLYLSPDRVENPFNPFARIAREGRKFNVGLIAITQLASMIEKQILGNFNTLIVLRT
ECCCCEEECCHHCCCCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEE
KSRSDIELLKDIGVPSETLPFLNDREGYLYTPDLPIKEPLPVYIPAWFEHEDDIRRIEEK
CCCCHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHC
PGEPDKGKSSKEDLKSILL
CCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]