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The map label for this gene is purE [H]

Identifier: 218883838

GI number: 218883838

Start: 495232

End: 495618

Strand: Direct

Name: purE [H]

Synonym: DKAM_0527

Alternate gene names: 218883838

Gene position: 495232-495618 (Clockwise)

Preceding gene: 218883837

Following gene: 218883839

Centisome position: 36.27

GC content: 47.8

Gene sequence:

>387_bases
GTGGCTGTAATAGTTGGAAGCGAGCGGGATCTACCTCATGTAGAGAAAGCATTGAAGATACTCAAAGAGAACAATATAGA
CGTTGATGTCAGGGTTCTAAGTGCTCATAGAACCCCGAAGCAGCTTGAGGAGTATGTTGAGAGGGCAGATGTAGACGTAT
ACATAGCAATGGCTGGACTCGCTGCACACCTACCTGGGTTCATTGCATCGAGGACAAGTAAGCCTGTCATAGGGGTACCA
TTAAATGTCGCACTTGGAGGGCTTGACGCGTTATTAAGCATCGTGCAGATGCCTAAGGGTGTTCCAGTTGCAACGGTGGG
CATTGATAACGCGGAGAACGCTGCATACCTTGCTCTGAGAATAATAAACCTGTGCAGGGATGGATAA

Upstream 100 bases:

>100_bases
AGGGGAGACACAGTAAGTGAAGCATTGGATAAGGTTAGGAAAGCTGGAAGACGGCTTAAAGTAGTGGAGGGATGGGGTAA
GGATGCCGTGTAAGGGTAAG

Downstream 100 bases:

>100_bases
CATGGGTGGTTCATGGAGTTATTCTAAATCCGGTGTAGACCTCTCTGCCCACAGGGAAATGCATAGGTATGTATTAGAGA
GGATGGGGAAGCTAGATGAT

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 128; Mature: 127

Protein sequence:

>128_residues
MAVIVGSERDLPHVEKALKILKENNIDVDVRVLSAHRTPKQLEEYVERADVDVYIAMAGLAAHLPGFIASRTSKPVIGVP
LNVALGGLDALLSIVQMPKGVPVATVGIDNAENAAYLALRIINLCRDG

Sequences:

>Translated_128_residues
MAVIVGSERDLPHVEKALKILKENNIDVDVRVLSAHRTPKQLEEYVERADVDVYIAMAGLAAHLPGFIASRTSKPVIGVP
LNVALGGLDALLSIVQMPKGVPVATVGIDNAENAAYLALRIINLCRDG
>Mature_127_residues
AVIVGSERDLPHVEKALKILKENNIDVDVRVLSAHRTPKQLEEYVERADVDVYIAMAGLAAHLPGFIASRTSKPVIGVPL
NVALGGLDALLSIVQMPKGVPVATVGIDNAENAAYLALRIINLCRDG

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=110, Percent_Identity=47.2727272727273, Blast_Score=94, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=126, Percent_Identity=47.6190476190476, Blast_Score=111, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 13675; Mature: 13544

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVIVGSERDLPHVEKALKILKENNIDVDVRVLSAHRTPKQLEEYVERADVDVYIAMAGL
CEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEHHHHH
AAHLPGFIASRTSKPVIGVPLNVALGGLDALLSIVQMPKGVPVATVGIDNAENAAYLALR
HHHCCHHHHHCCCCCEEECCHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHH
IINLCRDG
HHHHHCCC
>Mature Secondary Structure 
AVIVGSERDLPHVEKALKILKENNIDVDVRVLSAHRTPKQLEEYVERADVDVYIAMAGL
EEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEHHHHH
AAHLPGFIASRTSKPVIGVPLNVALGGLDALLSIVQMPKGVPVATVGIDNAENAAYLALR
HHHCCHHHHHCCCCCEEECCHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHH
IINLCRDG
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]