Click here to switch to the map view.

The map label for this gene is panE [C]

Identifier: 218883653

GI number: 218883653

Start: 315094

End: 316029

Strand: Reverse

Name: panE [C]

Synonym: DKAM_0342

Alternate gene names: 218883653

Gene position: 316029-315094 (Counterclockwise)

Preceding gene: 218883654

Following gene: 218883652

Centisome position: 23.15

GC content: 46.26

Gene sequence:

>936_bases
ATGAGCCACGATATCTGTATTATAGGGGGTGGAGCTGTAGGATCCACGCTAGCTTATTTCCTCTACAGGGCTGGTGTGAC
AGATATACCCGTGTACTTTGGTCATGAGGAAACAGTTAGAGCAGTTCTAAGGGAGAAATGGGTGAGGGTTTACGATAAAG
TTGAGAACCGGGATTACATCGTGCCGATAATACCTAGACACTATAGTAGCCCCATTGATAAATGCAGGTTTATCTTGAAC
ACGGTTAAAGCATACAGTGTACCGGAGACGTTTAGGCTAATGGAGAAAATCATGGATGTCGGCGGAGTAATCGTGATGCT
TCAGAATGGAATAGGTAGTTTAGAGCTTGCCGAGGAAAGATTTGGTGTACGAGTAGCCGGGGGAGTGGTCTACTTCGGTG
CCGAACGCGTCTCACCTGTTTACACAGTGTATCATGGGGGCCGGACGGTCATAGCAGGGTGTAGGCATGGCTTATGCATG
GAATTAACAGAGTTGAACAGGGTGTTTAAGCTGGGGGGCCTCGAGTTCAGGGTTGTATCGAATATAGACTACTACAGGTG
GTTGAAGCTGGCTTTGAATGCCGTGGTCAACCCGTTGACAGCTATCTCCAGGTCTAGAAACAGTATAGTGTTATCCAGGC
CAGGGCTGGAGCTGGCCTCATTGATCCTTACCGAATTCATCGAGGTGGCTGGTAAACATGGCTTCAGATTCGAGCTTAAC
AGATTGCTCGAATACGTGGTAAACAATGTGAGGAGTACAAGGGACAATTACTCCAGTATGGCTCAAGACGTGTTGAATAA
GTCTCCTACAGAAATAGACTTCATCAATGGCTTTATCGCTAAAGAACTCGGGGGAGGCCCCTCTATTAATAAAATCATAA
CCCTAATGATACACCTCATCGAGGAAAGCAATAAGTCTAAGAATAGTGTCCAATAG

Upstream 100 bases:

>100_bases
TGGATCTAGGGGGCAGGGGTCTCGAGCCCGTGGTGTACGTGTTTACAAGCAGTTATGAGGAGCTTGAAAGAATCCTGGTT
AACCTGGTGGAGGCGTGTCC

Downstream 100 bases:

>100_bases
CCATGAATTATATCCACTGGCTTAATTTAAATAGATCAGAACCCAATAGTGAAACCCGGTGTCAGCCTTGAATACAAGGG
TAACGGTTAGAGACATAGTT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSHDICIIGGGAVGSTLAYFLYRAGVTDIPVYFGHEETVRAVLREKWVRVYDKVENRDYIVPIIPRHYSSPIDKCRFILN
TVKAYSVPETFRLMEKIMDVGGVIVMLQNGIGSLELAEERFGVRVAGGVVYFGAERVSPVYTVYHGGRTVIAGCRHGLCM
ELTELNRVFKLGGLEFRVVSNIDYYRWLKLALNAVVNPLTAISRSRNSIVLSRPGLELASLILTEFIEVAGKHGFRFELN
RLLEYVVNNVRSTRDNYSSMAQDVLNKSPTEIDFINGFIAKELGGGPSINKIITLMIHLIEESNKSKNSVQ

Sequences:

>Translated_311_residues
MSHDICIIGGGAVGSTLAYFLYRAGVTDIPVYFGHEETVRAVLREKWVRVYDKVENRDYIVPIIPRHYSSPIDKCRFILN
TVKAYSVPETFRLMEKIMDVGGVIVMLQNGIGSLELAEERFGVRVAGGVVYFGAERVSPVYTVYHGGRTVIAGCRHGLCM
ELTELNRVFKLGGLEFRVVSNIDYYRWLKLALNAVVNPLTAISRSRNSIVLSRPGLELASLILTEFIEVAGKHGFRFELN
RLLEYVVNNVRSTRDNYSSMAQDVLNKSPTEIDFINGFIAKELGGGPSINKIITLMIHLIEESNKSKNSVQ
>Mature_310_residues
SHDICIIGGGAVGSTLAYFLYRAGVTDIPVYFGHEETVRAVLREKWVRVYDKVENRDYIVPIIPRHYSSPIDKCRFILNT
VKAYSVPETFRLMEKIMDVGGVIVMLQNGIGSLELAEERFGVRVAGGVVYFGAERVSPVYTVYHGGRTVIAGCRHGLCME
LTELNRVFKLGGLEFRVVSNIDYYRWLKLALNAVVNPLTAISRSRNSIVLSRPGLELASLILTEFIEVAGKHGFRFELNR
LLEYVVNNVRSTRDNYSSMAQDVLNKSPTEIDFINGFIAKELGGGPSINKIITLMIHLIEESNKSKNSVQ

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=205, Percent_Identity=28.2926829268293, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 34840; Mature: 34709

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHDICIIGGGAVGSTLAYFLYRAGVTDIPVYFGHEETVRAVLREKWVRVYDKVENRDYI
CCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCEE
VPIIPRHYSSPIDKCRFILNTVKAYSVPETFRLMEKIMDVGGVIVMLQNGIGSLELAEER
EEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEHHHH
FGVRVAGGVVYFGAERVSPVYTVYHGGRTVIAGCRHGLCMELTELNRVFKLGGLEFRVVS
CCEEEECCEEEECCCCCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEEC
NIDYYRWLKLALNAVVNPLTAISRSRNSIVLSRPGLELASLILTEFIEVAGKHGFRFELN
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHH
RLLEYVVNNVRSTRDNYSSMAQDVLNKSPTEIDFINGFIAKELGGGPSINKIITLMIHLI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHH
EESNKSKNSVQ
HHCCCCCCCCC
>Mature Secondary Structure 
SHDICIIGGGAVGSTLAYFLYRAGVTDIPVYFGHEETVRAVLREKWVRVYDKVENRDYI
CCCEEEEECCHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCEE
VPIIPRHYSSPIDKCRFILNTVKAYSVPETFRLMEKIMDVGGVIVMLQNGIGSLELAEER
EEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEHHHH
FGVRVAGGVVYFGAERVSPVYTVYHGGRTVIAGCRHGLCMELTELNRVFKLGGLEFRVVS
CCEEEECCEEEECCCCCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEEC
NIDYYRWLKLALNAVVNPLTAISRSRNSIVLSRPGLELASLILTEFIEVAGKHGFRFELN
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHH
RLLEYVVNNVRSTRDNYSSMAQDVLNKSPTEIDFINGFIAKELGGGPSINKIITLMIHLI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHH
EESNKSKNSVQ
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]