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The map label for this gene is ogt [H]

Identifier: 218883507

GI number: 218883507

Start: 182463

End: 182747

Strand: Reverse

Name: ogt [H]

Synonym: DKAM_0194

Alternate gene names: 218883507

Gene position: 182747-182463 (Counterclockwise)

Preceding gene: 218883510

Following gene: 218883506

Centisome position: 13.39

GC content: 44.21

Gene sequence:

>285_bases
ATGATCATACCCCCCGGTAAAACAACATCATACTCGAGTATAGCTAGGCTACTCAAGATACATCCCCGGGTAGTAGCTTA
CTGCCTCTCCATTAATAAACGCCCGGTTATCATCCCCTGTCATAGGGTCGTTTATAGTGATGGAGGAATAGGTGGTTTTT
CACTAGGAGGTAGCCATGTGAAGAAGAAGCTATTAAGCCTGGAAGGTGTGGAATTCCTGGATGGACACGTTAAAGAAGAC
TATATAATGGACCTGGAATCCAGCATCCTAAGTAAAACCTCTTAG

Upstream 100 bases:

>100_bases
AAAGGTGTAAGCCTTGATAGTAATCGAGATCAAAGGCAGAGAGGTCACCGCATACAAAGCGTCAATGAGAGATATATGTG
AAGCTGTCTATACGTTGACT

Downstream 100 bases:

>100_bases
AGTTTTTATCCAGTATAATGAATCCCGAGCTAGGTGAAGAACAACTAATTATTTTAATATCCTGGTCGCATTTAAATAAC
ATGGTTATAGGTGGTGAGTT

Product: methylated-DNA--protein-cysteine methyltransferase

Products: NA

Alternate protein names: 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase [H]

Number of amino acids: Translated: 94; Mature: 94

Protein sequence:

>94_residues
MIIPPGKTTSYSSIARLLKIHPRVVAYCLSINKRPVIIPCHRVVYSDGGIGGFSLGGSHVKKKLLSLEGVEFLDGHVKED
YIMDLESSILSKTS

Sequences:

>Translated_94_residues
MIIPPGKTTSYSSIARLLKIHPRVVAYCLSINKRPVIIPCHRVVYSDGGIGGFSLGGSHVKKKLLSLEGVEFLDGHVKED
YIMDLESSILSKTS
>Mature_94_residues
MIIPPGKTTSYSSIARLLKIHPRVVAYCLSINKRPVIIPCHRVVYSDGGIGGFSLGGSHVKKKLLSLEGVEFLDGHVKED
YIMDLESSILSKTS

Specific function: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a sui

COG id: COG0350

COG function: function code L; Methylated DNA-protein cysteine methyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MGMT family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01035 DNA_binding_1 [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 10269; Mature: 10269

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00374 MGMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPPGKTTSYSSIARLLKIHPRVVAYCLSINKRPVIIPCHRVVYSDGGIGGFSLGGSHV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHEEECCCCCCCCCCCHHHH
KKKLLSLEGVEFLDGHVKEDYIMDLESSILSKTS
HHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIIPPGKTTSYSSIARLLKIHPRVVAYCLSINKRPVIIPCHRVVYSDGGIGGFSLGGSHV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHEEECCCCCCCCCCCHHHH
KKKLLSLEGVEFLDGHVKEDYIMDLESSILSKTS
HHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]