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The map label for this gene is lpxD [H]

Identifier: 218710308

GI number: 218710308

Start: 2510870

End: 2511901

Strand: Reverse

Name: lpxD [H]

Synonym: VS_2342

Alternate gene names: 218710308

Gene position: 2511901-2510870 (Counterclockwise)

Preceding gene: 218710309

Following gene: 218710307

Centisome position: 76.13

GC content: 45.16

Gene sequence:

>1032_bases
ATGAAGAATCTGACCTTAGCCGAATTGGCAACGATTACCGGTGGAGAGCTACACGGAGACGGTACAGTTACCGTTTCAGC
AGTCGCTCCTATGGATAAAGCGCAAGAAGGAAATATTACGTTCCTTTCGAACGTGAAGTACAGCAAGCACCTTGGTGACT
GTAAAGCATCCGCTATTATGGTTAAAGAGAGCGAGCGTGAACTGTGTAAGACCAACGTTATTGTGGTCAGCGACCCTTAT
GTTGCTTTTGCTAAGGTTGCTCAAGCGCTTGATTCCACGCCAGCGCCAGCTACGGGTATTGCTGATTCTGCTTCAATTTC
AGGCGACGCGACCATTGGACAAAATGTGTCTATTGGTGCCAATGCTGTGATTGAAACTGGCGTAGTGCTTGGTGATGACG
TCGTTATCGGTGCTGGTTGCTTTATTGGTCAAAATGCAAAAATTGGCGCAGGTACTAAGCTTTGGGCTAACGTAAGTGTT
TACCATGAAGTGGTGATTGGCGAAGCATGTTTGATTCAATCTAGTACAGTGATTGGATCCGATGGTTTTGGTTATGCGAA
TGAGAAAGGCGAGTGGGTTAAGATCCCGCAAGTCGGTTCAGTTCGTGTTGGTAACCGCGTAGAAATCGGCGCGTGTACTA
CCGTTGACCGTGGCGCATTAGATGACACTATTATTGAAGATAACGTTATCTTAGATAACCAACTTCAGATAGCTCATAAT
GTTCACATCGGATATGGTTCTGCTATTGCAGGTGGTACTATCATCGCCGGCAGCACAACGATAGGTAAGTACTGTATTAT
TGGTGGCGGTTGTGTGATTAATGGTCATATAGAAATCGTTGACGGCGTTACAATCACCGGTATGGGGATGGTAATGCGCA
GTATCACCGAAAAAGGCATGTACTCTTCAGGTATTCCTTTGCAGCCAAATAAAGATTGGCGTAAAACAGCAACGCGAGTT
CATCGTATTGATGAAATGAACAAGCGTTTGAAAACCGTTGAAAAACTTATCGAGAACAGCGCGGAATCATAA

Upstream 100 bases:

>100_bases
AAGAAGGCTATGACATGATCGTTGATATTCAAGCTCTGCAGTACGGCAAGCCAGAATACAACATCTCTGAAAAAGTAATT
AAATCACTGAAATAAGTTTT

Downstream 100 bases:

>100_bases
TTCCAGCATTTCTAATAAAAGGCTCGCGTACAGCGAGTCTTTTTCGTTTATAATCCTTCTCATTAAATAAAGAATATACA
TAGGAATACGACTTTGACTA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MKNLTLAELATITGGELHGDGTVTVSAVAPMDKAQEGNITFLSNVKYSKHLGDCKASAIMVKESERELCKTNVIVVSDPY
VAFAKVAQALDSTPAPATGIADSASISGDATIGQNVSIGANAVIETGVVLGDDVVIGAGCFIGQNAKIGAGTKLWANVSV
YHEVVIGEACLIQSSTVIGSDGFGYANEKGEWVKIPQVGSVRVGNRVEIGACTTVDRGALDDTIIEDNVILDNQLQIAHN
VHIGYGSAIAGGTIIAGSTTIGKYCIIGGGCVINGHIEIVDGVTITGMGMVMRSITEKGMYSSGIPLQPNKDWRKTATRV
HRIDEMNKRLKTVEKLIENSAES

Sequences:

>Translated_343_residues
MKNLTLAELATITGGELHGDGTVTVSAVAPMDKAQEGNITFLSNVKYSKHLGDCKASAIMVKESERELCKTNVIVVSDPY
VAFAKVAQALDSTPAPATGIADSASISGDATIGQNVSIGANAVIETGVVLGDDVVIGAGCFIGQNAKIGAGTKLWANVSV
YHEVVIGEACLIQSSTVIGSDGFGYANEKGEWVKIPQVGSVRVGNRVEIGACTTVDRGALDDTIIEDNVILDNQLQIAHN
VHIGYGSAIAGGTIIAGSTTIGKYCIIGGGCVINGHIEIVDGVTITGMGMVMRSITEKGMYSSGIPLQPNKDWRKTATRV
HRIDEMNKRLKTVEKLIENSAES
>Mature_343_residues
MKNLTLAELATITGGELHGDGTVTVSAVAPMDKAQEGNITFLSNVKYSKHLGDCKASAIMVKESERELCKTNVIVVSDPY
VAFAKVAQALDSTPAPATGIADSASISGDATIGQNVSIGANAVIETGVVLGDDVVIGAGCFIGQNAKIGAGTKLWANVSV
YHEVVIGEACLIQSSTVIGSDGFGYANEKGEWVKIPQVGSVRVGNRVEIGACTTVDRGALDDTIIEDNVILDNQLQIAHN
VHIGYGSAIAGGTIIAGSTTIGKYCIIGGGCVINGHIEIVDGVTITGMGMVMRSITEKGMYSSGIPLQPNKDWRKTATRV
HRIDEMNKRLKTVEKLIENSAES

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=335, Percent_Identity=62.6865671641791, Blast_Score=447, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 35789; Mature: 35789

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLTLAELATITGGELHGDGTVTVSAVAPMDKAQEGNITFLSNVKYSKHLGDCKASAIM
CCCCCHHHHHEECCCEEECCCCEEEEEECCCCCCCCCCEEEEECCCHHHHCCCCCCEEEE
VKESERELCKTNVIVVSDPYVAFAKVAQALDSTPAPATGIADSASISGDATIGQNVSIGA
EECCHHHHHHCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NAVIETGVVLGDDVVIGAGCFIGQNAKIGAGTKLWANVSVYHEVVIGEACLIQSSTVIGS
CEEEECCEEECCCEEEECCEEECCCCCCCCCCEEEEEHEEEEHHHCCCCCEEECCEEECC
DGFGYANEKGEWVKIPQVGSVRVGNRVEIGACTTVDRGALDDTIIEDNVILDNQLQIAHN
CCCCCCCCCCCEEECCCCCCEECCCEEEEEEECCCCCCCCCCCEECCCEEECCCEEEEEE
VHIGYGSAIAGGTIIAGSTTIGKYCIIGGGCVINGHIEIVDGVTITGMGMVMRSITEKGM
EEECCCCCCCCCEEEECCCCCCCEEEEECCEEEECEEEEECCEEEEHHHHHHHHHHHCCC
YSSGIPLQPNKDWRKTATRVHRIDEMNKRLKTVEKLIENSAES
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKNLTLAELATITGGELHGDGTVTVSAVAPMDKAQEGNITFLSNVKYSKHLGDCKASAIM
CCCCCHHHHHEECCCEEECCCCEEEEEECCCCCCCCCCEEEEECCCHHHHCCCCCCEEEE
VKESERELCKTNVIVVSDPYVAFAKVAQALDSTPAPATGIADSASISGDATIGQNVSIGA
EECCHHHHHHCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NAVIETGVVLGDDVVIGAGCFIGQNAKIGAGTKLWANVSVYHEVVIGEACLIQSSTVIGS
CEEEECCEEECCCEEEECCEEECCCCCCCCCCEEEEEHEEEEHHHCCCCCEEECCEEECC
DGFGYANEKGEWVKIPQVGSVRVGNRVEIGACTTVDRGALDDTIIEDNVILDNQLQIAHN
CCCCCCCCCCCEEECCCCCCEECCCEEEEEEECCCCCCCCCCCEECCCEEECCCEEEEEE
VHIGYGSAIAGGTIIAGSTTIGKYCIIGGGCVINGHIEIVDGVTITGMGMVMRSITEKGM
EEECCCCCCCCCEEEECCCCCCCEEEEECCEEEECEEEEECCEEEEHHHHHHHHHHHCCC
YSSGIPLQPNKDWRKTATRVHRIDEMNKRLKTVEKLIENSAES
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]