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The map label for this gene is ptxR [H]

Identifier: 218709176

GI number: 218709176

Start: 1250878

End: 1251744

Strand: Direct

Name: ptxR [H]

Synonym: VS_1183

Alternate gene names: 218709176

Gene position: 1250878-1251744 (Clockwise)

Preceding gene: 218709174

Following gene: 218709180

Centisome position: 37.91

GC content: 44.87

Gene sequence:

>867_bases
ATGAGTAAGCTAAAGCAGATGTCGATTTTCGCTCACATCGTAGAGCAGGGCTCAGTATCAGCTGCGGCTGAAAAGCTTGA
GTTGTCTAAGTCCGTCGTCAGTCAGCACCTCAAAATTCTGGAACAAGAGTTAGGGGCTTCACTTCTCAAGCGCACAACAC
GCAGACAAACTCTGACTAGTATGGGTGAACGTTTTTATTTGAGTTGCAAAGACATCAACGTGATTGCTGACTCGGCTTGG
GATATGGCCAAAGCTGAGCTAGAAGAGCCACAAGGTCGGATTCGTATTACTGCACCGAATGCTCTTATGGACTTGCTCGT
TGCCCCAGTTGTCGCAGATCTAATGAAGCAATATCCCAAGCTAAAACCCGAGCTGATAAGCGATGATCAGCACTTAGATT
TCATGGAACACGATATTGATCTCGCAGTACGAGTAGGAACTTCTCGTGACAGTAACCTAAAGCAGAAACGCTTGGGCGAG
TTTAAAGACGTGTTGTGTGGCGTTGAAAGCATGCGTTCTCGTGAGCTTGAATCTATTCCTTACATTGCTAACTCATGGCA
AGGTAAGCAAGTCTCTCATCACTTTACTTCTCAAACAGATCAAAACTTTATTTACCAACAACAAGCAAGCTGCACTACGA
ACTCCTTTCATAGTTGTCTCGCGTTGATCAAATCTGGCGTTGGCATCGGTGTGATCCCAGACTTCTACCTATCTCAGTTA
TCGAATGAGGTTATCGACATCATGCCTAGCTTTCAATTACCCACTAACACGGTTTATGCGTTGAATCCATTCGCATCAAA
CACACCGATTGCCATCAAACTGTGCGTCCAAGCGTTGGAAGAGAAGCTCAAACAGAACTTTGTTTAA

Upstream 100 bases:

>100_bases
GATTTGGGTGTCTCGATAAGTTGGATTCAGTTTAGTCTTGGAAATTAAGCTGAAAAACAGAGATAATAGAAAATACTGTG
TGTAAAAAGAGAACAATAAG

Downstream 100 bases:

>100_bases
AACCAATTCGATAAGTCAGTGATTTAGTAAAGAGGCTTAAAACCAAACTTGCCTAATAGATTGCTCAAGAGTGAAGATAC
AAAAACATAAAGACACTAAA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSKLKQMSIFAHIVEQGSVSAAAEKLELSKSVVSQHLKILEQELGASLLKRTTRRQTLTSMGERFYLSCKDINVIADSAW
DMAKAELEEPQGRIRITAPNALMDLLVAPVVADLMKQYPKLKPELISDDQHLDFMEHDIDLAVRVGTSRDSNLKQKRLGE
FKDVLCGVESMRSRELESIPYIANSWQGKQVSHHFTSQTDQNFIYQQQASCTTNSFHSCLALIKSGVGIGVIPDFYLSQL
SNEVIDIMPSFQLPTNTVYALNPFASNTPIAIKLCVQALEEKLKQNFV

Sequences:

>Translated_288_residues
MSKLKQMSIFAHIVEQGSVSAAAEKLELSKSVVSQHLKILEQELGASLLKRTTRRQTLTSMGERFYLSCKDINVIADSAW
DMAKAELEEPQGRIRITAPNALMDLLVAPVVADLMKQYPKLKPELISDDQHLDFMEHDIDLAVRVGTSRDSNLKQKRLGE
FKDVLCGVESMRSRELESIPYIANSWQGKQVSHHFTSQTDQNFIYQQQASCTTNSFHSCLALIKSGVGIGVIPDFYLSQL
SNEVIDIMPSFQLPTNTVYALNPFASNTPIAIKLCVQALEEKLKQNFV
>Mature_287_residues
SKLKQMSIFAHIVEQGSVSAAAEKLELSKSVVSQHLKILEQELGASLLKRTTRRQTLTSMGERFYLSCKDINVIADSAWD
MAKAELEEPQGRIRITAPNALMDLLVAPVVADLMKQYPKLKPELISDDQHLDFMEHDIDLAVRVGTSRDSNLKQKRLGEF
KDVLCGVESMRSRELESIPYIANSWQGKQVSHHFTSQTDQNFIYQQQASCTTNSFHSCLALIKSGVGIGVIPDFYLSQLS
NEVIDIMPSFQLPTNTVYALNPFASNTPIAIKLCVQALEEKLKQNFV

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=298, Percent_Identity=27.8523489932886, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1786401, Length=279, Percent_Identity=27.2401433691756, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI145693193, Length=268, Percent_Identity=25, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI87081978, Length=168, Percent_Identity=31.547619047619, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789440, Length=163, Percent_Identity=29.4478527607362, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787128, Length=146, Percent_Identity=28.7671232876712, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082132, Length=162, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788706, Length=142, Percent_Identity=27.4647887323944, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787589, Length=150, Percent_Identity=28.6666666666667, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788748, Length=249, Percent_Identity=24.8995983935743, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32262; Mature: 32131

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLKQMSIFAHIVEQGSVSAAAEKLELSKSVVSQHLKILEQELGASLLKRTTRRQTLTS
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGERFYLSCKDINVIADSAWDMAKAELEEPQGRIRITAPNALMDLLVAPVVADLMKQYPK
HCHHEEEEECCCEEECCCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCC
LKPELISDDQHLDFMEHDIDLAVRVGTSRDSNLKQKRLGEFKDVLCGVESMRSRELESIP
CCCHHCCCCCCCHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YIANSWQGKQVSHHFTSQTDQNFIYQQQASCTTNSFHSCLALIKSGVGIGVIPDFYLSQL
CHHCCCCCCHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
SNEVIDIMPSFQLPTNTVYALNPFASNTPIAIKLCVQALEEKLKQNFV
HHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKLKQMSIFAHIVEQGSVSAAAEKLELSKSVVSQHLKILEQELGASLLKRTTRRQTLTS
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGERFYLSCKDINVIADSAWDMAKAELEEPQGRIRITAPNALMDLLVAPVVADLMKQYPK
HCHHEEEEECCCEEECCCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCC
LKPELISDDQHLDFMEHDIDLAVRVGTSRDSNLKQKRLGEFKDVLCGVESMRSRELESIP
CCCHHCCCCCCCHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YIANSWQGKQVSHHFTSQTDQNFIYQQQASCTTNSFHSCLALIKSGVGIGVIPDFYLSQL
CHHCCCCCCHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
SNEVIDIMPSFQLPTNTVYALNPFASNTPIAIKLCVQALEEKLKQNFV
HHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]