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The map label for this gene is atoC [H]

Identifier: 218708821

GI number: 218708821

Start: 842523

End: 843932

Strand: Direct

Name: atoC [H]

Synonym: VS_0821

Alternate gene names: 218708821

Gene position: 842523-843932 (Clockwise)

Preceding gene: 218708820

Following gene: 218708822

Centisome position: 25.54

GC content: 45.89

Gene sequence:

>1410_bases
ATGGCTCAAAGCAAAGTGTTAATCGTCGAAGATGATGAAGGTCTACGCGAAGCCCTTGTCGATACACTCGCGCTTGCTGG
TTATGAATGGCTGGAAGCGGATTGTGCGGAAGATGCTCTGGTAAAATTGAAATCAAACTCTGTTGATATCGTGGTCTCTG
ATGTACAGATGGCCGGTATGGGCGGTTTAGCATTGCTAAGAAACATCAAGCAGCATTGGCCAAATCTTCCGGTTCTATTG
ATGACGGCCTATGCCAACATTGAAGATGCGGTCGCGGCAATGAAAGAAGGCGCTATCGATTACATGGCAAAGCCATTTGC
TCCAGAAGTGCTGTTAAACATGGTGAGCCGTTACGCTCCCGTAAAGTCGGATGACAATGGCGATGCTATCGTTGCCGATG
AGAAAAGTATCAAACTAATGATGCTGGCTGACAAGGTGGCTAAAACCGATGCTAACGTGATGGTGCTAGGGCCAAGTGGC
TCTGGTAAAGAGGTCATGTCTCGCTATATTCATAACGCTTCGAGCCGTAAAGACGGTCCGTTTGTTGCGATTAACTGTGC
CGCGATTCCAGACAATATGTTGGAAGCAACACTGTTTGGCTACGATAAAGGTGCGTTCACCGGTGCGATTCAAGCTTGTC
CGGGTAAATTTGAGCAAGCTCAAGGCGGTACTATTTTGTTGGATGAGATCAGCGAAATGGATCTCAGCCTACAAGCGAAA
TTGCTGCGAGTGTTGCAAGAGCGCGAAGTTGAACGTCTTGGTAGCCGCAAGAGCATCAAATTGGATGTCCGTGTTCTAGC
AACCAGTAACCGCGACCTAAAACAGTATGTTTCTGAAGGGAATTTCCGTGAAGATTTATACTACCGACTGAATGTATTTC
CAATTACTTGGCCAGCGCTGTGTGAACGTAAAGGTGATATTGCGCCGCTTGCGAAACATTTGGTGGAACGTCATTGCACC
AAACTAGGAATGCCTGTTCCTGTTCTGTCTGAGCAAGCCATTAGTAAACTCGTCAATTATCCGTGGCCGGGAAATGTACG
TGAACTGGATAATGTCGTGCAGCGCGCTCTAATTTTGAGTGAGCAAGAAAATATTTCAGGCGAACATATTTTACTTGAAG
GTGTTGATTGGCAAGACGCAACTGGACTACAACAGATCGTTGAAGGGAACAGTGTTGCAGCGCCAGAAATTAAGCCGATT
GCTGAAGCGAATCCTATCAATAAAGTCGTGGCAGGTAGCGAAGGGCTTGGAAATGAACTTAGAGATCAAGAGTATGCGAT
CATTCTCGAAACATTGATTGCTTGTCATGGTCGACGTAAAGATATGGCTGAAAAGCTAGGCATTAGCCCTCGTACATTGC
GTTATAAATTAGCGAAAATGCGTGATGCTGGAATAGATATTCCAAATTGA

Upstream 100 bases:

>100_bases
AGAGGGTGACGGCGCATGCTTTACCATGTGCCTACCGTTGGAAAGAAGCTCTTCTTCTGAAGACTAATAAGTTTTAACTG
AATTTACACTGGAGAATCCT

Downstream 100 bases:

>100_bases
ACATAAATTAGTAGTGTCAGCTTTCTGACTAGTGTATTACGATAGCTAGTCAAATTGATGCATGGCACGTTAATTGCTCT
GTCAATAATAAAGCTAAATA

Product: FlaM

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MAQSKVLIVEDDEGLREALVDTLALAGYEWLEADCAEDALVKLKSNSVDIVVSDVQMAGMGGLALLRNIKQHWPNLPVLL
MTAYANIEDAVAAMKEGAIDYMAKPFAPEVLLNMVSRYAPVKSDDNGDAIVADEKSIKLMMLADKVAKTDANVMVLGPSG
SGKEVMSRYIHNASSRKDGPFVAINCAAIPDNMLEATLFGYDKGAFTGAIQACPGKFEQAQGGTILLDEISEMDLSLQAK
LLRVLQEREVERLGSRKSIKLDVRVLATSNRDLKQYVSEGNFREDLYYRLNVFPITWPALCERKGDIAPLAKHLVERHCT
KLGMPVPVLSEQAISKLVNYPWPGNVRELDNVVQRALILSEQENISGEHILLEGVDWQDATGLQQIVEGNSVAAPEIKPI
AEANPINKVVAGSEGLGNELRDQEYAIILETLIACHGRRKDMAEKLGISPRTLRYKLAKMRDAGIDIPN

Sequences:

>Translated_469_residues
MAQSKVLIVEDDEGLREALVDTLALAGYEWLEADCAEDALVKLKSNSVDIVVSDVQMAGMGGLALLRNIKQHWPNLPVLL
MTAYANIEDAVAAMKEGAIDYMAKPFAPEVLLNMVSRYAPVKSDDNGDAIVADEKSIKLMMLADKVAKTDANVMVLGPSG
SGKEVMSRYIHNASSRKDGPFVAINCAAIPDNMLEATLFGYDKGAFTGAIQACPGKFEQAQGGTILLDEISEMDLSLQAK
LLRVLQEREVERLGSRKSIKLDVRVLATSNRDLKQYVSEGNFREDLYYRLNVFPITWPALCERKGDIAPLAKHLVERHCT
KLGMPVPVLSEQAISKLVNYPWPGNVRELDNVVQRALILSEQENISGEHILLEGVDWQDATGLQQIVEGNSVAAPEIKPI
AEANPINKVVAGSEGLGNELRDQEYAIILETLIACHGRRKDMAEKLGISPRTLRYKLAKMRDAGIDIPN
>Mature_468_residues
AQSKVLIVEDDEGLREALVDTLALAGYEWLEADCAEDALVKLKSNSVDIVVSDVQMAGMGGLALLRNIKQHWPNLPVLLM
TAYANIEDAVAAMKEGAIDYMAKPFAPEVLLNMVSRYAPVKSDDNGDAIVADEKSIKLMMLADKVAKTDANVMVLGPSGS
GKEVMSRYIHNASSRKDGPFVAINCAAIPDNMLEATLFGYDKGAFTGAIQACPGKFEQAQGGTILLDEISEMDLSLQAKL
LRVLQEREVERLGSRKSIKLDVRVLATSNRDLKQYVSEGNFREDLYYRLNVFPITWPALCERKGDIAPLAKHLVERHCTK
LGMPVPVLSEQAISKLVNYPWPGNVRELDNVVQRALILSEQENISGEHILLEGVDWQDATGLQQIVEGNSVAAPEIKPIA
EANPINKVVAGSEGLGNELRDQEYAIILETLIACHGRRKDMAEKLGISPRTLRYKLAKMRDAGIDIPN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=481, Percent_Identity=38.4615384615385, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1790437, Length=464, Percent_Identity=37.7155172413793, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI1788905, Length=420, Percent_Identity=38.8095238095238, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI1790299, Length=476, Percent_Identity=34.6638655462185, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI87082117, Length=234, Percent_Identity=50.8547008547009, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1789087, Length=343, Percent_Identity=39.9416909620991, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI1789233, Length=326, Percent_Identity=39.2638036809816, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI87082152, Length=232, Percent_Identity=46.9827586206897, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI87081872, Length=213, Percent_Identity=42.7230046948357, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1786524, Length=228, Percent_Identity=42.5438596491228, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1787583, Length=234, Percent_Identity=40.1709401709402, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789828, Length=232, Percent_Identity=37.5, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI87081858, Length=249, Percent_Identity=32.5301204819277, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1786911, Length=104, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786599, Length=110, Percent_Identity=30, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790552, Length=107, Percent_Identity=37.3831775700935, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI145693157, Length=114, Percent_Identity=35.0877192982456, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51434; Mature: 51303

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQSKVLIVEDDEGLREALVDTLALAGYEWLEADCAEDALVKLKSNSVDIVVSDVQMAGM
CCCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHEEECCCCEEEEEECCHHCCC
GGLALLRNIKQHWPNLPVLLMTAYANIEDAVAAMKEGAIDYMAKPFAPEVLLNMVSRYAP
CHHHHHHHHHHHCCCCCEEEHHHHCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHCC
VKSDDNGDAIVADEKSIKLMMLADKVAKTDANVMVLGPSGSGKEVMSRYIHNASSRKDGP
CCCCCCCCEEEECCCCEEEEEEHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCC
FVAINCAAIPDNMLEATLFGYDKGAFTGAIQACPGKFEQAQGGTILLDEISEMDLSLQAK
EEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHCCCCCHHCCCCEEEECCHHHCCHHHHHH
LLRVLQEREVERLGSRKSIKLDVRVLATSNRDLKQYVSEGNFREDLYYRLNVFPITWPAL
HHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCCEEEEEEEEEECCHHH
CERKGDIAPLAKHLVERHCTKLGMPVPVLSEQAISKLVNYPWPGNVRELDNVVQRALILS
HCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
EQENISGEHILLEGVDWQDATGLQQIVEGNSVAAPEIKPIAEANPINKVVAGSEGLGNEL
CCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHH
RDQEYAIILETLIACHGRRKDMAEKLGISPRTLRYKLAKMRDAGIDIPN
CCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AQSKVLIVEDDEGLREALVDTLALAGYEWLEADCAEDALVKLKSNSVDIVVSDVQMAGM
CCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHEEECCCCEEEEEECCHHCCC
GGLALLRNIKQHWPNLPVLLMTAYANIEDAVAAMKEGAIDYMAKPFAPEVLLNMVSRYAP
CHHHHHHHHHHHCCCCCEEEHHHHCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHCC
VKSDDNGDAIVADEKSIKLMMLADKVAKTDANVMVLGPSGSGKEVMSRYIHNASSRKDGP
CCCCCCCCEEEECCCCEEEEEEHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCC
FVAINCAAIPDNMLEATLFGYDKGAFTGAIQACPGKFEQAQGGTILLDEISEMDLSLQAK
EEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHCCCCCHHCCCCEEEECCHHHCCHHHHHH
LLRVLQEREVERLGSRKSIKLDVRVLATSNRDLKQYVSEGNFREDLYYRLNVFPITWPAL
HHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCCEEEEEEEEEECCHHH
CERKGDIAPLAKHLVERHCTKLGMPVPVLSEQAISKLVNYPWPGNVRELDNVVQRALILS
HCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
EQENISGEHILLEGVDWQDATGLQQIVEGNSVAAPEIKPIAEANPINKVVAGSEGLGNEL
CCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHH
RDQEYAIILETLIACHGRRKDMAEKLGISPRTLRYKLAKMRDAGIDIPN
CCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]