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The map label for this gene is prs [H]

Identifier: 218708751

GI number: 218708751

Start: 769184

End: 770128

Strand: Reverse

Name: prs [H]

Synonym: VS_0748

Alternate gene names: 218708751

Gene position: 770128-769184 (Counterclockwise)

Preceding gene: 218708752

Following gene: 218708750

Centisome position: 23.34

GC content: 46.56

Gene sequence:

>945_bases
GTGCCTGATATGAAGCTATTTGCTGGTAACGCAACACCTGAACTAGCCCAACGTATTGCTGATCGTCTATACATCTCTCT
TGGCGATGCTACTGTAGACCGTTTTTCTGATGGCGAAGTCGCTGTTCAAATCAATGAAAACGTTCGTGGTAGCGATGTAT
TCCTGATTCAATCAACTTGTGCACCAACCAATGACAACCTTATGGAATTGGTGGTAATGATTGACGCAATGCGCCGTGCT
TCTGCTGGCCGTATTACTGCTGTAATCCCTTACTTCGGTTATGCCCGTCAAGATCGTCGTGTACGTTCTGCTCGTGTGCC
TATTACTGCAAAAGTTGTTGCAGATTTCCTTTCTAACGTTGGCGTTGACCGCGTTCTTACTATCGACCTACACGCGGAGC
AAATCCAAGGCTTCTTCGATGTACCTGTTGATAACATTTTCGGCACTCCAGTTCTTCTAGAAGACATGGCTAACCGTGGC
CTAGAAAACCCAGTAGTGGTTTCTCCAGACCTTGGTGGTGTTGTACGTGCTCGTGCTACAGCTAAAGCGCTAGGTGATGT
TGACATCGCTATCGTTGATAAGCGTCGTCCACGTGCTAACGTTTCTGAAGTAATGAACCTAATCGGTGATGTTGAAGGTC
GTGACTGCGTTATCGTTGATGACATGATCGATACTGGTGGCACACTATGTAAAGCAGCTGAAGCGCTTAAAGAGCGCGGT
GCTAAGCGTGTATTCGCTTACGCAACTCACGCAGTATTCTCTGGTACTGCTGCAGAAAACATCCGCAATTCAGTTCTAGA
CCAAGTTATTGTTACCGATTCAATCAAGCTTTCTCCGGAAATGGCCGCGACAGGTAAAGTAACTGAACTAAGCCTTTCTC
GCATGCTTGCTGAAGCGATTCGTCGTATCAGCAACGAAGAGTCTATCTCTGCGATGTTCAACTAA

Upstream 100 bases:

>100_bases
GAAAGGACGAAACATTTCGCCTTTGAAAGAAACTTTGGCTGAATACCAATCAGCCCACCCACAATCTATTTAAAACTGGA
CGCAACCCGAGGTTTCCACC

Downstream 100 bases:

>100_bases
TCAAAGCTCTATAGCTTTGCTTTAGCAGAACAATCTGAAAAAGATATTAAGCACTTCATTCGATGAAGTGCTTTTTTTAT
ATCCAATACCAATCACAGTA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MPDMKLFAGNATPELAQRIADRLYISLGDATVDRFSDGEVAVQINENVRGSDVFLIQSTCAPTNDNLMELVVMIDAMRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSNVGVDRVLTIDLHAEQIQGFFDVPVDNIFGTPVLLEDMANRG
LENPVVVSPDLGGVVRARATAKALGDVDIAIVDKRRPRANVSEVMNLIGDVEGRDCVIVDDMIDTGGTLCKAAEALKERG
AKRVFAYATHAVFSGTAAENIRNSVLDQVIVTDSIKLSPEMAATGKVTELSLSRMLAEAIRRISNEESISAMFN

Sequences:

>Translated_314_residues
MPDMKLFAGNATPELAQRIADRLYISLGDATVDRFSDGEVAVQINENVRGSDVFLIQSTCAPTNDNLMELVVMIDAMRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSNVGVDRVLTIDLHAEQIQGFFDVPVDNIFGTPVLLEDMANRG
LENPVVVSPDLGGVVRARATAKALGDVDIAIVDKRRPRANVSEVMNLIGDVEGRDCVIVDDMIDTGGTLCKAAEALKERG
AKRVFAYATHAVFSGTAAENIRNSVLDQVIVTDSIKLSPEMAATGKVTELSLSRMLAEAIRRISNEESISAMFN
>Mature_313_residues
PDMKLFAGNATPELAQRIADRLYISLGDATVDRFSDGEVAVQINENVRGSDVFLIQSTCAPTNDNLMELVVMIDAMRRAS
AGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSNVGVDRVLTIDLHAEQIQGFFDVPVDNIFGTPVLLEDMANRGL
ENPVVVSPDLGGVVRARATAKALGDVDIAIVDKRRPRANVSEVMNLIGDVEGRDCVIVDDMIDTGGTLCKAAEALKERGA
KRVFAYATHAVFSGTAAENIRNSVLDQVIVTDSIKLSPEMAATGKVTELSLSRMLAEAIRRISNEESISAMFN

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=316, Percent_Identity=47.7848101265823, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI4506129, Length=318, Percent_Identity=47.1698113207547, Blast_Score=298, Evalue=4e-81,
Organism=Homo sapiens, GI84875539, Length=320, Percent_Identity=46.875, Blast_Score=298, Evalue=6e-81,
Organism=Homo sapiens, GI28557709, Length=316, Percent_Identity=46.2025316455696, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=34.9854227405248, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=34.6938775510204, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI310128524, Length=153, Percent_Identity=32.0261437908497, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI310115209, Length=153, Percent_Identity=32.0261437908497, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI310118259, Length=153, Percent_Identity=32.0261437908497, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI310119946, Length=153, Percent_Identity=32.0261437908497, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=82.4281150159744, Blast_Score=534, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17554702, Length=316, Percent_Identity=45.8860759493671, Blast_Score=294, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI25149168, Length=316, Percent_Identity=45.8860759493671, Blast_Score=294, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI71989924, Length=316, Percent_Identity=45.8860759493671, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=45.6591639871383, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=33.0383480825959, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319403, Length=314, Percent_Identity=44.9044585987261, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6321776, Length=317, Percent_Identity=47.0031545741325, Blast_Score=265, Evalue=6e-72,
Organism=Saccharomyces cerevisiae, GI6320946, Length=313, Percent_Identity=44.408945686901, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6322667, Length=211, Percent_Identity=40.7582938388626, Blast_Score=152, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6324511, Length=111, Percent_Identity=39.6396396396396, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21355239, Length=316, Percent_Identity=46.8354430379747, Blast_Score=291, Evalue=4e-79,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=43.7869822485207, Blast_Score=282, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24651458, Length=356, Percent_Identity=31.1797752808989, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24651456, Length=356, Percent_Identity=31.1797752808989, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281362873, Length=356, Percent_Identity=31.1797752808989, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24651454, Length=356, Percent_Identity=31.1797752808989, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI45552010, Length=374, Percent_Identity=30.7486631016043, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24651462, Length=374, Percent_Identity=30.7486631016043, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24651464, Length=374, Percent_Identity=30.7486631016043, Blast_Score=182, Evalue=4e-46,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34012; Mature: 33881

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDMKLFAGNATPELAQRIADRLYISLGDATVDRFSDGEVAVQINENVRGSDVFLIQSTC
CCCCEEEECCCCHHHHHHHHHHHEEEECCHHHHCCCCCEEEEEECCCCCCCEEEEEEECC
APTNDNLMELVVMIDAMRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSNV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHCC
GVDRVLTIDLHAEQIQGFFDVPVDNIFGTPVLLEDMANRGLENPVVVSPDLGGVVRARAT
CCCEEEEEEEEHHHHCCEECCCHHHHCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHH
AKALGDVDIAIVDKRRPRANVSEVMNLIGDVEGRDCVIVDDMIDTGGTLCKAAEALKERG
HHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCC
AKRVFAYATHAVFSGTAAENIRNSVLDQVIVTDSIKLSPEMAATGKVTELSLSRMLAEAI
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHH
RRISNEESISAMFN
HHHCCCCHHHHHCC
>Mature Secondary Structure 
PDMKLFAGNATPELAQRIADRLYISLGDATVDRFSDGEVAVQINENVRGSDVFLIQSTC
CCCEEEECCCCHHHHHHHHHHHEEEECCHHHHCCCCCEEEEEECCCCCCCEEEEEEECC
APTNDNLMELVVMIDAMRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSNV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHCC
GVDRVLTIDLHAEQIQGFFDVPVDNIFGTPVLLEDMANRGLENPVVVSPDLGGVVRARAT
CCCEEEEEEEEHHHHCCEECCCHHHHCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHH
AKALGDVDIAIVDKRRPRANVSEVMNLIGDVEGRDCVIVDDMIDTGGTLCKAAEALKERG
HHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCC
AKRVFAYATHAVFSGTAAENIRNSVLDQVIVTDSIKLSPEMAATGKVTELSLSRMLAEAI
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHH
RRISNEESISAMFN
HHHCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]