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The map label for this gene is csd [H]

Identifier: 218708704

GI number: 218708704

Start: 717244

End: 718455

Strand: Reverse

Name: csd [H]

Synonym: VS_0683

Alternate gene names: 218708704

Gene position: 718455-717244 (Counterclockwise)

Preceding gene: 218708705

Following gene: 218708699

Centisome position: 21.78

GC content: 45.87

Gene sequence:

>1212_bases
ATGCTTGATATCAATCACATCCGAGAGCAGTTTCCTGCGCTATCACAAACCATCAATCAACAACCGTTGATTTATTTAGA
CAGCGCGGCAACGACACAAAAACCTCAGGTGGTTATTGATGCCATTAGCCAATACTACTCCAAACAAAATGCCAATGTTC
ACCGTGGTAGTCATAGCTTAACAGCCAACGCGACCAGTCAATTTGAAGCCGCCAGAGATAAGGTCGCTCAGTTTATCGGC
GCAAGCTCTTCAAAAGAGATTATTTGGACTCGCGGCGCAACCGAAGCACTTAACCTGATCGCACAAACTTACGCAAGAAG
CACGCTTAAACCTGGCGATGAGATCTTAGTCAGTGAAATGGAACATCACGCCAACATCGTGCCTTGGCAAATTGTGGCTG
AACAAACGGGTGCTAAAGTCGTGAAAGTACCAATGACATCAGATTGTGACTTTGACGTTGTTGCGTTTGACGCCCTTTTG
AATGAACGAACTAAGATTGTTGCTCTGGCTCAGATAACTAATGTGACTGGTTCTCGTCAGCCCATTGAAGAAGTGATCGA
GAAAGCGCACAAGATTAATGCGATTGTTGTGGTAGATGGAGCGCAAGGTATCGTTCATGAACCCGTTGATGTTGCGGCTT
TAGGTGCGGATTTCTACGTTTTCTCAGGACACAAGCTCTACGCCCCTGCAGGCATCGGTGTACTTTACGGCAAGCTAGAA
TTGCTCGAAGCGATGCCCCCTTGGCATGGCGGTGGCAAAATGGTTGAGCGCGTATCTTTCTCTGGTACCACATTTTCTGA
ACTGCCGGGGAAGTTTGAAGCGGGCACGCCAAATGTGGCGGGAGCGATAGCATTAAGTACCGCAATAGAATGGTTAAGTG
GTTTTGCTCAGAAAGATGTCGAAAATCATATCCACCAACTACAGCACGAGACTTATCTTGCACTCAGTAATCTGGATGAT
ATTCAGGTATTGGGTTATCAACCCAACGCAAGCGTGATTACTTTTGTAATGGACGGTGTTCACCATCAAGATATTGCTAC
TCTGCTGGATCAGCAAGGTATCGCAGTACGTGCTGGACACCACTGTGCTCACCCATTAATGGATGCACTTAATGTGAAAG
GAACGGTTCGTATTTCATTTGGTATTTATAACAATCTAGATGATGTTGAAAAGCTCGTAGCGGCGATAGAAAAAGCCGTT
GATATGCTGTAG

Upstream 100 bases:

>100_bases
TCATCAAGATTAGTCAGCAACGATTAACAAGTCGCGATAAAATAACGATACCGCTCAGCATAACGCTAGCAACAATTTCC
AAGATTTTAGGTAAGAATAG

Downstream 100 bases:

>100_bases
CGAGTAGCGAGTAGCGAGTAGCGAGTAGCGAGTAGCGAGTAGCGAGTAGCGAGTAGCGAGTAGCGAGTAGCGAGTAGCGA
GTAGCGAGTAGCGAGTAGCG

Product: putative cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MLDINHIREQFPALSQTINQQPLIYLDSAATTQKPQVVIDAISQYYSKQNANVHRGSHSLTANATSQFEAARDKVAQFIG
ASSSKEIIWTRGATEALNLIAQTYARSTLKPGDEILVSEMEHHANIVPWQIVAEQTGAKVVKVPMTSDCDFDVVAFDALL
NERTKIVALAQITNVTGSRQPIEEVIEKAHKINAIVVVDGAQGIVHEPVDVAALGADFYVFSGHKLYAPAGIGVLYGKLE
LLEAMPPWHGGGKMVERVSFSGTTFSELPGKFEAGTPNVAGAIALSTAIEWLSGFAQKDVENHIHQLQHETYLALSNLDD
IQVLGYQPNASVITFVMDGVHHQDIATLLDQQGIAVRAGHHCAHPLMDALNVKGTVRISFGIYNNLDDVEKLVAAIEKAV
DML

Sequences:

>Translated_403_residues
MLDINHIREQFPALSQTINQQPLIYLDSAATTQKPQVVIDAISQYYSKQNANVHRGSHSLTANATSQFEAARDKVAQFIG
ASSSKEIIWTRGATEALNLIAQTYARSTLKPGDEILVSEMEHHANIVPWQIVAEQTGAKVVKVPMTSDCDFDVVAFDALL
NERTKIVALAQITNVTGSRQPIEEVIEKAHKINAIVVVDGAQGIVHEPVDVAALGADFYVFSGHKLYAPAGIGVLYGKLE
LLEAMPPWHGGGKMVERVSFSGTTFSELPGKFEAGTPNVAGAIALSTAIEWLSGFAQKDVENHIHQLQHETYLALSNLDD
IQVLGYQPNASVITFVMDGVHHQDIATLLDQQGIAVRAGHHCAHPLMDALNVKGTVRISFGIYNNLDDVEKLVAAIEKAV
DML
>Mature_403_residues
MLDINHIREQFPALSQTINQQPLIYLDSAATTQKPQVVIDAISQYYSKQNANVHRGSHSLTANATSQFEAARDKVAQFIG
ASSSKEIIWTRGATEALNLIAQTYARSTLKPGDEILVSEMEHHANIVPWQIVAEQTGAKVVKVPMTSDCDFDVVAFDALL
NERTKIVALAQITNVTGSRQPIEEVIEKAHKINAIVVVDGAQGIVHEPVDVAALGADFYVFSGHKLYAPAGIGVLYGKLE
LLEAMPPWHGGGKMVERVSFSGTTFSELPGKFEAGTPNVAGAIALSTAIEWLSGFAQKDVENHIHQLQHETYLALSNLDD
IQVLGYQPNASVITFVMDGVHHQDIATLLDQQGIAVRAGHHCAHPLMDALNVKGTVRISFGIYNNLDDVEKLVAAIEKAV
DML

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=248, Percent_Identity=29.8387096774194, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI156713448, Length=429, Percent_Identity=24.7086247086247, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1789175, Length=398, Percent_Identity=50.7537688442211, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1787970, Length=404, Percent_Identity=43.5643564356436, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI48994898, Length=245, Percent_Identity=31.8367346938775, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25143064, Length=251, Percent_Identity=30.6772908366534, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI193211090, Length=378, Percent_Identity=26.4550264550265, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=251, Percent_Identity=29.8804780876494, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI20129463, Length=254, Percent_Identity=31.1023622047244, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR022471
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43756; Mature: 43756

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDINHIREQFPALSQTINQQPLIYLDSAATTQKPQVVIDAISQYYSKQNANVHRGSHSL
CCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCE
TANATSQFEAARDKVAQFIGASSSKEIIWTRGATEALNLIAQTYARSTLKPGDEILVSEM
ECCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EHHANIVPWQIVAEQTGAKVVKVPMTSDCDFDVVAFDALLNERTKIVALAQITNVTGSRQ
HHCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHCCCHHEEEEEEHHCCCCCCC
PIEEVIEKAHKINAIVVVDGAQGIVHEPVDVAALGADFYVFSGHKLYAPAGIGVLYGKLE
HHHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEECCCEEEECCCEEECCCCCHHHHHHHH
LLEAMPPWHGGGKMVERVSFSGTTFSELPGKFEAGTPNVAGAIALSTAIEWLSGFAQKDV
HHHHCCCCCCCCHHHHEEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ENHIHQLQHETYLALSNLDDIQVLGYQPNASVITFVMDGVHHQDIATLLDQQGIAVRAGH
HHHHHHHHHHHEEEECCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHCCCCEEECCC
HCAHPLMDALNVKGTVRISFGIYNNLDDVEKLVAAIEKAVDML
HHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDINHIREQFPALSQTINQQPLIYLDSAATTQKPQVVIDAISQYYSKQNANVHRGSHSL
CCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCE
TANATSQFEAARDKVAQFIGASSSKEIIWTRGATEALNLIAQTYARSTLKPGDEILVSEM
ECCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EHHANIVPWQIVAEQTGAKVVKVPMTSDCDFDVVAFDALLNERTKIVALAQITNVTGSRQ
HHCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHCCCHHEEEEEEHHCCCCCCC
PIEEVIEKAHKINAIVVVDGAQGIVHEPVDVAALGADFYVFSGHKLYAPAGIGVLYGKLE
HHHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEECCCEEEECCCEEECCCCCHHHHHHHH
LLEAMPPWHGGGKMVERVSFSGTTFSELPGKFEAGTPNVAGAIALSTAIEWLSGFAQKDV
HHHHCCCCCCCCHHHHEEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ENHIHQLQHETYLALSNLDDIQVLGYQPNASVITFVMDGVHHQDIATLLDQQGIAVRAGH
HHHHHHHHHHHEEEECCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHCCCCEEECCC
HCAHPLMDALNVKGTVRISFGIYNNLDDVEKLVAAIEKAVDML
HHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]