Click here to switch to the map view.

The map label for this gene is panE [H]

Identifier: 218708705

GI number: 218708705

Start: 718543

End: 719436

Strand: Reverse

Name: panE [H]

Synonym: VS_0684

Alternate gene names: 218708705

Gene position: 719436-718543 (Counterclockwise)

Preceding gene: 218708706

Following gene: 218708704

Centisome position: 21.81

GC content: 43.74

Gene sequence:

>894_bases
GTGAACATCACTATTGTTGGCCCTGGGGCTATAGGCTCTTTATGGGCAATAAAACTGCTTCAAGCAGGTCATAATGTGGC
TTTGTGGAGTCGTTCCACGGATCACTCAATTGACTTATCACTTGATGGACAAGCTTCACTTTCCTTCAGTAACAACAATA
TCGAGAAGCTATCAGAAAGTGACCTAGTGATCTTCACGGTCAAAGCCTGGCAAGTAGAAGAAGCAACCACTCCACTGCTT
CAACACCTAGACCCTGACACCATTCTCATGTTCATGCACAACGGTATGGGGGCGGTCGCTCAGATAGCAACTCAAATTGA
TACTCACCCAGTAGTATTGGCTACAACCACACAAGCGGCATTCAAACCCGACAAGAATAATGTTTCTCATACAGGGTTCG
GACAAACTCAATTGGGTGCTTTTAACCTCAAGGGTCAACAGTGCACTTTTTTAGTTGATGTGTTGGAACATGCCTTCCCT
GCCGTGAGTTGGAATCCAAAAATAACAACGGCGCTGTGGGCTAAACTCGCCATAAATTGTGCGATCAACCCACTGACTGG
GCTGGAACAAATCAAAAACGGAGAGCTTGCTGACAAAAGATTTAGCGAAGCTCTGAGTTCTATAATTAAAGAACTCACGC
AAGTGATGCAGGCGGAAGGCATTACTTGTTCATTCGACGAATTAGAAACAAGTGTAAAACACGTTATTCAAGCCACGGCT
CAAAACAACTCTTCCATGCAGCAAGATATGTTTTATGAGCGCAAGACAGAGATCGACTTCATTACCGGACACCTAATAAA
GACAGCACTCAAACATCAGATAGAAGTTCCTGTTAACCAAAAGCTGTTTACGCAGGTTAAAGAACGAGAAAATAGCTGGA
ATCATCAAGATTAG

Upstream 100 bases:

>100_bases
AAGAAAGTTTCCAAAATGGCACCCTCGGGTGCCATTTTTTATTGCTTTCATTTAATGCCTCGCTATCCTTGCAGCACCAC
TTTCTTATCTCGGTATTGCT

Downstream 100 bases:

>100_bases
TCAGCAACGATTAACAAGTCGCGATAAAATAACGATACCGCTCAGCATAACGCTAGCAACAATTTCCAAGATTTTAGGTA
AGAATAGATGCTTGATATCA

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MNITIVGPGAIGSLWAIKLLQAGHNVALWSRSTDHSIDLSLDGQASLSFSNNNIEKLSESDLVIFTVKAWQVEEATTPLL
QHLDPDTILMFMHNGMGAVAQIATQIDTHPVVLATTTQAAFKPDKNNVSHTGFGQTQLGAFNLKGQQCTFLVDVLEHAFP
AVSWNPKITTALWAKLAINCAINPLTGLEQIKNGELADKRFSEALSSIIKELTQVMQAEGITCSFDELETSVKHVIQATA
QNNSSMQQDMFYERKTEIDFITGHLIKTALKHQIEVPVNQKLFTQVKERENSWNHQD

Sequences:

>Translated_297_residues
MNITIVGPGAIGSLWAIKLLQAGHNVALWSRSTDHSIDLSLDGQASLSFSNNNIEKLSESDLVIFTVKAWQVEEATTPLL
QHLDPDTILMFMHNGMGAVAQIATQIDTHPVVLATTTQAAFKPDKNNVSHTGFGQTQLGAFNLKGQQCTFLVDVLEHAFP
AVSWNPKITTALWAKLAINCAINPLTGLEQIKNGELADKRFSEALSSIIKELTQVMQAEGITCSFDELETSVKHVIQATA
QNNSSMQQDMFYERKTEIDFITGHLIKTALKHQIEVPVNQKLFTQVKERENSWNHQD
>Mature_297_residues
MNITIVGPGAIGSLWAIKLLQAGHNVALWSRSTDHSIDLSLDGQASLSFSNNNIEKLSESDLVIFTVKAWQVEEATTPLL
QHLDPDTILMFMHNGMGAVAQIATQIDTHPVVLATTTQAAFKPDKNNVSHTGFGQTQLGAFNLKGQQCTFLVDVLEHAFP
AVSWNPKITTALWAKLAINCAINPLTGLEQIKNGELADKRFSEALSSIIKELTQVMQAEGITCSFDELETSVKHVIQATA
QNNSSMQQDMFYERKTEIDFITGHLIKTALKHQIEVPVNQKLFTQVKERENSWNHQD

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=297, Percent_Identity=38.047138047138, Blast_Score=194, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 32834; Mature: 32834

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITIVGPGAIGSLWAIKLLQAGHNVALWSRSTDHSIDLSLDGQASLSFSNNNIEKLSES
CEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCEEEEECCCCHHHHCCC
DLVIFTVKAWQVEEATTPLLQHLDPDTILMFMHNGMGAVAQIATQIDTHPVVLATTTQAA
CEEEEEEEEEECCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCEEEEECCHHH
FKPDKNNVSHTGFGQTQLGAFNLKGQQCTFLVDVLEHAFPAVSWNPKITTALWAKLAINC
CCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AINPLTGLEQIKNGELADKRFSEALSSIIKELTQVMQAEGITCSFDELETSVKHVIQATA
CCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
QNNSSMQQDMFYERKTEIDFITGHLIKTALKHQIEVPVNQKLFTQVKERENSWNHQD
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNITIVGPGAIGSLWAIKLLQAGHNVALWSRSTDHSIDLSLDGQASLSFSNNNIEKLSES
CEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCEEEEECCCCHHHHCCC
DLVIFTVKAWQVEEATTPLLQHLDPDTILMFMHNGMGAVAQIATQIDTHPVVLATTTQAA
CEEEEEEEEEECCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCEEEEECCHHH
FKPDKNNVSHTGFGQTQLGAFNLKGQQCTFLVDVLEHAFPAVSWNPKITTALWAKLAINC
CCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AINPLTGLEQIKNGELADKRFSEALSSIIKELTQVMQAEGITCSFDELETSVKHVIQATA
CCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
QNNSSMQQDMFYERKTEIDFITGHLIKTALKHQIEVPVNQKLFTQVKERENSWNHQD
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]