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The map label for this gene is arcA [H]

Identifier: 218708515

GI number: 218708515

Start: 503977

End: 504870

Strand: Reverse

Name: arcA [H]

Synonym: VS_0479

Alternate gene names: 218708515

Gene position: 504870-503977 (Counterclockwise)

Preceding gene: 218708517

Following gene: 218708510

Centisome position: 15.3

GC content: 43.74

Gene sequence:

>894_bases
TTGAAAGGCGTACTGGATCTACGTTATTGGGCAATACTTCAAGGAAGGCAGATAGCTGGAAGTAAGTGTTTTTTTGAAAA
CTTTAAGTTATCATCAAAAATACATTACCTGTATGTTATGTTTTGCCTAGAATTTATTCTATTAGCACAGTTTCGTCACA
AATTTAGGTACCGCCAAATGCAAACCCCGCAGATTCTTATCGTTGAAGATGAGCAAGTAACTCGTAACACTCTAAAGAGT
ATTTTTGAAGCAGAGGGATATGCTGTTTTTGAGGCTAGCGACGGTGAAGAGATGCACCAAGTGCTATCTGACAACCAAGT
TAACCTTGTAATTATGGACATCAACCTTCCAGGTAAGAATGGCCTACTACTTGCTCGTGAACTGCGTGAGCAAGCAAACG
TAGCGCTTATGTTCTTAACAGGTCGTGATAATGAAGTTGATAAGATCCTTGGCCTAGAGATCGGCGCAGATGACTACATC
ACAAAGCCTTTTAACCCTCGTGAGCTGACTATCCGTGCACGCAACCTTCTGAACCGTTCAATGAGCACAAGCTCTGTTCA
AGAAGAAAAGCGTAGCGTTGAGAAGTACGAGTTCAATGGTTGGGTACTAGATATCAACAGTCGTTCTCTGGTTAGCCCAG
ATGGCGAAGGCTACAAGCTACCTCGTTCAGAGTTCCGTGCTCTACTTCACTTCTGTGAGAACCCAGGTAAGATCCAAACA
CGTGCAGACCTTCTTAAGAAGATGACTGGCCGTGAGCTTAAGCCACACGATCGTACTGTAGACGTAACAATCCGTCGTAT
TCGTAAGCACTTTGAATCTGTTTCTGGTACGCCAGAAATCATCGCGACGATTCACGGTGAAGGCTACCGCTTTTGTGGTG
ACCTAGAAGACTAA

Upstream 100 bases:

>100_bases
GGCAATTGATGTAAATCAACAAAGTGAATGGAATTAACATTCTCGCGTTGTTAGCATGCTGTTAACATTATAGAATCCTC
TTAAATCACTAAAAGAATGA

Downstream 100 bases:

>100_bases
TTCGATTCGCGCTTCTGGCCGTTTAGTTCTTGCCGTCGATTAGCACTTCTAAACCGATAGCACTTCTAACCAGTTAGTAC
TTATAAACAGTTAGTACTTC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MKGVLDLRYWAILQGRQIAGSKCFFENFKLSSKIHYLYVMFCLEFILLAQFRHKFRYRQMQTPQILIVEDEQVTRNTLKS
IFEAEGYAVFEASDGEEMHQVLSDNQVNLVIMDINLPGKNGLLLARELREQANVALMFLTGRDNEVDKILGLEIGADDYI
TKPFNPRELTIRARNLLNRSMSTSSVQEEKRSVEKYEFNGWVLDINSRSLVSPDGEGYKLPRSEFRALLHFCENPGKIQT
RADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVSGTPEIIATIHGEGYRFCGDLED

Sequences:

>Translated_297_residues
MKGVLDLRYWAILQGRQIAGSKCFFENFKLSSKIHYLYVMFCLEFILLAQFRHKFRYRQMQTPQILIVEDEQVTRNTLKS
IFEAEGYAVFEASDGEEMHQVLSDNQVNLVIMDINLPGKNGLLLARELREQANVALMFLTGRDNEVDKILGLEIGADDYI
TKPFNPRELTIRARNLLNRSMSTSSVQEEKRSVEKYEFNGWVLDINSRSLVSPDGEGYKLPRSEFRALLHFCENPGKIQT
RADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVSGTPEIIATIHGEGYRFCGDLED
>Mature_297_residues
MKGVLDLRYWAILQGRQIAGSKCFFENFKLSSKIHYLYVMFCLEFILLAQFRHKFRYRQMQTPQILIVEDEQVTRNTLKS
IFEAEGYAVFEASDGEEMHQVLSDNQVNLVIMDINLPGKNGLLLARELREQANVALMFLTGRDNEVDKILGLEIGADDYI
TKPFNPRELTIRARNLLNRSMSTSSVQEEKRSVEKYEFNGWVLDINSRSLVSPDGEGYKLPRSEFRALLHFCENPGKIQT
RADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVSGTPEIIATIHGEGYRFCGDLED

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=87.3949579831933, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=41.6309012875536, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1789809, Length=235, Percent_Identity=35.3191489361702, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=33.4763948497854, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=34.4827586206897, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=33.6283185840708, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=235, Percent_Identity=32.7659574468085, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.0175438596491, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082012, Length=232, Percent_Identity=33.6206896551724, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=29.2576419213974, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=29.5154185022026, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=29.7413793103448, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=27.7533039647577, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790552, Length=235, Percent_Identity=30.2127659574468, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788550, Length=223, Percent_Identity=26.457399103139, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787487, Length=139, Percent_Identity=33.0935251798561, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 34328; Mature: 34328

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVLDLRYWAILQGRQIAGSKCFFENFKLSSKIHYLYVMFCLEFILLAQFRHKFRYRQM
CCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QTPQILIVEDEQVTRNTLKSIFEAEGYAVFEASDGEEMHQVLSDNQVNLVIMDINLPGKN
CCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEEEEEECCCCC
GLLLARELREQANVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLNRS
CEEHHHHHHHHCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHC
MSTSSVQEEKRSVEKYEFNGWVLDINSRSLVSPDGEGYKLPRSEFRALLHFCENPGKIQT
CCHHHHHHHHHHHHHEECCCEEEEECCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCHH
RADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVSGTPEIIATIHGEGYRFCGDLED
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEECCCCCC
>Mature Secondary Structure
MKGVLDLRYWAILQGRQIAGSKCFFENFKLSSKIHYLYVMFCLEFILLAQFRHKFRYRQM
CCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QTPQILIVEDEQVTRNTLKSIFEAEGYAVFEASDGEEMHQVLSDNQVNLVIMDINLPGKN
CCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEEEEEECCCCC
GLLLARELREQANVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLNRS
CEEHHHHHHHHCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHC
MSTSSVQEEKRSVEKYEFNGWVLDINSRSLVSPDGEGYKLPRSEFRALLHFCENPGKIQT
CCHHHHHHHHHHHHHEECCCEEEEECCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCHH
RADLLKKMTGRELKPHDRTVDVTIRRIRKHFESVSGTPEIIATIHGEGYRFCGDLED
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]