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The map label for this gene is cobD [H]

Identifier: 218708503

GI number: 218708503

Start: 482653

End: 483606

Strand: Reverse

Name: cobD [H]

Synonym: VS_0467

Alternate gene names: 218708503

Gene position: 483606-482653 (Counterclockwise)

Preceding gene: 218708504

Following gene: 218708502

Centisome position: 14.66

GC content: 46.02

Gene sequence:

>954_bases
ATGCAAACACTGTTTGATCAGGTATTTGCAAATGGCGTGCTCCTTGTGATGTGGGGAGCACTGCTTTTTCATTTAATTTT
ACCTATCCCCCATGCCGCACACCCCACGACCTTATGGCATAAGTTTGCTGAGCTTTTAGCAAGCAAGGTTAATAACAACC
ACAACTATTCCCAAAGTTTAATCTCAGGCACATTAGCCTGGGGGTTAATGGTACTGCCGACTCTGGTTATTCTTCTGGCA
CTGCAACCATTGGTTTGGCAATCTCAACTATTTGAATTAGCACTGTTATTACTCGCAATTGATTGGCGCAATAATGAAAA
GCTGGCAAATCAGTTAATCAAAGCATTAGGCCGAGAAGATAAAGCTGCTGCTCGTCAGTTACTGGCTCCGATTATCAATC
GTCAAACTGAATCACTTTCGTCACTTGGCCTAGGCAAAGCCGCCACAGAAACCATCATCATGGGCTACGCTCGTAACGTA
GTTTGTGTGTTGTTCTGGTACGCCATTGGTGGTGGAATCGCCGCGTTAATGTATCGCCTTGTGGTCGAATTAGCTCGAGC
TTGGTCGCCAAGTCGCAAGCAATTTTCTCCGTTCGGCTCAACGGCGATCAAGATAGTCGCGATTCTCGAATTTATACCGA
TGCGTTTTTTTGCTTTGATGATCGTATGTGGTGATAAAGCCACACACACGTTTAAGATGATGTTAGTTCAGAGTCGCTCT
TGGCCACTGCCCGGCCCTGCCTGGTTGATCACGGCCGTTGGCAACAAGCTGGAGTTATCATTAGGTGGCCCTGCGATTTA
CGACAACACTAAAGCCATTCGCGCGAAATTAGGCGGAAGAATAGCACCGTCAGCTCTGCATCTGTCTCAGGTTCAGAAAC
TACTCTTTGGTCGCATCGCTATCTGGATATTTTTACAAAGCCTAGCCTTACTATTTAATCACCAAGGGATTTAG

Upstream 100 bases:

>100_bases
GAATCACCAATGAGCTTCGAAGAGTTCCTGCCACTAGCAGCGCAAAGCTCTTCTGAAATGGTTATCAAGATGGTTGCCCT
ACTAAAGTAAGCGACTAGAC

Downstream 100 bases:

>100_bases
AGTGAAACCTTCAGCACTTGTTACAAGCCTTACTATTTTGTTTTCCAGCTTATGGCTGCCTTTGTCATTTGCAGAAGAAA
CACTACTGACTTCAGAAAAA

Product: adenosylcobinamide-phosphate synthase

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MQTLFDQVFANGVLLVMWGALLFHLILPIPHAAHPTTLWHKFAELLASKVNNNHNYSQSLISGTLAWGLMVLPTLVILLA
LQPLVWQSQLFELALLLLAIDWRNNEKLANQLIKALGREDKAAARQLLAPIINRQTESLSSLGLGKAATETIIMGYARNV
VCVLFWYAIGGGIAALMYRLVVELARAWSPSRKQFSPFGSTAIKIVAILEFIPMRFFALMIVCGDKATHTFKMMLVQSRS
WPLPGPAWLITAVGNKLELSLGGPAIYDNTKAIRAKLGGRIAPSALHLSQVQKLLFGRIAIWIFLQSLALLFNHQGI

Sequences:

>Translated_317_residues
MQTLFDQVFANGVLLVMWGALLFHLILPIPHAAHPTTLWHKFAELLASKVNNNHNYSQSLISGTLAWGLMVLPTLVILLA
LQPLVWQSQLFELALLLLAIDWRNNEKLANQLIKALGREDKAAARQLLAPIINRQTESLSSLGLGKAATETIIMGYARNV
VCVLFWYAIGGGIAALMYRLVVELARAWSPSRKQFSPFGSTAIKIVAILEFIPMRFFALMIVCGDKATHTFKMMLVQSRS
WPLPGPAWLITAVGNKLELSLGGPAIYDNTKAIRAKLGGRIAPSALHLSQVQKLLFGRIAIWIFLQSLALLFNHQGI
>Mature_317_residues
MQTLFDQVFANGVLLVMWGALLFHLILPIPHAAHPTTLWHKFAELLASKVNNNHNYSQSLISGTLAWGLMVLPTLVILLA
LQPLVWQSQLFELALLLLAIDWRNNEKLANQLIKALGREDKAAARQLLAPIINRQTESLSSLGLGKAATETIIMGYARNV
VCVLFWYAIGGGIAALMYRLVVELARAWSPSRKQFSPFGSTAIKIVAILEFIPMRFFALMIVCGDKATHTFKMMLVQSRS
WPLPGPAWLITAVGNKLELSLGGPAIYDNTKAIRAKLGGRIAPSALHLSQVQKLLFGRIAIWIFLQSLALLFNHQGI

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 35050; Mature: 35050

Theoretical pI: Translated: 10.66; Mature: 10.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLFDQVFANGVLLVMWGALLFHLILPIPHAAHPTTLWHKFAELLASKVNNNHNYSQSL
CCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
ISGTLAWGLMVLPTLVILLALQPLVWQSQLFELALLLLAIDWRNNEKLANQLIKALGRED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCH
KAAARQLLAPIINRQTESLSSLGLGKAATETIIMGYARNVVCVLFWYAIGGGIAALMYRL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVELARAWSPSRKQFSPFGSTAIKIVAILEFIPMRFFALMIVCGDKATHTFKMMLVQSRS
HHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
WPLPGPAWLITAVGNKLELSLGGPAIYDNTKAIRAKLGGRIAPSALHLSQVQKLLFGRIA
CCCCCHHHHHEECCCEEEEEECCCCHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
IWIFLQSLALLFNHQGI
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQTLFDQVFANGVLLVMWGALLFHLILPIPHAAHPTTLWHKFAELLASKVNNNHNYSQSL
CCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
ISGTLAWGLMVLPTLVILLALQPLVWQSQLFELALLLLAIDWRNNEKLANQLIKALGRED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCH
KAAARQLLAPIINRQTESLSSLGLGKAATETIIMGYARNVVCVLFWYAIGGGIAALMYRL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVELARAWSPSRKQFSPFGSTAIKIVAILEFIPMRFFALMIVCGDKATHTFKMMLVQSRS
HHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
WPLPGPAWLITAVGNKLELSLGGPAIYDNTKAIRAKLGGRIAPSALHLSQVQKLLFGRIA
CCCCCHHHHHEECCCEEEEEECCCCHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
IWIFLQSLALLFNHQGI
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA