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The map label for this gene is diaA [H]

Identifier: 218708474

GI number: 218708474

Start: 446974

End: 447564

Strand: Reverse

Name: diaA [H]

Synonym: VS_0437

Alternate gene names: 218708474

Gene position: 447564-446974 (Counterclockwise)

Preceding gene: 218708475

Following gene: 218708473

Centisome position: 13.57

GC content: 45.69

Gene sequence:

>591_bases
ATGCTAGACAGCATCAAAGAAAGTTTTACAGAAAGTATTCAAATCCAAATTGCGGCGGCAGAAGCTCTGCCAGACGCAAT
CACGCATGCCGCTCAAGCAATGGTTGCAACCCTGCTTAACGGAAACAAGATTCTTTGTTGTGGTAACGGTGGTTCGGCAT
CGAATGCTCAGCAATTTGTCTCTTGCCTACTTAATCGCTTTGAAACCGAGCGCCCTAGTCTTCCAGCAATGGCTCTCACT
GCTGATAACACCACACTAACGGCTGTGGCAAACGACTACCACTATGAAGAGATCTTCTCTAAGCAGGTACGTGCGTTTGG
TCAAACTGGTGATATTTTACTGGCTATATCTACTAGTGGTAACAGTAAAAATATCATCAAAGCAATGGAAGCTGCGGTAA
CACGTGATATGACAATCATCGCCTTTACTGGTAAAGATGGTGGTGAAATGGCTGGCCTGCTTGGTGAGCACGATGTAGAA
ATTCGTATTCCCTCACACCGTACAGCACGTATCCACGAAGTACACATGGTGACACTACACTGCTTATGTGACCTAATCGA
TCAAGTACTCTTCCCAGCTCACGAAGAGTGA

Upstream 100 bases:

>100_bases
TGTCGGTACACTCTACAGATTACAGGTTTGATATCATTGCCATCGAAGGGCCGAATGACACTATCGACTGGATTCAAAAC
GCGATTACCCAAGGATAAAC

Downstream 100 bases:

>100_bases
TATACGGAGCATCACGATGAAATCATTAACTTCTATGAAGCTGCTTAAGCTGATTAGTGTTTCGCTACTTACACTGTCGT
TATCTGGTTGTGCTGGTCTT

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MLDSIKESFTESIQIQIAAAEALPDAITHAAQAMVATLLNGNKILCCGNGGSASNAQQFVSCLLNRFETERPSLPAMALT
ADNTTLTAVANDYHYEEIFSKQVRAFGQTGDILLAISTSGNSKNIIKAMEAAVTRDMTIIAFTGKDGGEMAGLLGEHDVE
IRIPSHRTARIHEVHMVTLHCLCDLIDQVLFPAHEE

Sequences:

>Translated_196_residues
MLDSIKESFTESIQIQIAAAEALPDAITHAAQAMVATLLNGNKILCCGNGGSASNAQQFVSCLLNRFETERPSLPAMALT
ADNTTLTAVANDYHYEEIFSKQVRAFGQTGDILLAISTSGNSKNIIKAMEAAVTRDMTIIAFTGKDGGEMAGLLGEHDVE
IRIPSHRTARIHEVHMVTLHCLCDLIDQVLFPAHEE
>Mature_196_residues
MLDSIKESFTESIQIQIAAAEALPDAITHAAQAMVATLLNGNKILCCGNGGSASNAQQFVSCLLNRFETERPSLPAMALT
ADNTTLTAVANDYHYEEIFSKQVRAFGQTGDILLAISTSGNSKNIIKAMEAAVTRDMTIIAFTGKDGGEMAGLLGEHDVE
IRIPSHRTARIHEVHMVTLHCLCDLIDQVLFPAHEE

Specific function: Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein [H]

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1789539, Length=196, Percent_Identity=68.8775510204082, Blast_Score=291, Evalue=2e-80,
Organism=Escherichia coli, GI1786416, Length=164, Percent_Identity=45.1219512195122, Blast_Score=143, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023070
- InterPro:   IPR001347 [H]

Pfam domain/function: PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 21140; Mature: 21140

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSIKESFTESIQIQIAAAEALPDAITHAAQAMVATLLNGNKILCCGNGGSASNAQQFV
CCCHHHHHHHHHEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHH
SCLLNRFETERPSLPAMALTADNTTLTAVANDYHYEEIFSKQVRAFGQTGDILLAISTSG
HHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCC
NSKNIIKAMEAAVTRDMTIIAFTGKDGGEMAGLLGEHDVEIRIPSHRTARIHEVHMVTLH
CCHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
CLCDLIDQVLFPAHEE
HHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLDSIKESFTESIQIQIAAAEALPDAITHAAQAMVATLLNGNKILCCGNGGSASNAQQFV
CCCHHHHHHHHHEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHH
SCLLNRFETERPSLPAMALTADNTTLTAVANDYHYEEIFSKQVRAFGQTGDILLAISTSG
HHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCC
NSKNIIKAMEAAVTRDMTIIAFTGKDGGEMAGLLGEHDVEIRIPSHRTARIHEVHMVTLH
CCHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
CLCDLIDQVLFPAHEE
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]