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The map label for this gene is lysC [H]

Identifier: 218708357

GI number: 218708357

Start: 306534

End: 307901

Strand: Reverse

Name: lysC [H]

Synonym: VS_0316

Alternate gene names: 218708357

Gene position: 307901-306534 (Counterclockwise)

Preceding gene: 218708359

Following gene: 218708355

Centisome position: 9.33

GC content: 45.47

Gene sequence:

>1368_bases
GTGAGTGCATCTAATGTAGCTGGTTCTTTTAATGTCGCTAAGTTTGGTGGAACAAGTGTTGCCAACTTTGAAGCAATGAG
CCGTTGTGCTGCCATTATTGAAAACAACTCAAATACGAAACTGGTCGTGAGTAGCGCATGCTCTGGCGTGACTAACCTGC
TTGTTGAACTCGCGAATGGTGTTCAAGATAAAACTCGTCGCCAAAAACTAGTGACACAGTTAACCGACATTCATAATACG
ATTCTTGCTCAGCTAGCTGACCCAATTAACATTGAAAAAGATGTGCACTGTATTCTGGATGATATTGCGAGCGCTGCAGA
AGCGGCATCATTCCAAGCCAGTACCAAACTCACCGATCACCTAGTGGCATGTGGCGAACTGATGTCGACACATATTCTGA
CTCAGATCATTCGTGAACGTGGGACACCCGCTGTTCGTTTTGATATCAGAGAAGTGATGCGCACCAATGATGACTTCGGT
AAAGCAGAACCACAATTAAAAGATATTGCAGCTTTAGCACAGCAGAAATTGATTCCACTATGCCAACAGCAAGTTGTCGT
TACCCAAGGCTTTATCGGTGCCGATAGCGAAGGTAACACCACAACGTTAGGTCGTGGCGGCAGTGATTATTCTGCTGCAC
TAATTGCCGAATCAGTACAAGCGATTGGTTTAGAGATCTGGACTGATGTTCCAGGGATCTACACCACAGATCCACGTATC
GCATCGAAAGCATCTCCTATCCCAGAGATCAGCTTCAGTGAGGCATCTGAGATGGCAAACTTTGGCGCGAAAATATTACA
CCCTTCAACTCTGGTTCCTGCACTACGCCATCAAATCCCTGTTTTTGTCGGCTCATCAAAAGCACCAGAGCTTGGTGGAA
CATGGATTCGTCAACAAGTTGAAAGCTCTCCTCTGTTCAGAGCGCTTGCCCTACGCTGCAACCAAACCATGGTTACGCTA
CGCAGCGCTAACATGTTCCATGCCTATGGTTTTTTGGCAAAGGTATTCGAGATCCTGGCTAAACATAAGATCTCAGTCGA
TCTTATCACTACCTCAGAGATCAGTGTCTCACTGACTCTCGATCAAACCGATACCTCTGGTGGTGCTCCTGAGTTACCTG
AAGCCGCTCGCCTTGAGCTTGAAGAGTTGTGTTCCGTAGATATTGAGCACGACCTATGCCTTGTTGCTCTTATTGGTAAC
AACATGAGCGAAAGCAAAGGCTATGCAAAGCAGGTATTCGGCACTCTAGAAGATTTCAACCTACGTATGATTTGTTACGG
AGCAAGCCCACACAACCTATGCTTCTTACTAAATGAATCTGTGTCTAAGTTGGCAATTCAAAAACTTCATCAAGAGTTAT
TTGAGTAG

Upstream 100 bases:

>100_bases
ATAATTCCTCTCTTTTTTGCTCTAAAACTCTCTTCGAAAAACATCGGACGTTGGATTACCCAACAGTAATTTTATTTTAG
GAAATCGTGGGAGATATATC

Downstream 100 bases:

>100_bases
ATAATCCGTTTATCATCGACAGATAAATAACTAAATTACAGATACAAAAAGGGTTGCTATTAAGCAACCCTTTCTCTTTT
TTACGTTACGAATCAAAGCT

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSASNVAGSFNVAKFGGTSVANFEAMSRCAAIIENNSNTKLVVSSACSGVTNLLVELANGVQDKTRRQKLVTQLTDIHNT
ILAQLADPINIEKDVHCILDDIASAAEAASFQASTKLTDHLVACGELMSTHILTQIIRERGTPAVRFDIREVMRTNDDFG
KAEPQLKDIAALAQQKLIPLCQQQVVVTQGFIGADSEGNTTTLGRGGSDYSAALIAESVQAIGLEIWTDVPGIYTTDPRI
ASKASPIPEISFSEASEMANFGAKILHPSTLVPALRHQIPVFVGSSKAPELGGTWIRQQVESSPLFRALALRCNQTMVTL
RSANMFHAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDQTDTSGGAPELPEAARLELEELCSVDIEHDLCLVALIGN
NMSESKGYAKQVFGTLEDFNLRMICYGASPHNLCFLLNESVSKLAIQKLHQELFE

Sequences:

>Translated_455_residues
MSASNVAGSFNVAKFGGTSVANFEAMSRCAAIIENNSNTKLVVSSACSGVTNLLVELANGVQDKTRRQKLVTQLTDIHNT
ILAQLADPINIEKDVHCILDDIASAAEAASFQASTKLTDHLVACGELMSTHILTQIIRERGTPAVRFDIREVMRTNDDFG
KAEPQLKDIAALAQQKLIPLCQQQVVVTQGFIGADSEGNTTTLGRGGSDYSAALIAESVQAIGLEIWTDVPGIYTTDPRI
ASKASPIPEISFSEASEMANFGAKILHPSTLVPALRHQIPVFVGSSKAPELGGTWIRQQVESSPLFRALALRCNQTMVTL
RSANMFHAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDQTDTSGGAPELPEAARLELEELCSVDIEHDLCLVALIGN
NMSESKGYAKQVFGTLEDFNLRMICYGASPHNLCFLLNESVSKLAIQKLHQELFE
>Mature_454_residues
SASNVAGSFNVAKFGGTSVANFEAMSRCAAIIENNSNTKLVVSSACSGVTNLLVELANGVQDKTRRQKLVTQLTDIHNTI
LAQLADPINIEKDVHCILDDIASAAEAASFQASTKLTDHLVACGELMSTHILTQIIRERGTPAVRFDIREVMRTNDDFGK
AEPQLKDIAALAQQKLIPLCQQQVVVTQGFIGADSEGNTTTLGRGGSDYSAALIAESVQAIGLEIWTDVPGIYTTDPRIA
SKASPIPEISFSEASEMANFGAKILHPSTLVPALRHQIPVFVGSSKAPELGGTWIRQQVESSPLFRALALRCNQTMVTLR
SANMFHAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDQTDTSGGAPELPEAARLELEELCSVDIEHDLCLVALIGNN
MSESKGYAKQVFGTLEDFNLRMICYGASPHNLCFLLNESVSKLAIQKLHQELFE

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=445, Percent_Identity=55.7303370786517, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1786183, Length=470, Percent_Identity=28.936170212766, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1790376, Length=467, Percent_Identity=26.1241970021413, Blast_Score=122, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320893, Length=494, Percent_Identity=28.9473684210526, Blast_Score=168, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 49134; Mature: 49002

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASNVAGSFNVAKFGGTSVANFEAMSRCAAIIENNSNTKLVVSSACSGVTNLLVELANG
CCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHC
VQDKTRRQKLVTQLTDIHNTILAQLADPINIEKDVHCILDDIASAAEAASFQASTKLTDH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVACGELMSTHILTQIIRERGTPAVRFDIREVMRTNDDFGKAEPQLKDIAALAQQKLIPL
HHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
CQQQVVVTQGFIGADSEGNTTTLGRGGSDYSAALIAESVQAIGLEIWTDVPGIYTTDPRI
HHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCHHHCCCCCCCEECCCCH
ASKASPIPEISFSEASEMANFGAKILHPSTLVPALRHQIPVFVGSSKAPELGGTWIRQQV
HCCCCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHH
ESSPLFRALALRCNQTMVTLRSANMFHAYGFLAKVFEILAKHKISVDLITTSEISVSLTL
HCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEEE
DQTDTSGGAPELPEAARLELEELCSVDIEHDLCLVALIGNNMSESKGYAKQVFGTLEDFN
ECCCCCCCCCCCCHHHHCCHHHHHCCCCCCCEEEEEEECCCCHHHCHHHHHHHHHHHCCC
LRMICYGASPHNLCFLLNESVSKLAIQKLHQELFE
EEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SASNVAGSFNVAKFGGTSVANFEAMSRCAAIIENNSNTKLVVSSACSGVTNLLVELANG
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHC
VQDKTRRQKLVTQLTDIHNTILAQLADPINIEKDVHCILDDIASAAEAASFQASTKLTDH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVACGELMSTHILTQIIRERGTPAVRFDIREVMRTNDDFGKAEPQLKDIAALAQQKLIPL
HHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
CQQQVVVTQGFIGADSEGNTTTLGRGGSDYSAALIAESVQAIGLEIWTDVPGIYTTDPRI
HHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCHHHCCCCCCCEECCCCH
ASKASPIPEISFSEASEMANFGAKILHPSTLVPALRHQIPVFVGSSKAPELGGTWIRQQV
HCCCCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHH
ESSPLFRALALRCNQTMVTLRSANMFHAYGFLAKVFEILAKHKISVDLITTSEISVSLTL
HCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEEE
DQTDTSGGAPELPEAARLELEELCSVDIEHDLCLVALIGNNMSESKGYAKQVFGTLEDFN
ECCCCCCCCCCCCHHHHCCHHHHHCCCCCCCEEEEEEECCCCHHHCHHHHHHHHHHHCCC
LRMICYGASPHNLCFLLNESVSKLAIQKLHQELFE
EEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]