| Definition | Escherichia coli UMN026 chromosome, complete genome. |
|---|---|
| Accession | NC_011751 |
| Length | 5,202,090 |
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The map label for this gene is yvgN [H]
Identifier: 218703582
GI number: 218703582
Start: 362936
End: 363787
Strand: Reverse
Name: yvgN [H]
Synonym: ECUMN_0336
Alternate gene names: 218703582
Gene position: 363787-362936 (Counterclockwise)
Preceding gene: 218703584
Following gene: 218703581
Centisome position: 6.99
GC content: 50.59
Gene sequence:
>852_bases ATGCAAAAAGTAAAACTGAACAACGGTATTGAAATGCCCCTGTTGGGCTTTGGTGTATTTCAGATGACCGATGCCGCCGA ATGCGAAAGAGCGGTCATTGACGCTATTAACATCGGTTATCGACTGATTGACACCGCCGCCTCCTATCAAAATGAAACCC AGGTCGGGAACGCACTGAAACGAAGCGGTATCGCCCGTAACGAACTCTTTGTCACCACAAAACTCTGGTTGCAGGATACC AGTTACGAAGGGGCCAAAGCCCAGTTCGAACGCTCTCTGAATCGACTGCAACTTGATTACGTTGACCTGTATTTGATTCA CCAGCCATACGGCGATGTCCACGGAGCCTGGCGTGCCATGGAAGAGCTGCAACAGGCCGGTAAAATTCGCGCTATTGGCG TCAGTAACTTCCATCCTGACCGACTGGCAGACCTTATCGCTTTTAATAACGTCGTTCCGGCGGTAAACCAGGTTGAAGTT AACCCTTTCAATCAGCAGCTACAGGCCGTTCCCTGGATGCAAAGTCGTGGCATTCAGCCAGAAGCCTGGGCACCGTTTGC GGAAGGGAAAAATGGTCTGTTCCAGCATCCTGTTCTCACGGCAATTGGCGAGAAGTATGGCAAAAGCGTGGGCCAGGTTG TTCTGCGCTGGATCTACCAACGAGGCATTGTTTCACTGGCAAAATCAGTGCGAAAAGAACGCATGGAAGAGAACATCAAC ATTCTCGATTTTGAACTCAGCCCTGAAGATATGCTGCAAATTACCGCCCTGGATACCGCAACCAGCGCGTTCTTCTCTCA CCGCGATCCCGCAATGGTGGAATGGCTGACTGGCCGCAAACTTGATGTTTAA
Upstream 100 bases:
>100_bases TTTATGAATTTCGTTCATAACCCCTGACAAATCCTGCCGTCTAATCGAGCTCTTCCCTTTACGTTATGCTTCTCATGAAC GATAACGGAAGGATAACACC
Downstream 100 bases:
>100_bases GCCGCGATAAAAGAGGTATTCATTCAATGCAAAAACGTTATCTGGGTAAATCCGGACTCGAAGTCTCCGCCCTTGGGCTC GGTTGCATGGGCTTAAGCCA
Product: putative aldo-keto reductase
Products: NA
Alternate protein names: GR; Methylglyoxal reductase [H]
Number of amino acids: Translated: 283; Mature: 283
Protein sequence:
>283_residues MQKVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINIGYRLIDTAASYQNETQVGNALKRSGIARNELFVTTKLWLQDT SYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEV NPFNQQLQAVPWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENIN ILDFELSPEDMLQITALDTATSAFFSHRDPAMVEWLTGRKLDV
Sequences:
>Translated_283_residues MQKVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINIGYRLIDTAASYQNETQVGNALKRSGIARNELFVTTKLWLQDT SYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEV NPFNQQLQAVPWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENIN ILDFELSPEDMLQITALDTATSAFFSHRDPAMVEWLTGRKLDV >Mature_283_residues MQKVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINIGYRLIDTAASYQNETQVGNALKRSGIARNELFVTTKLWLQDT SYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAMEELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEV NPFNQQLQAVPWMQSRGIQPEAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENIN ILDFELSPEDMLQITALDTATSAFFSHRDPAMVEWLTGRKLDV
Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=289, Percent_Identity=35.2941176470588, Blast_Score=187, Evalue=8e-48, Organism=Homo sapiens, GI5174391, Length=289, Percent_Identity=35.2941176470588, Blast_Score=187, Evalue=8e-48, Organism=Homo sapiens, GI310109922, Length=276, Percent_Identity=37.3188405797101, Blast_Score=164, Evalue=1e-40, Organism=Homo sapiens, GI310109920, Length=297, Percent_Identity=35.3535353535354, Blast_Score=163, Evalue=2e-40, Organism=Homo sapiens, GI45446745, Length=297, Percent_Identity=35.3535353535354, Blast_Score=162, Evalue=2e-40, Organism=Homo sapiens, GI4503285, Length=297, Percent_Identity=35.3535353535354, Blast_Score=162, Evalue=2e-40, Organism=Homo sapiens, GI5453543, Length=296, Percent_Identity=34.4594594594595, Blast_Score=160, Evalue=1e-39, Organism=Homo sapiens, GI24497583, Length=304, Percent_Identity=33.8815789473684, Blast_Score=160, Evalue=2e-39, Organism=Homo sapiens, GI5174695, Length=296, Percent_Identity=32.0945945945946, Blast_Score=159, Evalue=4e-39, Organism=Homo sapiens, GI24497585, Length=299, Percent_Identity=33.7792642140468, Blast_Score=154, Evalue=7e-38, Organism=Homo sapiens, GI223468663, Length=290, Percent_Identity=32.4137931034483, Blast_Score=154, Evalue=7e-38, Organism=Homo sapiens, GI4502049, Length=304, Percent_Identity=34.5394736842105, Blast_Score=148, Evalue=5e-36, Organism=Homo sapiens, GI300116273, Length=279, Percent_Identity=30.8243727598566, Blast_Score=143, Evalue=2e-34, Organism=Homo sapiens, GI93277124, Length=296, Percent_Identity=29.7297297297297, Blast_Score=139, Evalue=3e-33, Organism=Homo sapiens, GI291291012, Length=281, Percent_Identity=30.9608540925267, Blast_Score=135, Evalue=5e-32, Organism=Homo sapiens, GI300116271, Length=273, Percent_Identity=31.5018315018315, Blast_Score=134, Evalue=1e-31, Organism=Homo sapiens, GI207028673, Length=115, Percent_Identity=47.8260869565217, Blast_Score=92, Evalue=7e-19, Organism=Homo sapiens, GI310109926, Length=115, Percent_Identity=47.8260869565217, Blast_Score=92, Evalue=7e-19, Organism=Homo sapiens, GI310109924, Length=151, Percent_Identity=31.1258278145695, Blast_Score=82, Evalue=6e-16, Organism=Escherichia coli, GI87082198, Length=258, Percent_Identity=42.6356589147287, Blast_Score=212, Evalue=2e-56, Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=34.1176470588235, Blast_Score=148, Evalue=4e-37, Organism=Escherichia coli, GI1788081, Length=267, Percent_Identity=29.2134831460674, Blast_Score=97, Evalue=9e-22, Organism=Escherichia coli, GI48994888, Length=241, Percent_Identity=28.2157676348548, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI87081735, Length=280, Percent_Identity=26.7857142857143, Blast_Score=68, Evalue=6e-13, Organism=Escherichia coli, GI1788070, Length=315, Percent_Identity=21.9047619047619, Blast_Score=63, Evalue=2e-11, Organism=Caenorhabditis elegans, GI71998625, Length=264, Percent_Identity=37.1212121212121, Blast_Score=175, Evalue=2e-44, Organism=Caenorhabditis elegans, GI17564128, Length=304, Percent_Identity=34.2105263157895, Blast_Score=168, Evalue=3e-42, Organism=Caenorhabditis elegans, GI17561298, Length=273, Percent_Identity=32.967032967033, Blast_Score=162, Evalue=1e-40, Organism=Caenorhabditis elegans, GI17537075, Length=292, Percent_Identity=33.2191780821918, Blast_Score=156, Evalue=1e-38, Organism=Caenorhabditis elegans, GI17537077, Length=292, Percent_Identity=32.5342465753425, Blast_Score=155, Evalue=2e-38, Organism=Caenorhabditis elegans, GI17550248, Length=284, Percent_Identity=33.8028169014084, Blast_Score=154, Evalue=5e-38, Organism=Caenorhabditis elegans, GI17537079, Length=294, Percent_Identity=30.6122448979592, Blast_Score=141, Evalue=3e-34, Organism=Caenorhabditis elegans, GI17566692, Length=276, Percent_Identity=33.695652173913, Blast_Score=140, Evalue=9e-34, Organism=Caenorhabditis elegans, GI17552492, Length=280, Percent_Identity=31.0714285714286, Blast_Score=139, Evalue=2e-33, Organism=Caenorhabditis elegans, GI17561300, Length=262, Percent_Identity=32.4427480916031, Blast_Score=135, Evalue=2e-32, Organism=Caenorhabditis elegans, GI17538386, Length=275, Percent_Identity=30.9090909090909, Blast_Score=130, Evalue=6e-31, Organism=Caenorhabditis elegans, GI17562292, Length=278, Percent_Identity=26.978417266187, Blast_Score=129, Evalue=1e-30, Organism=Saccharomyces cerevisiae, GI6324694, Length=282, Percent_Identity=39.0070921985816, Blast_Score=181, Evalue=1e-46, Organism=Saccharomyces cerevisiae, GI6320576, Length=285, Percent_Identity=37.5438596491228, Blast_Score=177, Evalue=1e-45, Organism=Saccharomyces cerevisiae, GI6321896, Length=325, Percent_Identity=31.0769230769231, Blast_Score=147, Evalue=2e-36, Organism=Saccharomyces cerevisiae, GI6322556, Length=262, Percent_Identity=33.206106870229, Blast_Score=145, Evalue=7e-36, Organism=Saccharomyces cerevisiae, GI6320079, Length=281, Percent_Identity=31.3167259786477, Blast_Score=129, Evalue=4e-31, Organism=Saccharomyces cerevisiae, GI6319625, Length=272, Percent_Identity=29.4117647058824, Blast_Score=108, Evalue=8e-25, Organism=Drosophila melanogaster, GI24657054, Length=278, Percent_Identity=37.0503597122302, Blast_Score=173, Evalue=1e-43, Organism=Drosophila melanogaster, GI24663317, Length=289, Percent_Identity=34.6020761245675, Blast_Score=172, Evalue=2e-43, Organism=Drosophila melanogaster, GI21356425, Length=310, Percent_Identity=33.5483870967742, Blast_Score=167, Evalue=8e-42, Organism=Drosophila melanogaster, GI45553081, Length=290, Percent_Identity=33.1034482758621, Blast_Score=164, Evalue=5e-41, Organism=Drosophila melanogaster, GI24644950, Length=298, Percent_Identity=34.5637583892617, Blast_Score=164, Evalue=6e-41, Organism=Drosophila melanogaster, GI20129731, Length=277, Percent_Identity=37.1841155234657, Blast_Score=164, Evalue=9e-41, Organism=Drosophila melanogaster, GI221378297, Length=318, Percent_Identity=32.3899371069182, Blast_Score=156, Evalue=1e-38, Organism=Drosophila melanogaster, GI24662789, Length=290, Percent_Identity=34.8275862068965, Blast_Score=155, Evalue=2e-38, Organism=Drosophila melanogaster, GI24662781, Length=278, Percent_Identity=32.7338129496403, Blast_Score=131, Evalue=6e-31, Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=30.859375, Blast_Score=130, Evalue=1e-30, Organism=Drosophila melanogaster, GI24662785, Length=279, Percent_Identity=32.258064516129, Blast_Score=128, Evalue=5e-30,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.283 [H]
Molecular weight: Translated: 31924; Mature: 31924
Theoretical pI: Translated: 5.70; Mature: 5.70
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQKVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINIGYRLIDTAASYQNETQVGNALK CCEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHH RSGIARNELFVTTKLWLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAM HCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHH EELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQP HHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCHHHCCCCC EAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENIN CCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC ILDFELSPEDMLQITALDTATSAFFSHRDPAMVEWLTGRKLDV EEEEECCHHHHEEEEEHHHHHHHHHHCCCCHHHHHHCCCCCCC >Mature Secondary Structure MQKVKLNNGIEMPLLGFGVFQMTDAAECERAVIDAINIGYRLIDTAASYQNETQVGNALK CCEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHH RSGIARNELFVTTKLWLQDTSYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHGAWRAM HCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHH EELQQAGKIRAIGVSNFHPDRLADLIAFNNVVPAVNQVEVNPFNQQLQAVPWMQSRGIQP HHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCHHHCCCCC EAWAPFAEGKNGLFQHPVLTAIGEKYGKSVGQVVLRWIYQRGIVSLAKSVRKERMEENIN CCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC ILDFELSPEDMLQITALDTATSAFFSHRDPAMVEWLTGRKLDV EEEEECCHHHHEEEEEHHHHHHHHHHCCCCHHHHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9639930; 9384377 [H]