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The map label for this gene is yccK [H]

Identifier: 218703581

GI number: 218703581

Start: 361920

End: 362909

Strand: Reverse

Name: yccK [H]

Synonym: ECUMN_0335

Alternate gene names: 218703581

Gene position: 362909-361920 (Counterclockwise)

Preceding gene: 218703582

Following gene: 218703578

Centisome position: 6.98

GC content: 51.41

Gene sequence:

>990_bases
ATGCAAAAACGTTATCTGGGTAAATCCGGACTCGAAGTCTCCGCCCTTGGGCTCGGTTGCATGGGCTTAAGCCACGGCTA
CGGCCCGGCGACCGATACCCGTCAGGCTATCGAACTTATTCGTGCTGCGGTTGAACGTGGCGTCACCTTCTTCGATACCG
CCGAAGTGTATGGTCCGTATCTGAATGAAGAAGTGGTCGGCGAAGCCTTAAAACCGTTTCGTGACCGCGTGGTAATTGCC
ACTAAATTCGGTTTTACCTTCGGCGATGATAATAAGCAGCAGATTTTAAACAGCCGTCCGGAACATATCCGTGAAGCCGT
TGAAGGATCATTACGTCGTCTGAAAACAGATGTTATTGACCTGCTGTATCAACACCGTGTTGATCCGGATGTTCCTATTG
AGGATGTTGCAGGAACGGTGAAAGACCTCATCGCAGAAGGTAAGGTCAAACATTTCGGCCTGTCGGAAGCGGGAGCACAA
ACCATTCGTCGTGCACATGCGGTACAACCTGTCACCGCCCTGCAAAGCGAATATTCCATGTGGTGGCGTGAGCCTGAACA
GGAAATTCTGCCGTTACTGGAGGAACTGGGAATTGGTTTTGTCCCCTTCAGCCCACTAGGTAAAGGTTTCCTGACAGGGG
CGATTAAGCCGGGAACCACTTTCGGCAAAGATGATTACCGCAGCACCGTACCGCGTTTCGCAGCACAAGCCATTGAAGCC
AATGAAAAACTGGTCACCTTGTTAGGTGAACTGGCTGCGGAGAAAGGGGTAACGTCTGCACAAATCGCACTGGCATGGCT
ATTAGCACAAAAGCCGTGGATTGTTCCCATCCCTGGCACCACTAAACTGAACCGGCTGGAAGAAAACCTGGCCGCTGCTG
ACATTGTTCTTTCGCAGAAAGATACGCAGCAGATAACCGAGGCGCTGGAAACAATTAAAATCGTCGGTGAACGTTACTCG
CCTGAACATCAGGCACGCGTAGGCCGCTAA

Upstream 100 bases:

>100_bases
CAACCAGCGCGTTCTTCTCTCACCGCGATCCCGCAATGGTGGAATGGCTGACTGGCCGCAAACTTGATGTTTAAGCCGCG
ATAAAAGAGGTATTCATTCA

Downstream 100 bases:

>100_bases
TACCCAAACGGGTCCAGGATAAAGGACCCGTTATTCGGTGTAGCGAAGCGCATCGATCAACAGCGCAAAAGCTGGCGGAT
GCTGCTTGCGGCTGGGGTAG

Product: putative aldo-keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQKRYLGKSGLEVSALGLGCMGLSHGYGPATDTRQAIELIRAAVERGVTFFDTAEVYGPYLNEEVVGEALKPFRDRVVIA
TKFGFTFGDDNKQQILNSRPEHIREAVEGSLRRLKTDVIDLLYQHRVDPDVPIEDVAGTVKDLIAEGKVKHFGLSEAGAQ
TIRRAHAVQPVTALQSEYSMWWREPEQEILPLLEELGIGFVPFSPLGKGFLTGAIKPGTTFGKDDYRSTVPRFAAQAIEA
NEKLVTLLGELAAEKGVTSAQIALAWLLAQKPWIVPIPGTTKLNRLEENLAAADIVLSQKDTQQITEALETIKIVGERYS
PEHQARVGR

Sequences:

>Translated_329_residues
MQKRYLGKSGLEVSALGLGCMGLSHGYGPATDTRQAIELIRAAVERGVTFFDTAEVYGPYLNEEVVGEALKPFRDRVVIA
TKFGFTFGDDNKQQILNSRPEHIREAVEGSLRRLKTDVIDLLYQHRVDPDVPIEDVAGTVKDLIAEGKVKHFGLSEAGAQ
TIRRAHAVQPVTALQSEYSMWWREPEQEILPLLEELGIGFVPFSPLGKGFLTGAIKPGTTFGKDDYRSTVPRFAAQAIEA
NEKLVTLLGELAAEKGVTSAQIALAWLLAQKPWIVPIPGTTKLNRLEENLAAADIVLSQKDTQQITEALETIKIVGERYS
PEHQARVGR
>Mature_329_residues
MQKRYLGKSGLEVSALGLGCMGLSHGYGPATDTRQAIELIRAAVERGVTFFDTAEVYGPYLNEEVVGEALKPFRDRVVIA
TKFGFTFGDDNKQQILNSRPEHIREAVEGSLRRLKTDVIDLLYQHRVDPDVPIEDVAGTVKDLIAEGKVKHFGLSEAGAQ
TIRRAHAVQPVTALQSEYSMWWREPEQEILPLLEELGIGFVPFSPLGKGFLTGAIKPGTTFGKDDYRSTVPRFAAQAIEA
NEKLVTLLGELAAEKGVTSAQIALAWLLAQKPWIVPIPGTTKLNRLEENLAAADIVLSQKDTQQITEALETIKIVGERYS
PEHQARVGR

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436971, Length=321, Percent_Identity=31.1526479750779, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI27436964, Length=326, Percent_Identity=29.4478527607362, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI27436969, Length=310, Percent_Identity=30.6451612903226, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI4504825, Length=307, Percent_Identity=30.6188925081433, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI27436966, Length=326, Percent_Identity=29.4478527607362, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI27436962, Length=326, Percent_Identity=29.4478527607362, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI223718702, Length=295, Percent_Identity=29.1525423728814, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI41152114, Length=293, Percent_Identity=28.6689419795222, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI41327764, Length=279, Percent_Identity=30.1075268817204, Blast_Score=78, Evalue=9e-15,
Organism=Escherichia coli, GI87081735, Length=335, Percent_Identity=33.4328358208955, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789375, Length=333, Percent_Identity=28.8288288288288, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787674, Length=297, Percent_Identity=31.3131313131313, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1788070, Length=331, Percent_Identity=32.9305135951662, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789199, Length=336, Percent_Identity=27.0833333333333, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788081, Length=312, Percent_Identity=24.3589743589744, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI48994888, Length=286, Percent_Identity=27.972027972028, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325169, Length=354, Percent_Identity=27.9661016949153, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6323998, Length=328, Percent_Identity=29.2682926829268, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6319958, Length=297, Percent_Identity=28.6195286195286, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6325384, Length=337, Percent_Identity=27.299703264095, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6319951, Length=314, Percent_Identity=27.3885350318471, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322615, Length=266, Percent_Identity=27.4436090225564, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321052, Length=156, Percent_Identity=32.6923076923077, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640980, Length=327, Percent_Identity=25.6880733944954, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45549126, Length=327, Percent_Identity=25.6880733944954, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646155, Length=313, Percent_Identity=27.1565495207668, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646159, Length=223, Percent_Identity=26.9058295964126, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 36215; Mature: 36215

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKRYLGKSGLEVSALGLGCMGLSHGYGPATDTRQAIELIRAAVERGVTFFDTAEVYGPY
CCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHCCC
LNEEVVGEALKPFRDRVVIATKFGFTFGDDNKQQILNSRPEHIREAVEGSLRRLKTDVID
CCHHHHHHHHHHHHCCEEEEEECCCEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LLYQHRVDPDVPIEDVAGTVKDLIAEGKVKHFGLSEAGAQTIRRAHAVQPVTALQSEYSM
HHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
WWREPEQEILPLLEELGIGFVPFSPLGKGFLTGAIKPGTTFGKDDYRSTVPRFAAQAIEA
HHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
NEKLVTLLGELAAEKGVTSAQIALAWLLAQKPWIVPIPGTTKLNRLEENLAAADIVLSQK
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCCH
DTQQITEALETIKIVGERYSPEHQARVGR
HHHHHHHHHHHHHHHHCCCCCHHHHCCCC
>Mature Secondary Structure
MQKRYLGKSGLEVSALGLGCMGLSHGYGPATDTRQAIELIRAAVERGVTFFDTAEVYGPY
CCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHCCC
LNEEVVGEALKPFRDRVVIATKFGFTFGDDNKQQILNSRPEHIREAVEGSLRRLKTDVID
CCHHHHHHHHHHHHCCEEEEEECCCEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LLYQHRVDPDVPIEDVAGTVKDLIAEGKVKHFGLSEAGAQTIRRAHAVQPVTALQSEYSM
HHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
WWREPEQEILPLLEELGIGFVPFSPLGKGFLTGAIKPGTTFGKDDYRSTVPRFAAQAIEA
HHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
NEKLVTLLGELAAEKGVTSAQIALAWLLAQKPWIVPIPGTTKLNRLEENLAAADIVLSQK
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCCH
DTQQITEALETIKIVGERYSPEHQARVGR
HHHHHHHHHHHHHHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9106203 [H]