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The map label for this gene is bisC

Identifier: 218697268

GI number: 218697268

Start: 4086038

End: 4088317

Strand: Reverse

Name: bisC

Synonym: EC55989_4007

Alternate gene names: 218697268

Gene position: 4088317-4086038 (Counterclockwise)

Preceding gene: 218697271

Following gene: 218697265

Centisome position: 79.31

GC content: 54.12

Gene sequence:

>2280_bases
ATGCTGGTTGAAACCGACGGCGAAACCGTGTTTAGCTCGCATGGCGCGTTAGCCACAGGAATGGAAAACTCCTTGCAGAG
CGCGGTTCGCGACCAGGTTCACAGCAATACACGGGTACGATTTCCAATGGTGCGCAAAGGCTTTCTTGCGTCACCGGAAA
ATCCGCAAGGCATTCGTGGGCAGGATGAATTTGTTCGCGTGAGTTGGGATGAGGCGCTGGATCTTATTCACCAACAACAT
AAACGCATTCGTGAGGCTTATGGTCCGGCATCGATTTTTGCTGGTTCCTACGGCTGGCGTTCAAACGGCGTGCTGCATAA
GGCCTCGACATTATTACAACGCTATATGGCGCTGGCAGGCGGTTATACCGGGCATCTGGGGGATTATTCGACCGGCGCGG
CACAGGCGATCATGCCGTATGTCGTGGGTGGTAGCGAAGTTTATCAACAGCAAACCAGTTGGCCGCTGGTGCTGGAACAT
AGCGATGTCGTGGTGTTGTGGAGTGCTAACCCACTCAATACGCTGAAAATTGCGTGGAATGCATCTGATGAGCAGGGGCT
TTCTTACTTTTCCGCACTGCGTGACAGCGGGAAAAAGCTGATCTGTATTGATCCAATGCGATCGGAAACCGTCGATTTCT
TTGGCGATAAAATGGAGTGGGTGGCACCGCACATGGGCACCGATGTTGCGCTGATGCTGGGGATCGCCCATACGCTGGTG
GAAAATGGTTGGCACGACGAAGCGTTTCTGACGCGTTGCACCACAGGTTATGCCGTCTTCGCCTCTTATTTGCTGGGCGA
GAGTGACGGAATAGCGAAAAACGCCGAATGGGCGGCAGAGATTTGTGGGGTTAACGCAGCGAAAATCCGCGAGCTGGCGG
CTCTTTTCCACCAAAACACGACCATGCTGATGGCTGGCTGGGGAATGCAGCGCCAACAGTTTGGTGAGCAAAAACACTGG
ATGATCGTCACGCTGGCGGCAATGTTGGGGCAAATCGGCACACCCGGCGGCGGTTTTGGTCTTTCTTATCATTTTGCCAA
TGGTGGTAACCCCACGCGGCGTTCTGCGGTGCTCTCTTCCATGCAGGGCAGCTTGCCGGGTGGCTGCGATGCGGTGGATA
AAATCCCTGTTGCCCGCATTGTTGAAGCACTGGAAAACCCTGGTGGCGCATATCAACACAACGGTATGAACCGACATTTC
CCGGATATTCGTTTTATCTGGTGGGCGGGCGGTGCCAACTTTACTCATCATCAGGATACCAATCGTCTGATCCGTGCCTG
GCAAAAACCGGAGCTGGTGGTGATCTCTGAATGCTTCTGGACGGCGGCGGCGAAACACGCGGATATCGTTCTGCCTGCGA
CTACCTCTTTTGAGCGTAATGATCTCACCATGACCGGTGATTACAGTAATCAGCATCTGGTGCCGATGAAGCAAGTGGTG
CCGCCACGCTATGAAGCGCGTAATGATTTTGATGTTTTTGCCGAGTTAAGTGAACGCTGGGAGAAGGGCGGTTATGCACG
TTTTACGGAAGGAAAAAGTGAGCTGCAATGGCTGGAAACGTTTTATAACGTTGCCCGGCAGCGCGGGGCAAGCCAGCAGG
TTGAATTGCCGCCATTTGCTGAGTTCTGGCAAGCCAACCAGTTAATTGAGATGCCGGAAAACCCGGACAGCGAGCGGTTT
ATTCGCTTCGCTGATTTTTGCCGCGATCCGCTGGCGCATCCGTTAAAAACCGCCAGCGGCAAGATTGAAATCTTCTCACA
GCGTATTGCCGATTACGGTTACCCGGATTGCCCTGGGCATCCAATGTGGCTGGAGCCGGACGAATGGCAGGGCAATGCCG
AACCAGAACAGTTGCAGGTACTTTCTGCCCATCCGGCGCACCGCCTGCACAGCCAGCTGAATTACAGTTCTCTGCGCGAA
TTGTACGCGGTAGCAAACCGTGAGCCTGTCACCATTCATCCTGACGATGCTCAGGCGCGCGGCATTCAAGATGGCGATAC
TGTTCGGCTGTGGAACGCACGCGGGCAAATTCTTGCCGGAGCGGTCATTAGCGAGGGAATTAAACCTGGCGTGATTTGTA
TTCACGAAGGGGCATGGCCGGATTTGGATTTAACCGCTGACGGTATTTGTAAAAACGGCGCAGTCAACGTGCTGACCAAA
GATCTCCCCAGCTCGCGGCTGGGGAATGGCTGTGCGGGTAATACGGCGCTGGCATGGCTGGAAAAATACAACGGTCCGGA
ACTGACACTTACAGCGTTTGAACCACCGGCCAGCTCATAA

Upstream 100 bases:

>100_bases
TAATATTTAACTGCTCAATACATCTAACCTTTCAGGAGTTTTCGGTTTGGCCAACTCATCCTCACGATATTCCGTTCTGA
CTGCCGCCCATTGGGGGCCC

Downstream 100 bases:

>100_bases
TCCAGGTGGGTAGTTGGGTTTCATCCTGCCATGCGCAATCGACAATGTGAAAACCCTGCGCACGGTAAAAATCTATCGCC
GGTTGATTTTTTTGATAAAC

Product: biotin sulfoxide reductase

Products: Biotin. [C]

Alternate protein names: BDS reductase; BSO reductase [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MLVETDGETVFSSHGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVRVSWDEALDLIHQQH
KRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEH
SDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
ENGWHDEAFLTRCTTGYAVFASYLLGESDGIAKNAEWAAEICGVNAAKIRELAALFHQNTTMLMAGWGMQRQQFGEQKHW
MIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRSAVLSSMQGSLPGGCDAVDKIPVARIVEALENPGGAYQHNGMNRHF
PDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
PPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWQANQLIEMPENPDSERF
IRFADFCRDPLAHPLKTASGKIEIFSQRIADYGYPDCPGHPMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRE
LYAVANREPVTIHPDDAQARGIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
DLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS

Sequences:

>Translated_759_residues
MLVETDGETVFSSHGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVRVSWDEALDLIHQQH
KRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEH
SDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
ENGWHDEAFLTRCTTGYAVFASYLLGESDGIAKNAEWAAEICGVNAAKIRELAALFHQNTTMLMAGWGMQRQQFGEQKHW
MIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRSAVLSSMQGSLPGGCDAVDKIPVARIVEALENPGGAYQHNGMNRHF
PDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
PPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWQANQLIEMPENPDSERF
IRFADFCRDPLAHPLKTASGKIEIFSQRIADYGYPDCPGHPMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRE
LYAVANREPVTIHPDDAQARGIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
DLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS
>Mature_759_residues
MLVETDGETVFSSHGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVRVSWDEALDLIHQQH
KRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEH
SDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
ENGWHDEAFLTRCTTGYAVFASYLLGESDGIAKNAEWAAEICGVNAAKIRELAALFHQNTTMLMAGWGMQRQQFGEQKHW
MIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRSAVLSSMQGSLPGGCDAVDKIPVARIVEALENPGGAYQHNGMNRHF
PDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
PPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWQANQLIEMPENPDSERF
IRFADFCRDPLAHPLKTASGKIEIFSQRIADYGYPDCPGHPMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRE
LYAVANREPVTIHPDDAQARGIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
DLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS

Specific function: This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI145693196, Length=759, Percent_Identity=99.2094861660079, Blast_Score=1571, Evalue=0.0,
Organism=Escherichia coli, GI87081994, Length=763, Percent_Identity=63.9580602883355, Blast_Score=1049, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=747, Percent_Identity=44.3105756358768, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI87081797, Length=757, Percent_Identity=31.8361955085865, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI1787870, Length=753, Percent_Identity=30.1460823373174, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI171474008, Length=777, Percent_Identity=29.98712998713, Blast_Score=276, Evalue=4e-75,
Organism=Escherichia coli, GI3868721, Length=473, Percent_Identity=23.2558139534884, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 83957; Mature: 83957

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVETDGETVFSSHGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRG
CEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCC
QDEFVRVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAG
CCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHC
GYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWN
CCCCCCCCCCCCHHHHHHHHEECCHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEEC
ASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
CCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHH
ENGWHDEAFLTRCTTGYAVFASYLLGESDGIAKNAEWAAEICGVNAAKIRELAALFHQNT
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCC
TMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRSAVLSS
EEEEECCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHH
MQGSLPGGCDAVDKIPVARIVEALENPGGAYQHNGMNRHFPDIRFIWWAGGANFTHHQDT
HCCCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHH
NRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
HHHHHHCCCCCEEEEEHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCHHHHC
PPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFA
CCCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
EFWQANQLIEMPENPDSERFIRFADFCRDPLAHPLKTASGKIEIFSQRIADYGYPDCPGH
HHHCCCCEEECCCCCCHHHHHHHHHHHCCHHHCHHHCCCCCHHHHHHHHHHCCCCCCCCC
PMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELYAVANREPVTIHPDDAQAR
CCCCCCCCCCCCCCHHHEEEECCCCHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCHHHC
GIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
CCCCCCEEEEECCCCCEEEHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEC
DLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS
CCCCHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MLVETDGETVFSSHGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRG
CEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCC
QDEFVRVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAG
CCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHC
GYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWN
CCCCCCCCCCCCHHHHHHHHEECCHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEEC
ASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLV
CCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHH
ENGWHDEAFLTRCTTGYAVFASYLLGESDGIAKNAEWAAEICGVNAAKIRELAALFHQNT
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCC
TMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRSAVLSS
EEEEECCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHH
MQGSLPGGCDAVDKIPVARIVEALENPGGAYQHNGMNRHFPDIRFIWWAGGANFTHHQDT
HCCCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHH
NRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVV
HHHHHHCCCCCEEEEEHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCHHHHC
PPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFA
CCCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
EFWQANQLIEMPENPDSERFIRFADFCRDPLAHPLKTASGKIEIFSQRIADYGYPDCPGH
HHHCCCCEEECCCCCCHHHHHHHHHHHCCHHHCHHHCCCCCHHHHHHHHHHCCCCCCCCC
PMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELYAVANREPVTIHPDDAQAR
CCCCCCCCCCCCCCHHHEEEECCCCHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCHHHC
GIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTK
CCCCCCEEEEECCCCCEEEHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEC
DLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS
CCCCHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), [C]

Specific reaction: Reduces A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), Back To Biotin. [C]

General reaction: Reduction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2180922; 8041620; 9278503 [H]