Click here to switch to the map view.

The map label for this gene is msrB

Identifier: 218695337

GI number: 218695337

Start: 2010446

End: 2010859

Strand: Reverse

Name: msrB

Synonym: EC55989_1947

Alternate gene names: 218695337

Gene position: 2010859-2010446 (Counterclockwise)

Preceding gene: 218695340

Following gene: 218695336

Centisome position: 39.01

GC content: 48.31

Gene sequence:

>414_bases
ATGGCTAATAAACCTTCGGCAGAAGAACTGAAAAAAAATTTGTCCGAGATGCAGTTTTACGTGACGCAGAATCATGGGAC
AGAGCCGCCATTTACGGGTCGTTTACTGCATAACAAGCGTGACGGCGTATATCACTGTTTGATCTGCGATGCCCCGCTGT
TTCATTCCCAAACCAAGTATGATTCCGGCTGTGGTTGGCCCAGTTTCTACGAACCGGTGAGTGAAGAATCCATTCGTTAT
ATCAAAGACTTGTCACATGGAATGCAGCGCATAGAAATTCGTTGCGGTAACTGTGATGCCCATCTGGGGCATGTCTTCCC
TGACGGGCCGCAGCCAACGGGCGAACGTTATTGTGTTAACTCTGCCTCTTTACGCTTTACCGATGGCGAAAACGGCGAAG
AAATCAACGGTTGA

Upstream 100 bases:

>100_bases
CGTCGAGATCAAGTTTAGGACAAAATTTTGCCAGTTGGTGTTAATGTTTTGTTAGAATCAGTCACGTAATGTGAGCACGA
TTAAAGTGAGATGTGAGCAA

Downstream 100 bases:

>100_bases
AAAAACGATTCAGCAACTTATTCCACAGGAGCGGAAAAATTATGAATCTTGATGACATTATCAACAGCATGACGCCTGAG
GTATACCAGCGTTTGTCGAC

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide-methionine (R)-S-oxide reductase

Number of amino acids: Translated: 137; Mature: 136

Protein sequence:

>137_residues
MANKPSAEELKKNLSEMQFYVTQNHGTEPPFTGRLLHNKRDGVYHCLICDAPLFHSQTKYDSGCGWPSFYEPVSEESIRY
IKDLSHGMQRIEIRCGNCDAHLGHVFPDGPQPTGERYCVNSASLRFTDGENGEEING

Sequences:

>Translated_137_residues
MANKPSAEELKKNLSEMQFYVTQNHGTEPPFTGRLLHNKRDGVYHCLICDAPLFHSQTKYDSGCGWPSFYEPVSEESIRY
IKDLSHGMQRIEIRCGNCDAHLGHVFPDGPQPTGERYCVNSASLRFTDGENGEEING
>Mature_136_residues
ANKPSAEELKKNLSEMQFYVTQNHGTEPPFTGRLLHNKRDGVYHCLICDAPLFHSQTKYDSGCGWPSFYEPVSEESIRYI
KDLSHGMQRIEIRCGNCDAHLGHVFPDGPQPTGERYCVNSASLRFTDGENGEEING

Specific function: Unknown

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrB Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI301336164, Length=132, Percent_Identity=50, Blast_Score=157, Evalue=4e-39,
Organism=Homo sapiens, GI301336162, Length=132, Percent_Identity=50, Blast_Score=157, Evalue=4e-39,
Organism=Homo sapiens, GI73089054, Length=132, Percent_Identity=50, Blast_Score=157, Evalue=4e-39,
Organism=Homo sapiens, GI37620216, Length=132, Percent_Identity=50, Blast_Score=156, Evalue=5e-39,
Organism=Homo sapiens, GI117606353, Length=128, Percent_Identity=53.125, Blast_Score=138, Evalue=2e-33,
Organism=Escherichia coli, GI1788077, Length=137, Percent_Identity=100, Blast_Score=291, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17553450, Length=120, Percent_Identity=49.1666666666667, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI115532676, Length=120, Percent_Identity=49.1666666666667, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319816, Length=132, Percent_Identity=43.1818181818182, Blast_Score=109, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24645799, Length=124, Percent_Identity=49.1935483870968, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45553335, Length=124, Percent_Identity=49.1935483870968, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21356369, Length=124, Percent_Identity=49.1935483870968, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI221378664, Length=121, Percent_Identity=50.4132231404959, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24645801, Length=135, Percent_Identity=45.1851851851852, Blast_Score=129, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24645804, Length=135, Percent_Identity=45.1851851851852, Blast_Score=129, Evalue=5e-31,
Organism=Drosophila melanogaster, GI221378662, Length=128, Percent_Identity=47.65625, Blast_Score=129, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRB_ECO24 (A7ZMP8)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001463077.1
- ProteinModelPortal:   A7ZMP8
- SMR:   A7ZMP8
- STRING:   A7ZMP8
- EnsemblBacteria:   EBESCT00000023297
- GeneID:   5588805
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_2002
- eggNOG:   COG0229
- GeneTree:   EBGT00050000011436
- HOGENOM:   HBG715255
- OMA:   EVRCNHC
- ProtClustDB:   PRK00222
- BioCyc:   ECOL331111:ECE24377A_2002-MONOMER
- HAMAP:   MF_01400
- InterPro:   IPR002579
- InterPro:   IPR011057
- Gene3D:   G3DSA:2.170.150.20
- TIGRFAMs:   TIGR00357

Pfam domain/function: PF01641 SelR; SSF51316 Mss4_like

EC number: =1.8.4.12

Molecular weight: Translated: 15451; Mature: 15320

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: ACT_SITE 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKPSAEELKKNLSEMQFYVTQNHGTEPPFTGRLLHNKRDGVYHCLICDAPLFHSQTKY
CCCCCCHHHHHHHHHHHEEEEECCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCCCCCC
DSGCGWPSFYEPVSEESIRYIKDLSHGMQRIEIRCGNCDAHLGHVFPDGPQPTGERYCVN
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCEEECC
SASLRFTDGENGEEING
CCEEEECCCCCCCCCCC
>Mature Secondary Structure 
ANKPSAEELKKNLSEMQFYVTQNHGTEPPFTGRLLHNKRDGVYHCLICDAPLFHSQTKY
CCCCCHHHHHHHHHHHEEEEECCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCCCCCC
DSGCGWPSFYEPVSEESIRYIKDLSHGMQRIEIRCGNCDAHLGHVFPDGPQPTGERYCVN
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCEEECC
SASLRFTDGENGEEING
CCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA