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The map label for this gene is sorE [H]

Identifier: 218692300

GI number: 218692300

Start: 4688196

End: 4689437

Strand: Reverse

Name: sorE [H]

Synonym: ECED1_4730

Alternate gene names: 218692300

Gene position: 4689437-4688196 (Counterclockwise)

Preceding gene: 218692301

Following gene: 218692299

Centisome position: 90.02

GC content: 53.06

Gene sequence:

>1242_bases
ATGAGGTGGTTTATGAAAACAACAGCTCTGCGTCTTTATGGCAAACGTGACCTGCGTCTGGAAACCTTTGACCTTCCTGA
AATGCAGGAGGATGAAATCCTCGCAACGGTGGTCACTGACAGCCTGTGCCTCTCTTCCTGGAAAGAGGCCAATCTGGGTG
AAAACCATAAAAAAGTACCCGACGATGTGGCGACCAATCCCATCATCATCGGCCACGAATTTTGCGGCGATATTCTGGCC
GTGGGTAAAAAGTGGCAGCACAAATTCCAGCCGGGTCAGCGTTATGTGATTCAGGCCAACCTGCAACTCCCCGACCGCCC
GGATTGCCCCGGCTACTCCTTCCCGTGGGTAGGCGGCGAAGCGACGCATGTGGTTATTCCCAACGAGGTCATGGAACAAG
ATTGCCTGCTGGCATACGACGGCGAAACCTATTTTGAAGGCTCGCTGGTTGAACCGCTTTCCTGCGTGATTGGCGCGTTC
AACGCCAACTATCATCTTCAGGAAGGTAGTTATAACCACACGATGGGGATTCGCCCGCAAGGGCGCACGCTGATCCTCGG
CGGCACCGGCCCGATGGGGCTGCTGGCGATTGATTATGCGCTACATGGACCCGTTAACCCTTCGCTGCTCGTCATTACCG
ATACCGACAACGACAAATTGAGTTATGCGCGCAAGCACTATCCATCAGAACCGCAAACACTGATTCATTATCTCAATGCC
ACCGATGCAGCATTTGATACGTTAATGGCACTGAGTGGCGGTCACGGCTTCGATGATATTTTCGTCTTTGTGCCTAATGA
AGGACTGGTGACTCTCGCCTTTTCCTTGCTGGCGACAGATGGTTGTCTGAATTTCTTCGCCGGACCGCAGGATAAGCACT
TCAGCGCGCCAATTAATTTCTACGATGTGCATTATGCATTTACCCACTACGTGGGCACATCAGGCGGCAATACCGACGAC
ATGCGCGCAGCGGTCAAATTGATTGAAGAGAAAAAAGTGCAGGCCGCAAAAGTGGTAACACATATTCTTGGGCTGAATGC
CGCGGGCGAAACCACGCTTGAATTGCCTGCCATCGGCGGCGGCAAAAAGCTGGTGTATACCGGGAAATACCTGCCGCTGA
CGTCACTCACGCAGATTCAGGATCAAGCACTGGCGGTGATTCTGGCGCATCATCAGGGGATCTGGTCCGGTGAGGCGGAG
CAATACCTGCTCGCCCATGCAGAGGCAATTTCCCATGATTAA

Upstream 100 bases:

>100_bases
GCTGATTTTCGCCCTGTTTGGTTTAGGGATTATCGGTAATGCGCTGGGCTTCCTGTCCTGATTCTTCGCCCCGGCGCAAC
CGTCGGGGCCATCGTTCAAC

Downstream 100 bases:

>100_bases
TCGCGCTACTTAACTCTGCATGTCGCTGGCTGGTCGCCGCGGCAACTTCGCGACCTGATGTGCGGCTGATTGCTGAAGCG
GCACAATGTGCACGAGAAGG

Product: L-sorbose 1-phosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MRWFMKTTALRLYGKRDLRLETFDLPEMQEDEILATVVTDSLCLSSWKEANLGENHKKVPDDVATNPIIIGHEFCGDILA
VGKKWQHKFQPGQRYVIQANLQLPDRPDCPGYSFPWVGGEATHVVIPNEVMEQDCLLAYDGETYFEGSLVEPLSCVIGAF
NANYHLQEGSYNHTMGIRPQGRTLILGGTGPMGLLAIDYALHGPVNPSLLVITDTDNDKLSYARKHYPSEPQTLIHYLNA
TDAAFDTLMALSGGHGFDDIFVFVPNEGLVTLAFSLLATDGCLNFFAGPQDKHFSAPINFYDVHYAFTHYVGTSGGNTDD
MRAAVKLIEEKKVQAAKVVTHILGLNAAGETTLELPAIGGGKKLVYTGKYLPLTSLTQIQDQALAVILAHHQGIWSGEAE
QYLLAHAEAISHD

Sequences:

>Translated_413_residues
MRWFMKTTALRLYGKRDLRLETFDLPEMQEDEILATVVTDSLCLSSWKEANLGENHKKVPDDVATNPIIIGHEFCGDILA
VGKKWQHKFQPGQRYVIQANLQLPDRPDCPGYSFPWVGGEATHVVIPNEVMEQDCLLAYDGETYFEGSLVEPLSCVIGAF
NANYHLQEGSYNHTMGIRPQGRTLILGGTGPMGLLAIDYALHGPVNPSLLVITDTDNDKLSYARKHYPSEPQTLIHYLNA
TDAAFDTLMALSGGHGFDDIFVFVPNEGLVTLAFSLLATDGCLNFFAGPQDKHFSAPINFYDVHYAFTHYVGTSGGNTDD
MRAAVKLIEEKKVQAAKVVTHILGLNAAGETTLELPAIGGGKKLVYTGKYLPLTSLTQIQDQALAVILAHHQGIWSGEAE
QYLLAHAEAISHD
>Mature_413_residues
MRWFMKTTALRLYGKRDLRLETFDLPEMQEDEILATVVTDSLCLSSWKEANLGENHKKVPDDVATNPIIIGHEFCGDILA
VGKKWQHKFQPGQRYVIQANLQLPDRPDCPGYSFPWVGGEATHVVIPNEVMEQDCLLAYDGETYFEGSLVEPLSCVIGAF
NANYHLQEGSYNHTMGIRPQGRTLILGGTGPMGLLAIDYALHGPVNPSLLVITDTDNDKLSYARKHYPSEPQTLIHYLNA
TDAAFDTLMALSGGHGFDDIFVFVPNEGLVTLAFSLLATDGCLNFFAGPQDKHFSAPINFYDVHYAFTHYVGTSGGNTDD
MRAAVKLIEEKKVQAAKVVTHILGLNAAGETTLELPAIGGGKKLVYTGKYLPLTSLTQIQDQALAVILAHHQGIWSGEAE
QYLLAHAEAISHD

Specific function: Reduces L-sorbose 1-phosphate to D-glucitol 6-phosphate [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994910, Length=416, Percent_Identity=45.4326923076923, Blast_Score=377, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17562876, Length=228, Percent_Identity=29.8245614035088, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 45403; Mature: 45403

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWFMKTTALRLYGKRDLRLETFDLPEMQEDEILATVVTDSLCLSSWKEANLGENHKKVP
CCCCHHHHEEHEECCCCCEEEECCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCC
DDVATNPIIIGHEFCGDILAVGKKWQHKFQPGQRYVIQANLQLPDRPDCPGYSFPWVGGE
HHHCCCCEEECHHHHHHHHHHCHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
ATHVVIPNEVMEQDCLLAYDGETYFEGSLVEPLSCVIGAFNANYHLQEGSYNHTMGIRPQ
EEEEECCHHHHCCCCEEEECCCCEECCCCCCHHHHHHHHCCCCEEEECCCCCCEECCCCC
GRTLILGGTGPMGLLAIDYALHGPVNPSLLVITDTDNDKLSYARKHYPSEPQTLIHYLNA
CCEEEEECCCCCEEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHCCCCCHHHHHHHHCC
TDAAFDTLMALSGGHGFDDIFVFVPNEGLVTLAFSLLATDGCLNFFAGPQDKHFSAPINF
CHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEE
YDVHYAFTHYVGTSGGNTDDMRAAVKLIEEKKVQAAKVVTHILGLNAAGETTLELPAIGG
EEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
GKKLVYTGKYLPLTSLTQIQDQALAVILAHHQGIWSGEAEQYLLAHAEAISHD
CCEEEEECCCCCCCHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRWFMKTTALRLYGKRDLRLETFDLPEMQEDEILATVVTDSLCLSSWKEANLGENHKKVP
CCCCHHHHEEHEECCCCCEEEECCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCC
DDVATNPIIIGHEFCGDILAVGKKWQHKFQPGQRYVIQANLQLPDRPDCPGYSFPWVGGE
HHHCCCCEEECHHHHHHHHHHCHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
ATHVVIPNEVMEQDCLLAYDGETYFEGSLVEPLSCVIGAFNANYHLQEGSYNHTMGIRPQ
EEEEECCHHHHCCCCEEEECCCCEECCCCCCHHHHHHHHCCCCEEEECCCCCCEECCCCC
GRTLILGGTGPMGLLAIDYALHGPVNPSLLVITDTDNDKLSYARKHYPSEPQTLIHYLNA
CCEEEEECCCCCEEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHCCCCCHHHHHHHHCC
TDAAFDTLMALSGGHGFDDIFVFVPNEGLVTLAFSLLATDGCLNFFAGPQDKHFSAPINF
CHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEE
YDVHYAFTHYVGTSGGNTDDMRAAVKLIEEKKVQAAKVVTHILGLNAAGETTLELPAIGG
EEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
GKKLVYTGKYLPLTSLTQIQDQALAVILAHHQGIWSGEAEQYLLAHAEAISHD
CCEEEEECCCCCCCHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7947968; 7652212 [H]