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The map label for this gene is pepE [H]

Identifier: 218692299

GI number: 218692299

Start: 4687125

End: 4687814

Strand: Reverse

Name: pepE [H]

Synonym: ECED1_4729

Alternate gene names: 218692299

Gene position: 4687814-4687125 (Counterclockwise)

Preceding gene: 218692300

Following gene: 218692294

Centisome position: 89.99

GC content: 54.49

Gene sequence:

>690_bases
ATGGAACTGCTTTTATTGAGTAACTCGACGCTGCCGGGTAAAGCCTGGCTGGAACACGCGCTGCCGCTGATTGCTGAACA
GTTGCAGGGTCGCCGTTCTGCGGTATTTATTCCTTTCGCTGGCGTAACGCAGACCTGGGATGATTACACAGCGAAAACGG
CTGCGGTTCTCGCTCCGCTGGGTGTTTCTGTCACCGGTATTCATAGCGTTGTCGATCCCGTTGCCGCGATTGAAAATGCG
GAAATTGTGATTGTCGGCGGCGGTAATACTTTCCAGTTGCTGAAACAGTGCCGCGAGCGCGGGCTGCTGGCACCAATTAC
TGACGTGGTGAAACGTGGCGCGCTGTATATTGGCTGGAGCGCAGGCGCTAACCTTGCTTGCCCAACCATTCGTACCACCA
ACGATATGCCGATTGTCGATCCGCAAGGTTTCGATGCGCTAAATCTGTTCCCGCTACAAATCAACCCGCACTTCACCAAC
GCGCTGCCGGAAGGCCATAAAGGTGAAACCCGTGAGCAGCGTATTCGCGAACTGCTGGTCGTCGCGCCAGAACTGACGAT
TATTGGTCTGCCGGAAGGTAACTGGATCACAGTAAGTAAAGGTCACGCTACGCTGGGTGGCCCGAACACCACTTATGTGT
TTAAGGCTGGTGAAGAAGCGGTGCCGCTGGAAGTGGGTCACCGTTTTTAA

Upstream 100 bases:

>100_bases
CAGCGCCTGTGCAATATGTGACATCGTGAGCCATGTCAGTAAGTGGTTAAATTCGCAGTGGTAGCATTCCTTCCGTGTTT
TCTTACTAACCGGAGAAGTA

Downstream 100 bases:

>100_bases
GTGAATTGCCGGATGCATGATCCGGCATCTTGTTCATAGTGCCTGATGCGACGCTTTACGCGTCTTATCAGGCCTTCAGG
GTCACGATATTAATACTCGT

Product: peptidase E

Products: NA

Alternate protein names: Alpha-aspartyl dipeptidase; Asp-specific dipeptidase; Dipeptidase E [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MELLLLSNSTLPGKAWLEHALPLIAEQLQGRRSAVFIPFAGVTQTWDDYTAKTAAVLAPLGVSVTGIHSVVDPVAAIENA
EIVIVGGGNTFQLLKQCRERGLLAPITDVVKRGALYIGWSAGANLACPTIRTTNDMPIVDPQGFDALNLFPLQINPHFTN
ALPEGHKGETREQRIRELLVVAPELTIIGLPEGNWITVSKGHATLGGPNTTYVFKAGEEAVPLEVGHRF

Sequences:

>Translated_229_residues
MELLLLSNSTLPGKAWLEHALPLIAEQLQGRRSAVFIPFAGVTQTWDDYTAKTAAVLAPLGVSVTGIHSVVDPVAAIENA
EIVIVGGGNTFQLLKQCRERGLLAPITDVVKRGALYIGWSAGANLACPTIRTTNDMPIVDPQGFDALNLFPLQINPHFTN
ALPEGHKGETREQRIRELLVVAPELTIIGLPEGNWITVSKGHATLGGPNTTYVFKAGEEAVPLEVGHRF
>Mature_229_residues
MELLLLSNSTLPGKAWLEHALPLIAEQLQGRRSAVFIPFAGVTQTWDDYTAKTAAVLAPLGVSVTGIHSVVDPVAAIENA
EIVIVGGGNTFQLLKQCRERGLLAPITDVVKRGALYIGWSAGANLACPTIRTTNDMPIVDPQGFDALNLFPLQINPHFTN
ALPEGHKGETREQRIRELLVVAPELTIIGLPEGNWITVSKGHATLGGPNTTYVFKAGEEAVPLEVGHRF

Specific function: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids [H]

COG id: COG3340

COG function: function code E; Peptidase E

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S51 family [H]

Homologues:

Organism=Escherichia coli, GI1790452, Length=229, Percent_Identity=99.5633187772926, Blast_Score=463, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24641669, Length=220, Percent_Identity=40.4545454545455, Blast_Score=144, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005320
- InterPro:   IPR023172 [H]

Pfam domain/function: PF03575 Peptidase_S51 [H]

EC number: =3.4.13.21 [H]

Molecular weight: Translated: 24599; Mature: 24599

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLLLSNSTLPGKAWLEHALPLIAEQLQGRRSAVFIPFAGVTQTWDDYTAKTAAVLAPL
CEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCC
GVSVTGIHSVVDPVAAIENAEIVIVGGGNTFQLLKQCRERGLLAPITDVVKRGALYIGWS
CCEEHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEC
AGANLACPTIRTTNDMPIVDPQGFDALNLFPLQINPHFTNALPEGHKGETREQRIRELLV
CCCCEECCEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHE
VAPELTIIGLPEGNWITVSKGHATLGGPNTTYVFKAGEEAVPLEVGHRF
ECCCEEEEECCCCCEEEEECCCEEECCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MELLLLSNSTLPGKAWLEHALPLIAEQLQGRRSAVFIPFAGVTQTWDDYTAKTAAVLAPL
CEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCC
GVSVTGIHSVVDPVAAIENAEIVIVGGGNTFQLLKQCRERGLLAPITDVVKRGALYIGWS
CCEEHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEC
AGANLACPTIRTTNDMPIVDPQGFDALNLFPLQINPHFTNALPEGHKGETREQRIRELLV
CCCCEECCEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHE
VAPELTIIGLPEGNWITVSKGHATLGGPNTTYVFKAGEEAVPLEVGHRF
ECCCEEEEECCCCCEEEEECCCEEECCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA