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The map label for this gene is tadA [H]

Identifier: 218690674

GI number: 218690674

Start: 2954380

End: 2954916

Strand: Reverse

Name: tadA [H]

Synonym: ECED1_2987

Alternate gene names: 218690674

Gene position: 2954916-2954380 (Counterclockwise)

Preceding gene: 218690675

Following gene: 218690672

Centisome position: 56.72

GC content: 52.89

Gene sequence:

>537_bases
ATGCGCCGCGCTTTTATAACCGGAGTTTTCTTTTTGTCTGAAGTCGAATTTAGCCACGAATACTGGATGCGTCATGCAAT
GACGCTGGCGAAGCGTGCCTGGGATGAGCGGGAAGTACCGGTCGGCGCGGTATTAGTGCATAACAATCGTGTTATTGGCG
AAGGCTGGAACCGTCCGATTGGTCGACATGATCCCACCGCACATGCAGAAATCATGGCTCTGCGGCAGGGCGGTCTGGTG
ATGCAAAATTATCGTCTGATCGACGCCACGTTGTATGTCACGCTTGAACCCTGTGTAATGTGTGCCGGAGCGATGATCCA
CAGTCGCATTGGTCGCGTGGTCTTTGGTGCGCGTGACGCGAAAACTGGCGCTGCGGGATCTTTAATGGATGTGCTACATC
ATCCGGGTATGAATCACCGGGTGGAAATTACGGAAGGAATACTGGCGGATGAGTGCGCGGCGTTGCTCAGTGACTTCTTT
CGCATGCGCCGCCAGGAAATTAAAGCGCAGAAAAAAGCCCAATCCTCGACAGATTAA

Upstream 100 bases:

>100_bases
GGACAACCCGCTGCTTTATTTCTGTCAGCATCGTTGGCGAGTAACTCCGCGCGGTGAACTCCAGCAACTGGAATAGAGTA
AAGCATAGCGTCCGTGTATA

Downstream 100 bases:

>100_bases
TTTTGTTTCTCTTCACTCCCTTTTCTGGAAAACAGCAGAGAGGGAGTGTGGGTCAAATAGTTTGATGACGACTGGGAAAG
AAACGAGAGAAAAGGAAATT

Product: tRNA-specific adenosine deaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MRRAFITGVFFLSEVEFSHEYWMRHAMTLAKRAWDEREVPVGAVLVHNNRVIGEGWNRPIGRHDPTAHAEIMALRQGGLV
MQNYRLIDATLYVTLEPCVMCAGAMIHSRIGRVVFGARDAKTGAAGSLMDVLHHPGMNHRVEITEGILADECAALLSDFF
RMRRQEIKAQKKAQSSTD

Sequences:

>Translated_178_residues
MRRAFITGVFFLSEVEFSHEYWMRHAMTLAKRAWDEREVPVGAVLVHNNRVIGEGWNRPIGRHDPTAHAEIMALRQGGLV
MQNYRLIDATLYVTLEPCVMCAGAMIHSRIGRVVFGARDAKTGAAGSLMDVLHHPGMNHRVEITEGILADECAALLSDFF
RMRRQEIKAQKKAQSSTD
>Mature_178_residues
MRRAFITGVFFLSEVEFSHEYWMRHAMTLAKRAWDEREVPVGAVLVHNNRVIGEGWNRPIGRHDPTAHAEIMALRQGGLV
MQNYRLIDATLYVTLEPCVMCAGAMIHSRIGRVVFGARDAKTGAAGSLMDVLHHPGMNHRVEITEGILADECAALLSDFF
RMRRQEIKAQKKAQSSTD

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=151, Percent_Identity=34.4370860927152, Blast_Score=94, Evalue=6e-20,
Organism=Escherichia coli, GI145693172, Length=167, Percent_Identity=98.8023952095808, Blast_Score=346, Evalue=6e-97,
Organism=Escherichia coli, GI1786616, Length=168, Percent_Identity=32.1428571428571, Blast_Score=64, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17541138, Length=155, Percent_Identity=38.0645161290323, Blast_Score=93, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17554608, Length=97, Percent_Identity=38.1443298969072, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322425, Length=167, Percent_Identity=34.1317365269461, Blast_Score=83, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355527, Length=160, Percent_Identity=33.125, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: NA

Molecular weight: Translated: 20044; Mature: 20044

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRAFITGVFFLSEVEFSHEYWMRHAMTLAKRAWDEREVPVGAVLVHNNRVIGEGWNRPI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEECCCCCCCC
GRHDPTAHAEIMALRQGGLVMQNYRLIDATLYVTLEPCVMCAGAMIHSRIGRVVFGARDA
CCCCCCCHHHHHHHHCCCEEEECCEEEEEEEEEEECHHHHHHHHHHHHHHHHHEECCCCC
KTGAAGSLMDVLHHPGMNHRVEITEGILADECAALLSDFFRMRRQEIKAQKKAQSSTD
CCCCCHHHHHHHHCCCCCCEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRRAFITGVFFLSEVEFSHEYWMRHAMTLAKRAWDEREVPVGAVLVHNNRVIGEGWNRPI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEEECCCCCCCC
GRHDPTAHAEIMALRQGGLVMQNYRLIDATLYVTLEPCVMCAGAMIHSRIGRVVFGARDA
CCCCCCCHHHHHHHHCCCEEEECCEEEEEEEEEEECHHHHHHHHHHHHHHHHHEECCCCC
KTGAAGSLMDVLHHPGMNHRVEITEGILADECAALLSDFFRMRRQEIKAQKKAQSSTD
CCCCCHHHHHHHHCCCCCCEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]