Click here to switch to the map view.

The map label for this gene is mdtD [H]

Identifier: 218690135

GI number: 218690135

Start: 2370489

End: 2371904

Strand: Direct

Name: mdtD [H]

Synonym: ECED1_2423

Alternate gene names: 218690135

Gene position: 2370489-2371904 (Clockwise)

Preceding gene: 218690134

Following gene: 218690136

Centisome position: 45.5

GC content: 56.0

Gene sequence:

>1416_bases
ATGACAGATCTTCCCGACAGCACCCGCTGGCAATTGTGGATTGTGGCTTTCGGCTTCTTTATGCAGTCGCTGGACACCAC
CATCGTTAACACCGCGCTTCCCTCAATGGCGCAAAGCCTCGGGGAAAGTCCGTTGCATATGCACATGGTCATTGTCTCTT
ATGTACTGACCGTGGCGGTGATGCTGCCCGCCAGCGGCTGGCTGGCGGACAAAGTCGGCGTGCGCAATATTTTCTTTACC
GCCATCGTGCTGTTTACTCTCGGTTCACTGTTTTGCGCGCTTTCCGGCACGCTGAACGAACTGTTGCTGGCACGCGCGTT
ACAGGGCGTTGGCGGCGCGATGATGGTGCCGGTCGGCAGGTTGACGGTGATGAAAATCGTACCGCGCGAGCAATATATGG
CGGCGATGACCTTTGTCACGCTGCCCGGTCAGATCGGGCCGCTGCTTGGCCCGGCGCTCGGCGGTCTGCTGGTGGAGTAC
GCATCGTGGCACTGGATCTTTTTGATCAACATTCCGGTGGGGATTATTGGCGCGATCGCCACACTGATGTTAATGCCGAA
CTACACCATGCAGACGCGGCGCTTTGATCTCTCCGGCTTTCTGTTGCTGGCGGTTGGCATGGCGGTCTTAACCCTGGCGC
TGGACGGCAGTAAAGGTACAGGTTTCTCGCCGCTGGCGATTGCTGGCCTGGTCGCAGTTGGCGTGGTAGCACTGGTGCTT
TATCTGCTGCACGCCCAAAATAACAACCGCGCCCTGTTCAGTCTGAAACTGTTCCGCACTCGTACCTTTTCGCTGGGCCT
GGCGGGGAGCTTTGCCGGACGTATTGGCAGTGGCATGTTGCCCTTTATGACACCGGTTTTCCTGCAAATTGGTCTCGGTT
TCTCGCCGTTTCATGCCGGACTGATGATGATCCCGATGGTACTCGGCAGCATGGGAATGAAGCGAATTGTGGTACAGGTA
GTGAATCGCTTTGGTTATCGTTGGGTACTGGTGGCGACCACGCTGGGCCTGTCGCTGGTCACCCTGTTGTTTATGACTAC
CGCTCTGCTGGGCTGGTACTACGTTTTGCCGTTCGTCCTGTTTTTACAAGGAATGGTCAACTCGACGCGTTTCTCCTCCA
TGAACACCCTGACGCTGAAAGATCTCCCGGACAACCTGGCGAGCAGCGGCAACAGTTTACTGTCGATGATTATGCAATTG
TCGATGAGTATTGGCGTCACCATCGCCGGGCTGTTGCTGGGGCTTTTTGGTTCGCAGCATGTCAGCGTCGACAGCGGCAC
CACACAAACCGTCTTTATGTACACCTGGCTTAGCATGGCGTTTATCATCGCCCTTCCGGCGTTTGTCTTTGCCAGAGTGC
CGAGCGATACGCATCAAAATGTGGCTATTTCACGGCGAAAAAGGAGCGCGCAATGA

Upstream 100 bases:

>100_bases
CCAGCTTCTGACGCTGTATACCACGCCGGTGGTGTATCTCTTTTTCGACCGTCTGCGACTGCGTTTTTCGCGTAAACCTA
AACAAGCGGTAACCGAGTAA

Downstream 100 bases:

>100_bases
AGTTCTGGCGACCCGGTATTACCGGCAAACTGTTTCTGGCGATTTTCGCCACCTGCATTGTCTTATTGATCACGATGCAC
TGGGCGGTACGTATCAGTTT

Product: multidrug efflux system protein MdtE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADKVGVRNIFFT
AIVLFTLGSLFCALSGTLNELLLARALQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQIGPLLGPALGGLLVEY
ASWHWIFLINIPVGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGFSPLAIAGLVAVGVVALVL
YLLHAQNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQV
VNRFGYRWVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQL
SMSIGVTIAGLLLGLFGSQHVSVDSGTTQTVFMYTWLSMAFIIALPAFVFARVPSDTHQNVAISRRKRSAQ

Sequences:

>Translated_471_residues
MTDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADKVGVRNIFFT
AIVLFTLGSLFCALSGTLNELLLARALQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQIGPLLGPALGGLLVEY
ASWHWIFLINIPVGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGFSPLAIAGLVAVGVVALVL
YLLHAQNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQV
VNRFGYRWVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQL
SMSIGVTIAGLLLGLFGSQHVSVDSGTTQTVFMYTWLSMAFIIALPAFVFARVPSDTHQNVAISRRKRSAQ
>Mature_470_residues
TDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADKVGVRNIFFTA
IVLFTLGSLFCALSGTLNELLLARALQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQIGPLLGPALGGLLVEYA
SWHWIFLINIPVGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGFSPLAIAGLVAVGVVALVLY
LLHAQNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVV
NRFGYRWVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLS
MSIGVTIAGLLLGLFGSQHVSVDSGTTQTVFMYTWLSMAFIIALPAFVFARVPSDTHQNVAISRRKRSAQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1788392, Length=471, Percent_Identity=98.0891719745223, Blast_Score=914, Evalue=0.0,
Organism=Escherichia coli, GI1790195, Length=464, Percent_Identity=46.1206896551724, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1789042, Length=404, Percent_Identity=28.960396039604, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1788710, Length=430, Percent_Identity=29.0697674418605, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081983, Length=428, Percent_Identity=28.9719626168224, Blast_Score=128, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6319770, Length=283, Percent_Identity=28.2685512367491, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323735, Length=314, Percent_Identity=26.4331210191083, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322958, Length=174, Percent_Identity=25.8620689655172, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325455, Length=126, Percent_Identity=31.7460317460317, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=28, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50933; Mature: 50802

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MLPASGWLADKVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARALQGVGGAMMVPVGR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
LTVMKIVPREQYMAAMTFVTLPGQIGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIA
HHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHH
TLMLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGFSPLAIAGLVAVGVVALVL
HHHHCCCCCHHHHEECCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
YLLHAQNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAG
HHHHCCCCCCEEEEEEEHHHHHHEEECCHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHH
LMMIPMVLGSMGMKRIVVQVVNRFGYRWVLVATTLGLSLVTLLFMTTALLGWYYVLPFVL
HHHHHHHHHHCCHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFGSQH
HHHHHHCCHHCCCCCEEEEHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSVDSGTTQTVFMYTWLSMAFIIALPAFVFARVPSDTHQNVAISRRKRSAQ
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
TDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MLPASGWLADKVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARALQGVGGAMMVPVGR
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
LTVMKIVPREQYMAAMTFVTLPGQIGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIA
HHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHH
TLMLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGFSPLAIAGLVAVGVVALVL
HHHHCCCCCHHHHEECCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
YLLHAQNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAG
HHHHCCCCCCEEEEEEEHHHHHHEEECCHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHH
LMMIPMVLGSMGMKRIVVQVVNRFGYRWVLVATTLGLSLVTLLFMTTALLGWYYVLPFVL
HHHHHHHHHHCCHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFGSQH
HHHHHHCCHHCCCCCEEEEHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSVDSGTTQTVFMYTWLSMAFIIALPAFVFARVPSDTHQNVAISRRKRSAQ
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA