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The map label for this gene is nhaB [H]

Identifier: 218689129

GI number: 218689129

Start: 1313007

End: 1314548

Strand: Reverse

Name: nhaB [H]

Synonym: ECED1_1328

Alternate gene names: 218689129

Gene position: 1314548-1313007 (Counterclockwise)

Preceding gene: 218689131

Following gene: 218689128

Centisome position: 25.23

GC content: 51.88

Gene sequence:

>1542_bases
ATGGAGATCTCCTGGGGCCGCGCACTATGGCGCAATTTTTTGGGCCAGTCCCCCGACTGGTACAAACTCGCCCTCATCAT
TTTCTTAATCGTAAATCCGTTAATTTTCCTCATCAGCCCTTTCGTCGCTGGCTGGTTGCTGGTAGCGGAATTTATTTTCA
CTCTGGCGATGGCCCTGAAATGCTACCCGCTGCTCCCCGGTGGTCTGTTGGCTATCGAAGCGGTATTCATCGGCATGACC
AGCGCGGAACATGTTCGTGAAGAAGTGGCGGCAAATCTTGAAGTCTTGCTGTTACTGATGTTTATGGTGGCGGGTATCTA
TTTTATGAAACAGCTGTTGTTGTTCATATTTACCCGTTTGCTGTTAAGTATTCGCTCCAAAATGCTGCTGTCGCTCTCTT
TTTGCGTGGCGGCGGCGTTCCTCTCCGCGTTCCTCGATGCCTTAACCGTCGTGGCGGTGGTGATCAGCGTTGCAGTCGGT
TTTTATGGTATTTATCACCGCGTAGCCTCTTCCCGTACTGAAGATACCGACCTGCAAGACGATAGTCATATCGACAAGCA
TTACAAAGTGGTTCTGGAACAGTTCCGTGGCTTTCTGCGTAGTCTGATGATGCATGCCGGTGTCGGCACCGCATTAGGCG
GCGTGATGACCATGGTGGGCGAACCACAAAACCTGATCATCGCTAAAGCGGCTGGCTGGCATTTTGGCGATTTCTTCCTG
CGCATGTCGCCGGTGACCGTCCCGGTTCTGATTTGTGGCCTGTTAACCTGCCTGCTGGTAGAGAAGCTGCGTTGGTTTGG
CTACGGTGAAACGCTGCCGGAGAAAGTCCGCGAAGTGCTGCAACAGTTTGACGATCAAAGCCGTCTCCAGCGTACACGTC
AGGACAAAATTCGTCTGATTGTGCAGGCGATTATCGGCGTCTGGCTGGTCACCGCGCTGGCACTACATCTGGCAGAAGTC
GGTTTGATTGGTTTGTCGGTCATTATTCTGGCGACATCATTGACCGGTGTTACCGATGAACATGCTATCGGTAAAGCCTT
CACCGAATCTCTGCCATTCACCGCACTGTTGACGGTGTTTTTCTCAGTAGTCGCGGTGATTATCGACCAACAACTGTTTT
CGCCGATTATTCAGTTTGTGTTGCAGGCATCTGAACATGCTCAGCTGTCGTTGTTCTATATTTTCAACGGTCTGCTGTCA
TCCATTTCGGATAACGTCTTCGTGGGGACGATTTATATCAACGAAGCGAAAGCGGCAATGAAAAGTGGCGCTATCACGTT
GAAGCAATATGAGCTGCTGGCGGTCGCCATTAATACCGGTACCAATCTGCCCTCCGTCGCTACGCCGAACGGTCAGGCTG
CGTTCCTGTTCCTGCTGACCTCTGCACTCGCGCCATTGATTCGTCTCTCTTATGGCCGCATGGTGTGGATGGCCCTGCCT
TACACCCTCGTCCTGACACTCGTCGGGCTGCTCTGCGTCGAGTTTACGCTTGCTCCTGTAACCGAATGGTTTATGCAAAT
GGGCTGGATAGCAACGCTTTGA

Upstream 100 bases:

>100_bases
CCCTTGACTATCAAGACTTGCCTCACTCCTGTCTGACCGTTAAGCTTTGCGTTTAAACATAAAAACATCATTGATTATTT
CTAAGGTAAGGGAAACCATC

Downstream 100 bases:

>100_bases
TAACAACTTACCGGGCATATAAATGCCCGGTTTGCCTTTTCGCCCGATAATTGTCCAATTGCGTCCTATTTTTGCTGCCT
CCTGGTGGCGCAGCGAATGA

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MEISWGRALWRNFLGQSPDWYKLALIIFLIVNPLIFLISPFVAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVFIGMT
SAEHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMLLSLSFCVAAAFLSAFLDALTVVAVVISVAVG
FYGIYHRVASSRTEDTDLQDDSHIDKHYKVVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFL
RMSPVTVPVLICGLLTCLLVEKLRWFGYGETLPEKVREVLQQFDDQSRLQRTRQDKIRLIVQAIIGVWLVTALALHLAEV
GLIGLSVIILATSLTGVTDEHAIGKAFTESLPFTALLTVFFSVVAVIIDQQLFSPIIQFVLQASEHAQLSLFYIFNGLLS
SISDNVFVGTIYINEAKAAMKSGAITLKQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALP
YTLVLTLVGLLCVEFTLAPVTEWFMQMGWIATL

Sequences:

>Translated_513_residues
MEISWGRALWRNFLGQSPDWYKLALIIFLIVNPLIFLISPFVAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVFIGMT
SAEHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMLLSLSFCVAAAFLSAFLDALTVVAVVISVAVG
FYGIYHRVASSRTEDTDLQDDSHIDKHYKVVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFL
RMSPVTVPVLICGLLTCLLVEKLRWFGYGETLPEKVREVLQQFDDQSRLQRTRQDKIRLIVQAIIGVWLVTALALHLAEV
GLIGLSVIILATSLTGVTDEHAIGKAFTESLPFTALLTVFFSVVAVIIDQQLFSPIIQFVLQASEHAQLSLFYIFNGLLS
SISDNVFVGTIYINEAKAAMKSGAITLKQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALP
YTLVLTLVGLLCVEFTLAPVTEWFMQMGWIATL
>Mature_513_residues
MEISWGRALWRNFLGQSPDWYKLALIIFLIVNPLIFLISPFVAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVFIGMT
SAEHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMLLSLSFCVAAAFLSAFLDALTVVAVVISVAVG
FYGIYHRVASSRTEDTDLQDDSHIDKHYKVVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFL
RMSPVTVPVLICGLLTCLLVEKLRWFGYGETLPEKVREVLQQFDDQSRLQRTRQDKIRLIVQAIIGVWLVTALALHLAEV
GLIGLSVIILATSLTGVTDEHAIGKAFTESLPFTALLTVFFSVVAVIIDQQLFSPIIQFVLQASEHAQLSLFYIFNGLLS
SISDNVFVGTIYINEAKAAMKSGAITLKQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALP
YTLVLTLVGLLCVEFTLAPVTEWFMQMGWIATL

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1787435, Length=513, Percent_Identity=99.6101364522417, Blast_Score=1026, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004671 [H]

Pfam domain/function: PF06450 NhaB [H]

EC number: NA

Molecular weight: Translated: 56704; Mature: 56704

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA